8QQM: Acetylcholine receptor subunit alpha

nicotinic acetylcholine receptor in intact synaptic membrane. Determined by electron microscopy at 4.7 Å resolution. Released 8 May 2024.

Method
Electron microscopy
Resolution
4.7 Å
Organism
Tetronarce californica
Chains
5
Atoms
7,118
Mol. weight
268.03 kDa
Released
8 May 2024

Explore 8QQM in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8QQM contains 50 α-helices and 2 β-strands across 5 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 10 helices, 0 β-strands

ElementResiduesLengthSheet
α-helix213-2142
α-helix215-2195
α-helix220-22910
α-helix230-2345
α-helix242-26322
α-helix273-29927
α-helix310-3123
α-helix313-3197
α-helix320-3234
α-helix371-43060
Chain B: 10 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix227-2282
α-helix229-2335
α-helix234-2418
α-helix242-2476
α-helix256-27520
α-helix287-31327
α-helix324-3274
α-helix328-3336
α-helix334-3374
α-helix417-47761
Chain C: 11 helices, 1 β-strand
ElementResiduesLengthSheet
α-helix219-2202
α-helix221-2255
α-helix226-23712
α-helix238-2403
α-helix243-2453
α-helix248-26720
α-helix279-30527
β-strand31211
α-helix316-3194
α-helix320-3256
α-helix326-3305
α-helix399-45961
Chain D: 10 helices, 1 β-strand
ElementResiduesLengthSheet
α-helix213-2142
α-helix215-2195
α-helix220-23112
α-helix232-2343
α-helix242-26322
α-helix273-29927
α-helix310-3134
α-helix314-3196
α-helix320-3234
β-strand32911
α-helix371-43262
Chain E: 9 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix221-2222
α-helix223-2275
α-helix228-2347
α-helix235-2428
α-helix251-27020
α-helix282-30827
α-helix319-3235
α-helix324-3285
α-helix411-46959

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Acetylcholine receptor subunit alphaA, Dprotein437Tetronarce californicaP02710 (AlphaFold model)
Acetylcholine receptor subunit deltaBprotein501Tetronarce californicaP02718 (AlphaFold model)
Acetylcholine receptor subunit betaCprotein469Tetronarce californicaP02712 (AlphaFold model)
Acetylcholine receptor subunit gammaEprotein489Tetronarce californicaP02714 (AlphaFold model)
Sequence of entity 1 (A, D), FASTA
>8QQM_1 Acetylcholine receptor subunit alpha (chains A, D)
SEHETRLVANLLENYNKVIRPVEHHTHFVDITVGLQLIQLISVDEVNQIVETNVRLRQQW
IDVRLRWNPADYGGIKKIRLPSDDVWLPDLVLYNNADGDFAIVHMTKLLLDYTGKIMWTP
PAIFKSYCEIIVTHFPFDQQNCTMKLGIWTYDGTKVSISPESDRPDLSTFMESGEWVMKD
YRGWKHWVYYTCCPDTPYLDITYHFIMQRIPLYFVVNVIIPCLLFSFLTGLVFYLPTDSG
EKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMIFVISSIIITVVVINTHH
RSPSTHTMPQWVRKIFIDTIPNVMFFSTMKRASKEKQENKIFADDIDISDISGKQVTGEV
IFQTPLIKNPDVKSAIEGVKYIAEHMKSDEESSNAAEEWKYVAMVIDHILLCVFMLICII
GTVSVFAGRLIELSQEG
Sequence of entity 2 (B), FASTA
>8QQM_2 Acetylcholine receptor subunit delta (chains B)
VNEEERLINDLLIVNKYNKHVRPVKHNNEVVNIALSLTLSNLISLKETDETLTSNVWMDH
AWYDHRLTWNASEYSDISILRLPPELVWIPDIVLQNNNDGQYHVAYFCNVLVRPNGYVTW
LPPAIFRSSCPINVLYFPFDWQNCSLKFTALNYDANEITMDLMTDTIDGKDYPIEWIIID
PEAFTENGEWEIIHKPAKKNIYPDKFPNGTNYQDVTFYLIIRRKPLFYVINFITPCVLIS
FLASLAFYLPAESGEKMSTAISVLLAQAVFLLLTSQRLPETALAVPLIGKYLMFIMSLVT
GVIVNCGIVLNFHFRTPSTHVLSTRVKQIFLEKLPRILHMSRADESEQPDWQNDLKLRRS
SSVGYISKAQEYFNIKSRSELMFEKQSERHGLVPRVTPRIGFGNNNENIAASDQLHDEIK
SGIDSTNYIVKQIKEKNAYDEEVGNWNLVGQTIDRLSMFIITPVMVLGTIFIFVMGNFNH
PPAKPFEGDPFDYSSDHPRCA
Sequence of entity 3 (C), FASTA
>8QQM_3 Acetylcholine receptor subunit beta (chains C)
SVMEDTLLSVLFETYNPKVRPAQTVGDKVTVRVGLTLTNLLILNEKIEEMTTNVFLNLAW
TDYRLQWDPAAYEGIKDLRIPSSDVWQPDIVLMNNNDGSFEITLHVNVLVQHTGAVSWQP
SAIYRSSCTIKVMYFPFDWQNCTMVFKSYTYDTSEVTLQHALDAKGEREVKEIVINKDAF
TENGQWSIEHKPSRKNWRSDDPSYEDVTFYLIIQRKPLFYIVYTIIPCILISILAILVFY
LPPDAGEKMSLSISALLAVTVFLLLLADKVPETSLSVPIIIRYLMFIMILVAFSVILSVV
VLNLHHRSPNTHTMPNWIRQIFIETLPPFLWIQRPVTTPSPDSKPTIISRANDEYFIRKP
AGDFVCPVDNARVAVQPERLFSEMKWHLNGLTQPVTLPQDLKEAVEAIKYIAEQLESASE
FDDLKKDWQYVAMVADRLFLYVFFVICSIGTFSIFLDASHNVPPDNPFA
Sequence of entity 4 (E), FASTA
>8QQM_4 Acetylcholine receptor subunit gamma (chains E)
ENEEGRLIEKLLGDYDKRIIPAKTLDHIIDVTLKLTLTNLISLNEKEEALTTNVWIEIQW
NDYRLSWNTSEYEGIDLVRIPSELLWLPDVVLENNVDGQFEVAYYANVLVYNDGSMYWLP
PAIYRSTCPIAVTYFPFDWQNCSLVFRSQTYNAHEVNLQLSAEEGEAVEWIHIDPEDFTE
NGEWTIRHRPAKKNYNWQLTKDDTDFQEIIFFLIIQRKPLFYIINIIAPCVLISSLVVLV
YFLPAQAGGQKCTLSISVLLAQTIFLFLIAQKVPETSLNVPLIGKYLIFVMFVSMLIVMN
CVIVLNVSLRTPNTHSLSEKIKHLFLGFLPKYLGMQLEPSEETPEKPQPRRRSSFGIMIK
AEEYILKKPRSELMFEEQKDRHGLKRVNKMTSDIDIGTTVDLYKDLANFAPEIKSCVEAC
NFIAKSTKEQNDSGSENENWVLIGKVIDKACFWIALLLFSIGTLAIFLTGHFNQVPEFPF
PGDPRKYVP

Primary citation

Influence of lipid bilayer on the structure of the muscle-type nicotinic acetylcholine receptor. Unwin, N. Proc Natl Acad Sci U S A (2024) 121:e2319913121-e2319913121. DOI 10.1073/pnas.2319913121 · PubMed

Other PDB entries of the same protein (UniProt P02710 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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