Pleckstrin homology domain-containing family M member 2 (PLEKHM2) is a 1019-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8IWE5.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 64.5 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 32% |
| 70 to 90 | Confident: backbone generally right | 21% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 42% |
What pLDDT means and how to read it
Plays a role in lysosomes movement and localization at the cell periphery acting as an effector of ARL8B. Required for ARL8B to exert its effects on lysosome location, recruits kinesin-1 to lysosomes and hence direct their movement toward microtubule plus ends. Binding to ARL8B provides a link from lysosomal membranes to plus-end-directed motility (PubMed:22172677, PubMed:24088571, PubMed:25898167, PubMed:28325809). Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). Required for maintenance of the…
Interacts with KLC2 (via TPR repeats) (Probable). Interacts with KIF5B (PubMed:15905402). Interacts with BORCS5 (PubMed:25898167). Interacts (via RUN domain) with ARL8B (GTP-bound form); PLEKHM1 and PLEKHM2 compete for interaction with ARL8B (PubMed:22172677, PubMed:28325809). Interacts with ARL8A (PubMed:28325809)
Cytoplasm, Lysosome membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8JCA | X-ray | 1.65 Å | B=1-165 |
| 3CXB | X-ray | 2.6 Å | B=773-884 |
| 3ZFW | X-ray | 2.9 Å | X/Y=203-212 |
| 3HW2 | X-ray | 3.3 Å | B=771-875 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.