CryoEM Structure INO80core Hexasome complex Arp5 Ies6 refinement state2. Determined by electron microscopy at 2.85 Å resolution. Released 26 Jul 2023.
Explore 8OOT in 3D Show helices and sheets RCSB PDB PDBe
8OOT contains 37 α-helices and 24 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 8-20 | 13 | |
| α-helix | 38-40 | 3 | |
| α-helix | 44-49 | 6 | |
| α-helix | 165-167 | 3 | |
| β-strand | 169 | 1 | 1 |
| β-strand | 176 | 1 | 1 |
| β-strand | 179-180 | 2 | 2 |
| β-strand | 187-188 | 2 | 2 |
| α-helix | 191-198 | 8 | |
| α-helix | 204-212 | 9 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 18-21 | 4 | |
| α-helix | 23-26 | 4 | |
| β-strand | 27-29 | 3 | 3 |
| α-helix | 30-31 | 2 | |
| α-helix | 43-51 | 9 | |
| α-helix | 53 | 1 | |
| β-strand | 59-63 | 5 | 4 |
| β-strand | 68-72 | 5 | 4 |
| β-strand | 80-82 | 3 | 4 |
| β-strand | 85-91 | 7 | 5 |
| β-strand | 96-100 | 5 | 5 |
| β-strand | 115-117 | 3 | 5 |
| β-strand | 119 | 1 | 6 |
| α-helix | 120 | 1 | |
| β-strand | 126 | 1 | 6 |
| α-helix | 129-142 | 14 | |
| β-strand | 156-159 | 4 | 4 |
| α-helix | 166-174 | 9 | |
| α-helix | 175-179 | 5 | |
| β-strand | 184-188 | 5 | 4 |
| α-helix | 190-197 | 8 | |
| β-strand | 203-208 | 6 | 7 |
| β-strand | 213-219 | 7 | 7 |
| β-strand | 222-223 | 2 | 7 |
| α-helix | 225-227 | 3 | |
| β-strand | 229-230 | 2 | 7 |
| α-helix | 235-249 | 15 | |
| α-helix | 260-270 | 11 | |
| α-helix | 277-282 | 6 | |
| α-helix | 290-293 | 4 | |
| β-strand | 296-298 | 3 | 3 |
| α-helix | 604-606 | 3 | |
| α-helix | 608-614 | 7 | |
| β-strand | 629-631 | 3 | 3 |
| α-helix | 635-638 | 4 | |
| α-helix | 640-642 | 3 | |
| α-helix | 646-650 | 5 | |
| α-helix | 657-663 | 7 | |
| α-helix | 664-668 | 5 | |
| α-helix | 669-671 | 3 | |
| α-helix | 680-683 | 4 | |
| β-strand | 686-689 | 4 | 7 |
| α-helix | 691-693 | 3 | |
| α-helix | 698-709 | 12 | |
| α-helix | 711 | 1 | |
| β-strand | 718-720 | 3 | 7 |
| α-helix | 721 | 1 | |
| α-helix | 727-735 | 9 | |
| α-helix | 739-744 | 6 | |
| β-strand | 746-747 | 2 | 4 |
| α-helix | 748-754 | 7 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Chromatin-remodeling complex subunit IES6 | I | protein | 219 | Thermochaetoides thermophila | G0S590 (AlphaFold model) |
| Actin-related protein 5 | J | protein | 769 | Thermochaetoides thermophila | G0S589 (AlphaFold model) |
>8OOT_1 Chromatin-remodeling complex subunit IES6 (chains I) MSNPDAQSAQAAHQALVEQLDLHSIHKTFRNPNWRPNQRRNKTIKAILGESQRKEASSTS AVATPRADDNGGGSGADTPANNDNNDGLSTSGTSTPANGNGSGAGTPASNGQPNLAQASR SLQKLVLEKSLASAQAPDKKAANGFASSAPTATYTNIESAPSLAPMKHYCDVTGLPAPYL DPKTRLRYHNKEIFAMIRNLPQGMGEQFLEARGAHTVLK
>8OOT_2 Actin-related protein 5 (chains J) MAPSAVAEPPPIPQRDEPWKRLPPPTVYPVKEARFEKYIPPQLDGRERALAQPPGQVAIV IDNGSHSVRAGWNFEDKPRLAIPPIMSKYRDRKMGKTFSFAGSDCYADTTARSHIRNAFE AGTGIVSNWDVMEHVLDYVFVKLGMNECDGAIDMPIVMTEAVANLPYSRKSMSEIIFECY GAPSLVYGIDSLFSFRHNQGQTGLVVSSSYSATHVIPVYNRKALLSQAIRLNWGGWHMAE YMLKLLKLKYYTGFPGKLNSSQTEHMVRDFCYVSLDYDRELAGYLDWTGLEDRERIVQYP YTEEVVVQKTEEELARIAERKKESGRRLQEQAAKMRLERLMKKEQELEYYKDIQRRMQGE SKKEIKRLLDEAELKDEAALERVIRDLERSIKRARQKDLGEPEEEEVPDFSLLDVPDDQL DEAGLRQKRQQRLLKSNWEARQRAKAEKEAEKARLAEEARLDEERRKNDLEGWLEEKRQL RLAKLNQLKERERLKADLGNRKSLASQIRMKNIANLASDNPTGSGSRKRRRGGAGADQDD DFGADDADWGVYRSVAIGANKGDDSDDEEGEEDLEAAIRSLENDLLRYDKTFSYDMTLDA QRDWSKSLLHAFRYGPRPFDPSSQAETHRVHLNVERIRVPEVLFQPAAIAGVDQAGLVEI AGDILCQRLPSLPGIQDAPDAFLRDVFLTGGNTLFQNFDERLRQGLMALLPVGAPLRVRR AQDAILDAWRGAAGWACTEEAKAAWITREEYLEKGGEYIKEHDLGNAFA
Hexasome-INO80 complex reveals structural basis of noncanonical nucleosome remodeling. Zhang, M., Jungblut, A., Kunert, F. et al. Science (2023) 381:313-319. DOI 10.1126/science.adf6287 · PubMed
Other PDB entries of the same protein (UniProt G0S590 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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