Structure of Epstein-Barr virus major glycoprotein gp350 in complex with the receptor CR2. Determined by electron microscopy at 3.29 Å resolution. Released 15 Jan 2025.
Explore 8ZNI in 3D Show helices and sheets RCSB PDB PDBe
8ZNI contains 6 α-helices and 35 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 7-9 | 3 | |
| β-strand | 27-29 | 3 | 1 |
| β-strand | 38-39 | 2 | 2 |
| β-strand | 43-45 | 3 | 1 |
| β-strand | 46 | 1 | 3 |
| β-strand | 56 | 1 | 3 |
| α-helix | 59-61 | 3 | |
| β-strand | 62-63 | 2 | 2 |
| α-helix | 73-75 | 3 | |
| β-strand | 83 | 1 | 4 |
| β-strand | 95 | 1 | 5 |
| β-strand | 96 | 1 | 4 |
| β-strand | 111 | 1 | 5 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 15-16 | 2 | 6 |
| β-strand | 45-50 | 6 | 7 |
| β-strand | 65-68 | 4 | 7 |
| β-strand | 128-130 | 3 | 7 |
| β-strand | 145-146 | 2 | 6 |
| β-strand | 165-174 | 10 | 8 |
| β-strand | 196 | 1 | 9 |
| β-strand | 200-203 | 4 | 8 |
| β-strand | 208-211 | 4 | 8 |
| β-strand | 213 | 1 | 10 |
| β-strand | 218 | 1 | 9 |
| β-strand | 228-229 | 2 | 11 |
| β-strand | 230 | 1 | 10 |
| β-strand | 242-243 | 2 | 11 |
| β-strand | 279-285 | 7 | 8 |
| β-strand | 297-305 | 9 | 8 |
| α-helix | 315-316 | 2 | |
| β-strand | 317 | 1 | 12 |
| β-strand | 321-323 | 3 | 13 |
| β-strand | 330-332 | 3 | 14 |
| α-helix | 333-336 | 4 | |
| β-strand | 348-351 | 4 | 12 |
| β-strand | 380-382 | 3 | 14 |
| β-strand | 390-392 | 3 | 14 |
| α-helix | 393 | 1 | |
| β-strand | 404-407 | 4 | 12 |
| β-strand | 415-418 | 4 | 12 |
| β-strand | 420-422 | 3 | 13 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Complement receptor type 2 | A | protein | 977 | Homo sapiens | P20023 (AlphaFold model) |
| BLLF1 | B | protein | 864 | human gammaherpesvirus 4 | Q3KST4 (AlphaFold model) |
>8ZNI_1 Complement receptor type 2 (chains A) MGAAGLLGVFLALVAPGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGE KSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKT NFSMNGNKSVWCQANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVT YSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANF FCDEGYRLQGPPSSRCVIAGQGVAWTKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSI VTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGR MVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPPNILNGQ KEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLT KPQHQFVRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTG SSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAV QCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKE TCQHVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCH PPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCL RSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGV PTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTW SQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQ WNPPLAVCRSRHHHHHH
>8ZNI_2 BLLF1 (chains B) MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARGSHHHHHHHHHHEAALLVCQYTIQS LIHLTGEDPGFFNVEIPEFPFYPTCNVCTADVNVTINFDVGGKKHQLDLDFGQLTPHTKA VYQPRGAFGGSENATNLFLLELLGAGELALTMRSKKLPINVTTGEEQQVSLESVDVYFQD VFGTMWCHHAEMQNPVYLIPETVPYIKWDNCNSTNITAVVRAQGLDVTLPLSLPTSAQDS NFSVKTQMLGNEIDIECIMEDGEISQVLPGDNKFNITCSGYESHVPSGGILTSTSPVATP IPGTGYAYSLRLTPRPVSRFLGNNSILYVFYSGNGPKASGGDYCIQSNIVFSDEIPASQD MPTNTTDITYVGDNATYSVPMVTSEDANSPNVTVTAFWAWPNNTETDFKCKWTLTSGTPS GCENISGAFASNRTFDITVSGLGTAPKTLIITRTATNATTTTHKVIFSKAPESTTTSPTL NTTGFADPNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSP RDNGTESKAPDMTSPTSAVTTPTPNGTSPTPAMTTPTPNATSPTLGKTSPTSAVTTPTPN ATSPTPAVTTPTPNATSPTVGETSPQANATNHTLGGTSPTPVVTSPPKNATSDVTTGQHN RTSSSTSSMSLRPSSIPETTSHMPLLTSAHPTGGENITQVTPASISTHHVSTSSPAPRPG TTSQASGPGNSSTSTKPGEVNVTKGTPPKNATSPQAPSGQKTAVPTVTSTGGKANSTTGG KHTTGHGARTSTEPTTDYGDDSTTPRPRYNATTYLPPSTSSKLRPRWTFTSPPVTTAQAT VPVPPTSQPRFSNLHHHHHHHHHH
| ID | Name | Formula | Copies |
|---|---|---|---|
| NAG | 2-acetamido-2-deoxy-beta-D-glucopyranose | C8 H15 N O6 | 6 |
Structural basis of Epstein-Barr virus gp350 receptor recognition and neutralization. Sun, C., Fang, X.Y., Bu, G.L. et al. Cell Rep (2025) 44:115168-115168. DOI 10.1016/j.celrep.2024.115168 · PubMed
Other PDB entries of the same protein (UniProt P20023 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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