8OOP: RuvB-like protein 1

CryoEM Structure INO80core Hexasome complex composite model state2. Determined by electron microscopy at 2.7 Å resolution. Released 26 Jul 2023.

Method: Electron microscopy
Resolution: 2.7 Å
Organisms: Thermochaetoides thermophila, synthetic construct, Homo sapiens
Chains: 18
Atoms: 40,747
Mol. weight: 830.3 kDa
Ligands: ATP, ALF, MG, ADP
Released: 26 Jul 2023

Explore 8OOP in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8OOP contains 265 α-helices and 241 β-strands across 16 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 24 helices, 27 β-strands

Element	Residues	Length	Sheet
β-strand	16	1	1
β-strand	27	1	2
β-strand	33	1	2
β-strand	36-37	2	3
β-strand	40-41	2	3
α-helix	44-58	15
β-strand	62	1	4
β-strand	66-70	5	5
α-helix	77-88	12
β-strand	94-98	5	5
α-helix	99-102	4
α-helix	109-119	11
β-strand	121-144	24	6
β-strand	154-163	10	6
β-strand	168-173	6	6
α-helix	175-183	9
β-strand	190-195	6	6
β-strand	200-207	8	6
α-helix	208-210	3
β-strand	215	1	7
β-strand	221-222	2	6
α-helix	223-226	4
β-strand	230-240	11	6
α-helix	241-249	9
α-helix	257-262	6
α-helix	266-267	2
α-helix	274-289	16
β-strand	293-297	5	6
β-strand	299-303	5	5
α-helix	305-307	3
α-helix	310-319	10
β-strand	327-332	6	5
β-strand	334	1	8
β-strand	336-338	3	9
α-helix	339	1
β-strand	346-348	3	9
α-helix	353-356	4
β-strand	359-363	5	5
α-helix	366-368	3
α-helix	369-383	15
β-strand	387	1	10
α-helix	389-401	13
α-helix	404-409	6
α-helix	411-420	10
β-strand	426	1	10
α-helix	428-437	10
β-strand	439	1	11
α-helix	441-451	11
α-helix	456-458	3
α-helix	460	1
β-strand	461	1	12

Chain B: 24 helices, 29 β-strands

Element	Residues	Length	Sheet
β-strand	16	1	13
β-strand	27	1	14
α-helix	32	1
β-strand	33	1	14
α-helix	34	1
β-strand	36-37	2	15
β-strand	40-41	2	15
α-helix	44-58	15
β-strand	62	1	16
β-strand	66-71	6	17
α-helix	77-87	11
β-strand	94-98	5	17
α-helix	99-102	4
α-helix	109-119	11
β-strand	121-141	21	18
β-strand	158-164	7	18
β-strand	167-173	7	18
α-helix	174	1
α-helix	175-183	9
β-strand	190-195	6	18
β-strand	200-207	8	18
α-helix	208-210	3
β-strand	216	1	19
β-strand	221-222	2	18
α-helix	223-225	3
β-strand	230-240	11	18
α-helix	241-249	9
α-helix	253-255	3
α-helix	257-261	5
α-helix	263-265	3
α-helix	274-289	16
β-strand	293-297	5	18
β-strand	299-303	5	17
α-helix	305-307	3
β-strand	309	1	20
α-helix	310-319	10
β-strand	327-332	6	17
β-strand	334	1	21
β-strand	336-339	4	22
β-strand	340	1	20
β-strand	342-348	7	22
α-helix	353-356	4
β-strand	359-364	6	17
α-helix	365-368	4
α-helix	369-383	15
β-strand	387	1	23
α-helix	389-401	13
α-helix	404-420	17
β-strand	426	1	23
α-helix	428-437	10
β-strand	439	1	24
α-helix	441-451	11
β-strand	461	1	25

Chain C: 24 helices, 27 β-strands

Element	Residues	Length	Sheet
β-strand	5	1	26
α-helix	13-15	3
β-strand	16	1	27
β-strand	27	1	28
α-helix	32	1
β-strand	33	1	28
α-helix	34	1
β-strand	36-37	2	29
β-strand	40-41	2	29
α-helix	44-59	16
β-strand	62	1	30
β-strand	66-71	6	31
α-helix	77-88	12
β-strand	94-98	5	31
α-helix	99-102	4
α-helix	109-119	11
β-strand	121-143	23	7
α-helix	147-148	2
β-strand	153-164	12	7
β-strand	167-173	7	7
α-helix	175-177	3
α-helix	178-184	7
β-strand	190-195	6	7
β-strand	201-207	7	7
α-helix	208-210	3
β-strand	216	1	26
β-strand	221-222	2	7
α-helix	223-225	3
β-strand	230-240	11	7
α-helix	241-249	9
α-helix	257-264	8
α-helix	274-290	17
β-strand	293-297	5	7
β-strand	299-303	5	31
α-helix	305-307	3
α-helix	310-321	12
β-strand	327-332	6	31
β-strand	336-339	4	32
β-strand	342-348	7	32
α-helix	353-356	4
β-strand	359-364	6	31
α-helix	369-383	15
β-strand	386-387	2	33
α-helix	389-401	13
α-helix	404-409	6
α-helix	411-419	9
β-strand	425-426	2	33
α-helix	428-437	10
β-strand	439	1	34
α-helix	441-451	11
β-strand	461	1	35

Chain D: 24 helices, 27 β-strands

Element	Residues	Length	Sheet
β-strand	21	1	30
β-strand	32	1	36
α-helix	38	1
β-strand	39	1	36
α-helix	40	1
β-strand	42-43	2	37
β-strand	46-47	2	37
α-helix	50-65	16
β-strand	68	1	1
β-strand	72-76	5	11
α-helix	83-94	12
β-strand	100-104	5	11
α-helix	105-108	4
α-helix	115-125	11
β-strand	127-150	24	7
β-strand	156-163	8	7
β-strand	168-173	6	7
α-helix	175-183	9
β-strand	190-195	6	7
β-strand	201-206	6	7
α-helix	209-211	3
β-strand	223	1	7
α-helix	225-227	3
β-strand	232-242	11	7
α-helix	243-250	8
α-helix	258-261	4
α-helix	269-284	16
β-strand	288-292	5	7
β-strand	294-298	5	11
α-helix	300-302	3
β-strand	304	1	38
α-helix	305-314	10
α-helix	320-321	2
β-strand	322-327	6	11
β-strand	329	1	12
β-strand	331-333	3	39
α-helix	334	1
β-strand	335	1	38
β-strand	340-342	3	39
α-helix	347-350	4
β-strand	353-357	5	11
α-helix	360-362	3
α-helix	363-376	14
β-strand	381	1	40
α-helix	383-396	14
α-helix	398-414	17
β-strand	420	1	40
α-helix	422-431	10
β-strand	433	1	31
α-helix	435-443	9
α-helix	450-451	2

Chain E: 25 helices, 29 β-strands

Element	Residues	Length	Sheet
β-strand	21	1	4
β-strand	32	1	41
α-helix	38	1
β-strand	39	1	41
α-helix	40	1
β-strand	42-43	2	42
β-strand	46-47	2	42
α-helix	50-65	16
β-strand	68	1	13
β-strand	72-76	5	24
α-helix	83-94	12
α-helix	95-97	3
β-strand	100-104	5	24
α-helix	105-108	4
α-helix	115-125	11
β-strand	127-148	22	19
β-strand	157-163	7	19
β-strand	168-173	6	19
α-helix	175-183	9
β-strand	190-195	6	19
β-strand	200-206	7	19
β-strand	207	1	43
α-helix	208-213	6
β-strand	224	1	43
α-helix	225-226	2
β-strand	232-242	11	19
α-helix	243-249	7
α-helix	255-257	3
α-helix	258-261	4
α-helix	269-285	17
β-strand	289-292	4	19
β-strand	294-298	5	24
α-helix	300-302	3
β-strand	304	1	44
α-helix	305-314	10
α-helix	320-321	2
β-strand	322-327	6	24
β-strand	329	1	25
β-strand	331-333	3	45
α-helix	334	1
β-strand	335	1	44
β-strand	340-342	3	45
α-helix	347-350	4
β-strand	353-357	5	24
α-helix	358-362	5
α-helix	363-376	14
β-strand	381	1	46
α-helix	383-396	14
α-helix	398-414	17
β-strand	420	1	46
α-helix	422-431	10
β-strand	433	1	5
α-helix	435-444	10
β-strand	450	1	8

Chain F: 24 helices, 29 β-strands

Element	Residues	Length	Sheet
β-strand	21	1	16
β-strand	32-33	2	47
β-strand	38-39	2	47
α-helix	40	1
β-strand	42-43	2	48
β-strand	46-47	2	48
α-helix	50-65	16
β-strand	68	1	27
β-strand	72-76	5	34
α-helix	83-94	12
β-strand	100-104	5	34
α-helix	105-108	4
α-helix	115-124	10
β-strand	127-148	22	26
β-strand	157-163	7	26
β-strand	168-173	6	26
α-helix	174	1
α-helix	175-183	9
β-strand	190-195	6	26
β-strand	200-207	8	26
α-helix	208-213	6
β-strand	216	1	18
β-strand	223-224	2	26
α-helix	225-227	3
β-strand	232-242	11	26
α-helix	243-251	9
α-helix	255-257	3
α-helix	258-261	4
α-helix	269-284	16
β-strand	288-292	5	26
β-strand	294-298	5	34
α-helix	300-302	3
β-strand	304	1	49
α-helix	305-315	11
α-helix	320-321	2
β-strand	322-327	6	34
β-strand	329	1	35
β-strand	331-333	3	50
α-helix	334	1
β-strand	335	1	49
β-strand	340-342	3	50
α-helix	347-350	4
β-strand	353-357	5	34
α-helix	360-362	3
α-helix	363-376	14
β-strand	381	1	51
α-helix	383-396	14
α-helix	398-414	17
β-strand	420	1	51
α-helix	422-431	10
β-strand	433	1	17
α-helix	435-444	10
β-strand	450	1	21

Chain G: 49 helices, 31 β-strands

Element	Residues	Length	Sheet
α-helix	966-968	3
α-helix	974-988	15
β-strand	993-995	3	52
α-helix	997-998	2
α-helix	1003-1018	16
β-strand	1024-1028	5	52
α-helix	1030-1032	3
α-helix	1033-1043	11
β-strand	1049-1052	4	52
α-helix	1056-1062	7
α-helix	1063-1065	3
β-strand	1081-1085	5	52
α-helix	1088-1091	4
α-helix	1093-1096	4
β-strand	1101	1	53
β-strand	1103-1106	4	52
α-helix	1109-1111	3
α-helix	1118-1124	7
β-strand	1128	1	53
β-strand	1131-1134	4	52
α-helix	1144-1153	10
α-helix	1187-1189	3
α-helix	1190-1193	4
β-strand	1198-1199	2	52
β-strand	1214-1217	4	54
β-strand	1220	1	55
α-helix	1224-1239	16
α-helix	1257-1269	13
α-helix	1271-1274	4
β-strand	1280	1	56
α-helix	1282	1
β-strand	1283-1284	2	57
β-strand	1286-1287	2	58
α-helix	1295-1297	3
β-strand	1300-1303	4	6
β-strand	1308-1309	2	58
β-strand	1312-1314	3	59
α-helix	1317-1320	4
β-strand	1330	1	60
β-strand	1333	1	60
α-helix	1334-1341	8
α-helix	1342-1346	5
α-helix	1352-1355	4
β-strand	1361	1	26
α-helix	1366-1370	5
α-helix	1375-1383	9
α-helix	1386-1392	7
α-helix	1393-1395	3
α-helix	1399-1406	8
α-helix	1410-1412	3
α-helix	1418-1420	3
α-helix	1424-1427	4
α-helix	1430-1434	5
β-strand	1437	1	7
α-helix	1441-1445	5
α-helix	1448-1455	8
α-helix	1462-1463	2
β-strand	1469-1470	2	57
α-helix	1472-1474	3
β-strand	1475-1477	3	59
α-helix	1481-1491	11
α-helix	1494-1501	8
α-helix	1505-1513	9
α-helix	1528-1530	3
β-strand	1541	1	56
α-helix	1545-1550	6
α-helix	1553-1568	16
β-strand	1572-1576	5	54
α-helix	1579-1590	12
β-strand	1596-1599	4	54
α-helix	1605-1617	13
β-strand	1623-1627	5	54
α-helix	1628-1632	5
β-strand	1642-1645	4	54
α-helix	1652-1662	11
β-strand	1672-1675	4	54
α-helix	1677	1
β-strand	1678	1	55
α-helix	1683-1699	17
β-strand	1705	1	52

Chain H: 1 helix, 2 β-strands

Element	Residues	Length	Sheet
β-strand	447-453	7	7
β-strand	456-461	6	7
α-helix	469-474	6

8 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
RuvB-like protein 1	A, B, C	protein	462	Thermochaetoides thermophila	G0RYI5 (AlphaFold model)
RuvB-like protein 2	D, E, F	protein	488	Thermochaetoides thermophila	G0RYC2 (AlphaFold model)
Chromatin-remodeling ATPase Ino80	G	protein	1134	Thermochaetoides thermophila
Ino eighty subunit 2	H	protein	492	Thermochaetoides thermophila	G0RY01 (AlphaFold model)
Chromatin-remodeling complex subunit IES6	I	protein	219	Thermochaetoides thermophila	G0S590 (AlphaFold model)
Actin-related protein 5	J	protein	769	Thermochaetoides thermophila	G0S589
DNA strand 1	K	DNA	226	synthetic construct
DNA Strand 2	L	DNA	226	synthetic construct
Histone H3.1	M, Q	protein	135	Homo sapiens	P68431
Histone H4	N, R	protein	102	Homo sapiens	P62805
Histone H2A	O	protein	129	Homo sapiens	Q93077
Histone H2B	P	protein	125	Homo sapiens	P62807

Sequence of entity 1 (A, B, C), FASTA

>8OOP_1 RuvB-like protein 1 (chains A, B, C)
MVQISEVRGNTRDHRTAAHTHIKGLGLNSSGIAEKQAAGFVGQCAAREACGVVVDLIKAH
KMAGRGVLLAGGPGTGKTALALAISQELGTKIPFCPITGSEIYSTEVKKTEVLMENFRRA
IGLRVRETKDVYEGEVTEMTPEEAENPLGGYGKTISTLLIGLKSARGQKKLRLDPSIYEA
IQKERVQVGDVIYIETNTGACKRVGRSDAYATEFDLEAEEYVPIPKGEVHKKKEIVQDVT
LHDLDVANARPQGGQDIISMMGQLMKPKMTEITDKLRMEINKVVQKYINQGVAELIPGVL
FIDEAHMLDIECFTYLNKALESPIAPIVVLASNRGIATIRGADDLKAAHGIPPDFLQRLL
IIPTHPYEPDEIRRIVRIRAQTEGVQLTDAAVDRVAEHGVRISLRYCLQLLAPASILARV
NGRTQVDVQDIAEAEELFLDARRSANILTSTGESGGLHGFIS

Sequence of entity 2 (D, E, F), FASTA

>8OOP_2 RuvB-like protein 2 (chains D, E, F)
MAAPLVTSVTETKELRGLNLIAAHSHIRGLGVDADTLEPRPSSQGLVGQEKARKAAAVVL
EMIKQGKIAGRAVLIAGPPSTGKTAIAMGMAQSLGQDVPFTTLAASEIFSLEMSKTEALT
QAFRKSIGVRIKEESEIMEGEVVEIQIDRSVTGGAKQGKLTIKTTDMEAIYDMGSKMIDA
MTKERVMAGDIISIDKSSGKITKLGRSYARSRDYDAMGVDTKFLQCPEGELQKRKEVVHT
VSLHEIDVINSRTQGFLALFSGDTGEIRSEIRDQINTKVAEWKEEGKAEIVPGVLFIDEV
HMLDIECFSYINRALESDLAPIVIMASNRGVSRIRGTDYKSPHGLPLDFLDRVVIINTHP
YTPDELRQILSIRAQEEEVDLTPDALALLTKIGQEAGLRYASNLITTSQLIAAKRRAKQV
GVEDVQRSFKLFYDPARSVRFVQESEKRLIGNDGVVDFSYQGAAEAAAPTLPAAAPVDPV
GGEKMDMS

Sequence of entity 3 (G), FASTA

>8OOP_3 Chromatin-remodeling ATPase Ino80 (chains G)
LELKFQSKGYNQIYDQIWRDLARKDVSKVFRLATDSYATKASNLKKTAILASKEAKRWQL
RTNKGTKDLQARAKRVMRDMMGFWKRNEREERDLRKAAERLELENARKEEADREAARQRR
KLNFLISQTELYSHFISKKIKTHEVERSTDHPDVATDEKDKIPEPTLNINVPEPTGPIAP
KVTDFNSLDFDNEDESALQAAAMANAQNAIAEAQKKAREFNKDETKLDEDGEMNFQHPEL
TEFEVAQPKLLNCQLKEYQLKGLNWLVNLYEQGINGILADEMGLGKTVQSISVMAYLAER
YDIWGPFLVVAPASTLHNWQQEVSKFVPDFKVLPYWGTAADRKVLRKFWDRKHTTYKKDS
PFHVMITSYQLVVSDVAYFQKMKWQYMILDEAQAIKSSQSSRWKCLLGFHCRNRLLLTGT
PIQNNMQELWALLHFIMPSLFDSHDEFSEWFSKDIESHAQSNTKLNEDQLKRLHMILKPF
MLRRVKKHVQKELGDKIEIDVFCELSYRQRAMYQSLRNQISIMDLIEKATVGDNEDSATL
MNLVMQFRKVCNHPDLFERADTSSPFFCGHFAETGSFLREGTNVALGYSTRSLVEYRLPR
LIWCDGGRLDKPGPGNLVAGFRSKYLNHMMNIWTPENIRSSLEGIENFTWLRFVDTSLQE
AYRASHTDVFARAVDLASKQNRLGHMQIVYDEPEDKKWTPVHALFQICERENPKAVAEIT
TEGVLRDLMNIARVKYRELGLCRLEKAARPRASAPPIEVVCDSRSAVIERENIMFHPAMR
KALFGPTPSEIKEASFGPRPVTLYPPRALLPAPDHDKQRFTNITVPSMARFVTDSGKLAK
LDELLRELKEGGHRVLLYFQMTRMIDLMEEYLTYRNYKYCRLDGSTKLEDRRDTVADFQT
RPEIFIFLLSTRAGGLGINLTTADTVIFYDSDWNPTIDSQAMDRAHRLGQTKQVTVYRLI
TRGTIEERIRKRALQKEEVQRVVITGTGSVDFSGRRPPENRNRDIAMWLADDEQAEMIER
REKELIESGEYDKIMQQRRKGGKRKRGAANGDTVPSLEDMYHEGEGHFDDNKGSGAATPV
DADSLGRGGKRKKAGGSKKAKTTKQRLAIADGEIDIDYKDDDDKGTDYKDDDDK

Sequence of entity 4 (H), FASTA

>8OOP_4 Ino eighty subunit 2 (chains H)
MSTRPRRHAAQRASQAITDLADRDRESDHSHGPISSRMSSFNSSSRSRLPGKGIASVSRS
EAGGASDPEHIHLTVKLPSSKLRQATSSSGIKKAGSVGSSSSSSGGGKAAVKRARGGKRS
RVLESSEEEEEENEVEVLGDEDEEEEEEEDEIEVREGEGYDEDEEDVEDEDEEMQDLGEE
DADGEDDEMDVDAEGEEDADGDVNMDAGVVGARATTVRAVPPAIKVTKPPKESPSNGKAA
TASKANDNAVPVKRPAPDSDDESLSSLESEPEEEVNVAGGEDAEGEDDDAEGEVDAEGEE
EEEEEEIEVADEDAEGEDVEQDEDEDEEEEDDDDEMISRAQTPDMSRLTARQRARLGEAS
GEYLKLSDEVQSKKHFTAEELSMRRAEMARRRRNLSEKRNEEIKMETVNKLLKKQAPRTT
RRAAQAAAAAEEAEEAAKQPKRPDPMMIRWVNNKMGSVVAVPEELLGTHAGVVFGAGPGK
GLPAGKMVEEVS

Sequence of entity 5 (I), FASTA

>8OOP_5 Chromatin-remodeling complex subunit IES6 (chains I)
MSNPDAQSAQAAHQALVEQLDLHSIHKTFRNPNWRPNQRRNKTIKAILGESQRKEASSTS
AVATPRADDNGGGSGADTPANNDNNDGLSTSGTSTPANGNGSGAGTPASNGQPNLAQASR
SLQKLVLEKSLASAQAPDKKAANGFASSAPTATYTNIESAPSLAPMKHYCDVTGLPAPYL
DPKTRLRYHNKEIFAMIRNLPQGMGEQFLEARGAHTVLK

Sequence of entity 6 (J), FASTA

>8OOP_6 Actin-related protein 5 (chains J)
MAPSAVAEPPPIPQRDEPWKRLPPPTVYPVKEARFEKYIPPQLDGRERALAQPPGQVAIV
IDNGSHSVRAGWNFEDKPRLAIPPIMSKYRDRKMGKTFSFAGSDCYADTTARSHIRNAFE
AGTGIVSNWDVMEHVLDYVFVKLGMNECDGAIDMPIVMTEAVANLPYSRKSMSEIIFECY
GAPSLVYGIDSLFSFRHNQGQTGLVVSSSYSATHVIPVYNRKALLSQAIRLNWGGWHMAE
YMLKLLKLKYYTGFPGKLNSSQTEHMVRDFCYVSLDYDRELAGYLDWTGLEDRERIVQYP
YTEEVVVQKTEEELARIAERKKESGRRLQEQAAKMRLERLMKKEQELEYYKDIQRRMQGE
SKKEIKRLLDEAELKDEAALERVIRDLERSIKRARQKDLGEPEEEEVPDFSLLDVPDDQL
DEAGLRQKRQQRLLKSNWEARQRAKAEKEAEKARLAEEARLDEERRKNDLEGWLEEKRQL
RLAKLNQLKERERLKADLGNRKSLASQIRMKNIANLASDNPTGSGSRKRRRGGAGADQDD
DFGADDADWGVYRSVAIGANKGDDSDDEEGEEDLEAAIRSLENDLLRYDKTFSYDMTLDA
QRDWSKSLLHAFRYGPRPFDPSSQAETHRVHLNVERIRVPEVLFQPAAIAGVDQAGLVEI
AGDILCQRLPSLPGIQDAPDAFLRDVFLTGGNTLFQNFDERLRQGLMALLPVGAPLRVRR
AQDAILDAWRGAAGWACTEEAKAAWITREEYLEKGGEYIKEHDLGNAFA

Sequence of entity 7 (K), FASTA

>8OOP_7 DNA strand 1 (chains K)
CTGGAGAATCCCGGTGCCGAGGCCGCTCAATTGGTCGTAGCAAGCTCTAGCACCGCTTAA
ACGCACGTACGCGCTGTCCCCCGCGTTTTAACCGCCAAGGGGATTACTCCCTAGTCTCCA
GGCACGTGTCAGATATATACATCCTGTGCATGTATTGAACAGCGACCTTGCCGGTGCCAG
TCGGATAGTGTTCCGAGCTCCCACTCTAGAGGATCCCCGGGTACCG

Sequence of entity 8 (L), FASTA

>8OOP_8 DNA Strand 2 (chains L)
CGGTACCCGGGGATCCTCTAGAGTGGGAGCTCGGAACACTATCCGACTGGCACCGGCAAG
GTCGCTGTTCAATACATGCACAGGATGTATATATCTGACACGTGCCTGGAGACTAGGGAG
TAATCCCCTTGGCGGTTAAAACGCGGGGGACAGCGCGTACGTGCGTTTAAGCGGTGCTAG
AGCTTGCTACGACCAATTGAGCGGCCTCGGCACCGGGATTCTCCAG

Sequence of entity 9 (M, Q), FASTA

>8OOP_9 Histone H3.1 (chains M, Q)
ARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTEL
LIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIM
PKDIQLARRIRGERA

Sequence of entity 10 (N, R), FASTA

>8OOP_10 Histone H4 (chains N, R)
SGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKV
FLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG

Sequence of entity 11 (O), FASTA

>8OOP_11 Histone H2A (chains O)
SGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTA
EILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPKKT
ESHHKAKGK

Sequence of entity 12 (P), FASTA

>8OOP_12 Histone H2B (chains P)
PEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMG
IMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTK
YTSSK

Ligands and cofactors

ID	Name	Formula	Copies
ATP	Adenosine-5'-triphosphate	C10 H16 N5 O13 P3	1
ALF	Tetrafluoroaluminate ion	Al F4	1
MG	Magnesium ion	Mg	2
ADP	Adenosine-5'-diphosphate	C10 H15 N5 O10 P2	7

Primary citation

Hexasome-INO80 complex reveals structural basis of noncanonical nucleosome remodeling. Zhang, M., Jungblut, A., Kunert, F. et al. Science (2023) 381:313-319. DOI 10.1126/science.adf6287 · PubMed

Other PDB entries of the same protein (UniProt G0RYI5 (AlphaFold model), which also has an AlphaFold model), best resolution first:

8OO7 2.8 Å, CryoEM Structure INO80core Hexasome complex composite model state1
8OOR 2.87 Å, CryoEM Structure INO80core Hexasome complex Rvb core refinement state2
5FM7 2.9 Å, Double-heterohexameric rings of full-length Rvb1(ADP)Rvb2(ADP)
8OOC 2.93 Å, CryoEM Structure INO80core Hexasome complex Rvb core refinement state1
4WW4 2.94 Å, Double-heterohexameric rings of full-length Rvb1(ADP)/Rvb2(ADP)
5FM6 3.0 Å, Double-heterohexameric rings of full-length Rvb1(ADP)Rvb2(apo)
4WVY 3.64 Å, Double-heterohexameric rings of full-length Rvb1(ATP)/Rvb2(apo)
6FHS 3.75 Å, CryoEM Structure of INO80core
6FML 4.34 Å, CryoEM Structure INO80core Nucleosome complex
8AV6 4.68 Å, CryoEM structure of INO80 core nucleosome complex in closed grappler conformation

Browse structure collections

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