Voltage-dependent L-type calcium channel subunit beta-3 (CACNB3) is a 484-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P54284.
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The mean pLDDT of this model is 73.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 51% |
| 70 to 90 | Confident: backbone generally right | 8% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 32% |
What pLDDT means and how to read it
Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:8119293). Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity)
Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1C) and the ancillary subunits CACNB3 and CACNA2D1 (PubMed:29742403). The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio (Probable). Interacts with CACNA2D4 (PubMed:12181424). Interacts with FASLG (PubMed:19807924). Interacts with CBARP; prevents the interaction of CACNB3…
Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8WE6 | EM | 2.9 Å | C=1-484 |
| 8WE8 | EM | 2.9 Å | C=1-484 |
| 8X93 | EM | 2.92 Å | C=1-484 |
| 8X90 | EM | 2.95 Å | C=1-484 |
| 7MIX | EM | 3.0 Å | C=1-484 |
| 7UHG | EM | 3.0 Å | C=1-484 |
| 8WE9 | EM | 3.0 Å | C=1-484 |
| 7MIY | EM | 3.1 Å | C=1-484 |
| 7UHF | EM | 3.1 Å | C=1-484 |
| 8E59 | EM | 3.1 Å | C=1-484 |
| 8EPL | EM | 3.1 Å | B=1-484 |
| 8X91 | EM | 3.11 Å | C=1-484 |
| 8WE7 | EM | 3.2 Å | C=1-484 |
| 8E5A | EM | 3.3 Å | C=1-484 |
| 8E5B | EM | 3.3 Å | C=1-484 |
| 8FHS | EM | 3.3 Å | C=1-484 |
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