8X90: P/Q type calcium channel

P/Q type calcium channel. Determined by electron microscopy at 2.95 Å resolution. Released 20 Mar 2024.

Method
Electron microscopy
Resolution
2.95 Å
Organism
Homo sapiens
Chains
3
Atoms
22,122
Mol. weight
479.84 kDa
Ligands
PT5, CLR, PS1, 3PE
Released
20 Mar 2024

Explore 8X90 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8X90 contains 127 α-helices and 75 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 76 helices, 15 β-strands

ElementResiduesLengthSheet
α-helix98-11619
α-helix128-1347
α-helix137-15519
α-helix164-1663
α-helix168-18417
α-helix188-1903
α-helix193-20311
α-helix204-2085
α-helix210-22314
α-helix226-24722
β-strand254-25851
β-strand26411
α-helix280-2823
β-strand285-28951
α-helix294-2974
α-helix304-31512
α-helix320-33112
α-helix337-3448
α-helix345-3495
α-helix350-36718
α-helix370-40132
α-helix471-48313
α-helix486-50520
α-helix512-54029
α-helix542-5476
α-helix549-57022
α-helix578-59215
α-helix596-60813
α-helix611-63424
α-helix636-6394
α-helix653-66513
α-helix669-67911
α-helix687-6893
α-helix690-74556
α-helix768-7725
α-helix773-78816
α-helix1232-12409
α-helix1243-126018
α-helix1271-129828
α-helix1307-13093
α-helix1311-132919
α-helix1338-13469
α-helix1347-13504
α-helix1352-13554
α-helix1360-137516
α-helix1377-139721
β-strand140312
β-strand1419-142463
β-strand1427-143263
α-helix14361
β-strand143712
α-helix14381
α-helix1445-145713
α-helix1461-14699
α-helix1484-14863
α-helix1487-149610
α-helix1497-15015
α-helix1502-151110
α-helix1530-15389
α-helix1555-15628
α-helix1565-158319
α-helix1591-161929
α-helix1621-16244
α-helix1628-164922
α-helix1658-16647
α-helix1665-16728
α-helix1675-169016
α-helix1694-171320
β-strand171614
α-helix1741-175212
α-helix1757-17637
β-strand176815
α-helix17691
β-strand177014
α-helix17711
α-helix1772-17743
β-strand178115
α-helix1786-181126
α-helix1813-18164
α-helix1825-183814
β-strand1845-184736
α-helix1850-18578
α-helix18591
α-helix1870-188011
β-strand188317
β-strand1889-189136
α-helix1892-190413
α-helix1914-192916
α-helix1935-19417
β-strand195117
α-helix1952-197827
Chain B: 39 helices, 47 β-strands
ElementResiduesLengthSheet
α-helix27-293
α-helix30-5122
α-helix54-6310
β-strand68-7258
α-helix75-11036
β-strand122-12439
β-strand142-14439
β-strand160110
β-strand165-167311
α-helix177-1859
α-helix186-1883
α-helix189-19911
β-strand205-210611
β-strand215-217311
β-strand220110
α-helix222-2243
α-helix238-2403
α-helix242-2487
β-strand253-259712
α-helix262-2643
α-helix267-28115
β-strand288-294712
β-strand298-300312
β-strand308-309212
α-helix314-32310
α-helix333-34311
β-strand356-362712
α-helix370-3767
β-strand383-389712
α-helix398-4058
β-strand410-413412
α-helix417-4248
α-helix426-4305
α-helix432-4376
β-strand445-446211
α-helix447-4493
β-strand450-451211
β-strand458-466911
β-strand486-493811
α-helix494-4996
β-strand511-515513
β-strand520114
β-strand521-523313
α-helix531-5333
α-helix537-5393
β-strand560114
α-helix569-58012
β-strand584-5931013
β-strand600-6111213
β-strand618-624713
α-helix626-6283
β-strand629-63358
α-helix638-64710
α-helix650-6523
α-helix653-6564
β-strand658-661415
β-strand667116
α-helix676-68914
β-strand697116
α-helix699-71517
α-helix716-7205
β-strand729-736815
β-strand740-743415
α-helix746-7516
α-helix762-7698
β-strand774-776315
α-helix777-7793
β-strand792-797615
β-strand800117
β-strand807117
β-strand810-816715
α-helix8171
α-helix818-82912
β-strand848-853618
β-strand858119
β-strand859-862418
α-helix865-8695
β-strand874119
α-helix880-8889
β-strand892-899820
β-strand976-983820
β-strand989-993518
β-strand1002-1008718
β-strand1013-1019718
β-strand1036-1037220
α-helix1043-10464
Chain C: 12 helices, 13 β-strands
ElementResiduesLengthSheet
α-helix39-5416
β-strand62-66521
β-strand71122
β-strand84121
β-strand86122
β-strand92-95421
β-strand103-108621
α-helix113-1153
β-strand116-119421
α-helix121-13111
α-helix156-1583
β-strand171-173321
β-strand180-183423
α-helix1841
α-helix191-20717
β-strand212-215423
α-helix247-26216
β-strand266-269423
α-helix277-2804
β-strand288-292523
α-helix297-3059
α-helix310-3123
α-helix315-32612
β-strand335-337323
α-helix342-35918

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Voltage-dependent P/Q-type calcium channel subunit alpha-1AAprotein2549Homo sapiensO00555 (AlphaFold model)
Voltage-dependent calcium channel subunit alpha-2/delta-1Bprotein1115Homo sapiensP54289 (AlphaFold model)
Voltage-dependent L-type calcium channel subunit beta-3Cprotein496Homo sapiensP54284 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>8X90_1 Voltage-dependent P/Q-type calcium channel subunit alpha-1A (chains A)
MASWSHPQFEKGGGARGGSGGGSWSHPQFEKGFDYKDDDDKGTMARFGDEMPARYGGGGS
GAAAGVVVGSGGGRGAGGSRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRS
LFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTE
PYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRTLRAV
RVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCF
EEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITM
EGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFL
KLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPFDALRRTTIKKSKTDLLNPEE
AEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVA
LNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGV
IIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLL
FLLFLFIVVFALLGMQLFGGQFNFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGI
KSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKL
ALQKAKEVAEVSPLSAANMSIAVKEQQKNQKPAKSVWEQRTSEMRKQNLLASREALYNEM
DPDERWKAAYTRHLRPDMKTHLDRPLVVDPQENRNNNTNKSRAAEPTVDQRLGQQRAEDF
LRKQARYHDRARDPSGSAGLDARRPWAGSQEAELSREGPYGRESDHHAREGSLEQPGFWE
GEAERGKAGDPHRRHVHRQGGSRESRSGSPRTGADGEHRRHRAHRRPGEEGPEDKAERRA
RHREGSRPARGGEGEGEGPDGGERRRRHRHGAPATYEGDARREDKERRHRRRKENQGSGV
PVSGPNLSTTRPIQQDLGRQDPPLAEDIDNMKNNKLATAESAAPHGSLGHAGLPQSPAKM
GNSTDPGPMLAIPAMATNPQNAASRRTPNNPGNPSNPGPPKTPENSLIVTNPSGTQTNSA
KTARKPDHTTVDIPPACPPPLNHTVVQVNKNANPDPLPKKEEEKKEEEEDDRGEDGPKPM
PPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLR
YFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKD
INTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQL
FKGKFFHCTDESKEFEKDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVST
GEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQG
DKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIAL
NTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTV
LGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLL
IAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAW
HNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLT
RDSSILGPHHLDEYVRVWAEYDPAAWGRMPYLDMYQMLRHMSPPLGLGKKCPARVAYKRL
LRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKT
LDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAMREEQDRTPLMFQRMEPPSPTQ
EGGPGQNALPSTQLDPGGALMAHESGLKESPSWVTQRAQEMFQKTGTWSPEQGPPTDMPN
SQPNSQSVEMREMGRDGYSDSEHYLPMEGQGRAASMPRLPAENQRRRGRPRGNNLSTISD
TSPMKRSASVLGPKARRLDDYSLERVPPEENQRHHQRRRDRSHRASERSLGRYTDVDTGL
GTDLSMTTQSGDLPSKERDQERGRPKDRKHRQHHHHHHHHHHPPPPDKDRYAQERPDHGR
ARARDQRWSRSPSEGREHMAHRQGSSSVSGSPAPSTSGTSTPRRGRRQLPQTPSTPRPHV
SYSPVIRKAGGSGPPQQQQQQQQQQQQQAVARPGRAATSGPRRYPGPTAEPLAGDRPPTG
GHSSGRSPRMERRVPGPARSESPRACRHGGARWPASGPHVSEGPPGPRHHGYYRGSDYDE
ADGPGSGGGEEAMAGAYDAPPPVRHASSGATGRSPRTPRASGPACASPSRHGRRLPNGYY
PAHGLARPRGPGSRKGLHEPYSESDDDWC
Sequence of entity 2 (B), FASTA
>8X90_2 Voltage-dependent calcium channel subunit alpha-2/delta-1 (chains B)
MAAGCLLALTLTLFQSLLIGPSSEEPFPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDI
YEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASN
EVVYYNAKDDLDPEKNDSEPGSQRIKPVFIEDANFGRQISYQHAAVHIPTDIYEGSTIVL
NELNWTSALDEVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRR
RPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQD
VSCFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSRANCNKIIML
FTDGGEERAQEIFNKYNKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIR
INTQEYLDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPVFNITGQFENKTNLK
NQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKPIGVGIPTIN
LRKRRPNIQNPKSQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYI
DKGNRTYTWTPVNGTDYSLALVLPTYSFYYIKAKLEETITQARYSETLKPDNFEESGYTF
IAPRDYCNDLKISDNNTEFLLNFNEFIDRKTPNNPSCNADLINRVLLDAGFTNELVQNYW
SKQKNIKGVKARFVVTDGGITRVYPKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYF
NKSGPGAYESGIMVSKAVEIYIQGKLLKPAVVGIKIDVNSWIENFTKTSIRDPCAGPVCD
CKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSLMRHLVNISVYAFNKSYDY
QSVCEPGAAPKQGAGHRSAYVPSVADILQIGWWATAAAWSILQQFLLSLTFPRLLEAVEM
EDDDFTASLSKQSCITEQTQYFFDNDSKSFSGVLDCGNCSRIFHGEKLMNTNLIFIMVES
KGTCPCDTRLLIQAEQTSDGPNPCDMVKQPRYRKGPDVCFDNNVLEDYTDCGGVSGLNPS
LWYIIGIQFLLLWLVSGSTHRLLLEHHHHHHHHHH
Sequence of entity 3 (C), FASTA
>8X90_3 Voltage-dependent L-type calcium channel subunit beta-3 (chains C)
MYDDSYVPGFEDSEAGSADSYTSRPSLDSDVSLEEDRESARREVESQAQQQLERAKHKPV
AFAVRTNVSYCGVLDEECPVQGSGVNFEAKDFLHIKEKYSNDWWIGRLVKEGGDIAFIPS
PQRLESIRLKQEQKARRSGNPSSLSDIGNRRSPPPSLAKQKQKQAEHVPPYDVVPSMRPV
VLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADLSLAKRSVLNNPGKRTIIER
SSARSSIAEVQSEIERIFELAKSLQLVVLDADTINHPAQLAKTSLAPIIVFVKVSSPKVL
QRLIRSRGKSQMKHLTVQMMAYDKLVQCPPESFDVILDENQLEDACEHLAEYLEVYWRAT
HHPAPGPGLLGPPSAIPGLQNQQLLGERGEEHSPLERDSLMPSDEASESSRQAWTGSSQR
SSRHLEEDYADAYQDLYQPHRQHTSGLPSANGHDPQDRLLAQDSEHNHSDRNWQRNRPWP
KDSYLEHHHHHHHHHH

Ligands and cofactors

IDNameFormulaCopies
PT5[(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4…C47 H85 O19 P31
CLRCholesterolC27 H46 O5
PS11,2-didecanoyl-sn-glycero-3-[phospho-L-serine]C26 H49 N O10 P1
3PE1,2-Distearoyl-sn-glycerophosphoethanolamineC41 H82 N O8 P2
Y01Cholesterol hemisuccinateC31 H50 O43
NAG2-acetamido-2-deoxy-beta-D-glucopyranoseC8 H15 N O62
CACalcium ionCa2

Primary citation

Structural basis for different omega-agatoxin IVA sensitivities of the P-type and Q-type Ca v 2.1 channels. Li, Z., Cong, Y., Wu, T. et al. Cell Res (2024) 34:455-457. DOI 10.1038/s41422-024-00940-5 · PubMed

Other PDB entries of the same protein (UniProt O00555 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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