9YDB: Cytoplasmic 60S subunit biogenesis factor REH1

Eukaryotic pre-60S ribosomes from uL16 P-site loop mutants in bypass condition. Lsg1,Nmd3 and Tif6 present. Determined by electron microscopy at 2.83 Å resolution. Released 30 Sept 2026.

Method
Electron microscopy
Resolution
2.83 Å
Organism
Saccharomyces cerevisiae S288C
Chains
47
Atoms
126,907
Mol. weight
2134.77 kDa
Ligands
3HE
Released
30 Sept 2026

Explore 9YDB in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9YDB contains 352 α-helices and 340 β-strands across 44 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain La: 6 helices, 11 β-strands

ElementResiduesLengthSheet
α-helix12-209
α-helix24-307
β-strand32-3432
β-strand3513
α-helix37-437
β-strand47-4932
β-strand55-5733
β-strand67-6933
β-strand70-7454
α-helix75-773
β-strand79-8244
β-strand86-8835
β-strand94-9635
β-strand9914
α-helix101-1033
β-strand106-10833
α-helix113-1219
Chain Lb: 6 helices, 5 β-strands
ElementResiduesLengthSheet
β-strand9-1356
β-strand22-2986
β-strand40-4896
α-helix49-535
α-helix59-646
β-strand69-7686
α-helix77-793
β-strand80-8676
α-helix90-923
α-helix98-1025
α-helix104-12118
Chain Lc: 7 helices, 7 β-strands
ElementResiduesLengthSheet
α-helix42-487
β-strand72-7437
α-helix75-784
α-helix79-813
α-helix84-929
α-helix96-983
β-strand99-100261
β-strand101-10338
α-helix104-1074
β-strand111-11337
β-strand124-12748
β-strand129-13027
α-helix132-1409
β-strand144-14748
Chain Ld: 4 helices, 1 β-strand
ElementResiduesLengthSheet
α-helix12-187
α-helix211
β-strand221100
α-helix23-242
α-helix37-5721
Chain LD: 12 helices, 19 β-strands
ElementResiduesLengthSheet
α-helix6-83
α-helix14-163
α-helix34-385
β-strand40-49109
α-helix571
β-strand58-6479
β-strand71-7779
α-helix781
β-strand79110
β-strand80111
β-strand82111
β-strand83112
β-strand87-9159
β-strand101-10339
α-helix104-1063
β-strand112-11439
β-strand116113
β-strand126113
β-strand134-14079
β-strand145-14959
β-strand155-15959
β-strand163-16649
α-helix1681
β-strand169110
α-helix174-1763
α-helix178-1792
α-helix182-1898
α-helix201-2033
β-strand224-225214
α-helix229-2302
β-strand237-238214
Chain Le: 4 helices, 4 β-strands
ElementResiduesLengthSheet
α-helix10-1910
β-strand22-25420
α-helix27-3610
β-strand41-44420
α-helix50-6314
β-strand66-69420
α-helix74-818
β-strand89-94620
Chain LE: 14 helices, 18 β-strands
ElementResiduesLengthSheet
α-helix9-102
α-helix33-353
α-helix40-412
β-strand42-43215
β-strand45-591516
β-strand71-801016
α-helix82-832
β-strand84-931017
β-strand100-106717
α-helix112-1154
α-helix116-1183
α-helix131-1344
α-helix138-15316
β-strand157-163717
α-helix166-1683
β-strand178-182517
β-strand183-184215
α-helix188-19710
β-strand202-203217
α-helix205-2073
β-strand214-220716
β-strand223-227518
α-helix229-2335
α-helix235-2395
β-strand268-271418
β-strand274-2851216
β-strand311119
β-strand315119
β-strand321-325516
β-strand335-340616
β-strand356-359416
α-helix373-3808
Chain Lf: 5 helices, 5 β-strands
ElementResiduesLengthSheet
β-strand8-15824
α-helix16-194
α-helix25-273
α-helix28-4316
β-strand49-51324
α-helix521
α-helix53-597
β-strand70-791024
β-strand89-95724
β-strand107-108224

36 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
25S RNAARNA3396Saccharomyces cerevisiae S288C
5S RNABRNA121Saccharomyces cerevisiae S288C
8S RNACRNA158Saccharomyces cerevisiae S288C
Cytoplasmic 60S subunit biogenesis factor REH1zprotein432Saccharomyces cerevisiae S288CQ06709 (AlphaFold model)
60S ribosomal protein L2-ALDprotein254Saccharomyces cerevisiae S288CP0CX45 (AlphaFold model)
60S ribosomal protein L3LEprotein387Saccharomyces cerevisiae S288CP14126 (AlphaFold model)
60S ribosomal protein L4-ALFprotein362Saccharomyces cerevisiae S288CP10664 (AlphaFold model)
60S ribosomal protein L5LGprotein297Saccharomyces cerevisiae S288CP26321
Large ribosomal subunit protein eL6BLHprotein176Saccharomyces cerevisiae S288CP05739
60S ribosomal protein L7-ALIprotein244Saccharomyces cerevisiae S288CP05737
60S ribosomal protein L8-ALJprotein256Saccharomyces cerevisiae S288CP17076
60S ribosomal protein L9-ALKprotein191Saccharomyces cerevisiae S288CP05738

35 more molecules are not listed.

Sequence of entity 1 (A), FASTA
>9YDB_1 25S RNA (chains A)
GUUUGACCUCAAAUCAGGUAGGAGUACCCGCUGAACUUAAGCAUAUCAAUAAGCGGAGGA
AAAGAAACCAACCGGGAUUGCCUUAGUAACGGCGAGUGAAGCGGCAAAAGCUCAAAUUUG
AAAUCUGGUACCUUCGGUGCCCGAGUUGUAAUUUGGAGAGGGCAACUUUGGGGCCGUUCC
UUGUCUAUGUUCCUUGGAACAGGACGUCAUAGAGGGUGAGAAUCCCGUGUGGCGAGGAGU
GCGGUUCUUUGUAAAGUGCCUUCGAAGAGUCGAGUUGUUUGGGAAUGCAGCUCUAAGUGG
GUGGUAAAUUCCAUCUAAAGCUAAAUAUUGGCGAGAGACCGAUAGCGAACAAGUACAGUG
AUGGAAAGAUGAAAAGAACUUUGAAAAGAGAGUGAAAAAGUACGUGAAAUUGUUGAAAGG
GAAGGGCAUUUGAUCAGACAUGGUGUUUUGUGCCCUCUGCUCCUUGUGGGUAGGGGAAUC
UCGCAUUUCACUUGGCCAGCAUCAGUUUUGGUGGCAGGAUAAAUCCAUAGGAAUGUAGCU
UGCCUCGGUAAGUAUUAUAGCCUGUGGGAAUACUGCCAGCUGGGACUGAGGACUGCGACG
UAAGUCAAGGAUGCUGGCAUAAUGGUUAUAUGCCGCCCGUCUUGAAACACGGACCAAGGA
GUCUAACGUCUAUGCGAGUGUUUGGGUGUAAAACCCAUACGCGUAAUGAAAGUGAACGUA
GGUUGGGGCCUCGCAAGAGGUGCACAAUCGACCGAUCCUGAUGUCUUCGGAUGGAUUUGA
GUAAGAGCAUAGCUGUUGGGACCCGAAAGAUGGUGAACUAUGCCUGAAUAGGGUGAAGCC
AGAGGAAACUCUGGUGGAGGCUCGUAGCGGUUCUGACGUGCAAAUCGAUCGUCGAAUUUG
GGUAUAGGGGCGAAAGACUAAUCGAACCAUCUAGUAGCUGGUUCCUGCCGAAGUUUCCCU
CAGGAUAGCAGAAGCUCGUAUCAGUUUUAUGAGGUAAAGCGAAUGAUUAGAGGUUCCGGG
GUCGAAAUGACCUUGACCUAUUCUCAAACUUUAAAUAUGUAAGAAGUCCUUGUUACUUAA
UUGAACGUGGACAUUUGAAUGAAGAGCUUUUAGUGGGCCAUUUUUGGUAAGCAGAACUGG
CGAUGCGGGAUGAACCGAACGUAGAGUUAAGGUGCCGGAAUACACGCUCAUCAGACACCA
CAAAAGGUGUUAGUUCAUCUAGACAGCCGGACGGUGGCCAUGGAAGUCGGAAUCCGCUAA
GGAGUGUGUAACAACUCACCGGCCGAAUGAACUAGCCCUGAAAAUGGAUGGCGCUCAAGC
GUGUUACCUAUACUCUACCGUCAGGGUUGAUAUGAUGCCCUGACGAGUAGGCAGGCGUGG
AGGUCAGUGACGAAGCCUAGACCGUAAGGUCGGGUCGAACGGCCUCUAGUGCAGAUCUUG
GUGGUAGUAGCAAAUAUUCAAAUGAGAACUUUGAAGACUGAAGUGGGGAAAGGUUCCACG
UCAACAGCAGUUGGACGUGGGUUAGUCGAUCCUAAGAGAUGGGGAAGCUCCGUUUCAAAG
GCCUGAUUUUAUGCAGGCCACCAUCGAAAGGGAAUCCGGUUAAGAUUCCGGAACCUGGAU
AUGGAUUCUUCACGGUAACGUAACUGAAUGUGGAGACGUCGGCGCGAGCCCUGGGAGGAG
UUAUCUUUUCUUCUUAACAGCUUAUCACCCCGGAAUUGGUUUAUCCGGAGAUGGGGUCUU
AUGGCUGGAAGAGGCCAGCACCUUUGCUGGCUCCGGUGCGCUUGUGACGGCCCGUGAAAA
UCCACAGGAAGGAAUAGUUUUCAUGCCAGGUCGUACUGAUAACCGCAGCAGGUCUCCAAG
GUGAACAGCCUCUAGUUGAUAGAAUAAUGUAGAUAAGGGAAGUCGGCAAAAUAGAUCCGU
AACUUCGGGAUAAGGAUUGGCUCUAAGGGUCGGGUAGUGAGGGCCUUGGUCAGACGCAGC
GGGCGUGCUUGUGGACUGCUUGGUGGGGCUUGCUCUGCUAGGCGGACUACUUGCGUGCCU
UGUUGUAGACGGCCUUGGUAGGUCUCUUGUAGACCGUCGCUUGCUACAAUUAACGAUCAA
CUUAGAACUGGUACGGACAAGGGGAAUCUGACUGUCUAAUUAAAACAUAGCAUUGCGAUG
GUCAGAAAGUGAUGUUGACGCAAUGUGAUUUCUGCCCAGUGCUCUGAAUGUCAAAGUGAA
GAAAUUCAACCAAGCGCGGGUAAACGGCGGGAGUAACUAUGACUCUCUUAAGGUAGCCAA
AUGCCUCGUCAUCUAAUUAGUGACGCGCAUGAAUGGAUUAACGAGAUUCCCACUGUCCCU
AUCUACUAUCUAGCGAAACCACAGCCAAGGGAACGGGCUUGGCAGAAUCAGCGGGGAAAG
AAGACCCUGUUGAGCUUGACUCUAGUUUGACAUUGUGAAGAGACAUAGAGGGUGUAGAAU
AAGUGGGAGCUUCGGCGCCAGUGAAAUACCACUACCUUUAUAGUUUCUUUACUUAUUCAA
UGAAGCGGAGCUGGAAUUCAUUUUCCACGUUCUAGCAUUCAAGGUCCCAUUCGGGGCUGA
UCCGGGUUGAAGACAUUGUCAGGUGGGGAGUUUGGCUGGGGCGGCACAUCUGUUAAACGA
UAACGCAGAUGUCCUAAGGGGGGCUCAUGGAGAACAGAAAUCUCCAGUAGAACAAAAGGG
UAAAAGCCCCCUUGAUUUUGAUUUUCAGUGUGAAUACAAACCAUGAAAGUGUGGCCUAUC
GAUCCUUUAGUCCCUCGGAAUUUGAGGCUAGAGGUGCCAGAAAAGUUACCACAGGGAUAA
CUGGCUUGUGGCAGUCAAGCGUUCAUAGCGACAUUGCUUUUUGAUUCUUCGAUGUCGGCU
CUUCCUAUCAUACCGAAGCAGAAUUCGGUAAGCGUUGGAUUGUUCACCCACUAAUAGGGA
ACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUACCCUACUGAUGAAUGUUA
CCGCAAUAGUAAUUGAACUUAGUACGAGAGGAACAGUUCAUUCGGAUAAUUGGUUUUUGC
GGCUGUCUGAUCAGGCAUUGCCGCGAAGCUACCAUCCGCUGGAUUAUGGCUGAACGCCUC
UAAGUCAGAAUCCAUGCUAGAACGCGGUGAUUUCUUUGCUCCACACAAUAUAGAUGGAUA
CGAAUAAGGCGUCCUUGUGGCGUCGCUGAACCAUAGCAGGCUAGCAACGGUGCACUUGGC
GGAAAGGCCUUGGGUGCUUGCUGGCGAAUUGCAAUGUCAUUUUGCGUGGGGAUAAAUCAU
UUGUAUACGACUUAGAUGUACAACGGGGUAUUGUAAGCAGUAGAGUAGCCUUGUUGUUAC
GAUCUGCUGAGAUUAAGCCUUUGUUGUCUGAUUUGU
Sequence of entity 2 (B), FASTA
>9YDB_2 5S RNA (chains B)
GGUUGCGGCCAUAUCUACCAGAAAGCACCGUUUCCCGUCCGAUCAACUGUAGUUAAGCUG
GUAAGAGCCUGACCGAGUAGUGUAGUGGGUGACCAUACGCGAAACUCAGGUGCUGCAAUC
U
Sequence of entity 3 (C), FASTA
>9YDB_3 8S RNA (chains C)
AAACUUUCAACAACGGAUCUCUUGGUUCUCGCAUCGAUGAAGAACGCAGCGAAAUGCGAU
ACGUAAUGUGAAUUGCAGAAUUCCGUGAAUCAUCGAAUCUUUGAACGCACAUUGCGCCCC
UUGGUAUUCCAGGGGGCAUGCCUGUUUGAGCGUCAUUU
Sequence of entity 4 (z), FASTA
>9YDB_4 Cytoplasmic 60S subunit biogenesis factor REH1 (chains z)
MSSTFFTCNCCVIQFKTSDLQRYHMKTEWHRYNLKRRIANLPPIGAEQFAEKLQISEKEQ
AENQVDEFGFPVLKPVMNQSNALPQKQKKPIKSKRGRKVGTNLLKRKDRDIAKEKQNRSV
SPSGSISSQLSNLTVGTENTNTDYGEDTVSEYGFTSDSNYEYATSDEELDIADKPSDKEN
EKITITECIYCGKDNKEVERNVKHMFSEHGLFIPERSYLIDLNGLLEFLIKMIVIDHNCL
CCNFHGSGLESIRAHMASKRHCRLPYETKEERQLFAPFYDFTYDDHSISKNLQNDRAITS
KLSSVYGAKNDEEDGEVDITLVSSENDINANYTTVSIDESGLELTLPTGARLGHRAGQRY
YRQNLPSQPNPNESRRTITAADRRMVSGVTEKQYKKGMKKMQQLEKNAINTQIRREIKRV
NFQTHYRDELLQ
Sequence of entity 5 (LD), FASTA
>9YDB_5 60S ribosomal protein L2-A (chains LD)
MGRVIRNQRKGAGSIFTSHTRLRQGAAKLRTLDYAERHGYIRGIVKQIVHDSGRGAPLAK
VVFRDPYKYRLREEIFIANEGVHTGQFIYAGKKASLNVGNVLPLGSVPEGTIVSNVEEKP
GDRGALARASGNYVIIIGHNPDENKTRVRLPSGAKKVISSDARGVIGVIAGGGRVDKPLL
KAGRAFHKYRLKRNSWPKTRGVAMNPVDHPHGGGNHQHIGKASTISRGAVSGQKAGLIAA
RRTGLLRGSQKTQD
Sequence of entity 6 (LE), FASTA
>9YDB_6 60S ribosomal protein L3 (chains LE)
MSHRKYEAPRHGHLGFLPRKRAASIRARVKAFPKDDRSKPVALTSFLGYKAGMTTIVRDL
DRPGSKFHKREVVEAVTVVDTPPVVVVGVVGYVETPRGLRSLTTVWAEHLSDEVKRRFYK
NWYKSKKKAFTKYSAKYAQDGAGIERELARIKKYASVVRVLVHTQIRKTPLAQKKAHLAE
IQLNGGSISEKVDWAREHFEKTVAVDSVFEQNEMIDAIAVTKGHGFEGVTHRWGTKKLPR
KTHRGLRKVACIGAWHPAHVMWSVARAGQRGYHSRTSINHKIYRVGKGDDEANGATSFDR
TKKTITPMGGFVHYGEIKNDFIMVKGCIPGNRKRIVTLRKSLYTNTSRKALEEVSLKWID
TASKFGKGRFQTPAEKHAFMGTLKKDL
Sequence of entity 7 (LF), FASTA
>9YDB_7 60S ribosomal protein L4-A (chains LF)
MSRPQVTVHSLTGEATANALPLPAVFSAPIRPDIVHTVFTSVNKNKRQAYAVSEKAGHQT
SAESWGTGRAVARIPRVGGGGTGRSGQGAFGNMCRGGRMFAPTKTWRKWNVKVNHNEKRY
ATASAIAATAVASLVLARGHRVEKIPEIPLVVSTDLESIQKTKEAVAALKAVGAHSDLLK
VLKSKKLRAGKGKYRNRRWTQRRGPLVVYAEDNGIVKALRNVPGVETANVASLNLLQLAP
GAHLGRFVIWTEAAFTKLDQVWGSETVASSKVGYTLPSHIISTSDVTRIINSSEIQSAIR
PAGQATQKRTHVLKKNPLKNKQVLLRLNPYAKVFAAEKLGSKKAEKTGTKPAAVFTETLK
HD
Sequence of entity 8 (LG), FASTA
>9YDB_8 60S ribosomal protein L5 (chains LG)
MAFQKDAKSSAYSSRFQTPFRRRREGKTDYYQRKRLVTQHKAKYNTPKYRLVVRFTNKDI
ICQIISSTITGDVVLAAAYSHELPRYGITHGLTNWAAAYATGLLIARRTLQKLGLDETYK
GVEEVEGEYELTEAVEDGPRPFKVFLDIGLQRTTTGARVFGALKGASDGGLYVPHSENRF
PGWDFETEEIDPELLRSYIFGGHVSQYMEELADDDEERFSELFKGYLADDIDADSLEDIY
TSAHEAIRADPAFKPTEKKFTKEQYAAESKKYRQTKLSKEERAARVAAKIAALAGQQ
Sequence of entity 9 (LH), FASTA
>9YDB_9 Large ribosomal subunit protein eL6B (chains LH)
MTAQQAPKWYPSEDVAAPKKTRKAVRPQKLRASLVPGTVLILLAGRFRGKRVVYLKHLED
NTLLVTGPFKVNGVPLRRVNARYVIATSTKVSVEGVNVEKFNVEYFAKEKLTKKEKKEAN
LFPEQQTKEIKTERVEDQKVVDKALLAEIKKTPLLKQYLSASFSLKNGDKPHLLKF
Sequence of entity 10 (LI), FASTA
>9YDB_10 60S ribosomal protein L7-A (chains LI)
MAAEKILTPESQLKKSKAQQKTAEQVAAERAARKAANKEKRAIILERNAAYQKEYETAER
NIIQAKRDAKAAGSYYVEAQHKLVFVVRIKGINKIPPKPRKVLQLLRLTRINSGTFVKVT
KATLELLKLIEPYVAYGYPSYSTIRQLVYKRGFGKINKQRVPLSDNAIIEANLGKYGILS
IDDLIHEIITVGPHFKQANNFLWPFKLSNPSGGWGVPRKFKHFIQGGSFGNREEFINKLV
KSMN
Sequence of entity 11 (LJ), FASTA
>9YDB_11 60S ribosomal protein L8-A (chains LJ)
MAPGKKVAPAPFGAKSTKSNKTRNPLTHSTPKNFGIGQAVQPKRNLSRYVKWPEYVRVQR
QKKILSIRLKVPPTIAQFQYTLDRNTAAETFKLFNKYRPETAAEKKERLTKEAAAVAEGK
SKQDASPKPYAVKYGLNHVVALIENKKAKLVLIANDVDPIELVVFLPALCKKMGVPYAIV
KGKARLGTLVNQKTSAVAALTEVRAEDEAALAKLVSTIDANFADKYDEVKKHWGGGILGN
KAQAKMDKRAKNSDSA
Sequence of entity 12 (LK), FASTA
>9YDB_12 60S ribosomal protein L9-A (chains LK)
MKYIQTEQQIEVPEGVTVSIKSRIVKVVGPRGTLTKNLKHIDVTFTKVNNQLIKVAVHNG
GRKHVAALRTVKSLVDNMITGVTKGYKYKMRYVYAHFPINVNIVEKDGAKFIEVRNFLGD
KKIRNVPVRDGVTIEFSTNVKDEIVLSGNSVEDVSQNAADLQQICRVRNKDIRKFLDGIY
VSHKGFITEDL

Ligands and cofactors

IDNameFormulaCopies
3HE4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2…C15 H23 N O41

Primary citation

Cryo-EM structure of 60S ribosomal subunit with Rpl10 loop deletion produced in bypass mutatn. Guan, K., Taylor, D.W. To be published.

Other PDB entries of the same protein (UniProt Q06709 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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