Cryo-EM structure of the human TREX-2 complex. Determined by electron microscopy at 3.5 Å resolution. Released 11 Jun 2025.
Explore 8R7J in 3D Show helices and sheets RCSB PDB PDBe
8R7J contains 41 α-helices and 5 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 645-652 | 8 | |
| α-helix | 673-676 | 4 | |
| α-helix | 694-703 | 10 | |
| α-helix | 704-708 | 5 | |
| α-helix | 717-735 | 19 | |
| α-helix | 742-761 | 20 | |
| α-helix | 772-796 | 25 | |
| α-helix | 803-813 | 11 | |
| α-helix | 820-824 | 5 | |
| α-helix | 829-832 | 4 | |
| α-helix | 837-848 | 12 | |
| α-helix | 853-859 | 7 | |
| α-helix | 864-869 | 6 | |
| α-helix | 874-882 | 9 | |
| β-strand | 899-900 | 2 | 1 |
| α-helix | 904-907 | 4 | |
| α-helix | 913-923 | 11 | |
| β-strand | 931-932 | 2 | 1 |
| α-helix | 963-967 | 5 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 6-18 | 13 | |
| α-helix | 24 | 1 | |
| α-helix | 25-29 | 5 | |
| α-helix | 47-53 | 7 | |
| α-helix | 56-73 | 18 | |
| α-helix | 78-96 | 19 | |
| α-helix | 105-112 | 8 | |
| α-helix | 114-120 | 7 | |
| α-helix | 137-152 | 16 | |
| α-helix | 168-182 | 15 | |
| α-helix | 189-196 | 8 | |
| α-helix | 206-221 | 16 | |
| α-helix | 226-238 | 13 | |
| α-helix | 247-262 | 16 | |
| α-helix | 268-273 | 6 | |
| α-helix | 280-287 | 8 | |
| α-helix | 293-300 | 8 | |
| α-helix | 311-314 | 4 | |
| α-helix | 315-317 | 3 | |
| α-helix | 318-333 | 16 | |
| β-strand | 337-339 | 3 | 2 |
| α-helix | 340-348 | 9 | |
| α-helix | 357-370 | 14 | |
| β-strand | 376-377 | 2 | 2 |
| β-strand | 383-385 | 3 | 2 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 20-22 | 3 | |
| α-helix | 51-59 | 9 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Germinal-center associated nuclear protein | A | protein | 423 | Homo sapiens | O60318 (AlphaFold model) |
| PCI domain-containing protein 2 | B | protein | 399 | Homo sapiens | Q5JVF3 (AlphaFold model) |
| 26S proteasome complex subunit SEM1 | C | protein | 70 | Homo sapiens | P60896 (AlphaFold model) |
>8R7J_1 Germinal-center associated nuclear protein (chains A) SEGLGPCVLSLSTLIGTVAETSKEKYRLLDQRDRIMRQARVKRTDLDKARTFVGTCLDMC PEKERYMRETRSQLSVFEVVPGTDQVDHAAAVKEYSRSSADQEEPLPHELRPLPVLSRTM DYLVTQIMDQKEGSLRDWYDFVWNRTRGIRKDITQQHLCDPLTVSLIEKCTRFHIHCAHF MCEEPMSSFDAKINNENMTKCLQSLKEMYQDLRNKGVFCASEAEFQGYNVLLSLNKGDIL REVQQFHPAVRNSSEVKFAVQAFAALNSNNFVRFFKLVQSASYLNACLLHCYFSQIRKDA LRALNFAYTVSTQRSTIFPLDGVVRMLLFRDCEEATDFLTCHGLTVSDGCVELNRSAFLE PEGLSKTRKSVFITRKLTVSVGEIVNGGPLPPVPRHTPVCSFNSQNKYIGESLAAELPVS TQR
>8R7J_2 PCI domain-containing protein 2 (chains B) MAHITINQYLQQVYEAIDSRDGASCAELVSFKHPHVANPRLQMASPEEKCQQVLEPPYDE MFAAHLRCTYAVGNHDFIEAYKCQTVIVQSFLRAFQAHKEENWALPVMYAVALDLRVFAN NADQQLVKKGKSKVGDMLEKAAELLMSCFRVCASDTRAGIEDSKKWGMLFLVNQLFKIYF KINKLHLCKPLIRAIDSSNLKDDYSTAQRVTYKYYVGRKAMFDSDFKQAEEYLSFAFEHC HRSSQKNKRMILIYLLPVKMLLGHMPTVELLKKYHLMQFAEVTRAVSEGNLLLLHEALAK HEAFFIRCGIFLILEKLKIITYRNLFKKVYLLLKTHQLSLDAFLVALKFMQVEDVDIDEV QCILANLIYMGHVKGYISHQHQKLVVSKQNPFPPLSTVC
>8R7J_3 26S proteasome complex subunit SEM1 (chains C) MSEKKQPVDLGLLEEDDEFEEFPAEDWAGLDEDEDAHVWEDNWDDDNVEDDFSNQLRAEL EKHGYKMETS
An ATP-gated molecular switch orchestrates human messenger RNA export. Hohmann, U., Graf, M., Tirian, L. et al. Nature (2025). DOI 10.1038/s41586-025-09832-z · PubMed
Other PDB entries of the same protein (UniProt O60318 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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