8ZJ1: Human left ventricle F-actin

Human left ventricle F-actin. Determined by electron microscopy at 4.25 Å resolution. Released 29 Jan 2025.

Method: Electron microscopy
Resolution: 4.25 Å
Organism: Homo sapiens
Chains: 5
Atoms: 14,625
Mol. weight: 208.85 kDa
Ligands: ADP
Released: 29 Jan 2025

Explore 8ZJ1 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8ZJ1 contains 110 α-helices and 105 β-strands across 5 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A and E: 23 helices, 21 β-strands

Element	Residues	Length	Sheet
β-strand	8-10	3	25
β-strand	11	1	26
β-strand	17-19	3	26
β-strand	21	1	25
β-strand	29-31	3	26
β-strand	35-38	4	27
β-strand	53-54	2	27
α-helix	56-60	5
α-helix	62-64	3
β-strand	65-68	4	27
β-strand	71	1	28
β-strand	76	1	28
α-helix	79-88	10
α-helix	89-94	6
α-helix	98-100	3
β-strand	103-107	5	25
α-helix	113-125	13
β-strand	131-136	6	25
α-helix	137-145	9
β-strand	150-155	6	29
β-strand	160-166	7	29
β-strand	169-170	2	29
α-helix	172-174	3
β-strand	176-178	3	29
α-helix	182-192	11
α-helix	193-196	4
α-helix	205-216	12
α-helix	223-232	10
β-strand	238-242	5	30
β-strand	245-250	6	30
α-helix	253-256	4
α-helix	258-261	4
α-helix	264-267	4
α-helix	274-284	11
α-helix	290-295	6
β-strand	297-300	4	29
α-helix	302-304	3
α-helix	309-320	12
β-strand	329-330	2	29
α-helix	338-348	11
α-helix	350-354	5
β-strand	357-358	2	25
α-helix	359-365	7
α-helix	367-370	4

Chain C: 22 helices, 21 β-strands

Element	Residues	Length	Sheet
β-strand	8-10	3	1
β-strand	11	1	2
β-strand	17-19	3	2
β-strand	21	1	1
β-strand	29-31	3	2
β-strand	35-38	4	3
β-strand	53-54	2	3
α-helix	57-59	3
β-strand	65-68	4	3
β-strand	71	1	4
β-strand	76	1	4
α-helix	80-88	9
α-helix	89-94	6
β-strand	103-107	5	1
α-helix	113-125	13
β-strand	131-136	6	1
α-helix	137-145	9
β-strand	150-155	6	5
β-strand	160-166	7	5
β-strand	169-170	2	5
α-helix	172-174	3
β-strand	176-178	3	5
α-helix	182-193	12
α-helix	194-196	3
α-helix	203-216	14
α-helix	223-232	10
β-strand	238-242	5	6
β-strand	245-250	6	6
α-helix	253-256	4
α-helix	258-261	4
α-helix	264-267	4
α-helix	274-283	10
α-helix	290-295	6
β-strand	297-300	4	5
α-helix	302-304	3
α-helix	309-320	12
β-strand	329-330	2	5
α-helix	335-337	3
α-helix	338-347	10
α-helix	350-352	3
β-strand	357-358	2	1
α-helix	359-365	7
α-helix	367-370	4

Chain D: 21 helices, 21 β-strands

Element	Residues	Length	Sheet
β-strand	8-10	3	7
β-strand	11	1	8
β-strand	17-19	3	8
β-strand	21	1	7
β-strand	29-31	3	8
β-strand	35-38	4	9
β-strand	53-54	2	9
α-helix	57-60	4
β-strand	65-68	4	9
β-strand	71	1	10
β-strand	76	1	10
α-helix	79-88	10
α-helix	89-94	6
α-helix	98-100	3
β-strand	103-107	5	7
α-helix	113-125	13
β-strand	131-136	6	7
α-helix	137-144	8
β-strand	150-154	5	11
β-strand	160-166	7	11
β-strand	169-170	2	11
α-helix	172-174	3
β-strand	176-178	3	11
α-helix	182-193	12
α-helix	203-216	14
α-helix	223-232	10
β-strand	238-240	3	12
β-strand	248-250	3	12
α-helix	253-256	4
α-helix	258-261	4
α-helix	264-267	4
α-helix	274-284	11
α-helix	291-295	5
β-strand	297-300	4	11
α-helix	302-304	3
α-helix	309-320	12
β-strand	329-330	2	11
α-helix	338-348	11
α-helix	351-354	4
β-strand	357-358	2	7
α-helix	359-365	7
α-helix	367-370	4

Chain F: 21 helices, 21 β-strands

Element	Residues	Length	Sheet
β-strand	8-10	3	19
β-strand	11	1	20
β-strand	17-19	3	20
β-strand	21	1	19
β-strand	29-31	3	20
β-strand	35-38	4	21
β-strand	53-54	2	21
α-helix	57-60	4
α-helix	61-64	4
β-strand	65-68	4	21
β-strand	71	1	22
β-strand	76	1	22
α-helix	79-87	9
α-helix	88-94	7
α-helix	98-100	3
β-strand	103-107	5	19
α-helix	113-125	13
β-strand	131-136	6	19
α-helix	137-144	8
β-strand	150-155	6	23
β-strand	160-166	7	23
β-strand	169-170	2	23
α-helix	172-174	3
β-strand	176-178	3	23
α-helix	182-193	12
α-helix	203-216	14
α-helix	223-232	10
β-strand	238-243	6	24
β-strand	245-250	6	24
α-helix	253-256	4
α-helix	258-261	4
α-helix	274-284	11
α-helix	290-295	6
β-strand	297-300	4	23
α-helix	302-305	4
α-helix	309-320	12
β-strand	329-330	2	23
α-helix	338-348	11
α-helix	351-354	4
β-strand	357-358	2	19
α-helix	359-365	7
α-helix	366-371	6

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Actin, alpha cardiac muscle 1	A, C, D, E, F	protein	371	Homo sapiens	P68032 (AlphaFold model)

Sequence of entity 1 (A, C, D, E, F), FASTA

>8ZJ1_1 Actin, alpha cardiac muscle 1 (chains A, C, D, E, F)
TTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGI
LTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMF
ETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRD
LTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPD
GQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVLSGGTT
MYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDE
AGPSIVHRKCF

Ligands and cofactors

ID	Name	Formula	Copies
ADP	Adenosine-5'-diphosphate	C10 H15 N5 O10 P2	5

Primary citation

Human left ventricle F-actin. Li, D.N., Zhao, Q.Y. To be published.

Other PDB entries of the same protein (UniProt P68032 (AlphaFold model), which also has an AlphaFold model), best resolution first:

8GT1 1.35 Å, Crystal structure of human cardiac alpha actin A108G mutant (ADP-Pi state) in complex…
8GSW 1.4 Å, Crystal structure of human cardiac alpha actin A108G mutant (AMPPNP state) in complex…
8GT5 1.4 Å, Crystal structure of human cardiac alpha actin Q137A mutant (ADP-Pi state) in complex…
8GSU 1.5 Å, Crystal structure of human cardiac alpha actin (WT_ADP-Pi) in complex with fragmin F1…
8GT2 1.5 Å, Crystal structure of human cardiac alpha actin P109A mutant (AMPPNP state) in complex…
8GT3 1.5 Å, Crystal structure of human cardiac alpha actin P109A mutant (ADP-Pi state) in complex…
8GT4 1.55 Å, Crystal structure of human cardiac alpha actin Q137A mutant (AMPPNP state) in complex…
9ZBL 2.79 Å, Helical Reconstruction of the Human Cardiac F-Actin-Tropomyosin Complex
8ZI9 3.08 Å, Human left ventricle actin and myosin complex
9BPH 3.12 Å, cryo-EM structure of cardiac muscle alpha-actin M305L hcm mutant
9ZBP 3.12 Å, Helical Reconstruction of the Complex of Pseudo-Acetylated Human Cardiac Actin…
8ZB7 3.19 Å, Human left ventricle ATM complex

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