8JFY: RDGC/Ca2+-CaM complex

Cryo-EM structure of RDGC/Ca2+-CaM complex. Determined by electron microscopy at 2.79 Å resolution. Released 27 Nov 2024.

Method
Electron microscopy
Resolution
2.79 Å
Organism
Drosophila melanogaster
Chains
4
Atoms
11,870
Mol. weight
172.22 kDa
Ligands
PO4, FE, ZN, CA
Released
27 Nov 2024

Explore 8JFY in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8JFY contains 78 α-helices and 48 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A and B: 9 helices, 4 β-strands

ElementResiduesLengthSheet
α-helix2-43
α-helix7-2014
β-strand27-2821
α-helix30-3910
α-helix46-5510
β-strand64-6521
α-helix66-7813
α-helix82-9312
β-strand10112
α-helix103-11311
α-helix119-12911
β-strand13712
α-helix139-1479
Chains C and D: 30 helices, 20 β-strands
ElementResiduesLengthSheet
α-helix3-2826
α-helix31-399
α-helix40-445
α-helix45-517
β-strand91111
α-helix92-932
α-helix102-11312
β-strand119111
α-helix120-1212
α-helix122-13817
β-strand142-145412
β-strand152-156513
α-helix163-17311
β-strand177114
β-strand180114
β-strand182-184313
α-helix195-20814
β-strand213-215313
α-helix223-2297
α-helix231-2388
α-helix243-25614
β-strand260-263412
β-strand267-269312
α-helix280-2834
α-helix307-31812
β-strand320-321215
β-strand327-329315
β-strand337-339315
α-helix341-35111
β-strand355-358412
β-strand367-370412
β-strand375-378412
β-strand392-398713
β-strand403-408613
α-helix414-4174
α-helix428-43811
α-helix439-4424
α-helix443-45311
β-strand460-462316
α-helix463-47311
α-helix480-4878
β-strand495-497316
α-helix498-5069
α-helix508-5125
α-helix520-5256
α-helix531-5388
α-helix548-55811
α-helix565-5673
α-helix568-57811
α-helix588-60417

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
AT15141pA, Bprotein149Drosophila melanogasterC6SUZ2 (AlphaFold model)
Serine/threonine-protein phosphatase rdgCC, Dprotein599Drosophila melanogasterP40421 (AlphaFold model)
Sequence of entity 1 (A, B), FASTA
>8JFY_1 AT15141p (chains A, B)
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG
NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGFISAAELRHVMTNLGEKLTDE
EVDEMIREADIDGDGQVNYEEFVTMMTSK
Sequence of entity 2 (C, D), FASTA
>8JFY_2 Serine/threonine-protein phosphatase rdgC (chains C, D)
MDENAIRAAIFIQKWYRRHQARREMQRRCNWQIFQNLEYASEQDQAELYKFFNDLIKHMP
QAAGRKNQYQGSDDKDDLVEEFGDIVNAKIELPIRKNHIDLLIDVFRKKRGNRLHPKYVA
LILREAAKSLKQLPNISPVSTAVSQQVTVCGDLHGKLDDLLVVLHKNGLPSSSNPYVFNG
DFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNARYGFIREVESKYPRNHKRI
LAFIDEVYRWLPLGSVLNSRVLIVHGGFSDSTSLDLIKSIDRGKYVSILRPPLTDGEPLD
KTEWQQIFDIMWSDPQATMGCVPNTLRGAGVWFGPDVTDNFLQRHRLSYVIRSHECKPNG
HEFMHDNKIITIFSASNYYAIGSNKGAYIRLNNQLMPHFVQYISAASQTKRLSFKQRMGI
VESSALKELAVRMRDHRDELEDEFRKYDPKDSGYISISHWCKVMENVTKLGLPWRLLRDK
LAPGTDSQKVNYNRTLDLLDTDVILEAEADGMSVMDALYANKASLVAIFNIIDADNSGEI
TLDEFETAIDLLVAHMPGAYSKAEMLEKCRMMDLNGDGKVDLNEFLEAFRLSDLHRKEQ

Ligands and cofactors

IDNameFormulaCopies
PO4Phosphate ionO4 P2
FEFE (III) ionFe2
ZNZinc ionZn2
CACalcium ionCa12

Primary citation

Cryo-EM structure of RDGC/Ca2+-CaM complex. Liu, Z.M., Liu, W., Wu, C. et al. To be published.

Other PDB entries of the same protein (UniProt C6SUZ2 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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