9A90: PDB entry 9A90

PTEN model. Model restrained with crosslinking-MS data from "strained" conformation and CTT. AlphaFold2-generated initial structure. Released 16 Jul 2025.

Chains

1

Atoms

3,323

Mol. weight

47.23 kDa

Released

16 Jul 2025

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Molecules and chains

>9A90_1 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (chains A)
MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSK
HKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVA
AIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSY
LLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMY
FEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEI
DSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEAS
SSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHTQITKV

Primary citation

Elucidating PTEN conformational dynamics and phosphatase regulation via integrative modeling and mutation prediction. Dawson, J.E., Smith, I.N., Tushar, A.M. et al. Structure (2025). DOI 10.1016/j.str.2025.06.002 · PubMed

Related structures

Other PDB entries of the same protein (UniProt P60484 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 8X3S 1.87 Å, Crystal structure of human WDR5 in complex with PTEN
• 4O1V 2.0 Å, SPOP Promotes Tumorigenesis by Acting as a Key Regulatory Hub in Kidney Cancer
• 1D5R 2.1 Å, Crystal Structure of the PTEN Tumor Suppressor
• 7PC7 2.1 Å, The PDZ domain of SNTG1 complexed with the acetylated PDZ-binding motif of PTEN
• 5BZZ 2.2 Å, Crystal structure of human phosphatase PTEN in its reduced state
• 5BUG 2.4 Å, Crystal structure of human phosphatase PTEN oxidized by H2O2
• 5BZX 2.5 Å, Crystal structure of human phosphatase PTEN treated with a bisperoxovanadium complex
• 7JUL 2.53 Å, Crystal structure of non phosphorylated PTEN (n-crPTEN-13sp-T1, SDTTDSDPENEG)
• 7JUK 3.15 Å, Crystal structure of PTEN with a tetra-phosphorylated tail (4p-crPTEN-13sp-T2,…
• 7JVX 3.2 Å, Crystal structure of PTEN (aa 7-353 followed by spacer TGGGSGGTGGGSGGTGGGCY ligated to…
• 7JTX 3.23 Å, the structural basis of PTEN regulation by multi-site phosphorylation
• 2KYL Solution structure of MAST2-PDZ complexed with the C-terminus of PTEN

Browse structure collections

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