Cryo-EM structure of LGR4 in state I. Determined by electron microscopy at 3.35 Å resolution. Released 30 Oct 2024.
Explore 8WVV in 3D Show helices and sheets RCSB PDB PDBe
8WVV contains 20 α-helices and 33 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 34 | 1 | 1 |
| β-strand | 40-42 | 3 | 2 |
| β-strand | 43 | 1 | 1 |
| β-strand | 61-63 | 3 | 2 |
| β-strand | 85-87 | 3 | 2 |
| β-strand | 109-111 | 3 | 2 |
| β-strand | 119 | 1 | 3 |
| α-helix | 122-125 | 4 | |
| β-strand | 133-135 | 3 | 2 |
| β-strand | 143 | 1 | 3 |
| β-strand | 157-159 | 3 | 2 |
| α-helix | 170-173 | 4 | |
| β-strand | 181-183 | 3 | 2 |
| β-strand | 191-192 | 2 | 4 |
| β-strand | 205-207 | 3 | 2 |
| β-strand | 215-216 | 2 | 4 |
| β-strand | 229-231 | 3 | 2 |
| α-helix | 242-246 | 5 | |
| β-strand | 252-254 | 3 | 2 |
| β-strand | 262-263 | 2 | 5 |
| β-strand | 276-278 | 3 | 2 |
| β-strand | 286-287 | 2 | 5 |
| β-strand | 301-304 | 4 | 6 |
| β-strand | 323-327 | 5 | 6 |
| β-strand | 333 | 1 | 7 |
| α-helix | 338-341 | 4 | |
| β-strand | 347-349 | 3 | 6 |
| β-strand | 357 | 1 | 7 |
| α-helix | 358-360 | 3 | |
| β-strand | 369-370 | 2 | 6 |
| β-strand | 379-380 | 2 | 8 |
| β-strand | 393-394 | 2 | 6 |
| β-strand | 403-404 | 2 | 8 |
| β-strand | 417-419 | 3 | 6 |
| β-strand | 438-440 | 3 | 6 |
| α-helix | 450-452 | 3 | |
| β-strand | 461 | 1 | 6 |
| α-helix | 467-473 | 7 | |
| α-helix | 539-563 | 25 | |
| α-helix | 572-600 | 29 | |
| α-helix | 606-613 | 8 | |
| α-helix | 616-643 | 28 | |
| α-helix | 644-646 | 3 | |
| α-helix | 659-674 | 16 | |
| α-helix | 675-677 | 3 | |
| α-helix | 678-681 | 4 | |
| β-strand | 688 | 1 | 9 |
| β-strand | 690 | 1 | 9 |
| α-helix | 706-728 | 23 | |
| α-helix | 743-767 | 25 | |
| α-helix | 781-788 | 8 | |
| α-helix | 793-796 | 4 | |
| α-helix | 807-816 | 10 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Leucine-rich repeat-containing G-protein coupled receptor 4 | A | protein | 832 | Homo sapiens | Q9BXB1 (AlphaFold model) |
>8WVV_1 Leucine-rich repeat-containing G-protein coupled receptor 4 (chains A) MKTIIALSYIFCLVFADYKDDDDAAPPLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQ ALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTV PSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQ ALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEF PQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHS LVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPS FNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDV SFNELTSFPTEGLNGLNQLKLVGNFKLKEALAAKDFVNLRSLSVPYAYQCCAFWGCDSYA NLNTEDNSLQDHSVAQEKGTADAANVTSTLENEEHSQIIIHCTPSTGAFKPCEYLLGSWM IRLTVWFIFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNLFMGIYTGILTFLDAV SWGRFAEFGIWWETGSGCKVAGFLAVFSSESAIFLLMLATVERSLSAKDIMKNGKSNHLK QFRVAALLAFLGATVAGCFPLFHRGEYSASPLCLPFPTGETPSLGFTVTLVLLNSLAFLL MAVIYTKLYCNLEKEDLSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISISPE IMKSVTLIFFPLPACLNPVLYVFFNPKFKEDWKLLKRRVTKKSGSVSVSISS
Cryo-EM structure of LGR4 in state I. Lin, C., Chang, Z. To be published.
Other PDB entries of the same protein (UniProt Q9BXB1 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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