8UTI: Cytoplasmic 60S subunit biogenesis factor REH1

Eukaryotic 80S ribosome with Reh1 and A/P site tRNA. Determined by electron microscopy at 3.13 Å resolution. Released 6 Nov 2024.

Method
Electron microscopy
Resolution
3.13 Å
Organism
Saccharomyces cerevisiae
Chains
82
Atoms
196,410
Mol. weight
3139.29 kDa
Ligands
3HE
Released
6 Nov 2024

Explore 8UTI in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8UTI contains 514 α-helices and 519 β-strands across 75 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain AA: 5 helices, 3 β-strands

ElementResiduesLengthSheet
α-helix12-165
α-helix17-193
α-helix44-5310
β-strand60191
α-helix62-698
α-helix74-8613
β-strand91-94491
β-strand99-101391
Chain La: 5 helices, 11 β-strands
ElementResiduesLengthSheet
α-helix12-209
α-helix24-307
β-strand32-34378
β-strand35179
α-helix37-437
β-strand47-49378
β-strand55-58479
β-strand67-69379
β-strand70-74580
β-strand79-82480
β-strand86-88381
β-strand94-96381
β-strand99180
α-helix101-1033
β-strand104-108579
α-helix113-12210
Chain Lb: 6 helices, 5 β-strands
ElementResiduesLengthSheet
β-strand9-13590
β-strand22-29890
β-strand40-48990
α-helix49-524
α-helix59-657
β-strand69-76890
α-helix77-793
β-strand80-86790
α-helix98-1025
α-helix104-12320
α-helix128-1314
Chain Lc: 6 helices, 7 β-strands
ElementResiduesLengthSheet
α-helix7-104
α-helix42-476
β-strand72-74392
α-helix75-784
α-helix84-929
β-strand99-1002162
β-strand101-103393
α-helix104-1074
β-strand111-113392
β-strand124-127493
β-strand129-130292
α-helix132-14110
β-strand144-147493
Chain Ld: 3 helices, 1 β-strand
ElementResiduesLengthSheet
α-helix12-176
β-strand22139
α-helix23-253
α-helix37-5721
Chain LD: 8 helices, 17 β-strands
ElementResiduesLengthSheet
α-helix6-94
α-helix14-163
α-helix34-385
β-strand40-491098
α-helix571
β-strand58-64798
β-strand71-77798
β-strand83126
β-strand87-91598
β-strand101-103398
α-helix104-1063
β-strand112-114398
β-strand116199
β-strand1201100
β-strand1221100
β-strand126199
β-strand134-140798
β-strand145-149598
β-strand155-159598
β-strand163-166498
α-helix182-1909
α-helix201-2033
β-strand224-2252101
α-helix229-2302
β-strand237-2382101
Chain Le: 4 helices, 4 β-strands
ElementResiduesLengthSheet
α-helix10-1910
β-strand22-254109
α-helix27-3610
β-strand41-455109
α-helix50-6314
β-strand66-705109
α-helix74-818
β-strand89-946109
Chain LE: 14 helices, 18 β-strands
ElementResiduesLengthSheet
α-helix9-102
α-helix14-163
α-helix40-412
β-strand42-432104
β-strand45-6016105
β-strand70-8011105
α-helix82-832
β-strand84-9512106
β-strand98-1069106
α-helix112-1154
α-helix116-1183
α-helix131-1344
α-helix142-15312
β-strand157-1648106
α-helix166-1683
β-strand178-1825106
β-strand183-1842104
α-helix188-19710
β-strand201-2033106
α-helix205-2073
β-strand214-2207105
β-strand226-2272107
α-helix229-2324
α-helix235-2395
β-strand268-2692107
β-strand274-28613105
β-strand3111108
β-strand3151108
β-strand321-3255105
β-strand335-3406105
β-strand358-3592105
α-helix373-3808

67 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
25S rRNAARNA3394Saccharomyces cerevisiae
5S rRNABRNA121Saccharomyces cerevisiae
5.8S rRNACRNA158Saccharomyces cerevisiae
Messenger RNA (5'-R(P*AP*AP*UP*AP*AP*UP*GP*AP*AP*AP*A)-3')DRNA10Saccharomyces cerevisiae
A site tRNAmRNA76Saccharomyces cerevisiae
P site initiator tRNAnRNA75Saccharomyces cerevisiae
Cytoplasmic 60S subunit biogenesis factor REH1 (N-terminal 3xFLAG tag)zprotein588Saccharomyces cerevisiaeQ06709 (AlphaFold model)
18S rRNAERNA1800Saccharomyces cerevisiae
40S ribosomal protein S0-ASPprotein206Saccharomyces cerevisiaeP32905 (AlphaFold model)
40S ribosomal protein S1-ASQprotein232Saccharomyces cerevisiaeP33442 (AlphaFold model)
40S ribosomal protein S15SEprotein117Saccharomyces cerevisiaeQ01855 (AlphaFold model)
40S ribosomal protein S2SRprotein216Saccharomyces cerevisiaeP25443

70 more molecules are not listed.

Sequence of entity 1 (A), FASTA
>8UTI_1 25S rRNA (chains A)
UUGACCUCAAAUCAGGUAGGAGUACCCGCUGAACUUAAGCAUAUCAAUAAGCGGAGGAAA
AGAAACCAACCGGGAUUGCCUUAGUAACGGCGAGUGAAGCGGCAAAAGCUCAAAUUUGAA
AUCUGGUACCUUCGGUGCCCGAGUUGUAAUUUGGAGAGGGCAACUUUGGGGCCGUUCCUU
GUCUAUGUUCCUUGGAACAGGACGUCAUAGAGGGUGAGAAUCCCGUGUGGCGAGGAGUGC
GGUUCUUUGUAAAGUGCCUUCGAAGAGUCGAGUUGUUUGGGAAUGCAGCUCUAAGUGGGU
GGUAAAUUCCAUCUAAAGCUAAAUAUUGGCGAGAGACCGAUAGCGAACAAGUACAGUGAU
GGAAAGAUGAAAAGAACUUUGAAAAGAGAGUGAAAAAGUACGUGAAAUUGUUGAAAGGGA
AGGGCAUUUGAUCAGACAUGGUGUUUUGUGCCCUCUGCUCCUUGUGGGUAGGGGAAUCUC
GCAUUUCACUUGGCCAGCAUCAGUUUUGGUGGCAGGAUAAAUCCAUAGGAAUGUAGCUUG
CCUCGGUAAGUAUUAUAGCCUGUGGGAAUACUGCCAGCUGGGACUGAGGACUGCGACGUA
AGUCAAGGAUGCUGGCAUAAUGGUUAUAUGCCGCCCGUCUUGAAACACGGACCAAGGAGU
CUAACGUCUAUGCGAGUGUUUGGGUGUAAAACCCAUACGCGUAAUGAAAGUGAACGUAGG
UUGGGGCCUCGCAAGAGGUGCACAAUCGACCGAUCCUGAUGUCUUCGGAUGGAUUUGAGU
AAGAGCAUAGCUGUUGGGACCCGAAAGAUGGUGAACUAUGCCUGAAUAGGGUGAAGCCAG
AGGAAACUCUGGUGGAGGCUCGUAGCGGUUCUGACGUGCAAAUCGAUCGUCGAAUUUGGG
UAUAGGGGCGAAAGACUAAUCGAACCAUCUAGUAGCUGGUUCCUGCCGAAGUUUCCCUCA
GGAUAGCAGAAGCUCGUAUCAGUUUUAUGAGGUAAAGCGAAUGAUUAGAGGUUCCGGGGU
CGAAAUGACCUUGACCUAUUCUCAAACUUUAAAUAUGUAAGAAGUCCUUGUUACUUAAUU
GAACGUGGACAUUUGAAUGAAGAGCUUUUAGUGGGCCAUUUUUGGUAAGCAGAACUGGCG
AUGCGGGAUGAACCGAACGUAGAGUUAAGGUGCCGGAAUACACGCUCAUCAGACACCACA
AAAGGUGUUAGUUCAUCUAGACAGCCGGACGGUGGCCAUGGAAGUCGGAAUCCGCUAAGG
AGUGUGUAACAACUCACCGGCCGAAUGAACUAGCCCUGAAAAUGGAUGGCGCUCAAGCGU
GUUACCUAUACUCUACCGUCAGGGUUGAUAUGAUGCCCUGACGAGUAGGCAGGCGUGGAG
GUCAGUGACGAAGCCUAGACCGUAAGGUCGGGUCGAACGGCCUCUAGUGCAGAUCUUGGU
GGUAGUAGCAAAUAUUCAAAUGAGAACUUUGAAGACUGAAGUGGGGAAAGGUUCCACGUC
AACAGCAGUUGGACGUGGGUUAGUCGAUCCUAAGAGAUGGGGAAGCUCCGUUUCAAAGGC
CUGAUUUUAUGCAGGCCACCAUCGAAAGGGAAUCCGGUUAAGAUUCCGGAACCUGGAUAU
GGAUUCUUCACGGUAACGUAACUGAAUGUGGAGACGUCGGCGCGAGCCCUGGGAGGAGUU
AUCUUUUCUUCUUAACAGCUUAUCACCCCGGAAUUGGUUUAUCCGGAGAUGGGGUCUUAU
GGCUGGAAGAGGCCAGCACCUUUGCUGGCUCCGGUGCGCUUGUGACGGCCCGUGAAAAUC
CACAGGAAGGAAUAGUUUUCAUGCCAGGUCGUACUGAUAACCGCAGCAGGUCUCCAAGGU
GAACAGCCUCUAGUUGAUAGAAUAAUGUAGAUAAGGGAAGUCGGCAAAAUAGAUCCGUAA
CUUCGGGAUAAGGAUUGGCUCUAAGGGUCGGGUAGUGAGGGCCUUGGUCAGACGCAGCGG
GCGUGCUUGUGGACUGCUUGGUGGGGCUUGCUCUGCUAGGCGGACUACUUGCGUGCCUUG
UUGUAGACGGCCUUGGUAGGUCUCUUGUAGACCGUCGCUUGCUACAAUUAACGAUCAACU
UAGAACUGGUACGGACAAGGGGAAUCUGACUGUCUAAUUAAAACAUAGCAUUGCGAUGGU
CAGAAAGUGAUGUUGACGCAAUGUGAUUUCUGCCCAGUGCUCUGAAUGUCAAAGUGAAGA
AAUUCAACCAAGCGCGGGUAAACGGCGGGAGUAACUAUGACUCUCUUAAGGUAGCCAAAU
GCCUCGUCAUCUAAUUAGUGACGCGCAUGAAUGGAUUAACGAGAUUCCCACUGUCCCUAU
CUACUAUCUAGCGAAACCACAGCCAAGGGAACGGGCUUGGCAGAAUCAGCGGGGAAAGAA
GACCCUGUUGAGCUUGACUCUAGUUUGACAUUGUGAAGAGACAUAGAGGGUGUAGAAUAA
GUGGGAGCUUCGGCGCCAGUGAAAUACCACUACCUUUAUAGUUUCUUUACUUAUUCAAUG
AAGCGGAGCUGGAAUUCAUUUUCCACGUUCUAGCAUUCAAGGUCCCAUUCGGGGCUGAUC
CGGGUUGAAGACAUUGUCAGGUGGGGAGUUUGGCUGGGGCGGCACAUCUGUUAAACGAUA
ACGCAGAUGUCCUAAGGGGGGCUCAUGGAGAACAGAAAUCUCCAGUAGAACAAAAGGGUA
AAAGCCCCCUUGAUUUUGAUUUUCAGUGUGAAUACAAACCAUGAAAGUGUGGCCUAUCGA
UCCUUUAGUCCCUCGGAAUUUGAGGCUAGAGGUGCCAGAAAAGUUACCACAGGGAUAACU
GGCUUGUGGCAGUCAAGCGUUCAUAGCGACAUUGCUUUUUGAUUCUUCGAUGUCGGCUCU
UCCUAUCAUACCGAAGCAGAAUUCGGUAAGCGUUGGAUUGUUCACCCACUAAUAGGGAAC
GUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUACCCUACUGAUGAAUGUUACC
GCAAUAGUAAUUGAACUUAGUACGAGAGGAACAGUUCAUUCGGAUAAUUGGUUUUUGCGG
CUGUCUGAUCAGGCAUUGCCGCGAAGCUACCAUCCGCUGGAUUAUGGCUGAACGCCUCUA
AGUCAGAAUCCAUGCUAGAACGCGGUGAUUUCUUUGCUCCACACAAUAUAGAUGGAUACG
AAUAAGGCGUCCUUGUGGCGUCGCUGAACCAUAGCAGGCUAGCAACGGUGCACUUGGCGG
AAAGGCCUUGGGUGCUUGCUGGCGAAUUGCAAUGUCAUUUUGCGUGGGGAUAAAUCAUUU
GUAUACGACUUAGAUGUACAACGGGGUAUUGUAAGCAGUAGAGUAGCCUUGUUGUUACGA
UCUGCUGAGAUUAAGCCUUUGUUGUCUGAUUUGU
Sequence of entity 2 (B), FASTA
>8UTI_2 5S rRNA (chains B)
GGUUGCGGCCAUAUCUACCAGAAAGCACCGUUUCCCGUCCGAUCAACUGUAGUUAAGCUG
GUAAGAGCCUGACCGAGUAGUGUAGUGGGUGACCAUACGCGAAACUCAGGUGCUGCAAUC
U
Sequence of entity 3 (C), FASTA
>8UTI_3 5.8S rRNA (chains C)
AAACUUUCAACAACGGAUCUCUUGGUUCUCGCAUCGAUGAAGAACGCAGCGAAAUGCGAU
ACGUAAUGUGAAUUGCAGAAUUCCGUGAAUCAUCGAAUCUUUGAACGCACAUUGCGCCCC
UUGGUAUUCCAGGGGGCAUGCCUGUUUGAGCGUCAUUU
Sequence of entity 4 (D), FASTA
>8UTI_4 Messenger RNA (5'-R(P*AP*AP*UP*AP*AP*UP*GP*AP*AP*AP*A)-3') (chains D)
AAUAUGAAAA
Sequence of entity 5 (m), FASTA
>8UTI_5 A site tRNA (chains m)
GGGUCGUUAGCUCAGUUGGUAGAGCAGUUGACUUUUAAUCAAUUGGUCGCAGGUUCGAAU
CCUGCACGACCCACCA
Sequence of entity 6 (n), FASTA
>8UTI_6 P site initiator tRNA (chains n)
AGCGCCGUGGCGCAGUGGAAGCGCGCAGGGCUCAUAACCCUGAUGUCCUCGGAUCGAAAC
CGAGCGGCGCUACCA
Sequence of entity 7 (z), FASTA
>8UTI_7 Cytoplasmic 60S subunit biogenesis factor REH1 (N-terminal 3xFLAG tag) (chains z)
MKTAALAQHDEAVDNKFNKEQQNAFYEILHLPNLNEEQRNAFIQSLKDDPSQSANLLAEA
KKLNDAQAPKVDNKFNKEQQNAFYEILHLPNLNEEQRNAFIQSLKDDPSQSANLLAEAKK
LNGAQAPKVDANSAGKSTGSGSENLYFQGDYKDDDDKSSTFFTCNCCVIQFKTSDLQRYH
MKTEWHRYNLKRRIANLPPIGAEQFAEKLQISEKEQAENQVDEFGFPVLKPVMNQSNALP
QKQKKPIKSKRGRKVGTNLLKRKDRDIAKEKQNRSVSPSGSISSQLSNLTVGTENTNTDY
GEDTVSEYGFTSDSNYEYATSDEELDIADKPSDKENEKITITECIYCGKDNKEVERNVKH
MFSEHGLFIPERSYLIDLNGLLEFLIKMIVIDHNCLCCNFHGSGLESIRAHMASKRHCRL
PYETKEERQLFAPFYDFTYDDHSISKNLQNDRAITSKLSSVYGAKNDEEDGEVDITLVSS
ENDINANYTTVSIDESGLELTLPTGARLGHRAGQRYYRQNLPSQPNPNESRRTITAADRR
MVSGVTEKQYKKGMKKMQQLEKNAINTQIRREIKRVNFQTHYRDELLQ
Sequence of entity 8 (E), FASTA
>8UTI_8 18S rRNA (chains E)
UAUCUGGUUGAUCCUGCCAGUAGUCAUAUGCUUGUCUCAAAGAUUAAGCCAUGCAUGUCU
AAGUAUAAGCAAUUUAUACAGUGAAACUGCGAAUGGCUCAUUAAAUCAGUUAUCGUUUAU
UUGAUAGUUCCUUUACUACAUGGUAUAACUGUGGUAAUUCUAGAGCUAAUACAUGCUUAA
AAUCUCGACCCUUUGGAAGAGAUGUAUUUAUUAGAUAAAAAAUCAAUGUCUUCGGACUCU
UUGAUGAUUCAUAAUAACUUUUCGAAUCGCAUGGCCUUGUGCUGGCGAUGGUUCAUUCAA
AUUUCUGCCCUAUCAACUUUCGAUGGUAGGAUAGUGGCCUACCAUGGUUUCAACGGGUAA
CGGGGAAUAAGGGUUCGAUUCCGGAGAGGGAGCCUGAGAAACGGCUACCACAUCCAAGGA
AGGCAGCAGGCGCGCAAAUUACCCAAUCCUAAUUCAGGGAGGUAGUGACAAUAAAUAACG
AUACAGGGCCCAUUCGGGUCUUGUAAUUGGAAUGAGUACAAUGUAAAUACCUUAACGAGG
AACAAUUGGAGGGCAAGUCUGGUGCCAGCAGCCGCGGUAAUUCCAGCUCCAAUAGCGUAU
AUUAAAGUUGUUGCAGUUAAAAAGCUCGUAGUUGAACUUUGGGCCCGGUUGGCCGGUCCG
AUUUUUUCGUGUACUGGAUUUCCAACGGGGCCUUUCCUUCUGGCUAACCUUGAGUCCUUG
UGGCUCUUGGCGAACCAGGACUUUUACUUUGAAAAAAUUAGAGUGUUCAAAGCAGGCGUA
UUGCUCGAAUAUAUUAGCAUGGAAUAAUAGAAUAGGACGUUUGGUUCUAUUUUGUUGGUU
UCUAGGACCAUCGUAAUGAUUAAUAGGGACGGUCGGGGGCAUCAGUAUUCAAUUGUCAGA
GGUGAAAUUCUUGGAUUUAUUGAAGACUAACUACUGCGAAAGCAUUUGCCAAGGACGUUU
UCAUUAAUCAAGAACGAAAGUUAGGGGAUCGAAGAUGAUCAGAUACCGUCGUAGUCUUAA
CCAUAAACUAUGCCGACUAGGGAUCGGGUGGUGUUUUUUUAAUGACCCACUCGGCACCUU
ACGAGAAAUCAAAGUCUUUGGGUUCUGGGGGGAGUAUGGUCGCAAGGCUGAAACUUAAAG
GAAUUGACGGAAGGGCACCACCAGGAGUGGAGCCUGCGGCUUAAUUUGACUCAACACGGG
GAAACUCACCAGGUCCAGACACAAUAAGGAUUGACAGAUUGAGAGCUCUUUCUUGAUUUU
GUGGGUGGUGGUGCAUGGCCGUUCUUAGUUGGUGGAGUGAUUUGUCUGCUUAAUUGCGAU
AACGAACGAGACCUUAACCUACUAAAUAGUGGUGCUAGCAUUUGCUGGUUAUCCACUUCU
UAGAGGGACUAUCGGUUUCAAGCCGAUGGAAGUUUGAGGCAAUAACAGGUCUGUGAUGCC
CUUAGACGUUCUGGGCCGCACGCGCGCUACACUGACGGAGCCAGCGAGUCUAACCUUGGC
CGAGAGGUCUUGGUAAUCUUGUGAAACUCCGUCGUGCUGGGGAUAGAGCAUUGUAAUUAU
UGCUCUUCAACGAGGAAUUCCUAGUAAGCGCAAGUCAUCAGCUUGCGUUGAUUACGUCCC
UGCCCUUUGUACACACCGCCCGUCGCUAGUACCGAUUGAAUGGCUUAGUGAGGCCUCAGG
AUCUGCUUAGAGAAGGGGGCAACUCCAUCUCAGAGCGGAGAAUUUGGACAAACUUGGUCA
UUUAGAGGAACUAAAAGUCGUAACAAGGUUUCCGUAGGUGAACCUGCGGAAGGAUCAUUA
Sequence of entity 9 (SP), FASTA
>8UTI_9 40S ribosomal protein S0-A (chains SP)
SLPATFDLTPEDAQLLLAANTHLGARNVQVHQEPYVFNARPDGVHVINVGKTWEKLVLAA
RIIAAIPNPEDVVAISSRTFGQRAVLKFAAHTGATPIAGRFTPGSFTNYITRSFKEPRLV
IVTDPRSDAQAIKEASYVNIPVIALTDLDSPSEFVDVAIPCNNRGKHSIGLIWYLLAREV
LRLRGALVDRTQPWSIMPDLYFYRDP
Sequence of entity 10 (SQ), FASTA
>8UTI_10 40S ribosomal protein S1-A (chains SQ)
AVGKNKRLSKGKKGQKKRVVDPFTRKEWFDIKAPSTFENRNVGKTLVNKSTGLKSASDAL
KGRVVEVCLADLQGSEDHSFRKIKLRVDEVQGKNLLTNFHGMDFTTDKLRSMVRKWQTLI
EANVTVKTSDDYVLRIFAIAFTRKQANQVKRHSYAQSSHIRAIRKVISEILTKEVQGSTL
AQLTSKLIPEVINKEIENATKDIFPLQNIHVRKVKLLKQPKFDVGALMALHG
Sequence of entity 11 (SE), FASTA
>8UTI_11 40S ribosomal protein S15 (chains SE)
KTHSYRGVDLEKLLEMSTEDFVKLAPARVRRRFARGMTSKPAGFMKKLRAAKLAAPENEK
PAPVRTHMRNMIIVPEMIGSVVGIYNGKAFNQVEIRPEMLGHYLGEFSITYTPVRHG
Sequence of entity 12 (SR), FASTA
>8UTI_12 40S ribosomal protein S2 (chains SR)
GWVPVTKLGRLVKAGKITTIEEIFLHSLPVKEFQIIDTLLPGLQDEVMNIKPVQKQTRAG
QRTRFKAVVVVGDSNGHVGLGIKTAKEVAGAIRAGIIIAKLSVIPIRRGYWGTNLGQPHS
LATKTTGKCGSVTVRLIPAPRGSGIVASPAVKKLLQLAGVEDVYTQSNGKTRTLENTLKA
AFVAIGNTYGFLTPNLWAEQPLPVSPLDIYSDEASA

Ligands and cofactors

IDNameFormulaCopies
3HE4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2…C15 H23 N O41

Primary citation

The assembly factor Reh1 is released from the ribosome during its initial round of translation. Musalgaonkar, S., Yelland, J.N., Chitale, R. et al. Nat Commun (2025) 16:1278-1278. DOI 10.1038/s41467-025-55844-8 · PubMed

Other PDB entries of the same protein (UniProt Q06709 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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