8RC4: Integrator-PP2A complex
Structure of Integrator-PP2A complex. Determined by electron microscopy at 3.1 Å resolution. Released 7 Feb 2024.
- Method
- Electron microscopy
- Resolution
- 3.1 Å
- Organisms
- Homo sapiens, Trichoplusia ni
- Chains
- 16
- Atoms
- 78,273
- Mol. weight
- 1435.16 kDa
- Ligands
- ZN, MN
- Released
- 7 Feb 2024
Explore 8RC4 in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
8RC4 contains 692 α-helices and 179 β-strands across 16 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain a: 116 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 122-131 | 10 | |
| α-helix | 137-151 | 15 | |
| α-helix | 159-168 | 10 | |
| α-helix | 172-176 | 5 | |
| α-helix | 178-187 | 10 | |
| α-helix | 203-212 | 10 | |
| α-helix | 214-216 | 3 | |
| α-helix | 224-233 | 10 | |
| α-helix | 247-256 | 10 | |
| α-helix | 322-337 | 16 | |
| α-helix | 350-356 | 7 | |
| α-helix | 361-369 | 9 | |
| α-helix | 378-380 | 3 | |
| α-helix | 381-394 | 14 | |
| α-helix | 400-410 | 11 | |
| α-helix | 417-433 | 17 | |
| α-helix | 437-450 | 14 | |
| α-helix | 456-468 | 13 | |
| α-helix | 473-484 | 12 | |
| α-helix | 492-505 | 14 | |
| α-helix | 514-520 | 7 | |
| α-helix | 526-529 | 4 | |
| α-helix | 535-549 | 15 | |
| α-helix | 550-552 | 3 | |
| α-helix | 555-563 | 9 | |
| α-helix | 573-584 | 12 | |
| α-helix | 589-594 | 6 | |
| α-helix | 597-600 | 4 | |
| α-helix | 605-614 | 10 | |
| α-helix | 621-625 | 5 | |
| α-helix | 636-644 | 9 | |
| α-helix | 651-661 | 11 | |
| α-helix | 669-683 | 15 | |
| α-helix | 701-709 | 9 | |
| α-helix | 719-720 | 2 | |
| α-helix | 724-726 | 3 | |
| α-helix | 731-747 | 17 | |
| α-helix | 752-759 | 8 | |
| α-helix | 761-771 | 11 | |
| α-helix | 785-789 | 5 | |
| α-helix | 790-818 | 29 | |
| α-helix | 828-830 | 3 | |
| α-helix | 841-846 | 6 | |
| α-helix | 847-860 | 14 | |
| α-helix | 947-958 | 12 | |
| α-helix | 965-976 | 12 | |
| α-helix | 984-998 | 15 | |
| α-helix | 1024-1026 | 3 | |
| α-helix | 1027 | 1 | |
| α-helix | 1028-1032 | 5 | |
| α-helix | 1033-1035 | 3 | |
| α-helix | 1039-1054 | 16 | |
| α-helix | 1060-1072 | 13 | |
| α-helix | 1079-1095 | 17 | |
| α-helix | 1097-1103 | 7 | |
| α-helix | 1111-1133 | 23 | |
| β-strand | 1150-1153 | 4 | 7 |
| β-strand | 1159-1162 | 4 | 7 |
| α-helix | 1164-1175 | 12 | |
| α-helix | 1184-1193 | 10 | |
| β-strand | 1203-1205 | 3 | 7 |
| β-strand | 1211 | 1 | 7 |
| α-helix | 1217-1224 | 8 | |
| α-helix | 1229-1235 | 7 | |
| α-helix | 1241-1249 | 9 | |
| α-helix | 1255-1271 | 17 | |
| α-helix | 1273-1275 | 3 | |
| α-helix | 1284-1296 | 13 | |
| α-helix | 1302-1311 | 10 | |
| α-helix | 1361-1368 | 8 | |
| α-helix | 1374-1392 | 19 | |
| α-helix | 1402-1414 | 13 | |
| α-helix | 1421-1427 | 7 | |
| α-helix | 1429-1445 | 17 | |
| α-helix | 1452-1467 | 16 | |
| α-helix | 1470-1472 | 3 | |
| α-helix | 1476-1489 | 14 | |
| α-helix | 1497-1510 | 14 | |
| α-helix | 1514-1530 | 17 | |
| α-helix | 1538-1551 | 14 | |
| α-helix | 1556-1565 | 10 | |
| α-helix | 1579-1588 | 10 | |
| α-helix | 1615-1625 | 11 | |
| α-helix | 1634-1641 | 8 | |
| α-helix | 1657-1667 | 11 | |
| α-helix | 1670-1680 | 11 | |
| α-helix | 1691-1702 | 12 | |
| α-helix | 1729-1746 | 18 | |
| α-helix | 1756-1769 | 14 | |
| α-helix | 1773-1790 | 18 | |
| α-helix | 1794-1809 | 16 | |
| α-helix | 1819-1822 | 4 | |
| α-helix | 1836-1847 | 12 | |
| α-helix | 1853-1855 | 3 | |
| α-helix | 1856-1872 | 17 | |
| α-helix | 1874-1878 | 5 | |
| α-helix | 1881-1887 | 7 | |
| α-helix | 1888-1890 | 3 | |
| α-helix | 1896-1901 | 6 | |
| α-helix | 1905-1918 | 14 | |
| α-helix | 1921-1923 | 3 | |
| α-helix | 1929-1944 | 16 | |
| α-helix | 1950-1952 | 3 | |
| α-helix | 1953-1969 | 17 | |
| α-helix | 1971-1980 | 10 | |
| α-helix | 1982-1991 | 10 | |
| α-helix | 1996-2002 | 7 | |
| α-helix | 2003-2006 | 4 | |
| α-helix | 2044-2056 | 13 | |
| α-helix | 2060-2076 | 17 | |
| α-helix | 2078-2083 | 6 | |
| α-helix | 2085-2091 | 7 | |
| α-helix | 2097-2113 | 17 | |
| α-helix | 2115-2117 | 3 | |
| α-helix | 2119-2121 | 3 | |
| α-helix | 2122-2129 | 8 | |
| α-helix | 2134-2142 | 9 | |
| α-helix | 2144-2151 | 8 | |
| α-helix | 2155-2168 | 14 | |
| α-helix | 2174-2188 | 15 | |
Chain b: 78 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 16-19 | 4 | |
| α-helix | 20-28 | 9 | |
| α-helix | 31-35 | 5 | |
| α-helix | 39-44 | 6 | |
| α-helix | 46-54 | 9 | |
| α-helix | 56-57 | 2 | |
| α-helix | 62-76 | 15 | |
| α-helix | 81-88 | 8 | |
| α-helix | 92-106 | 15 | |
| α-helix | 126-132 | 7 | |
| α-helix | 135-155 | 21 | |
| α-helix | 174-187 | 14 | |
| α-helix | 194-201 | 8 | |
| α-helix | 207-217 | 11 | |
| α-helix | 219-221 | 3 | |
| α-helix | 222-232 | 11 | |
| α-helix | 241-256 | 16 | |
| α-helix | 258-260 | 3 | |
| α-helix | 261-271 | 11 | |
| α-helix | 275-286 | 12 | |
| α-helix | 297-307 | 11 | |
| α-helix | 311-325 | 15 | |
| α-helix | 335-350 | 16 | |
| α-helix | 382-394 | 13 | |
| α-helix | 395-399 | 5 | |
| α-helix | 405-415 | 11 | |
| α-helix | 423-438 | 16 | |
| α-helix | 440-442 | 3 | |
| α-helix | 446-461 | 16 | |
| α-helix | 477-489 | 13 | |
| α-helix | 492-503 | 12 | |
| α-helix | 512-520 | 9 | |
| α-helix | 521-525 | 5 | |
| α-helix | 528-536 | 9 | |
| β-strand | 544 | 1 | 8 |
| α-helix | 553-563 | 11 | |
| α-helix | 574-581 | 8 | |
| β-strand | 584 | 1 | 8 |
| α-helix | 592-603 | 12 | |
| α-helix | 616-620 | 5 | |
| α-helix | 621-625 | 5 | |
| α-helix | 645-664 | 20 | |
| α-helix | 666-668 | 3 | |
| α-helix | 678-680 | 3 | |
| α-helix | 681-686 | 6 | |
| α-helix | 689-698 | 10 | |
| α-helix | 701-703 | 3 | |
| α-helix | 706-717 | 12 | |
| α-helix | 719-721 | 3 | |
| α-helix | 724-728 | 5 | |
| α-helix | 736-744 | 9 | |
| α-helix | 745-747 | 3 | |
| α-helix | 754-761 | 8 | |
| α-helix | 768-778 | 11 | |
| α-helix | 784-789 | 6 | |
| α-helix | 790-795 | 6 | |
| α-helix | 796-801 | 6 | |
| α-helix | 807-821 | 15 | |
| α-helix | 825-835 | 11 | |
| α-helix | 850-855 | 6 | |
| α-helix | 857-861 | 5 | |
| α-helix | 865-869 | 5 | |
| α-helix | 871-900 | 30 | |
| α-helix | 923-945 | 23 | |
| α-helix | 948-949 | 2 | |
| α-helix | 950-953 | 4 | |
| α-helix | 989-1007 | 19 | |
| α-helix | 1009-1018 | 10 | |
| α-helix | 1022-1024 | 3 | |
| α-helix | 1025-1031 | 7 | |
| α-helix | 1033-1037 | 5 | |
| α-helix | 1038-1046 | 9 | |
| α-helix | 1051-1067 | 17 | |
| α-helix | 1071-1088 | 18 | |
| α-helix | 1093-1103 | 11 | |
| α-helix | 1106-1113 | 8 | |
| α-helix | 1115-1117 | 3 | |
| α-helix | 1118-1138 | 21 | |
| α-helix | 1145-1148 | 4 | |
| α-helix | 1181-1199 | 19 | |
Chain d: 51 helices, 20 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 37-45 | 9 | |
| α-helix | 51-61 | 11 | |
| α-helix | 69-82 | 14 | |
| α-helix | 86-98 | 13 | |
| α-helix | 99-101 | 3 | |
| α-helix | 107-109 | 3 | |
| α-helix | 112-120 | 9 | |
| α-helix | 124-140 | 17 | |
| α-helix | 145-157 | 13 | |
| α-helix | 158-160 | 3 | |
| α-helix | 164-176 | 13 | |
| α-helix | 196-201 | 6 | |
| α-helix | 202-205 | 4 | |
| α-helix | 209-225 | 17 | |
| α-helix | 232-240 | 9 | |
| α-helix | 246-262 | 17 | |
| β-strand | 267-269 | 3 | 9 |
| β-strand | 276-278 | 3 | 9 |
| α-helix | 279-289 | 11 | |
| α-helix | 290-292 | 3 | |
| α-helix | 296-308 | 13 | |
| α-helix | 314-319 | 6 | |
| α-helix | 378-383 | 6 | |
| α-helix | 388-404 | 17 | |
| α-helix | 406-418 | 13 | |
| α-helix | 419-421 | 3 | |
| α-helix | 425-437 | 13 | |
| α-helix | 439-441 | 3 | |
| β-strand | 444 | 1 | 10 |
| α-helix | 446-454 | 9 | |
| α-helix | 461-473 | 13 | |
| β-strand | 476 | 1 | 10 |
| α-helix | 479-495 | 17 | |
| α-helix | 497-499 | 3 | |
| α-helix | 500-513 | 14 | |
| α-helix | 515-526 | 12 | |
| α-helix | 542-555 | 14 | |
| α-helix | 560-563 | 4 | |
| α-helix | 567-579 | 13 | |
| α-helix | 585-586 | 2 | |
| α-helix | 609-623 | 15 | |
| α-helix | 629-649 | 21 | |
| α-helix | 654-679 | 26 | |
| α-helix | 683-685 | 3 | |
| α-helix | 693-709 | 17 | |
| β-strand | 711 | 1 | 11 |
| α-helix | 716-740 | 25 | |
| α-helix | 744-764 | 21 | |
| α-helix | 766-771 | 6 | |
| α-helix | 776-782 | 7 | |
| α-helix | 784-789 | 6 | |
| α-helix | 792-804 | 13 | |
| α-helix | 806-810 | 5 | |
| α-helix | 812-814 | 3 | |
| β-strand | 819 | 1 | 11 |
| β-strand | 821-824 | 4 | 12 |
| α-helix | 833-834 | 2 | |
| β-strand | 835-836 | 2 | 13 |
| β-strand | 839 | 1 | 14 |
| β-strand | 842-852 | 11 | 12 |
| α-helix | 857-860 | 4 | |
| β-strand | 861-866 | 6 | 13 |
| β-strand | 872-875 | 4 | 13 |
| β-strand | 882-886 | 5 | 12 |
| β-strand | 889-899 | 11 | 12 |
| β-strand | 900 | 1 | 14 |
| β-strand | 903 | 1 | 15 |
| β-strand | 907-916 | 10 | 13 |
| β-strand | 945-947 | 3 | 13 |
| β-strand | 949 | 1 | 12 |
| β-strand | 952-957 | 6 | 13 |
Chain e: 62 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 30-40 | 11 | |
| β-strand | 42-43 | 2 | 16 |
| β-strand | 48-49 | 2 | 16 |
| α-helix | 52-65 | 14 | |
| α-helix | 67-70 | 4 | |
| α-helix | 71-92 | 22 | |
| α-helix | 119-121 | 3 | |
| α-helix | 122-135 | 14 | |
| α-helix | 137-158 | 22 | |
| α-helix | 167-168 | 2 | |
| α-helix | 173-180 | 8 | |
| α-helix | 184-203 | 20 | |
| α-helix | 207-218 | 12 | |
| α-helix | 224-233 | 10 | |
| α-helix | 235-253 | 19 | |
| α-helix | 291-302 | 12 | |
| α-helix | 308-319 | 12 | |
| α-helix | 340-347 | 8 | |
| α-helix | 355-361 | 7 | |
| α-helix | 366-375 | 10 | |
| α-helix | 381-398 | 18 | |
| α-helix | 403-414 | 12 | |
| α-helix | 429-450 | 22 | |
| α-helix | 472-477 | 6 | |
| α-helix | 481-488 | 8 | |
| α-helix | 495-509 | 15 | |
| α-helix | 515-525 | 11 | |
| α-helix | 529-543 | 15 | |
| α-helix | 549-562 | 14 | |
| α-helix | 568-586 | 19 | |
| α-helix | 590-595 | 6 | |
| α-helix | 599-603 | 5 | |
| α-helix | 604-606 | 3 | |
| α-helix | 607-610 | 4 | |
| α-helix | 611-615 | 5 | |
| α-helix | 619-631 | 13 | |
| α-helix | 633-635 | 3 | |
| α-helix | 641-662 | 22 | |
| α-helix | 664-667 | 4 | |
| α-helix | 668-680 | 13 | |
| α-helix | 682-696 | 15 | |
| α-helix | 703-705 | 3 | |
| α-helix | 727-734 | 8 | |
| α-helix | 759-760 | 2 | |
| α-helix | 769-787 | 19 | |
| β-strand | 788 | 1 | 17 |
| α-helix | 789-790 | 2 | |
| α-helix | 802-803 | 2 | |
| β-strand | 804 | 1 | 17 |
| α-helix | 805 | 1 | |
| α-helix | 806-820 | 15 | |
| α-helix | 834-838 | 5 | |
| α-helix | 841-853 | 13 | |
| α-helix | 856-866 | 11 | |
| α-helix | 868-872 | 5 | |
| α-helix | 875-891 | 17 | |
| α-helix | 901-916 | 16 | |
| α-helix | 927-929 | 3 | |
| α-helix | 931-933 | 3 | |
| α-helix | 936-952 | 17 | |
| α-helix | 957-959 | 3 | |
| α-helix | 960 | 1 | |
| β-strand | 961-963 | 3 | 18 |
| β-strand | 968-970 | 3 | 18 |
| α-helix | 974-976 | 3 | |
| α-helix | 982-994 | 13 | |
| α-helix | 996-999 | 4 | |
| α-helix | 1001-1006 | 6 | |
Chain f: 30 helices, 28 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 3-8 | 6 | 19 |
| β-strand | 11 | 1 | 20 |
| α-helix | 12-15 | 4 | |
| β-strand | 17 | 1 | 21 |
| β-strand | 23 | 1 | 21 |
| α-helix | 24-39 | 16 | |
| α-helix | 43-45 | 3 | |
| β-strand | 49-53 | 5 | 19 |
| α-helix | 58-61 | 4 | |
| β-strand | 62-64 | 3 | 19 |
| α-helix | 70-78 | 9 | |
| β-strand | 84 | 1 | 20 |
| α-helix | 88-99 | 12 | |
| α-helix | 103-106 | 4 | |
| β-strand | 115 | 1 | 22 |
| β-strand | 123-130 | 8 | 19 |
| α-helix | 132-133 | 2 | |
| β-strand | 134-135 | 2 | 23 |
| β-strand | 140-141 | 2 | 23 |
| α-helix | 151-152 | 2 | |
| α-helix | 155-157 | 3 | |
| β-strand | 158 | 1 | 24 |
| β-strand | 166-173 | 8 | 19 |
| α-helix | 187-192 | 6 | |
| α-helix | 196-203 | 8 | |
| β-strand | 207-210 | 4 | 19 |
| α-helix | 213-225 | 13 | |
| β-strand | 230-238 | 9 | 25 |
| β-strand | 263-269 | 7 | 25 |
| β-strand | 272 | 1 | 26 |
| β-strand | 279 | 1 | 26 |
| α-helix | 283-284 | 2 | |
| β-strand | 285 | 1 | 22 |
| α-helix | 286-287 | 2 | |
| α-helix | 298-300 | 3 | |
| β-strand | 301 | 1 | 24 |
| β-strand | 306-310 | 5 | 25 |
| β-strand | 314 | 1 | 25 |
| β-strand | 325-329 | 5 | 25 |
| α-helix | 330 | 1 | |
| α-helix | 333-341 | 9 | |
| β-strand | 347-352 | 6 | 25 |
| β-strand | 364-370 | 7 | 25 |
| β-strand | 377-381 | 5 | 25 |
| α-helix | 382-383 | 2 | |
| α-helix | 386-398 | 13 | |
| α-helix | 406-417 | 12 | |
| α-helix | 421-423 | 3 | |
| α-helix | 424-434 | 11 | |
| α-helix | 437-439 | 3 | |
| α-helix | 450-473 | 24 | |
| β-strand | 485 | 1 | 27 |
| β-strand | 528 | 1 | 27 |
| α-helix | 544-546 | 3 | |
| α-helix | 552-564 | 13 | |
| α-helix | 584-586 | 3 | |
| α-helix | 590-595 | 6 | |
| α-helix | 598-599 | 2 | |
Chain g: 50 helices, 14 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 22-33 | 12 | |
| α-helix | 38-54 | 17 | |
| α-helix | 58-74 | 17 | |
| α-helix | 77-89 | 13 | |
| α-helix | 93-96 | 4 | |
| α-helix | 100-108 | 9 | |
| α-helix | 109-112 | 4 | |
| α-helix | 116-128 | 13 | |
| α-helix | 137-147 | 11 | |
| α-helix | 152-168 | 17 | |
| α-helix | 170-185 | 16 | |
| α-helix | 191-197 | 7 | |
| α-helix | 198-203 | 6 | |
| α-helix | 208-224 | 17 | |
| α-helix | 228-245 | 18 | |
| α-helix | 249-262 | 14 | |
| α-helix | 266-282 | 17 | |
| α-helix | 284-286 | 3 | |
| α-helix | 289-300 | 12 | |
| α-helix | 305-319 | 15 | |
| α-helix | 323-327 | 5 | |
| α-helix | 343-351 | 9 | |
| α-helix | 357-373 | 17 | |
| α-helix | 377-379 | 3 | |
| α-helix | 381-398 | 18 | |
| α-helix | 403-422 | 20 | |
| α-helix | 424-426 | 3 | |
| α-helix | 427-438 | 12 | |
| α-helix | 443-459 | 17 | |
| α-helix | 461-467 | 7 | |
| α-helix | 468-479 | 12 | |
| α-helix | 486-500 | 15 | |
| α-helix | 507-519 | 13 | |
| α-helix | 523-535 | 13 | |
| α-helix | 539-549 | 11 | |
| α-helix | 556-574 | 19 | |
| α-helix | 583-607 | 25 | |
| β-strand | 609 | 1 | 28 |
| β-strand | 612 | 1 | 28 |
| α-helix | 615-625 | 11 | |
| α-helix | 629-640 | 12 | |
| α-helix | 644-646 | 3 | |
| α-helix | 647-650 | 4 | |
| α-helix | 662-664 | 3 | |
| α-helix | 666-690 | 25 | |
| α-helix | 697-717 | 21 | |
| α-helix | 718-722 | 5 | |
| α-helix | 743-760 | 18 | |
| α-helix | 771-786 | 16 | |
| α-helix | 788-789 | 2 | |
| α-helix | 793-796 | 4 | |
| β-strand | 803-804 | 2 | 29 |
| β-strand | 807-808 | 2 | 30 |
| β-strand | 819-822 | 4 | 31 |
| β-strand | 826 | 1 | 15 |
| β-strand | 827-834 | 8 | 30 |
| β-strand | 835-836 | 2 | 29 |
| β-strand | 847-858 | 12 | 31 |
| β-strand | 877-881 | 5 | 31 |
| β-strand | 887-894 | 8 | 30 |
| β-strand | 900-912 | 13 | 31 |
| β-strand | 917-918 | 2 | 31 |
| β-strand | 925-931 | 7 | 31 |
| α-helix | 934-944 | 11 | |
Chain h: 62 helices, 8 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 25-29 | 5 | |
| α-helix | 33-38 | 6 | |
| α-helix | 47-59 | 13 | |
| α-helix | 61 | 1 | |
| β-strand | 62-63 | 2 | 32 |
| β-strand | 69-70 | 2 | 32 |
| α-helix | 71-73 | 3 | |
| α-helix | 76-91 | 16 | |
| α-helix | 96-102 | 7 | |
| α-helix | 105-118 | 14 | |
| α-helix | 137-158 | 22 | |
| α-helix | 163-165 | 3 | |
| α-helix | 171-193 | 23 | |
| α-helix | 195-205 | 11 | |
| β-strand | 212-214 | 3 | 33 |
| α-helix | 217-224 | 8 | |
| β-strand | 241-243 | 3 | 33 |
| α-helix | 245-264 | 20 | |
| α-helix | 268-270 | 3 | |
| α-helix | 271-288 | 18 | |
| α-helix | 299-312 | 14 | |
| α-helix | 325-335 | 11 | |
| α-helix | 338-351 | 14 | |
| α-helix | 356-372 | 17 | |
| α-helix | 377-394 | 18 | |
| α-helix | 398-400 | 3 | |
| α-helix | 401-406 | 6 | |
| α-helix | 412-426 | 15 | |
| α-helix | 433-448 | 16 | |
| α-helix | 454-460 | 7 | |
| α-helix | 463-468 | 6 | |
| α-helix | 471-484 | 14 | |
| α-helix | 494-495 | 2 | |
| α-helix | 505-518 | 14 | |
| α-helix | 522-535 | 14 | |
| α-helix | 541-543 | 3 | |
| α-helix | 552-559 | 8 | |
| α-helix | 564-582 | 19 | |
| α-helix | 586-600 | 15 | |
| α-helix | 605-625 | 21 | |
| α-helix | 632-635 | 4 | |
| α-helix | 636-647 | 12 | |
| α-helix | 657-669 | 13 | |
| α-helix | 673-674 | 2 | |
| α-helix | 675-679 | 5 | |
| α-helix | 682-687 | 6 | |
| α-helix | 689-702 | 14 | |
| α-helix | 707-724 | 18 | |
| β-strand | 726 | 1 | 34 |
| β-strand | 727 | 1 | 35 |
| α-helix | 745-747 | 3 | |
| β-strand | 748 | 1 | 35 |
| α-helix | 754-761 | 8 | |
| α-helix | 767-782 | 16 | |
| α-helix | 790-792 | 3 | |
| α-helix | 806-808 | 3 | |
| β-strand | 809 | 1 | 34 |
| α-helix | 811-828 | 18 | |
| α-helix | 833-845 | 13 | |
| α-helix | 849-862 | 14 | |
| α-helix | 870-872 | 3 | |
| α-helix | 878-890 | 13 | |
| α-helix | 894-900 | 7 | |
| α-helix | 901-903 | 3 | |
| α-helix | 909-916 | 8 | |
| α-helix | 925-931 | 7 | |
| α-helix | 935-947 | 13 | |
| α-helix | 951-961 | 11 | |
| α-helix | 964-966 | 3 | |
| α-helix | 972-994 | 23 | |
Chain i: 35 helices, 38 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 2-5 | 4 | 36 |
| β-strand | 15-19 | 5 | 36 |
| β-strand | 22-26 | 5 | 36 |
| β-strand | 31 | 1 | 37 |
| α-helix | 32-37 | 6 | |
| β-strand | 38 | 1 | 38 |
| α-helix | 39-40 | 2 | |
| α-helix | 47-50 | 4 | |
| α-helix | 52-53 | 2 | |
| β-strand | 54 | 1 | 38 |
| α-helix | 55 | 1 | |
| β-strand | 68-71 | 4 | 38 |
| β-strand | 74-77 | 4 | 38 |
| β-strand | 83-84 | 2 | 37 |
| α-helix | 93-95 | 3 | |
| β-strand | 98-100 | 3 | 36 |
| α-helix | 110-111 | 2 | |
| α-helix | 112-116 | 5 | |
| β-strand | 122-125 | 4 | 36 |
| α-helix | 127-146 | 20 | |
| α-helix | 155-157 | 3 | |
| α-helix | 159-162 | 4 | |
| α-helix | 167-170 | 4 | |
| α-helix | 175-177 | 3 | |
| β-strand | 178-179 | 2 | 37 |
| α-helix | 180-183 | 4 | |
| α-helix | 184-191 | 8 | |
| β-strand | 194-196 | 3 | 36 |
| β-strand | 203-205 | 3 | 39 |
| β-strand | 209-215 | 7 | 39 |
| β-strand | 223-228 | 6 | 39 |
| β-strand | 233-237 | 5 | 39 |
| α-helix | 248-250 | 3 | |
| α-helix | 253-255 | 3 | |
| β-strand | 260-263 | 4 | 39 |
| α-helix | 266-267 | 2 | |
| α-helix | 274-290 | 17 | |
| β-strand | 295-298 | 4 | 40 |
| α-helix | 305-319 | 15 | |
| β-strand | 326-329 | 4 | 40 |
| α-helix | 333-342 | 10 | |
| α-helix | 349-352 | 4 | |
| α-helix | 353-355 | 3 | |
| α-helix | 364-369 | 6 | |
| β-strand | 373-376 | 4 | 40 |
| α-helix | 383-386 | 4 | |
| β-strand | 392-395 | 4 | 40 |
| α-helix | 404-412 | 9 | |
| β-strand | 419-422 | 4 | 40 |
| α-helix | 429-432 | 4 | |
| α-helix | 434-436 | 3 | |
| β-strand | 442-445 | 4 | 40 |
| α-helix | 454-464 | 11 | |
| β-strand | 468-470 | 3 | 39 |
| β-strand | 471-472 | 2 | 41 |
| α-helix | 473-476 | 4 | |
| β-strand | 498-499 | 2 | 41 |
| β-strand | 503-506 | 4 | 36 |
| β-strand | 514-518 | 5 | 42 |
| α-helix | 520-525 | 6 | |
| β-strand | 528-530 | 3 | 42 |
| β-strand | 536-547 | 12 | 42 |
| β-strand | 550-554 | 5 | 42 |
| β-strand | 586-587 | 2 | 43 |
| α-helix | 591-596 | 6 | |
| α-helix | 597-600 | 4 | |
| β-strand | 606-609 | 4 | 44 |
| β-strand | 616-619 | 4 | 44 |
| β-strand | 625-629 | 5 | 44 |
| β-strand | 632-636 | 5 | 44 |
| α-helix | 642-651 | 10 | |
| α-helix | 652-654 | 3 | |
| β-strand | 655-656 | 2 | 43 |
8 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform | p | protein | 591 | Homo sapiens | P30153 (AlphaFold model) |
| Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | q | protein | 311 | Homo sapiens | P67775 (AlphaFold model) |
| DSS1 | r | protein | 31 | Trichoplusia ni | |
| Integrator complex subunit 1 | a | protein | 2192 | Homo sapiens | Q8N201 (AlphaFold model) |
| Integrator complex subunit 2 | b | protein | 1204 | Homo sapiens | Q9H0H0 (AlphaFold model) |
| Integrator complex subunit 4 | d | protein | 963 | Homo sapiens | Q96HW7 |
| Integrator complex subunit 5 | e | protein | 1021 | Homo sapiens | Q6P9B9 |
| Integrator complex subunit 6 | f | protein | 892 | Homo sapiens | Q9UL03 |
| Integrator complex subunit 7 | g | protein | 964 | Homo sapiens | Q9NVH2 |
| Integrator complex subunit 8 | h | protein | 995 | Homo sapiens | Q75QN2 |
| Integrator complex subunit 9 | i | protein | 658 | Homo sapiens | Q9NV88 |
| Integrator complex subunit 11 | k | protein | 602 | Homo sapiens | Q5TA45 |
4 more molecules are not listed.
Sequence of entity 1 (p), FASTA
>8RC4_1 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (chains p)
SNMAAADGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDT
IYDEDEVLLALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHE
HSPSDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNLCSDDT
PMVRRAAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQE
DLEALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEV
RAAASHKVKEFCENLSADCRENVIMSQILPCIKELVSDANQHVKSALASVIMGLSPILGK
DNTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWR
VRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKEWA
HATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANVRF
NVAKSLQKIGPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEALTVLSLA
Sequence of entity 2 (q), FASTA
>8RC4_2 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (chains q)
SNMDEKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDV
HGQFHDLMELFRIGGKSPDTNYLFMGDYVNRGYYSVETVTLLVALKVRYRERITILRGNH
ESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLD
HIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVS
RAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEP
HVTRRTPDYFL
Sequence of entity 3 (r), FASTA
>8RC4_3 DSS1 (chains r)
AAADVSVWEENWEDDIVQDDFNQQLRLEMER
Sequence of entity 4 (a), FASTA
>8RC4_4 Integrator complex subunit 1 (chains a)
SNMNRAKPTTVRRPSAAAKPSGHPPPGDFIALGSKGQANESKTASTLLKPAPSGLPSERK
RDAAAALSSASALTGLTKRPKLSSTPPLSALGRLAEAAVAEKRAISPSIKEPSVVPIEVL
PTVLLDEIEAAELEGNDDRIEGVLCGAVKQLKVTRAKPDSTLYLSLMYLAKIKPNIFATE
GVIEALCSLLRRDASINFKAKGNSLVSVLACNLLMAAYEEDENWPEIFVKVYIEDSLGER
IWVDSPHCKTFVDNIQTAFNTRMPPRSVLLQGEAGRVAGDLGAGSSPHPSLTEEEDSQTE
LLIAEEKLSPEQEGQLMPRYEELAESVEEYVLDMLRDQLNRRQPIDNVSRNLLRLLTSTC
GYKEVRLLAVQKLEMWLQNPKLTRPAQDLLMSVCMNCNTHGSEDMDVISHLIKIRLKPKV
LLNHFMLCIRELLSAHKDNLGTTIKLVIFNELSSARNPNNMQVLYTALQHSSELAPKFLA
MVFQDLLTNKDDYLRASRALLREIIKQTKHEINFQAFCLGLMQERKEPQYLEMEFKERFV
VHITDVLAVSMMLGITAQVKEAGIAWDKGEKRNLEVLRSFQNQIAAIQRDAVWWLHTVVP
SISKLAPKDYVHCLHKVLFTEQPETYYKWDNWPPESDRNFFLRLCSEVPILEDTLMRILV
IGLSRELPLGPADAMELADHLVKRAAAVQADDVEVLKVGRTQLIDAVLNLCTYHHPENIQ
LPPGYQPPNLAISTLYWKAWPLLLVVAAFNPENIGLAAWEEYPTLKMLMEMVMTNNYSYP
PCTLTDEETRTEMLNRELQTAQREKQEILAFEGHLAAASTKQTITESSSLLLSQLTSLDP
QGPPRRPPPHILDQVKSLNQSLRLGHLLCRSRNPDFLLHIIQRQASSQSMPWLADLVQSS
EGSLDVLPVQCLCEFLLHDAVDDAASGEEDDEGESKEQKAKKRQRQQKQRQLLGRLQDLL
LGPKADEQTTCEVLDYFLRRLGSSQVASRVLAMKGLSLVLSEGSLRDGEEKEPPMEEDVG
DTDVLQGYQWLLRDLPRLPLFDSVRSTTALALQQAIHMETDPQTISAYLIYLSQHTPVEE
QAQHSDLALDVARLVVERSTIMSHLFSKLSPSAASDAVLSALLSIFSRYVRRMRQSKEGE
EVYSWSESQDQVFLRWSSGETATMHILVVHAMVILLTLGPPRADDSEFQALLDIWFPEEK
PLPTAFLVDTSEEALLLPDWLKLRMIRSEVLRLVDAALQDLEPQQLLLFVQSFGIPVSSM
SKLLQFLDQAVAHDPQTLEQNIMDKNYMAHLVEVQHERGASGGQTFHSLLTASLPPRRDS
TEAPKPKSSPEQPIGQGRIRVGTQLRVLGPEDDLAGMFLQIFPLSPDPRWQSSSPRPVAL
ALQQALGQELARVVQGSPEVPGITVRVLQALATLLSSPHGGALVMSMHRSHFLACPLLRQ
LCQYQRCVPQDTGFSSLFLKVLLQMLQWLDSPGVEGGPLRAQLRMLASQASAGRRLSDVR
GGLLRLAEALAFRQDLEVVSSTVRAVIATLRSGEQCSVEPDLISKVLQGLIEVRSPHLEE
LLTAFFSATADAASPFPACKPVVVVSSLLLQEEEPLAGGKPGADGGSLEAVRLGPSSGLL
VDWLEMLDPEVVSSCPDLQLRLLFSRRKGKGQAQVPSFRPYLLTLFTHQSSWPTLHQCIR
VLLGKSREQRFDPSASLDFLWACIHVPRIWQGRDQRTPQKRREELVLRVQGPELISLVEL
ILAEAETRSQDGDTAACSLIQARLPLLLSCCCGDDESVRKVTEHLSGCIQQWGDSVLGRR
CRDLLLQLYLQRPELRVPVPEVLLHSEGAASSSVCKLDGLIHRFITLLADTSDSRALENR
GADASMACRKLAVAHPLLLLRHLPMIAALLHGRTHLNFQEFRQQNHLSCFLHVLGLLELL
QPHVFRSEHQGALWDCLLSFIRLLLNYRKSSRHLAAFINKFVQFIHKYITYNAPAAISFL
QKHADPLHDLSFDNSDLVMLKSLLAGLSLPSRDDRTDRGLDEEGEEESSAGSLPLVSVSL
FTPLTAAEMAPYMKRLSRGQTVEDLLEVLSDIDEMSRRRPEILSFFSTNLQRLMSSAEEC
CRNLAFSLALRSMQNSPSIAAAFLPTFMYCLGSQDFEVVQTALRNLPEYALLCQEHAAVL
LHRAFLVGMYGQMDPSAQISEALRILHMEAVM
Sequence of entity 5 (b), FASTA
>8RC4_5 Integrator complex subunit 2 (chains b)
MKDQQTVIMTECTSLQFVSPFAFEAMQKVDVVCLASLSDPELRLLLPCLVRMALCAPADQ
SQSWAQDKKLILRLLSGVEAVNSIVALLSVDFHALEQDASKEQQLRHKLGGGSGESILVS
QLQHGLTLEFEHSDSPRRLRLVLSELLAIMNKVSESNGEFFFKSSELFESPVYLEEAADV
LCILQAELPSLLPIVDVAEALLHVRNGAWFLCLLVANVPDSFNEVCRGLIKNGERQDEES
LGGRRRTDALRFLCKMNPSQALKVRGMVVEECHLPGLGVALTLDHTKNEACEDGVSDLVC
FVSGLLLGTNAKVRTWFGTFIRNGQQRKRETSSSVLWQMRRQLLLELMGILPTVRSTRIV
EEADVDMEPNVSVYSGLKEEHVVKASALLRLYCALMGIAGLKPTEEEAEQLLQLMTSRPP
ATPAGVRFVSLSFCMLLAFSTLVSTPEQEQLMVVWLSWMIKEEAYFESTSGVSASFGEML
LLVAMYFHSNQLSAIIDLVCSTLGMKIVIKPSSLSRMKTIFTQEIFTEQVVTAHAVRVPV
TSNLSANITGFLPIHCIYQLLRSRSFTKHKVSIKDWIYRQLCETSTPLHPQLLPLIDVYI
NSILTPASKSNPEATNQPVTEQEILNIFQGVIGGDNIRLNQRFSITAQLLVLYYILSYEE
ALLANTKTLAAMQRKPKSYSSSLMDQIPIKFLIRQAQGLQQELGGLHSALLRLLATNYPH
LCIVDDWICEEEITGTDALLRRMLLTNNAKNHSPKQLQEAFSAVPVNNTQVMQIIEHLTL
LSASELIPYAEVLTSNMSQLLNSGVPRRILQTVNKLWMVLNTVMPRRLWVMTVNALQPSI
KFVRQQKYTQNDLMIDPLIVLRCDQRVHRCPPLMDITLHMLNGYLLASKAYLSAHLKETE
QDRPSQNNTIGLVGQTDAPEVTREELKNALLAAQDSAAVQILLEICLPTEEEKANGVNPD
SLLRNVQSVITTSAPNKGMEEGEDNLLCNLREVQCLICCLLHQMYIADPNIAKLVHFQGY
PCELLPLTVAGIPSMHICLDFIPELIAQPELEKQIFAIQLLSHLCIQYALPKSLSVARLA
VNVMGTLLTVLTQAKRYAFFMPTLPSLVSFCRAFPPLYEDIMSLLIQIGQVCASDVATQT
RDIDPIITRLQQIKEKPSGWSQICKDSSYKNGSRDTGSMDPDVQLCHCIERTVIEIINMS
VSGI
Sequence of entity 6 (d), FASTA
>8RC4_6 Integrator complex subunit 4 (chains d)
MAAHLKKRVYEEFTKVVQPQEEIATKKLRLTKPSKSAALHIDLCKATSPADALQYLLQFA
RKPVEAESVEGVVRILLEHYYKENDPSVRLKIASLLGLLSKTAGFSPDCIMDDAINILQN
EKSHQVLAQLLDTLLAIGTKLPENQAIQMRLVDVACKHLTDTSHGVRNKCLQLLGNLGSL
EKSVTKDAEGLAARDVQKIIGDYFSDQDPRVRTAAIKAMLQLHERGLKLHQTIYNQACKL
LSDDYEQVRSAAVQLIWVVSQLYPESIVPIPSSNEEIRLVDDAFGKICHMVSDGSWVVRV
QAAKLLGSMEQVSSHFLEQTLDKKLMSDLRRKRTAHERAKELYSSGEFSSGRKWGDDAPK
EEVDTGAVNLIESGACGAFVHGLEDEMYEVRIAAVEALCMLAQSSPSFAEKCLDFLVDMF
NDEIEEVRLQSIHTMRKISNNITLREDQLDTVLAVLEDSSRDIREALHELLCCTNVSTKE
GIHLALVELLKNLTKYPTDRDSIWKCLKFLGSRHPTLVLPLVPELLSTHPFFDTAEPDMD
DPAYIAVLVLIFNAAKTCPTMPALFSDHTFRHYAYLRDSLSHLVPALRLPGRKLVSSAVS
PSIIPQEDPSQQFLQQSLERVYSLQHLDPQGAQELLEFTIRDLQRLGELQSELAGVADFS
ATYLRCQLLLIKALQEKLWNVAAPLYLKQSDLASAAAKQIMEETYKMEFMYSGVENKQVV
IIHHMRLQAKALQLIVTARTTRGLDPLFGMCEKFLQEVDFFQRYFIADLPHLQDSFVDKL
LDLMPRLMTSKPAEVVKILQTMLRQSAFLHLPLPEQIHKASATIIEPAGESDNPLRFTSG
LVVALDVDATLEHVQDPQNTVKVQVLYPDGQAQMIHPKPADFRNPGPGRHRLITQVYLSH
TAWTEACQVEVRLLLAYNSSARIPKCPWMEGGEMSPQVETSIEGTIPFSKPVKVYIMPKP
ARR
Sequence of entity 7 (e), FASTA
>8RC4_7 Integrator complex subunit 5 (chains e)
SNMSALCDPPGAPGPPGPAPATHGPAPLSAQELSQEIKAFLTGVDPILGHQLSAREHARC
GLLLLRSLPPARAAVLDHLRGVFDESVRAHLAALDETPVAGPPHLRPPPPSHVPAGGPGL
EDVVQEVQQVLSEFIRANPKAWAPVISAWSIDLMGQLSSTYSGQHQRVPHATGALNELLQ
LWMGCRATRTLMDIYVQCLSALIGSCPDACVDALLDTSVQHSPHFDWVVAHIGSSFPGTI
ISRVLSCGLKDFCVHGGAGGGAGSSGGSSSQTPSTDPFPGSPAIPAEKRVPKIASVVGIL
GHLASRHGDSIRRELLRMFHDSLAGGSGGRSGDPSLQATVPFLLQLAVMSPALLGTVSGE
LVDCLKPPAVLSQLQQHLQGFPREELDNMLNLAVHLVSQASGAGAYRLLQFLVDTAMPAS
VITTQGLAVPDTVREACDRLIQLLLLHLQKLVHHRGGSPGEGVLGPPPPPRLVPFLDALK
NHVGELCGETLRLERKRFLWQHQLLGLLSVYTRPSCGPEALGHLLSRARSPEELSLATQL
YAGLVVSLSGLLPLAFRSCLARVHAGTLQPPFTARFLRNLALLVGWEQQGGEGPAALGAH
FGESASAHLSDLAPLLLHPEEEVAEAAASLLAICPFPSEALSPSQLLGLVRAGVHRFFAS
LRLHGPPGVASACQLLTRLSQTSPAGLKAVLQLLVEGALHRGNTELFGGQVDGDNETLSV
VSASLASASLLDTNRRHTAAVPGPGGIWSVFHAGVIGRGLKPPKFVQSRNQQEVIYNTQS
LLSLLVHCCSAPGGTECGECWGAPILSPEAAKAVAVTLVESVCPDAAGAELAWPPEEHAR
ATVERDLRIGRRFREQPLLFELLKLVAAAPPALCYCSVLLRGLLAALLGHWEASRHPDTT
HSPWHLEASCTLVAVMAEGSLLPPALGNMHEVFSQLAPFEVRLLLLSVWGFLREHGPLPQ
KFIFQSERGRFIRDFSREGGGEGGPHLAVLHSVLHRNIDRLGLFSGRFQAPSPSTLLRQG
T
Sequence of entity 8 (f), FASTA
>8RC4_8 Integrator complex subunit 6 (chains f)
YFQSNMPILLFLIDTSASMNQRSHLGTTYLDTAKGAVETFMKLRARDPASRGDRYMLVTF
EEPPYAIKAGWKENHATFMNELKNLQAEGLTTLGQSLRTAFDLLNLNRLVTGIDNYGQGR
NPFFLEPAIIITITDGSKLTTTSGVQDELHLPLNSPLPGSELTKEPFRWDQRLFALVLRL
PGTMSVESEQLTGVPLDDSAITPMCEVTGGRSYSVCSPRMLNQCLESLVQKVQSGVVINF
EKAGPDPSPVEDGQPDISRPFGSQPWHSCHKLIYVRPNPKTGVPIGHWPVPESFWPDQNS
PTLPPRTSHPVVKFSCTDCEPMVIDKLPFDKYELEPSPLTQFILERKSPQTCWQVYVSNS
AKYSELGHPFGYLKASTALNCVNLFVMPYNYPVLLPLLDDLFKVHKAKPTLKWRQSFESY
LKTMPPYYLGPLKKAVRMMGAPNLIADSMEYGLSYSVISYLKKLSQQAKIESDRVIGSVG
KKVVQETGIKVRSRSHGLSMAYRKDFQQLLQGISEDVPHRLLDLNMKEYTGFQVALLNKD
LKPQTFRNAYDIPRRNLLDHLTRMRSNLLKSTRRFLKGQDEDQVHSVPIAQMGNYQEYLK
QVPSPLRELDPDQPRRLHTFGNPFKLDKKGMMIDEADEFVAGPQNKHKRPGEPNMQGIPK
RRRCMSPLLRGRQQNPVVNNHIGGKGPPAPTTQAQPDLIKPLPLHKISETTNDSIIHDVV
ENHVADQLSSDITPNAMDTEFSASSPASLLERPTNHMEALGHDHLGTNDLTVGGFLENHE
EPRDKEQCAEENIPASSLNKGKKLMHCRSHEEVNTELKAQIMKEIRKPGRKYERIFTLLK
HVQGSLQTRLIFLQNVIKEASRFKKRMLIEQLENFLDEIHRRANQINHINSN
Sequence of entity 9 (g), FASTA
>8RC4_9 Integrator complex subunit 7 (chains g)
SNMASNSTKSFLADAGYGEQELDANSALMELDKGLRSGKLGEQCEAVVRFPRLFQKYPFP
ILINSAFLKLADVFRVGNNFLRLCVLKVTQQSEKHLEKILNVDEFVKRIFSVIHSNDPVA
RAITLRMLGSLASIIPERKNAHHSIRQSLDSHDNVEVEAAVFAAANFSAQSKDFAVGICN
KISEMIQGLATPVDLKLKLIPILQHMHHDAILASSARQLLQQLVTSYPSTKMVIVSLHTF
TLLAASSLVDTPKQIQLLLQYLKNDPRKAVKRLAIQDLKLLANKTPHTWSRENIQALCEC
ALQTPYDSLKLGMLSVLSTLSGTIAIKHYFSIVPGNVSSSPRSSDLVKLAQECCYHNNRG
IAAHGVRVLTNITVSCQEKDLLALEQDAVFGLESLLVLCSQDDSPGAQATLKIALNCMVK
LAKGRPHLSQSVVETLLTQLHSAQDAARILMCHCLAAIAMQLPVLGDGMLGDLMELYKVI
GRSATDKQQELLVSLATVIFVASQKALSVESKAVIKQQLESVSNGWTVYRIARQASRMGN
HDMAKELYQSLLTQVASEHFYFWLNSLKEFSHAEQCLTGLQEENYSSALSCIAESLKFYH
KGIASLTAASTPLNPLSFQCEFVKLRIDLLQAFSQLICTCNSLKTSPPPAIATTIAMTLG
NDLQRCGRISNQMKQSMEEFRSLASRYGDLYQASFDADSATLRNVELQQQSCLLISHAIE
ALILDPESASFQEYGSTGTAHADSEYERRMMSVYNHVLEEVESLNRKYTPVSYMHTACLC
NAIIALLKVPLSFQRYFFQKLQSTSIKLALSPSPRNPAEPIAVQNNQQLALKVEGVVQHG
SKPGLFRKIQSVCLNVSSTLQSKSGQDYKIPIDNMTNEMEQRVEPHNDYFSTQFLLNFAI
LGTHNITVESSVKDANGIVWKTGPRTTIFVKSLEDPYSQQIRLQQQQAQQPLQQQQQRNA
YTRF
Sequence of entity 10 (h), FASTA
>8RC4_10 Integrator complex subunit 8 (chains h)
MSAEAADREAATSSRPCTPPQTCWFEFLLEESLLEKHLRKPCPDPAPVQLIVQFLEQASK
PSVNEQNQVQPPPDNKRNRILKLLALKVAAHLKWDLDILEKSLSVPVLNMLLNELLCISK
VPPGTKHVDMDLATLPPTTAMAVLLYNRWAIRTIVQSSFPVKQAKPGPPQLSVMNQMQQE
KELTENILKVLKEQAADSILVLEAALKLNKDLYVHTMRTLDLLAMEPGMVNGETESSTAG
LKVKTEEMQCQVCYDLGAAYFQQGSTNSAVYENAREKFFRTKELIAEIGSLSLHCTIDEK
RLAGYCQACDVLVPSSDSTSQQLTPYSQVHICLRSGNYQEVIQIFIEDNLTLSLPVQFRQ
SVLRELFKKAQQGNEALDEICFKVCACNTVRDILEGRTISVQFNQLFLRPNKEKIDFLLE
VCSRSVNLEKASESLKGNMAAFLKNVCLGLEDLQYVFMISSHELFITLLKDEERKLLVDQ
MRKRSPRVNLCIKPVTSFYDIPASASVNIGQLEHQLILSVDPWRIRQILIELHGMTSERQ
FWTVSNKWEVPSVYSGVILGIKDNLTRDLVYILMAKGLHCSTVKDFSHAKQLFAACLELV
TEFSPKLRQVMLNEMLLLDIHTHEAGTGQAGERPPSDLISRVRGYLEMRLPDIPLRQVIA
EECVAFMLNWRENEYLTLQVPAFLLQSNPYVKLGQLLAATCKELPGPKESRRTAKDLWEV
VVQICSVSSQHKRGNDGRVSLIKQRESTLGIMYRSELLSFIKKLREPLVLTIILSLFVKL
HNVREDIVNDITAEHISIWPSSIPNLQSVDFEAVAITVKELVRYTLSINPNNHSWLIIQA
DIYFATNQYSAALHYYLQAGAVCSDFFNKAVPPDVYTDQVIKRMIKCCSLLNCHTQVAIL
CQFLREIDYKTAFKSLQEQNSHDAMDSYYDYIWDVTILEYLTYLHHKRGETDKRQIAIKA
IGQTELNASNPEEVLQLAAQRRKKKFLQAMAKLYF
Sequence of entity 11 (i), FASTA
>8RC4_11 Integrator complex subunit 9 (chains i)
MKLYCLSGHPTLPCNVLKFKSTTIMLDCGLDMTSTLNFLPLPLVQSPRLSNLPGWSLKDG
NAFLDKELKECSGHVFVDSVPEFCLPETELIDLSTVDVILISNYHCMMALPYITEHTGFT
GTVYATEPTVQIGRLLMEELVNFIERVPKAQSASLWKNKDIQRLLPSPLKDAVEVSTWRR
CYTMQEVNSALSKIQLVGYSQKIELFGAVQVTPLSSGYALGSSNWIIQSHYEKVSYVSGS
SLLTTHPQPMDQASLKNSDVLVLTGLTQIPTANPDGMVGEFCSNLALTVRNGGNVLVPCY
PSGVIYDLLECLYQYIDSAGLSSVPLYFISPVANSSLEFSQIFAEWLCHNKQSKVYLPEP
PFPHAELIQTNKLKHYPSIHGDFSNDFRQPCVVFTGHPSLRFGDVVHFMELWGKSSLNTV
IFTEPDFSYLEALAPYQPLAMKCIYCPIDTRLNFIQVSKLLKEVQPLHVVCPEQYTQPPP
AQSHRMDLMIDCQPPAMSYRRAEVLALPFKRRYEKIEIMPELADSLVPMEIKPGISLATV
SAVLHTKDNKHLLQPPPRPAQPTSGKKRKRVSDDVPDCKVLKPLLSGSIPVEQFVQTLEK
HGFSDIKVEDTAKGHIVLLQEAETLIQIEEDSTHIICDNDEMLRVRLRDLVLKFLQKF
Sequence of entity 12 (k), FASTA
>8RC4_12 Integrator complex subunit 11 (chains k)
SNMPEIRVTPLGAGQDVGRSCILVSIAGKNVMLDCGMHMGFNDDRRFPDFSYITQNGRLT
DFLDCVIISHFHLDHCGALPYFSEMVGYDGPIYMTHPTQAICPILLEDYRKIAVDKKGEA
NFFTSQMIKDCMKKVVAVHLHQTVQVDDELEIKAYYAGHVLGAAMFQIKVGSESVVYTGD
YNMTPDRHLGAAWIDKCRPNLLITQSTYATTIRDSKRCRERDFLKKVHETVERGGKVLIP
VFALGRAQELCILLETFWERMNLKVPIYFSTGLTEKANHYYKLFIPWTNQKIRKTFVQRN
MFEFKHIKAFDRAFADNPGPMVVFATPGMLHAGQSLQIFRKWAGNEKNMVIMPGYCVQGT
VGHKILSGQRKLEMEGRQVLEVKMQVEYMSFSAHADAKGIMQLVGQAEPESVLLVHGEAK
KMEFLKQKIEQELRVNCYMPANGETVTLPTSPSIPVGISLGLLKREMAQGLLPEAKKPRL
LHGTLIMKDSNFRLVSSEQALKELGLAEHQLRFTCRVHLHDTRKEQETALRVYSHLKSVL
KDHCVQHLPDGSVTVESVLLQAAAPSEDPGTKVLLVSWTYQDEELGSFLTSLLKKGLPQA
PS
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ZN | Zinc ion | Zn | 2 |
| MN | Manganese (II) ion | Mn | 2 |
Primary citation
Structural basis of Integrator-dependent RNA polymerase II termination. Fianu, I., Ochmann, M., Walshe, J.L. et al. Nature (2024) 629:219-227. DOI 10.1038/s41586-024-07269-4 · PubMed
Other PDB entries of the same protein (UniProt P30153 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 1B3U 2.3 Å, Crystal structure of constant regulatory domain of human PP2A, PR65ALPHA
- 4I5L 2.43 Å, Structural mechanism of trimeric PP2A holoenzyme involving PR70: insight for Cdc6…
- 8TWE 2.55 Å, Cryo-EM structure of the PP2A:B55-FAM122A complex, B55 body
- 2IE4 2.6 Å, Structure of the Protein Phosphatase 2A Core Enzyme Bound to okadaic acid
- 9C6B 2.6 Å, PP2A:B55-p107 substrate complex
- 8TWI 2.69 Å, Cryo-EM structure of the PP2A:B55-FAM122A complex, PP2Ac body
- 8U1X 2.7 Å, The structure of the PP2A-B56Delta holoenzyme mutant - E197K
- 9C7T 2.7 Å, PP2A:B55-Eya3 substrate complex
- 8TTB 2.77 Å, Cryo-EM structure of the PP2A:B55-ARPP19 complex
- 8SO0 2.8 Å, Cryo-EM structure of the PP2A:B55-FAM122A complex
- 2IE3 2.8 Å, Structure of the Protein Phosphatase 2A Core Enzyme Bound to Tumor-inducing Toxins
- 3C5W 2.8 Å, Complex between PP2A-specific methylesterase PME-1 and PP2A core enzyme
Browse structure collections
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