8PJ2: PDB entry 8PJ2
Structure of human 48S translation initiation complex in AUG recognition state after eIF5-induced GTP hydrolysis by eIF2 (48S-2). Determined by electron microscopy at 3.4 Å resolution. Released 14 Aug 2024.
- Method
- Electron microscopy
- Resolution
- 3.4 Å
- Organism
- Homo sapiens
- Chains
- 53
- Atoms
- 118,707
- Mol. weight
- 2253.4 kDa
- Ligands
- MG, ZN
- Released
- 14 Aug 2024
Explore 8PJ2 in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
8PJ2 contains 454 α-helices and 444 β-strands across 50 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain 1: 15 helices, 48 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 181 | 1 | 1 |
| β-strand | 187-190 | 4 | 2 |
| α-helix | 199-210 | 12 | |
| α-helix | 212-214 | 3 | |
| β-strand | 219 | 1 | 3 |
| β-strand | 225 | 1 | 4 |
| β-strand | 228 | 1 | 4 |
| β-strand | 232-235 | 4 | 2 |
| β-strand | 236 | 1 | 3 |
| α-helix | 240-242 | 3 | |
| α-helix | 243-249 | 7 | |
| β-strand | 264 | 1 | 2 |
| β-strand | 265 | 1 | 1 |
| α-helix | 285-291 | 7 | |
| β-strand | 309-310 | 2 | 5 |
| β-strand | 315-319 | 5 | 5 |
| β-strand | 328-333 | 6 | 5 |
| β-strand | 338-341 | 4 | 6 |
| β-strand | 349-352 | 4 | 6 |
| β-strand | 356-360 | 5 | 6 |
| β-strand | 367-372 | 6 | 6 |
| β-strand | 378-381 | 4 | 7 |
| β-strand | 387-396 | 10 | 7 |
| β-strand | 402-408 | 7 | 7 |
| β-strand | 413-417 | 5 | 7 |
| β-strand | 430-431 | 2 | 8 |
| β-strand | 437-442 | 6 | 8 |
| β-strand | 445-450 | 6 | 8 |
| β-strand | 456 | 1 | 8 |
| α-helix | 461-463 | 3 | |
| β-strand | 469-472 | 4 | 9 |
| β-strand | 478-482 | 5 | 9 |
| α-helix | 484-486 | 3 | |
| α-helix | 490 | 1 | |
| β-strand | 491-497 | 7 | 9 |
| β-strand | 507-509 | 3 | 9 |
| β-strand | 517-519 | 3 | 10 |
| β-strand | 525-531 | 7 | 10 |
| β-strand | 542-548 | 7 | 10 |
| β-strand | 556-561 | 6 | 10 |
| β-strand | 565-570 | 6 | 11 |
| α-helix | 571 | 1 | |
| β-strand | 576-581 | 6 | 11 |
| α-helix | 584-586 | 3 | |
| β-strand | 587-594 | 8 | 11 |
| β-strand | 600-609 | 10 | 11 |
| β-strand | 613-616 | 4 | 12 |
| β-strand | 622-626 | 5 | 12 |
| β-strand | 638-639 | 2 | 12 |
| β-strand | 644-645 | 2 | 12 |
| β-strand | 656-659 | 4 | 13 |
| β-strand | 665 | 1 | 14 |
| β-strand | 666-669 | 4 | 13 |
| β-strand | 676 | 1 | 15 |
| β-strand | 678 | 1 | 15 |
| β-strand | 680-683 | 4 | 13 |
| β-strand | 685 | 1 | 14 |
| β-strand | 692-695 | 4 | 13 |
| α-helix | 704-706 | 3 | |
| α-helix | 714-717 | 4 | |
| α-helix | 736-744 | 9 | |
| α-helix | 751-759 | 9 | |
| α-helix | 760-762 | 3 | |
Chain 2: 4 helices, 33 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 4-6 | 3 | 23 |
| β-strand | 13-18 | 6 | 24 |
| β-strand | 25-29 | 5 | 24 |
| β-strand | 34-37 | 4 | 25 |
| β-strand | 44-48 | 5 | 25 |
| β-strand | 57-60 | 4 | 26 |
| β-strand | 67-70 | 4 | 26 |
| β-strand | 75 | 1 | 27 |
| β-strand | 76-79 | 4 | 26 |
| α-helix | 80 | 1 | |
| β-strand | 91 | 1 | 27 |
| β-strand | 99-101 | 3 | 28 |
| β-strand | 107-111 | 5 | 28 |
| β-strand | 122-126 | 5 | 28 |
| α-helix | 129-131 | 3 | |
| β-strand | 140-142 | 3 | 28 |
| β-strand | 149-154 | 6 | 29 |
| α-helix | 156-158 | 3 | |
| β-strand | 161-165 | 5 | 29 |
| β-strand | 169 | 1 | 30 |
| β-strand | 170-171 | 2 | 29 |
| β-strand | 173-174 | 2 | 31 |
| β-strand | 179-180 | 2 | 31 |
| β-strand | 185 | 1 | 30 |
| β-strand | 195 | 1 | 28 |
| β-strand | 205-207 | 3 | 32 |
| β-strand | 211-215 | 5 | 32 |
| β-strand | 222-226 | 5 | 32 |
| α-helix | 237-238 | 2 | |
| β-strand | 243-246 | 4 | 33 |
| β-strand | 265-267 | 3 | 34 |
| β-strand | 268-271 | 4 | 33 |
| β-strand | 277 | 1 | 33 |
| β-strand | 281-284 | 4 | 34 |
| β-strand | 291-293 | 3 | 23 |
| β-strand | 300-303 | 4 | 23 |
| β-strand | 309-311 | 3 | 23 |
Chain 3: 13 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-16 | 14 | |
| α-helix | 27-38 | 12 | |
| α-helix | 44-56 | 13 | |
| α-helix | 63-74 | 12 | |
| α-helix | 81-87 | 7 | |
| α-helix | 91-95 | 5 | |
| α-helix | 97-110 | 14 | |
| α-helix | 115-120 | 6 | |
| α-helix | 126-130 | 5 | |
| α-helix | 134-149 | 16 | |
| β-strand | 153 | 1 | 40 |
| α-helix | 155-161 | 7 | |
| α-helix | 167-177 | 11 | |
| β-strand | 181 | 1 | 40 |
| β-strand | 187 | 1 | 40 |
| α-helix | 211-215 | 5 | |
Chain 4: 8 helices, 9 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 91-94 | 4 | 42 |
| α-helix | 96-108 | 13 | |
| α-helix | 109-111 | 3 | |
| β-strand | 118-125 | 8 | 43 |
| β-strand | 128-135 | 8 | 43 |
| α-helix | 150-163 | 14 | |
| β-strand | 168-174 | 7 | 43 |
| α-helix | 181-193 | 13 | |
| β-strand | 198-202 | 5 | 43 |
| β-strand | 213-216 | 4 | 43 |
| β-strand | 217 | 1 | 44 |
| β-strand | 233 | 1 | 44 |
| β-strand | 236-239 | 4 | 42 |
| α-helix | 245-257 | 13 | |
| α-helix | 266-293 | 28 | |
| α-helix | 302-314 | 13 | |
| α-helix | 320-355 | 36 | |
Chain 5: 28 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 50-76 | 27 | |
| α-helix | 81-92 | 12 | |
| α-helix | 93-99 | 7 | |
| α-helix | 100-106 | 7 | |
| α-helix | 111-114 | 4 | |
| α-helix | 119-122 | 4 | |
| α-helix | 126-143 | 18 | |
| α-helix | 150-168 | 19 | |
| α-helix | 180-202 | 23 | |
| α-helix | 204-206 | 3 | |
| α-helix | 209-216 | 8 | |
| α-helix | 224-238 | 15 | |
| α-helix | 240-248 | 9 | |
| α-helix | 253-256 | 4 | |
| α-helix | 259-262 | 4 | |
| α-helix | 264-284 | 21 | |
| α-helix | 287-292 | 6 | |
| α-helix | 304-307 | 4 | |
| α-helix | 309-325 | 17 | |
| α-helix | 329-350 | 22 | |
| α-helix | 354-377 | 24 | |
| α-helix | 384-402 | 19 | |
| α-helix | 406-416 | 11 | |
| α-helix | 425-426 | 2 | |
| α-helix | 438-464 | 27 | |
| β-strand | 469-471 | 3 | 47 |
| α-helix | 472-478 | 7 | |
| α-helix | 483-497 | 15 | |
| β-strand | 499-501 | 3 | 48 |
| β-strand | 512-514 | 3 | 48 |
| β-strand | 520-524 | 5 | 47 |
| β-strand | 527-531 | 5 | 47 |
| α-helix | 540-559 | 20 | |
Chain 6: 22 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 16-27 | 12 | |
| α-helix | 29-40 | 12 | |
| α-helix | 44-53 | 10 | |
| α-helix | 60-74 | 15 | |
| α-helix | 81-92 | 12 | |
| α-helix | 97-110 | 14 | |
| α-helix | 116-129 | 14 | |
| α-helix | 134-144 | 11 | |
| α-helix | 156-171 | 16 | |
| α-helix | 175-191 | 17 | |
| α-helix | 192-194 | 3 | |
| α-helix | 196-199 | 4 | |
| α-helix | 201-212 | 12 | |
| α-helix | 222-226 | 5 | |
| α-helix | 238-244 | 7 | |
| α-helix | 250-254 | 5 | |
| α-helix | 255-259 | 5 | |
| α-helix | 270-287 | 18 | |
| β-strand | 292-293 | 2 | 50 |
| α-helix | 294-299 | 6 | |
| α-helix | 305-307 | 3 | |
| α-helix | 308-317 | 10 | |
| β-strand | 324-325 | 2 | 50 |
| β-strand | 331-333 | 3 | 50 |
| α-helix | 343-368 | 26 | |
Chain 8: 11 helices, 11 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 32 | 1 | 55 |
| β-strand | 36 | 1 | 55 |
| α-helix | 43-54 | 12 | |
| β-strand | 65-68 | 4 | 56 |
| β-strand | 72 | 1 | 57 |
| β-strand | 75 | 1 | 57 |
| β-strand | 80-82 | 3 | 56 |
| α-helix | 84-86 | 3 | |
| α-helix | 93-106 | 14 | |
| β-strand | 119-122 | 4 | 56 |
| α-helix | 131-143 | 13 | |
| β-strand | 150-152 | 3 | 56 |
| β-strand | 164-166 | 3 | 56 |
| β-strand | 168-169 | 2 | 58 |
| α-helix | 171-177 | 7 | |
| β-strand | 198-199 | 2 | 58 |
| α-helix | 212-224 | 13 | |
| α-helix | 229-235 | 7 | |
| α-helix | 236-240 | 5 | |
| α-helix | 248-286 | 39 | |
| α-helix | 295-303 | 9 | |
| α-helix | 309-349 | 41 | |
Chain 9: 1 helix, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-21 | 19 | |
42 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Eukaryotic translation initiation factor 3 subunit B | 1 | protein | 814 | Homo sapiens | P55884 (AlphaFold model) |
| Eukaryotic translation initiation factor 3 subunit I | 2 | protein | 325 | Homo sapiens | Q13347 (AlphaFold model) |
| Eukaryotic translation initiation factor 3 subunit K | 3 | protein | 218 | Homo sapiens | Q9UBQ5 (AlphaFold model) |
| Eukaryotic translation initiation factor 3 subunit F | 4 | protein | 357 | Homo sapiens | O00303 (AlphaFold model) |
| Eukaryotic translation initiation factor 3 subunit L | 5 | protein | 564 | Homo sapiens | Q9Y262 |
| Eukaryotic translation initiation factor 3 subunit M | 6 | protein | 374 | Homo sapiens | Q7L2H7 |
| mRNA | 7 | RNA | 255 | Homo sapiens | |
| Eukaryotic translation initiation factor 3 subunit H | 8 | protein | 352 | Homo sapiens | O15372 |
| 60S ribosomal protein L41 | 9 | protein | 25 | Homo sapiens | P62945 |
| 18S rRNA | A | RNA | 1869 | Homo sapiens | |
| 40S ribosomal protein S11 | B | protein | 158 | Homo sapiens | P62280 |
| 40S ribosomal protein S4, X isoform | C | protein | 263 | Homo sapiens | P62701 |
41 more molecules are not listed.
Sequence of entity 1 (1), FASTA
>8PJ2_1 Eukaryotic translation initiation factor 3 subunit B (chains 1)
MQDAENVAVPEAAEERAEPGQQQPAAEPPPAEGLLRPAGPGAPEAAGTEASSEEVGIAEA
GPESEVRTEPAAEAEAASGPSESPSPPAAEELPGSHAEPPVPAQGEAPGEQARDERSDSR
AQAVSEDAGGNEGRAAEAEPRALENGDADEPSFSDPEDFVDDVSEEELLGDVLKDRPQEA
DGIDSVIVVDNVPQVGPDRLEKLKNVIHKIFSKFGKITNDFYPEEDGKTKGYIFLEYASP
AHAVDAVKNADGYKLDKQHTFRVNLFTDFDKYMTISDEWDIPEKQPFKDLGNLRYWLEEA
ECRDQYSVIFESGDRTSIFWNDVKDPVSIEERARWTETYVRWSPKGTYLATFHQRGIALW
GGEKFKQIQRFSHQGVQLIDFSPCERYLVTFSPLMDTQDDPQAIIIWDILTGHKKRGFHC
ESSAHWPIFKWSHDGKFFARMTLDTLSIYETPSMGLLDKKSLKISGIKDFSWSPGGNIIA
FWVPEDKDIPARVTLMQLPTRQEIRVRNLFNVVDCKLHWQKNGDYLCVKVDRTPKGTQGV
VTNFEIFRMREKQVPVDVVEMKETIIAFAWEPNGSKFAVLHGEAPRISVSFYHVKNNGKI
ELIKMFDKQQANTIFWSPQGQFVVLAGLRSMNGALAFVDTSDCTVMNIAEHYMASDVEWD
PTGRYVVTSVSWWSHKVDNAYWLWTFQGRLLQKNNKDRFCQLLWRPRPPTLLSQEQIKQI
KKDLKKYSKIFEQKDRLSQSKASKELVERRRTMMEDFRKYRKMAQELYMEQKNERLELRG
GVDTDELDSNVDDWEEETIEFFVTEEIIPLGNQE
Sequence of entity 2 (2), FASTA
>8PJ2_2 Eukaryotic translation initiation factor 3 subunit I (chains 2)
MKPILLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDA
DWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQC
FVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEV
LVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFRTERPVNSAALSPN
YDHVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSY
SSGGEDGYVRIHYFDPQYFEFEFEA
Sequence of entity 3 (3), FASTA
>8PJ2_3 Eukaryotic translation initiation factor 3 subunit K (chains 3)
MAMFEQMRANVGKLLKGIDRYNPENLATLERYVETQAKENAYDLEANLAVLKLYQFNPAF
FQTTVTAQILLKALTNLPHTDFTLCKCMIDQAHQEERPIRQILYLGDLLETCHFQAFWQA
LDENMDLLEGITGFEDSVRKFICHVVGITYQHIDRWLLAEMLGDLSDSQLKVWMSKYGWS
ADESGQIFICSQEESIKPKNIVEKIDFDSVSSIMASSQ
Sequence of entity 4 (4), FASTA
>8PJ2_4 Eukaryotic translation initiation factor 3 subunit F (chains 4)
MATPAVPVSAPPATPTPVPAAAPASVPAPTPAPAAAPVPAAAPASSSDPAAAAAATAAPG
QTPASAQAPAQTPAPALPGPALPGPFPGGRVVRLHPVILASIVDSYERRNEGAARVIGTL
LGTVDKHSVEVTNCFSVPHNESEDEVAVDMEFAKNMYELHKKVSPNELILGWYATGHDIT
EHSVLIHEYYSREAPNPIHLTVDTSLQNGRMSIKAYVSTLMGVPGRTMGVMFTPLTVKYA
YYDTERIGVDLIMKTCFSPNRVIGLSSDLQQVGGASARIQDALSTVLQYAEDVLSGKVSA
DNTVGRFLMSLVNQVPKIVPDDFETMLNSNINDLLMVTYLANLTQSQIALNEKLVNL
Sequence of entity 5 (5), FASTA
>8PJ2_5 Eukaryotic translation initiation factor 3 subunit L (chains 5)
MSYPADDYESEAAYDPYAYPSDYDMHTGDPKQDLAYERQYEQQTYQVIPEVIKNFIQYFH
KTVSDLIDQKVYELQASRVSSDVIDQKVYEIQDIYENSWTKLTERFFKNTPWPEAEAIAP
QVGNDAVFLILYKELYYRHIYAKVSGGPSLEQRFESYYNYCNLFNYILNADGPAPLELPN
QWLWDIIDEFIYQFQSFSQYRCKTAKKSEEEIDFLRSNPKIWNVHSVLNVLHSLVDKSNI
NRQLEVYTSGGDPESVAGEYGRHSLYKMLGYFSLVGLLRLHSLLGDYYQAIKVLENIELN
KKSMYSRVPECQVTTYYYVGFAYLMMRRYQDAIRVFANILLYIQRTKSMFQRTTYKYEMI
NKQNEQMHALLAIALTMYPMRIDESIHLQLREKYGDKMLRMQKGDPQVYEELFSYSCPKF
LSPVVPNYDNVHPNYHKEPFLQQLKVFSDEVQQQAQLSTIRSFLKLYTTMPVAKLAGFLD
LTEQEFRIQLLVFKHKMKNLVWTSGISALDGEFQSASEVDFYIDKDMIHIADTKVARRYG
DFFIRQIHKFEELNRTLKKMGQRP
Sequence of entity 6 (6), FASTA
>8PJ2_6 Eukaryotic translation initiation factor 3 subunit M (chains 6)
MSVPAFIDISEEDQAAELRAYLKSKGAEISEENSEGGLHVDLAQIIEACDVCLKEDDKDV
ESVMNSVVSLLLILEPDKQEALIESLCEKLVKFREGERPSLRLQLLSNLFHGMDKNTPVR
YTVYCSLIKVAASCGAIQYIPTELDQVRKWISDWNLTTEKKHTLLRLLYEALVDCKKSDA
ASKVMVELLGSYTEDNASQARVDAHRCIVRALKDPNAFLFDHLLTLKPVKFLEGELIHDL
LTIFVSAKLASYVKFYQNNKDFIDSLGLLHEQNMAKMRLLTFMGMAVENKEISFDTMQQE
LQIGADDVEAFVIDAVRTKMVYCKIDQTQRKVVVSHSTHRTFGKQQWQQLYDTLNAWKQN
LNKVKNSLLSLSDT
Sequence of entity 7 (7), FASTA
>8PJ2_7 mRNA (chains 7)
GGGCAACAACAACAAGCUAGCCACAACAACAACAACAACAACAACAAGUCGACCAACAAC
AACAACAACAACAACAACAACUCGAGCAACAACAACAACAACAACAACAACAAGGAUCCA
AAACAGACCACCAUGGUACGUUUCAAGGCUUGAGCCCUCGUCACUGCCCUGUGGGGCAAG
GUGACUCUGGAAGAAGUUGGUGGUGAGGCCCUGGGCAGGCUGCAGAGUGUGAGGGAAGGU
CUGGUUGUCUACCAA
Sequence of entity 8 (8), FASTA
>8PJ2_8 Eukaryotic translation initiation factor 3 subunit H (chains 8)
MASRKEGTGSTATSSSSTAGAAGKGKGKGGSGDSAVKQVQIDGLVVLKIIKHYQEEGQGT
EVVQGVLLGLVVEDRLEITNCFPFPQHTEDDADFDEVQYQMEMMRSLRHVNIDHLHVGWY
QSTYYGSFVTRALLDSQFSYQHAIEESVVLIYDPIKTAQGSLSLKAYRLTPKLMEVCKEK
DFSPEALKKANITFEYMFEEVPIVIKNSHLINVLMWELEKKSAVADKHELLSLASSNHLG
KNLQLLMDRVDEMSQDIVKYNTYMRNTSKQQQQKHQYQQRRQQENMQRQSRGEPPLPEED
LSKLFKPPQPPARMDSLLIAGQINTYCQNIKEFTAQNLGKLFMAQALQEYNN
Sequence of entity 9 (9), FASTA
>8PJ2_9 60S ribosomal protein L41 (chains 9)
MRAKWRKKRMRRLKRKRRKMRQRSK
Sequence of entity 10 (A), FASTA
>8PJ2_10 18S rRNA (chains A)
UACCUGGUUGAUCCUGCCAGUAGCAUAUGCUUGUCUCAAAGAUUAAGCCAUGCAUGUCUG
AGUACGCACGGCCGGUACAGUGAAACUGCGAAUGGCUCAUUAAAUCAGUUAUGGUUCCUU
UGGUCGCUCGCUCCUCUCCUACUUGGAUAACUGUGGUAAUUCUAGAGCUAAUACAUGCCG
ACGGGCGCUGACCCCCUUCGCGGGGGGGAUGCGUGCAUUUAUCAGAUCAAAACCAACCCG
GUCAGCCCCUCUCCGGCCCCGGCCGGGGGGCGGGCGCCGGCGGCUUUGGUGACUCUAGAU
AACCUCGGGCCGAUCGCACGCCCCCCGUGGCGGCGACGACCCAUUCGAACGUCUGCCCUA
UCAACUUUCGAUGGUAGUCGCCGUGCCUACCAUGGUGACCACGGGUGACGGGGAAUCAGG
GUUCGAUUCCGGAGAGGGAGCCUGAGAAACGGCUACCACAUCCAAGGAAGGCAGCAGGCG
CGCAAAUUACCCACUCCCGACCCGGGGAGGUAGUGACGAAAAAUAACAAUACAGGACUCU
UUCGAGGCCCUGUAAUUGGAAUGAGUCCACUUUAAAUCCUUUAACGAGGAUCCAUUGGAG
GGCAAGUCUGGUGCCAGCAGCCGCGGUAAUUCCAGCUCCAAUAGCGUAUAUUAAAGUUGC
UGCAGUUAAAAAGCUCGUAGUUGGAUCUUGGGAGCGGGCGGGCGGUCCGCCGCGAGGCGA
GCCACCGCCCGUCCCCGCCCCUUGCCUCUCGGCGCCCCCUCGAUGCUCUUAGCUGAGUGU
CCCGCGGGGCCCGAAGCGUUUACUUUGAAAAAAUUAGAGUGUUCAAAGCAGGCCCGAGCC
GCCUGGAUACCGCAGCUAGGAAUAAUGGAAUAGGACCGCGGUUCUAUUUUGUUGGUUUUC
GGAACUGAGGCCAUGAUUAAGAGGGACGGCCGGGGGCAUUCGUAUUGCGCCGCUAGAGGU
GAAAUUCUUGGACCGGCGCAAGACGGACCAGAGCGAAAGCAUUUGCCAAGAAUGUUUUCA
UUAAUCAAGAACGAAAGUCGGAGGUUCGAAGACGAUCAGAUACCGUCGUAGUUCCGACCA
UAAACGAUGCCGACCGGCGAUGCGGCGGCGUUAUUCCCAUGACCCGCCGGGCAGCUUCCG
GGAAACCAAAGUCUUUGGGUUCCGGGGGGAGUAUGGUUGCAAAGCUGAAACUUAAAGGAA
UUGACGGAAGGGCACCACCAGGAGUGGAGCCUGCGGCUUAAUUUGACXCAACACGGGAAA
CCUCACCCGGCCCGGACACGGACAGGAUUGACAGAUUGAUAGCUCUUUCUCGAUUCCGUG
GGUGGUGGUGCAUGGCCGUUCUUAGUUGGUGGAGCGAUUUGUCUGGUUAAUUCCGAUAAC
GAACGAGACUCUGGCAUGCUAACUAGUUACGCGACCCCCGAGCGGUCGGCGUCCCCCAAC
UUCUUAGAGGGACAAGUGGCGUUCAGCCACCCGAGAUUGAGCAAUAACAGGUCUGUGAUG
CCCUUAGAUGUCCGGGGCUGCACGCGCGCUACACUGACUGGCUCAGCGUGUGCCUACCCU
ACGCCGGCAGGCGCGGGUAACCCGUUGAACCCCAUUCGUGAUGGGGAUCGGGGAUUGCAA
UUAUUCCCCAUGAACGAGGAAUUCCCAGUAAGUGCGGGUCAUAAGCUUGCGUUGAUUAAG
UCCCUGCCCUUUGUACACACCGCCCGUCGCUACUACCGAUUGGAUGGUUUAGUGAGGCCC
UCGGAUCGGCCCCGCCGGGGUCGGCCCACGGCCCUGGCGGAGCGCUGAGAAGACGGUCGA
ACUUGACUAUCUAGAGGAAGUAAAAGUCGUAACAAGGUUUCCGUAGGUGAACCUGCGGAA
GGAUCAUUA
Sequence of entity 11 (B), FASTA
>8PJ2_11 40S ribosomal protein S11 (chains B)
MADIQTERAYQKQPTIFQNKKRVLLGETGKEKLPRYYKNIGLGFKTPKEAIEGTYIDKKC
PFTGNVSIRGRILSGVVTKMKMQRTIVIRRDYLHYIRKYNRFEKRHKNMSVHLSPCFRDV
QIGDIVTVGECRPLSKTVRFNVLKVTKAAGTKKQFQKF
Sequence of entity 12 (C), FASTA
>8PJ2_12 40S ribosomal protein S4, X isoform (chains C)
MARGPKKHLKRVAAPKHWMLDKLTGVFAPRPSTGPHKLRECLPLIIFLRNRLKYALTGDE
VKKICMQRFIKIDGKVRTDITYPAGFMDVISIDKTGENFRLIYDTKGRFAVHRITPEEAK
YKLCKVRKIFVGTKGIPHLVTHDARTIRYPDPLIKVNDTIQIDLETGKITDFIKFDTGNL
CMVTGGANLGRIGVITNRERHPGSFDVVHVKDANGNSFATRLSNIFVIGKGNKPWISLPR
GKGIRLTIAEERDKRLAAKQSSG
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| MG | Magnesium ion | Mg | 87 |
| ZN | Zinc ion | Zn | 2 |
Primary citation
Structural basis for translational control by the human 48S initiation complex. Petrychenko, V., Yi, S.H., Liedtke, D. et al. Nat Struct Mol Biol (2024). DOI 10.1038/s41594-024-01378-4 · PubMed
Other PDB entries of the same protein (UniProt P55884 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 6ZP4 2.9 Å, SARS-CoV-2 Nsp1 bound to a human 43S preinitiation ribosome complex - state 2
- 8PJ5 2.9 Å, Structure of human 48S translation initiation complex after eIF2 release prior 60S…
- 8PJ6 2.9 Å, Structure of human 48S translation initiation complex with initiator tRNA, eIF1A and…
- 6ZON 3.0 Å, SARS-CoV-2 Nsp1 bound to a human 43S preinitiation ribosome complex - state 1
- 8PJ4 3.2 Å, Structure of human 48S translation initiation complex after eIF5 release (48S-4)
- 8PJ1 3.4 Å, Structure of human 48S translation initiation complex in open codon scanning state (48S-1)
- 7A09 3.5 Å, Structure of a human ABCE1-bound 43S pre-initiation complex - State III
- 8OZ0 3.5 Å, Structure of a human 48S translation initiation complex with eIF4F and eIF4A
- 8XXN 3.6 Å, Cryo-EM structure of the human 43S ribosome with PDCD4
- 6ZMW 3.7 Å, Structure of a human 48S translational initiation complex
- 7QP7 3.7 Å, Structure of the human 48S initiation complex in closed state (h48S AUG closed)
- 8PJ3 3.7 Å, Structure of human 48S translation initiation complex upon transfer of initiator tRNA to…
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