Integrative structure determination of the A3G-CRL5-Vif complex (rigid). Released 5 May 2022.
Explore 9A1I in 3D Show helices and sheets RCSB PDB PDBe
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Cbfb | A | protein | 182 | Q13951 (AlphaFold model) | |
| Vif | B | protein | 175 | Q90QQ9 | |
| EloB | C | protein | 161 | Q15370 (AlphaFold model) | |
| EloC | D | protein | 112 | Q15369 (AlphaFold model) | |
| CUL5 | E | protein | 780 | Q93034 | |
| Rbx2 | F | protein | 113 | Q9UBF6 | |
| A3G | G | protein | 384 | Q9HC16 |
>9A1I_1 CBFB (chains A) MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVAT GTNLSLQFFPASWQGEQRQTPSREYVDLEREAGKVYLKAPMILNGVCVIWKGWIDLQRLD GMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEVRVSQLLAVTGKKTT RP
>9A1I_2 Vif (chains B) MENRWQVMIVWQVDRMRIRTWNSLVKHHMYISKKAKGWFYRHHYESRHPKVSSEVHIPLG DARLVVTTYWGLHTGERDWHLGHGVSIEWRQRRYSTQIDPDLADQLIHLHYFDCFSESAI RKAILGQIVSPRCEYQAGHNKVGSLQYLALTALITPKKTKPPLPSVRKLTEDHHH
>9A1I_3 EloB (chains C) MDVFLMIRRHKTTIFTDAKESSTVFELKRIVEGILKRPPDEQRLYKDDQLLDDGKTLGEC GFTSQTARPQAPATVGLAFRADDTFEALCIEPFSSPPELPDVMKPQDSGSSANEQAVHLH VHSQTMAKSRNTSWSQCPGLTACSTREPQDGPTQVHPRWGL
>9A1I_4 EloC (chains D) MDGEEKTYGGCEGPDAMYVKLISSDGHEFIVKREHALTSGTIKAMLSGPGQFAENETNEV NFREIPSHVLSKVCMYFTYKVRYTNSSTEIPEFPIAPEIALELLMAANFLDC
>9A1I_5 CUL5 (chains E) MATSNLLKNKGSLQFEDKWDFMRPIVLKLLRQESVTKQQWFDLFSDVHAVCLWDDKGPAK IHQALKEDILEFIKQAQARVLSHQDDTALLKAYIVEWRKFFTQCDILPKPFCQLEITLMG KQGSNKKSNVEDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDSQLVIGV RESYVNLCSNPEDKLQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKLKE EEKRALRYLETRRECNSVEALMECCVNALVTSFKETILAECQGMIKRNETEKLHLMFSLM DKVPNGIEPMLKDLEEHIISAGLADMVAAAETITTDSEKYVEQLLTLFNRFSKLVKEAFQ DDPRFLTARDKAYKAVVNDATIFKLELPLKQKGVGLKTQPESKCPELLANYCDMLLRKTP LSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMVEWL REVGMPADYVNKLARMFQDIKVSEDLNQAFKEMHKNNKLALPADSVNIKILNAGAWSRSS EKVFVSLPTELEDLIPEVEEFYKKNHSGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQL AVLFAWNQRPREKISFENLKLATELPDAELRRTLWSLVAFPKLKRQVLLYEPQVNSPKDF TEGTLFSVNQEFSLIKNAKVQKRGKINLIGRLQLTTERMREEENEGIVQLRILRTQEAII QIMKMRKKISNAQLQTELVEILKNMFLPQKKMIKEQIEWLIEHKYIRRDESDINTFIYMA
>9A1I_6 Rbx2 (chains F) MADVEDGEETCALASHSGSSGSKSGGDKMFSLKKWNAVAMWSWDVECDTCAICRVQVMDA CLRCQAENKQEDCVVVWGECNHSFHNCCMSLWVKQNNRCPLCQQDWVVQRIGK
>9A1I_7 A3G (chains G) MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYS ELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFV ARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPK YYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRG FLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFIS KNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQP WDGLDEHSQDLSGRLRAILQNQEN
Characterization of an A3G-Vif HIV-1-CRL5-CBFb structure using a cross-linking mass spectrometry pipeline for integrative modeling of host-pathogen complexes. Robyn M Kaake, Ignacia Echeverria, Seung Joong Kim et al. Mol Cell Proteomics (2021) 20:100132. DOI 10.1016/j.mcpro.2021.100132 · PubMed
Other PDB entries of the same protein (UniProt Q13951 (AlphaFold model), which also has an AlphaFold model), best resolution first:
MolViewer shows 9A1I directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.