Leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4) is a 951-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9BXB1.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 78.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 58% |
| 70 to 90 | Confident: backbone generally right | 17% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 21% |
What pLDDT means and how to read it
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G protein-coupled receptors, does not activate heterotrimeric G proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act…
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4QXE | X-ray | 2.2 Å | A=27-399 |
| 4QXF | X-ray | 2.25 Å | A/B=27-253 |
| 4KT1 | X-ray | 2.5 Å | A=26-527 |
| 9KGK | EM | 2.63 Å | A=1-950 |
| 8XUM | EM | 2.9 Å | A=1-951 |
| 9UOK | EM | 3.05 Å | C=24-951 |
| 8XT9 | EM | 3.1 Å | C=1-951 |
| 8XFS | EM | 3.2 Å | A=31-821 |
| 8XFP | EM | 3.21 Å | A=1-951 |
| 8XFT | EM | 3.24 Å | A=1-951 |
| 9KB8 | EM | 3.25 Å | A=1-822 |
| 8WVY | EM | 3.29 Å | A=24-832 |
| 8WVX | EM | 3.32 Å | A/B=24-832 |
| 8WVV | EM | 3.35 Å | A=24-832 |
| 8Y69 | EM | 3.38 Å | A/D=33-820 |
| 8WVW | EM | 3.53 Å | A=24-832 |
| 9KB6 | EM | 3.53 Å | A=1-822 |
| 9KB9 | EM | 3.59 Å | A/D=1-822 |
| 8WVU | EM | 3.61 Å | A=24-832 |
| 9KHH | EM | 3.65 Å | C/D=24-951 |
Showing 20 of 23 experimental structures (best resolution first).
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.