8P0W: Human Commander complex COMMD ring
Structure of the human Commander complex COMMD ring. Determined by electron microscopy at 2.9 Å resolution. Released 20 Mar 2024.
- Method
- Electron microscopy
- Resolution
- 2.9 Å
- Organism
- Homo sapiens
- Chains
- 12
- Atoms
- 17,512
- Mol. weight
- 354.99 kDa
- Released
- 20 Mar 2024
Explore 8P0W in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
8P0W contains 103 α-helices and 41 β-strands across 12 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 8 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 9-23 | 15 | |
| α-helix | 32-39 | 8 | |
| α-helix | 45-65 | 21 | |
| α-helix | 69-80 | 12 | |
| α-helix | 85-87 | 3 | |
| α-helix | 88-112 | 25 | |
| β-strand | 118-132 | 15 | 1 |
| β-strand | 141-150 | 10 | 1 |
| α-helix | 155-156 | 2 | |
| β-strand | 157-163 | 7 | 1 |
| α-helix | 165-187 | 23 | |
Chain B: 10 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 7-13 | 7 | |
| α-helix | 16-18 | 3 | |
| α-helix | 21-37 | 17 | |
| α-helix | 42-51 | 10 | |
| α-helix | 55-75 | 21 | |
| α-helix | 79-86 | 8 | |
| α-helix | 93-114 | 22 | |
| α-helix | 115-117 | 3 | |
| β-strand | 123-137 | 15 | 1 |
| β-strand | 145-156 | 12 | 1 |
| β-strand | 159-167 | 9 | 1 |
| α-helix | 169-185 | 17 | |
| α-helix | 189-197 | 9 | |
Chain C: 7 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 5-14 | 10 | |
| α-helix | 22-37 | 16 | |
| α-helix | 56-75 | 20 | |
| α-helix | 80-89 | 10 | |
| α-helix | 94-116 | 23 | |
| β-strand | 118 | 1 | 2 |
| α-helix | 122-123 | 2 | |
| β-strand | 124-138 | 15 | 1 |
| β-strand | 141 | 1 | 1 |
| β-strand | 146-155 | 10 | 1 |
| β-strand | 165-170 | 6 | 1 |
| α-helix | 172-193 | 22 | |
Chain D: 10 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 3 | 1 | 3 |
| β-strand | 9 | 1 | 3 |
| α-helix | 10-12 | 3 | |
| α-helix | 13-22 | 10 | |
| α-helix | 27-41 | 15 | |
| α-helix | 48-55 | 8 | |
| α-helix | 56-58 | 3 | |
| α-helix | 62-81 | 20 | |
| α-helix | 86-95 | 10 | |
| α-helix | 100-124 | 25 | |
| β-strand | 130-144 | 15 | 1 |
| β-strand | 152-162 | 11 | 1 |
| α-helix | 168-169 | 2 | |
| β-strand | 170-177 | 8 | 1 |
| α-helix | 178-198 | 21 | |
Chain E: 10 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 31-39 | 9 | |
| α-helix | 40-42 | 3 | |
| α-helix | 45-59 | 15 | |
| α-helix | 65-75 | 11 | |
| α-helix | 79-97 | 19 | |
| α-helix | 106-115 | 10 | |
| α-helix | 120-131 | 12 | |
| α-helix | 135-143 | 9 | |
| α-helix | 144-146 | 3 | |
| β-strand | 152-165 | 14 | 1 |
| β-strand | 168 | 1 | 1 |
| β-strand | 173-182 | 10 | 1 |
| β-strand | 187-192 | 6 | 1 |
| α-helix | 194-221 | 28 | |
Chain F: 2 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 17-32 | 16 | 1 |
| β-strand | 40-50 | 11 | 1 |
| α-helix | 52-54 | 3 | |
| β-strand | 56-64 | 9 | 1 |
| α-helix | 65-84 | 20 | |
Chain G: 7 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 14-24 | 11 | |
| α-helix | 27-41 | 15 | |
| α-helix | 47-61 | 15 | |
| α-helix | 65-85 | 21 | |
| α-helix | 89-99 | 11 | |
| α-helix | 103-127 | 25 | |
| β-strand | 133-147 | 15 | 1 |
| β-strand | 155-166 | 12 | 1 |
| β-strand | 169-178 | 10 | 1 |
| α-helix | 179-196 | 18 | |
Chain H: 9 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 8-14 | 7 | |
| α-helix | 17-19 | 3 | |
| α-helix | 20-32 | 13 | |
| α-helix | 35-37 | 3 | |
| α-helix | 39-41 | 3 | |
| α-helix | 48-67 | 20 | |
| α-helix | 72-78 | 7 | |
| α-helix | 84-110 | 27 | |
| β-strand | 115-130 | 16 | 1 |
| β-strand | 138-149 | 12 | 1 |
| β-strand | 152-160 | 9 | 1 |
| α-helix | 162-182 | 21 | |
4 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| COMM domain-containing protein 1 | A | protein | 190 | Homo sapiens | Q8N668 (AlphaFold model) |
| COMM domain-containing protein 2 | B | protein | 199 | Homo sapiens | Q86X83 (AlphaFold model) |
| COMM domain-containing protein 3 | C | protein | 195 | Homo sapiens | Q9UBI1 (AlphaFold model) |
| COMM domain-containing protein 4 | D | protein | 199 | Homo sapiens | Q9H0A8 (AlphaFold model) |
| COMM domain-containing protein 5 | E | protein | 224 | Homo sapiens | Q9GZQ3 |
| COMM domain-containing protein 6 | F | protein | 85 | Homo sapiens | Q7Z4G1 |
| COMM domain-containing protein 7 | G | protein | 200 | Homo sapiens | Q86VX2 |
| COMM domain-containing protein 8 | H | protein | 183 | Homo sapiens | Q9NX08 |
| COMM domain-containing protein 9 | I | protein | 198 | Homo sapiens | Q9P000 |
| COMM domain-containing protein 10 | J | protein | 202 | Homo sapiens | Q9Y6G5 |
| Coiled-coil domain-containing protein 93 | K | protein | 631 | Homo sapiens | Q567U6 |
| Coiled-coil domain-containing protein 22 | L | protein | 627 | Homo sapiens | O60826 |
Sequence of entity 1 (A), FASTA
>8P0W_1 COMM domain-containing protein 1 (chains A)
MAAGELEGGKPLSGLLNALAQDTFHGYPGITEELLRSQLYPEVPPEEFRPFLAKMRGILK
SIASADMDFNQLEAFLTAQTKKQGGITSDQAAVISKFWKSHKTKIRESLMNQSRWNSGLR
GLSWRVDGKSQSRHSAQIHTPVAIIELELGKYGQESEFLCLEFDEVKVNQILKTLSEVEE
SISTLISQPN
Sequence of entity 2 (B), FASTA
>8P0W_2 COMM domain-containing protein 2 (chains B)
MLLELSEEHKEHLAFLPQVDSAVVAEFGRIAVEFLRRGANPKIYEGAARKLNVSSDTVQH
GVEGLTYLLTESSKLMISELDFQDSVFVLGFSEELNKLLLQLYLDNRKEIRTILSELAPS
LPSYHNLEWRLDVQLASRSLRQQIKPAVTIKLHLNQNGDHNTKVLQTDPATLLHLVQQLE
QALEEMKTNHCRRVVRNIK
Sequence of entity 3 (C), FASTA
>8P0W_3 COMM domain-containing protein 3 (chains C)
MELSESVQKGFQMLADPRSFDSNAFTLLLRAAFQSLLDAQADEAVLDHPDLKHIDPVVLK
HCHAAAATYILEAGKHRADKSTLSTYLEDCKFDRERIELFCTEYQNNKNSLEILLGSIGR
SLPHITDVSWRLEYQIKTNQLHRMYRPAYLVTLSVQNTDSPSYPEISFSCSMEQLQDLVG
KLKDASKSLERATQL
Sequence of entity 4 (D), FASTA
>8P0W_4 COMM domain-containing protein 4 (chains D)
MRFRFCGDLDCPDWVLAEISTLAKMSSVKLRLLCSQVLKELLGQGIDYEKILKLTADAKF
ESGDVKATVAVLSFILSSAAKHSVDGESLSSELQQLGLPKEHAASLCRCYEEKQSPLQKH
LRVCSLRMNRLAGVGWRVDYTLSSSLLQSVEEPMVHLRLEVAAAPGTPAQPVAMSLSADK
FQVLLAELKQAQTLMSSLG
Sequence of entity 5 (E), FASTA
>8P0W_5 COMM domain-containing protein 5 (chains E)
MSAVGAATPYLHHPGDSHSGRVSFLGAQLPPEVAAMARLLGDLDRSTFRKLLKFVVSSLQ
GEDCREAVQRLGVSANLPEEQLGALLAGMHTLLQQALRLPPTSLKPDTFRDQLQELCIPQ
DLVGDLASVVFGSQRPLLDSVAQQQGAWLPHVADFRWRVDVAISTSALARSLQPSVLMQL
KLSDGSAYRFEVPTAKFQELRYSVALVLKEMADLEKRCERRLQD
Sequence of entity 6 (F), FASTA
>8P0W_6 COMM domain-containing protein 6 (chains F)
MEASSEPPLDAKSDVTNQLVDFQWKLGMAVSSDTCRSLKYPYVAVMLKVADHSGQVKTKC
FEMTIPQFQNFYRQFKEIAAVIETV
Sequence of entity 7 (G), FASTA
>8P0W_7 COMM domain-containing protein 7 (chains G)
MGRLHCTEDPVPEAVGGDMQQLNQLGAQQFSALTEVLFHFLTEPKEVERFLAQLSEFATT
NQISLGSLRSIVKSLLLVPNGALKKSLTAKQVQADFITLGLSEEKATYFSEKWKQNAPTL
ARWAIGQTLMINQLIDMEWKFGVTSGSSELEKVGSIFLQLKLVVKKGNQTENVYIELTLP
QFYSFLHEMERVRTSMECFC
Sequence of entity 8 (H), FASTA
>8P0W_8 COMM domain-containing protein 8 (chains H)
MEPEEGTPLWRLQKLPAELGPQLLHKIIDGICGRAYPVYQDYHTVWESEEWMHVLEDIAK
FFKAIVGKNLPDEEIFQQLNQLNSLHQETIMKCVKSRKDEIKQALSREIVAISSAQLQDF
DWQVKLALSSDKIAALRMPLLSLHLDVKENGEVKPYSIEMSREELQNLIQSLEAANKVVL
QLK
Sequence of entity 9 (I), FASTA
>8P0W_9 COMM domain-containing protein 9 (chains I)
MAALTAEHFAALQSLLKASSKDVVRQLCQESFSSSALGLKKLLDVTCSSLSVTQEEAEEL
LQALHRLTRLVAFRDLSSAEAILALFPENFHQNLKNLLTKIILEHVSTWRTEAQANQISL
PRLVDLDWRVDIKTSSDSISRMAVPTCLLQMKIQEDPSLCGDKPSISAVTVELSKETLDT
MLDGLGRIRDQLSAVASK
Sequence of entity 10 (J), FASTA
>8P0W_10 COMM domain-containing protein 10 (chains J)
MAVPAALILRESPSMKKAVSLINAIDTGRFPRLLTRILQKLHLKAESSFSEEEEEKLQAA
FSLEKQDLHLVLETISFILEQAVYHNVKPAALQQQLENIHLRQDKAEAFVNTWSSMGQET
VEKFRQRILAPCKLETVGWQLNLQMAHSAQAKLKSPQAVLQLGVNNEDSKSLEKVLVEFS
HKELFDFYNKLETIQAQLDSLT
Sequence of entity 11 (K), FASTA
>8P0W_11 Coiled-coil domain-containing protein 93 (chains K)
MGLPRGPEGQGLPEVETREDEEQNVKLTEILELLVAAGYFRARIKGLSPFDKVVGGMTWC
ITTCNFDVDVDLLFQENSTIGQKIALSEKIVSVLPRMKCPHQLEPHQIQGMDFIHIFPVV
QWLVKRAIETKEEMGDYIRSYSVSQFQKTYSLPEDDDFIKRKEKAIKTVVDLSEVYKPRR
KYKRHQGAEELLDEESRIHATLLEYGRRYGFSRQSKMEKAEDKKTALPAGLSATEKADAH
EEDELRAAEEQRIQSLMTKMTAMANEESRLTASSVGQIVGLCSAEIKQIVSEYAEKQSEL
SAEESPEKLGTSQLHRRKVISLNKQIAQKTKHLEELRASHTSLQARYNEAKKTLTELKTY
SEKLDKEQAALEKIESKADPSILQNLRALVAMNENLKSQEQEFKAHCREEMTRLQQEIEN
LKAERAPRGDEKTLSSGEPPGTLTSAMTHDEDLDRRYNMEKEKLYKIRLLQARRNREIAI
LHRKIDEVPSRAELIQYQKRFIELYRQISAVHKETKQFFTLYNTLDDKKVYLEKEISLLN
SIHENFSQAMASPAARDQFLRQMEQIVEGIKQSRMKMEKKKQENKMRRDQLNDQYLELLE
KQRLYFKTVKEFKEEGRKNEMLLSKVKAKAS
Sequence of entity 12 (L), FASTA
>8P0W_12 Coiled-coil domain-containing protein 22 (chains L)
MEEADRILIHSLRQAGTAVPPDVQTLRAFTTELVVEAVVRCLRVINPAVGSGLSPLLPLA
MSARFRLAMSLAQACMDLGYPLELGYQNFLYPSEPDLRDLLLFLAERLPTDASEDADQPA
GDSAILLRAIGSQIRDQLALPWVPPHLRTPKLQHLQGSALQKPFHASRLVVPELSSRGEP
REFQASPLLLPVPTQVPQPVGRVASLLEHHALQLCQQTGRDRPGDEDWVHRTSRLPPQED
TRAQRQRLQKQLTEHLRQSWGLLGAPIQARDLGELLQAWGAGAKTGAPKGSRFTHSEKFT
FHLEPQAQATQVSDVPATSRRPEQVTWAAQEQELESLREQLEGVNRSIEEVEADMKTLGV
SFVQAESECRHSKLSTAEREQALRLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQ
WEKHRVPLLAEYRHLRKLQDCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSE
LETLPRDVSRLAYTQRILEIVGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTD
ELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQIETELGKKTL
SNLEKIREDYRALRQENAGLLGRVREA
Primary citation
Structure and interactions of the endogenous human Commander complex. Laulumaa, S., Kumpula, E.P., Huiskonen, J.T. et al. Nat Struct Mol Biol (2024) 31:925-938. DOI 10.1038/s41594-024-01246-1 · PubMed
Other PDB entries of the same protein (UniProt Q8N668 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 8F2R 3.12 Å, Human CCC complex
- 8F2U 3.53 Å, Human CCC complex
- 2H2M Solution Structure of the N-terminal domain of COMMD1 (Murr1)
Browse structure collections
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