Human cohesin SMC3-HD(EQ)/RAD21-N complex - ATP-Mg-bound conformation - Form 2. Determined by X-ray diffraction at 3.11 Å resolution. Released 11 Sept 2024.
Explore 8ROL in 3D Show helices and sheets RCSB PDB PDBe
8ROL contains 22 α-helices and 18 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 2-9 | 8 | 1 |
| β-strand | 11 | 1 | 2 |
| β-strand | 14 | 1 | 2 |
| β-strand | 18-19 | 2 | 1 |
| α-helix | 20-24 | 5 | |
| β-strand | 27-32 | 6 | 3 |
| α-helix | 38-49 | 12 | |
| α-helix | 52-54 | 3 | |
| α-helix | 58-62 | 5 | |
| β-strand | 65 | 1 | 2 |
| β-strand | 75-83 | 9 | 1 |
| β-strand | 95-103 | 9 | 1 |
| β-strand | 106-111 | 6 | 1 |
| β-strand | 114-116 | 3 | 1 |
| α-helix | 118-126 | 9 | |
| β-strand | 138-140 | 3 | 3 |
| α-helix | 141-149 | 9 | |
| α-helix | 152-162 | 11 | |
| α-helix | 167-209 | 43 | |
| α-helix | 984-988 | 5 | |
| α-helix | 990-1025 | 36 | |
| α-helix | 1028-1047 | 20 | |
| β-strand | 1052-1058 | 7 | 4 |
| β-strand | 1095-1101 | 7 | 4 |
| β-strand | 1110-1111 | 2 | 4 |
| α-helix | 1112-1114 | 3 | |
| α-helix | 1117-1133 | 17 | |
| β-strand | 1139-1143 | 5 | 3 |
| α-helix | 1146-1148 | 3 | |
| α-helix | 1152-1165 | 14 | |
| β-strand | 1169-1173 | 5 | 3 |
| α-helix | 1177-1180 | 4 | |
| β-strand | 1185-1191 | 7 | 3 |
| β-strand | 1196-1200 | 5 | 3 |
| α-helix | 1203-1211 | 9 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 14-21 | 8 | |
| α-helix | 24-26 | 3 | |
| α-helix | 29-34 | 6 | |
| α-helix | 37-45 | 9 | |
| α-helix | 53-88 | 36 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Structural maintenance of chromosomes protein 3 | A | protein | 462 | Homo sapiens | Q9UQE7 (AlphaFold model) |
| Double-strand-break repair protein rad21 homolog | B | protein | 110 | Homo sapiens | O60216 (AlphaFold model) |
>8ROL_1 Structural maintenance of chromosomes protein 3 (chains A) MYIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYAIQFVLSDEFSHLRPEQ RLALLHEGTGPRVISAFVEIIFDNSDNRLPIDKEEVSLRRVIGAKKDQYFLDKKMVTKND VMNLLESAGFSRSNPYYIVKQGKINQMATAPDSQRLKLLREVAGTRVYDERKEESISLMK ETEGKREKINELLKYIEERLHTLEEEKEELAGSGSLVPRGSGSYSHVNKKALDQFVNFSE QKEKLIKRQEELDRGYKSIMELMNVLELRKYEAIQLTFKQVSKNFSEVFQKLVPGGKATL VMKKGDVEGSQSQDEGEGSGESERGSGSQSSVPSVDQFTGVGIRVSFTGKQGEMREMQQL SGGQKSLVALALIFAIQKCDPAPFYLFDQIDQALDAQHRKAVSDMIMELAVHAQFITTTF RPELLESADKFYGVKFRNKVSHIDVITAEMAKDFVEDDTTHG
>8ROL_2 Double-strand-break repair protein rad21 homolog (chains B) MFYAHFVLSKRGPLAKIWLAAHWDKKLTKAHVFECNLESSVESIISPKVKMALRTSGHLL LGVVRIYHRKAKYLLADCNEAFIKIKMAFRPGVVDLPEENREGSLEVLFQ
| ID | Name | Formula | Copies |
|---|---|---|---|
| MG | Magnesium ion | Mg | 1 |
| AGS | Phosphothiophosphoric acid-adenylate ester | C10 H16 N5 O12 P3 S | 1 |
The cohesin ATPase cycle is mediated by specific conformational dynamics and interface plasticity of SMC1A and SMC3 ATPase domains. Vitoria Gomes, M., Landwerlin, P., Diebold-Durand, M.L. et al. Cell Rep (2024) 43:114656-114656. DOI 10.1016/j.celrep.2024.114656 · PubMed
Other PDB entries of the same protein (UniProt Q9UQE7 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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