9B9G: PI4KA complex
Structure of the PI4KA complex bound to Calcineurin. Determined by electron microscopy at 3.5 Å resolution. Released 11 Sept 2024.
- Method
- Electron microscopy
- Resolution
- 3.5 Å
- Organism
- Homo sapiens
- Chains
- 10
- Atoms
- 48,676
- Mol. weight
- 912.8 kDa
- Ligands
- CA
- Released
- 11 Sept 2024
Explore 9B9G in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
9B9G contains 351 α-helices and 76 β-strands across 10 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 95 helices, 14 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 31-44 | 14 | |
| α-helix | 50-59 | 10 | |
| α-helix | 72-87 | 16 | |
| α-helix | 93-106 | 14 | |
| α-helix | 107-109 | 3 | |
| α-helix | 127-145 | 19 | |
| α-helix | 150-168 | 19 | |
| α-helix | 177-178 | 2 | |
| α-helix | 179-183 | 5 | |
| α-helix | 184-191 | 8 | |
| α-helix | 204-208 | 5 | |
| α-helix | 297-300 | 4 | |
| α-helix | 326-339 | 14 | |
| α-helix | 343-358 | 16 | |
| α-helix | 370-384 | 15 | |
| α-helix | 393-413 | 21 | |
| α-helix | 434-447 | 14 | |
| α-helix | 452-466 | 15 | |
| α-helix | 479-495 | 17 | |
| α-helix | 500-512 | 13 | |
| α-helix | 516-522 | 7 | |
| β-strand | 538-540 | 3 | 1 |
| α-helix | 563-580 | 18 | |
| α-helix | 587-600 | 14 | |
| α-helix | 612-626 | 15 | |
| α-helix | 634-643 | 10 | |
| α-helix | 653-664 | 12 | |
| α-helix | 669-685 | 17 | |
| α-helix | 703-705 | 3 | |
| α-helix | 707-718 | 12 | |
| α-helix | 723-739 | 17 | |
| α-helix | 768-770 | 3 | |
| α-helix | 771-778 | 8 | |
| α-helix | 782-784 | 3 | |
| α-helix | 789-804 | 16 | |
| α-helix | 818-827 | 10 | |
| α-helix | 858-872 | 15 | |
| α-helix | 876-882 | 7 | |
| α-helix | 887-906 | 20 | |
| α-helix | 913-920 | 8 | |
| α-helix | 923-927 | 5 | |
| α-helix | 934-951 | 18 | |
| α-helix | 959-973 | 15 | |
| α-helix | 974-976 | 3 | |
| α-helix | 981-996 | 16 | |
| α-helix | 998-1000 | 3 | |
| α-helix | 1006-1021 | 16 | |
| β-strand | 1032-1033 | 2 | 2 |
| β-strand | 1040-1041 | 2 | 2 |
| α-helix | 1047-1071 | 25 | |
| α-helix | 1073-1084 | 12 | |
| α-helix | 1088-1092 | 5 | |
| α-helix | 1098-1108 | 11 | |
| α-helix | 1137-1156 | 20 | |
| α-helix | 1170-1183 | 14 | |
| α-helix | 1186-1201 | 16 | |
| α-helix | 1208-1215 | 8 | |
| α-helix | 1218-1220 | 3 | |
| α-helix | 1224-1240 | 17 | |
| α-helix | 1245-1262 | 18 | |
| α-helix | 1276-1278 | 3 | |
| α-helix | 1294-1312 | 19 | |
| α-helix | 1316-1325 | 10 | |
| α-helix | 1343-1345 | 3 | |
| α-helix | 1347-1360 | 14 | |
| α-helix | 1370-1385 | 16 | |
| α-helix | 1401-1416 | 16 | |
| α-helix | 1478-1507 | 30 | |
| α-helix | 1520-1533 | 14 | |
| α-helix | 1541-1550 | 10 | |
| α-helix | 1552-1557 | 6 | |
| α-helix | 1558-1560 | 3 | |
| α-helix | 1567-1578 | 12 | |
| α-helix | 1586-1589 | 4 | |
| α-helix | 1590-1592 | 3 | |
| α-helix | 1609-1611 | 3 | |
| α-helix | 1613-1614 | 2 | |
| α-helix | 1617-1620 | 4 | |
| α-helix | 1621-1624 | 4 | |
| α-helix | 1632-1642 | 11 | |
| α-helix | 1647-1652 | 6 | |
| α-helix | 1654-1659 | 6 | |
| α-helix | 1660-1663 | 4 | |
| α-helix | 1668-1679 | 12 | |
| α-helix | 1682-1693 | 12 | |
| β-strand | 1696 | 1 | 3 |
| β-strand | 1704 | 1 | 3 |
| α-helix | 1709-1722 | 14 | |
| α-helix | 1725-1747 | 23 | |
| α-helix | 1755-1767 | 13 | |
| β-strand | 1783-1787 | 5 | 4 |
| β-strand | 1793-1794 | 2 | 4 |
| β-strand | 1803-1810 | 8 | 4 |
| α-helix | 1815-1823 | 9 | |
| β-strand | 1842-1851 | 10 | 4 |
| α-helix | 1857-1875 | 19 | |
| β-strand | 1886-1890 | 5 | 4 |
| β-strand | 1893-1898 | 6 | 4 |
| β-strand | 1904 | 1 | 5 |
| α-helix | 1916-1924 | 9 | |
| α-helix | 1930-1953 | 24 | |
| β-strand | 1963-1965 | 3 | 5 |
| β-strand | 1971-1973 | 3 | 5 |
| α-helix | 1999-2003 | 5 | |
| α-helix | 2011-2027 | 17 | |
| α-helix | 2028-2030 | 3 | |
| α-helix | 2031-2042 | 12 | |
| α-helix | 2053-2060 | 8 | |
| α-helix | 2067-2080 | 14 | |
Chain B: 98 helices, 12 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 30-44 | 15 | |
| α-helix | 51-59 | 9 | |
| α-helix | 72-87 | 16 | |
| α-helix | 97-106 | 10 | |
| α-helix | 107-109 | 3 | |
| α-helix | 128-145 | 18 | |
| α-helix | 147-149 | 3 | |
| α-helix | 150-166 | 17 | |
| α-helix | 178-181 | 4 | |
| α-helix | 183-191 | 9 | |
| α-helix | 298-300 | 3 | |
| α-helix | 326-339 | 14 | |
| α-helix | 342-358 | 17 | |
| α-helix | 370-384 | 15 | |
| α-helix | 393-413 | 21 | |
| α-helix | 435-447 | 13 | |
| α-helix | 452-466 | 15 | |
| α-helix | 479-495 | 17 | |
| α-helix | 499-502 | 4 | |
| α-helix | 504-511 | 8 | |
| α-helix | 516-521 | 6 | |
| β-strand | 540 | 1 | 6 |
| α-helix | 563-580 | 18 | |
| α-helix | 587-599 | 13 | |
| α-helix | 612-625 | 14 | |
| α-helix | 626-628 | 3 | |
| α-helix | 634-644 | 11 | |
| α-helix | 651-666 | 16 | |
| α-helix | 669-685 | 17 | |
| α-helix | 703-705 | 3 | |
| α-helix | 706-718 | 13 | |
| α-helix | 723-739 | 17 | |
| α-helix | 768-770 | 3 | |
| α-helix | 771-778 | 8 | |
| α-helix | 782-784 | 3 | |
| α-helix | 789-805 | 17 | |
| α-helix | 819-829 | 11 | |
| α-helix | 841-844 | 4 | |
| α-helix | 858-872 | 15 | |
| α-helix | 876-882 | 7 | |
| α-helix | 887-906 | 20 | |
| α-helix | 916-919 | 4 | |
| α-helix | 934-951 | 18 | |
| α-helix | 959-973 | 15 | |
| α-helix | 974-976 | 3 | |
| α-helix | 981-996 | 16 | |
| α-helix | 998-1000 | 3 | |
| α-helix | 1006-1019 | 14 | |
| β-strand | 1032-1033 | 2 | 7 |
| β-strand | 1040-1041 | 2 | 7 |
| α-helix | 1047-1071 | 25 | |
| α-helix | 1073-1084 | 12 | |
| α-helix | 1089-1092 | 4 | |
| α-helix | 1098-1108 | 11 | |
| α-helix | 1137-1157 | 21 | |
| α-helix | 1170-1183 | 14 | |
| α-helix | 1186-1201 | 16 | |
| α-helix | 1208-1215 | 8 | |
| α-helix | 1218-1220 | 3 | |
| α-helix | 1224-1240 | 17 | |
| α-helix | 1245-1262 | 18 | |
| α-helix | 1268-1270 | 3 | |
| α-helix | 1272-1275 | 4 | |
| α-helix | 1294-1312 | 19 | |
| α-helix | 1316-1325 | 10 | |
| α-helix | 1343-1345 | 3 | |
| α-helix | 1347-1360 | 14 | |
| α-helix | 1370-1384 | 15 | |
| α-helix | 1400-1415 | 16 | |
| α-helix | 1478-1507 | 30 | |
| α-helix | 1519-1533 | 15 | |
| α-helix | 1541-1550 | 10 | |
| α-helix | 1552-1557 | 6 | |
| α-helix | 1558-1560 | 3 | |
| α-helix | 1567-1578 | 12 | |
| α-helix | 1590-1592 | 3 | |
| α-helix | 1609-1611 | 3 | |
| α-helix | 1617-1620 | 4 | |
| α-helix | 1621-1624 | 4 | |
| α-helix | 1632-1643 | 12 | |
| α-helix | 1647-1652 | 6 | |
| α-helix | 1654-1660 | 7 | |
| α-helix | 1661-1663 | 3 | |
| α-helix | 1668-1679 | 12 | |
| α-helix | 1682-1694 | 13 | |
| α-helix | 1709-1719 | 11 | |
| α-helix | 1725-1748 | 24 | |
| α-helix | 1752 | 1 | |
| α-helix | 1755-1766 | 12 | |
| β-strand | 1782-1787 | 6 | 8 |
| β-strand | 1794 | 1 | 8 |
| α-helix | 1795-1796 | 2 | |
| β-strand | 1803-1811 | 9 | 8 |
| α-helix | 1815-1823 | 9 | |
| β-strand | 1842-1851 | 10 | 8 |
| α-helix | 1856-1875 | 20 | |
| β-strand | 1886-1890 | 5 | 8 |
| β-strand | 1893-1897 | 5 | 8 |
| α-helix | 1898-1899 | 2 | |
| β-strand | 1903-1904 | 2 | 9 |
| α-helix | 1916-1924 | 9 | |
| α-helix | 1930-1953 | 24 | |
| β-strand | 1963-1965 | 3 | 9 |
| β-strand | 1971-1973 | 3 | 9 |
| α-helix | 1998-2003 | 6 | |
| α-helix | 2011-2027 | 17 | |
| α-helix | 2028-2030 | 3 | |
| α-helix | 2031-2042 | 12 | |
| α-helix | 2053-2060 | 8 | |
| α-helix | 2067-2079 | 13 | |
Chain D: 30 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 137-152 | 16 | |
| α-helix | 168-193 | 26 | |
| α-helix | 218-231 | 14 | |
| α-helix | 235-247 | 13 | |
| α-helix | 249-250 | 2 | |
| α-helix | 255-272 | 18 | |
| α-helix | 324-339 | 16 | |
| α-helix | 353-374 | 22 | |
| α-helix | 380-389 | 10 | |
| α-helix | 397-408 | 12 | |
| α-helix | 414-426 | 13 | |
| α-helix | 432-441 | 10 | |
| α-helix | 449-459 | 11 | |
| α-helix | 466-485 | 20 | |
| α-helix | 491-510 | 20 | |
| α-helix | 515-527 | 13 | |
| α-helix | 531-544 | 14 | |
| α-helix | 550-561 | 12 | |
| α-helix | 565-578 | 14 | |
| α-helix | 584-596 | 13 | |
| α-helix | 599-616 | 18 | |
| α-helix | 690-707 | 18 | |
| α-helix | 712-723 | 12 | |
| α-helix | 730-743 | 14 | |
| α-helix | 748-757 | 10 | |
| α-helix | 764-777 | 14 | |
| α-helix | 782-793 | 12 | |
| α-helix | 798-809 | 12 | |
| α-helix | 814-828 | 15 | |
| α-helix | 836-838 | 3 | |
Chain E: 16 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 8-16 | 9 | |
| α-helix | 25-27 | 3 | |
| α-helix | 37-46 | 10 | |
| α-helix | 53-65 | 13 | |
| α-helix | 69-75 | 7 | |
| α-helix | 76-78 | 3 | |
| α-helix | 79-88 | 10 | |
| α-helix | 101-114 | 14 | |
| β-strand | 124-126 | 3 | 10 |
| β-strand | 159-161 | 3 | 10 |
| α-helix | 177-189 | 13 | |
| α-helix | 192-194 | 3 | |
| α-helix | 197-209 | 13 | |
| α-helix | 210-212 | 3 | |
| α-helix | 218-221 | 4 | |
| α-helix | 234-247 | 14 | |
| α-helix | 254-270 | 17 | |
| α-helix | 273-283 | 11 | |
Chain F: 33 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 137-149 | 13 | |
| α-helix | 150-154 | 5 | |
| α-helix | 168-194 | 27 | |
| α-helix | 217-232 | 16 | |
| α-helix | 235-244 | 10 | |
| α-helix | 248-250 | 3 | |
| α-helix | 255-267 | 13 | |
| α-helix | 268-272 | 5 | |
| α-helix | 275-277 | 3 | |
| α-helix | 324-341 | 18 | |
| α-helix | 356-374 | 19 | |
| α-helix | 380-389 | 10 | |
| α-helix | 397-409 | 13 | |
| α-helix | 414-426 | 13 | |
| α-helix | 432-441 | 10 | |
| α-helix | 449-459 | 11 | |
| α-helix | 467-486 | 20 | |
| α-helix | 490-510 | 21 | |
| α-helix | 515-526 | 12 | |
| α-helix | 531-544 | 14 | |
| α-helix | 549-561 | 13 | |
| α-helix | 565-578 | 14 | |
| α-helix | 583-595 | 13 | |
| α-helix | 599-616 | 18 | |
| α-helix | 690-709 | 20 | |
| α-helix | 712-725 | 14 | |
| α-helix | 730-743 | 14 | |
| α-helix | 747-757 | 11 | |
| α-helix | 765-775 | 11 | |
| α-helix | 781-793 | 13 | |
| α-helix | 798-811 | 14 | |
| α-helix | 814-828 | 15 | |
| α-helix | 836-838 | 3 | |
Chain G: 15 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 9-16 | 8 | |
| α-helix | 25-28 | 4 | |
| α-helix | 37-44 | 8 | |
| α-helix | 53-62 | 10 | |
| α-helix | 63-65 | 3 | |
| α-helix | 69-74 | 6 | |
| α-helix | 79-90 | 12 | |
| α-helix | 102-113 | 12 | |
| β-strand | 124-126 | 3 | 11 |
| α-helix | 127-128 | 2 | |
| β-strand | 159-161 | 3 | 11 |
| α-helix | 177-189 | 13 | |
| α-helix | 197-211 | 15 | |
| α-helix | 217-221 | 5 | |
| α-helix | 234-249 | 16 | |
| α-helix | 255-270 | 16 | |
| α-helix | 273-284 | 12 | |
Chain H: 11 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 17-30 | 14 | |
| β-strand | 38 | 1 | 12 |
| α-helix | 40-44 | 5 | |
| α-helix | 47-50 | 4 | |
| α-helix | 55-62 | 8 | |
| β-strand | 70 | 1 | 12 |
| α-helix | 72-80 | 9 | |
| α-helix | 88-99 | 12 | |
| β-strand | 107 | 1 | 13 |
| α-helix | 109-120 | 12 | |
| α-helix | 126-140 | 15 | |
| β-strand | 148 | 1 | 13 |
| α-helix | 150-157 | 8 | |
| α-helix | 158-160 | 3 | |
| α-helix | 162-165 | 4 | |
Chain I: 20 helices, 18 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 22-25 | 4 | |
| α-helix | 28 | 1 | |
| β-strand | 29 | 1 | 14 |
| α-helix | 30 | 1 | |
| α-helix | 31-34 | 4 | |
| β-strand | 35 | 1 | 15 |
| β-strand | 41 | 1 | 15 |
| α-helix | 43-51 | 9 | |
| β-strand | 56 | 1 | 14 |
| α-helix | 58-74 | 17 | |
| β-strand | 78-79 | 2 | 16 |
| α-helix | 81-82 | 2 | |
| α-helix | 84 | 1 | |
| β-strand | 85-88 | 4 | 1 |
| α-helix | 95-105 | 11 | |
| β-strand | 113-115 | 3 | 1 |
| α-helix | 126-139 | 14 | |
| β-strand | 144-146 | 3 | 1 |
| α-helix | 154-159 | 6 | |
| α-helix | 162-169 | 8 | |
| α-helix | 172-183 | 12 | |
| β-strand | 188-191 | 4 | 16 |
| β-strand | 195-197 | 3 | 16 |
| α-helix | 209-213 | 5 | |
| α-helix | 220-222 | 3 | |
| α-helix | 226-232 | 7 | |
| β-strand | 234 | 1 | 17 |
| β-strand | 248-250 | 3 | 17 |
| β-strand | 258-260 | 3 | 17 |
| α-helix | 262-272 | 11 | |
| β-strand | 276-279 | 4 | 16 |
| β-strand | 288-290 | 3 | 16 |
| β-strand | 302-305 | 4 | 16 |
| α-helix | 311-313 | 3 | |
| β-strand | 319-325 | 7 | 1 |
| β-strand | 328-334 | 7 | 1 |
| α-helix | 344-346 | 3 | |
| α-helix | 349-369 | 21 | |
2 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Phosphatidylinositol 4-kinase alpha | A, B | protein | 2102 | Homo sapiens | P42356 (AlphaFold model) |
| Tetratricopeptide repeat protein 7B | D, F | protein | 843 | Homo sapiens | Q86TV6 (AlphaFold model) |
| Hyccin | E, G | protein | 308 | Homo sapiens | Q9BYI3 (AlphaFold model) |
| Calcineurin subunit B type 1 | H, J | protein | 170 | Homo sapiens | P63098 (AlphaFold model) |
| Protein phosphatase 3 catalytic subunit alpha | I, K | protein | 620 | Homo sapiens | Q08209 |
Sequence of entity 1 (A, B), FASTA
>9B9G_1 Phosphatidylinositol 4-kinase alpha (chains A, B)
MAAAPARGGGGGGGGGGGCSGSGSSASRGFYFNTVLSLARSLAVQRPASLEKVQKLLCMC
PVDFHGIFQLDERRRDAVIALGIFLIESDLQHKDCVVPYLLRLLKGLPKVYWVEESTARK
GRGALPVAESFSFCLVTLLSDVAYRDPSLRDEILEVLLQVLHVLLGMCQALEIQDKEYLC
KYAIPCLIGISRAFGRYSNMEESLLSKLFPKIPPHSLRVLEELEGVRRRSFNDFRSILPS
NLLTVCQEGTLKRKTSSVSSISQVSPERGMPPPSSPGGSAFHYFEASCLPDGTALEPEYY
FSTISSSFSVSPLFNGVTYKEFNIPLEMLRELLNLVKKIVEEAVLKSLDAIVASVMEANP
SADLYYTSFSDPLYLTMFKMLRDTLYYMKDLPTSFVKEIHDFVLEQFNTSQGELQKILHD
ADRIHNELSPLKLRCQANAACVDLMVWAVKDEQGAENLCIKLSEKLQSKTSSKVIIAHLP
LLICCLQGLGRLCERFPVVVHSVTPSLRDFLVIPSPVLVKLYKYHSQYHTVAGNDIKISV
TNEHSESTLNVMSGKKSQPSMYEQLRDIAIDNICRCLKAGLTVDPVIVEAFLASLSNRLY
ISQESDKDAHLIPDHTIRALGHIAVALRDTPKVMEPILQILQQKFCQPPSPLDVLIIDQL
GCLVITGNQYIYQEVWNLFQQISVKASSVVYSATKDYKDHGYRHCSLAVINALANIAANI
QDEHLVDELLMNLLELFVQLGLEGKRASERASEKGPALKASSSAGNLGVLIPVIAVLTRR
LPPIKEAKPRLQKLFRDFWLYSVLMGFAVEGSGLWPEEWYEGVCEIATKSPLLTFPSKEP
LRSVLQYNSAMKNDTVTPAELSELRSTIINLLDPPPEVSALINKLDFAMSTYLLSVYRLE
YMRVLRSTDPDRFQVMFCYFEDKAIQKDKSGMMQCVIAVADKVFDAFLNMMADKAKTKEN
EEELERHAQFLLVNFNHIHKRIRRVADKYLSGLVDKFPHLLWSGTVLKTMLDILQTLSLS
LSADIHKDQPYYDIPDAPYRITVPDTYEARESIVKDFAARCGMILQEAMKWAPTVTKSHL
QEYLNKHQNWVSGLSQHTGLAMATESILHFAGYNKQNTTLGATQLSERPACVKKDYSNFM
ASLNLRNRYAGEVYGMIRFSGTTGQMSDLNKMMVQDLHSALDRSHPQHYTQAMFKLTAML
ISSKDCDPQLLHHLCWGPLRMFNEHGMETALACWEWLLAGKDGVEVPFMREMAGAWHMTV
EQKFGLFSAEIKEADPLAASEASQPKPCPPEVTPHYIWIDFLVQRFEIAKYCSSDQVEIF
SSLLQRSMSLNIGGAKGSMNRHVAAIGPRFKLLTLGLSLLHADVVPNATIRNVLREKIYS
TAFDYFSCPPKFPTQGEKRLREDISIMIKFWTAMFSDKKYLTASQLVPPDNQDTRSNLDI
TVGSRQQATQGWINTYPLSSGMSTISKKSGMSKKTNRGSQLHKYYMKRRTLLLSLLATEI
ERLITWYNPLSAPELELDQAGENSVANWRSKYISLSEKQWKDNVNLAWSISPYLAVQLPA
RFKNTEAIGNEVTRLVRLDPGAVSDVPEAIKFLVTWHTIDADAPELSHVLCWAPTDPPTG
LSYFSSMYPPHPLTAQYGVKVLRSFPPDAILFYIPQIVQALRYDKMGYVREYILWAASKS
QLLAHQFIWNMKTNIYLDEEGHQKDPDIGDLLDQLVEEITGSLSGPAKDFYQREFDFFNK
ITNVSAIIKPYPKGDERKKACLSALSEVKVQPGCYLPSNPEAIVLDIDYKSGTPMQSAAK
APYLAKFKVKRCGVSELEKEGLRCRSDSEDECSTQEADGQKISWQAAIFKVGDDCRQDML
ALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQLGRQTDFGMYDYF
TRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFMF
ESSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTL
MLDTGLPCFRGQTIKLLKHRFSPNMTEREAANFIMKVIQSCFLSNRSRTYDMIQYYQNDI
PY
Sequence of entity 2 (D, F), FASTA
>9B9G_2 Tetratricopeptide repeat protein 7B (chains D, F)
MATKKAGSRLETEIERCRSECQWERIPELVKQLSAKLIANDDMAELLLGESKLEQYLKEH
PLRQGASPRGPKPQLTEVRKHLTAALDRGNLKSEFLQESNLIMAKLNYVEGDYKEALNIY
ARVGLDDLPLTAVPPYRLRVIAEAYATKGLCLEKLPISSSTSNLHVDREQDVITCYEKAG
DIALLYLQEIERVILSNIQNRSPKPGPAPHDQELGFFLETGLQRAHVLYFKNGNLTRGVG
RFRELLRAVETRTTQNLRMTIARQLAEILLRGMCEQSYWNPLEDPPCQSPLDDPLRKGAN
TKTYTLTRRARVYSGENIFCPQENTEEALLLLLISESMANRDAVLSRIPEHKSDRLISLQ
SASVVYDLLTIALGRRGQYEMLSECLERAMKFAFEEFHLWYQFALSLMAAGKSARAVKVL
KECIRLKPDDATIPLLAAKLCMGSLHWLEEAEKFAKTVVDVGEKTSEFKAKGYLALGLTY
SLQATDASLRGMQEVLQRKALLAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGYVRQ
ALQLQGDDANSLHLLALLLSAQKHYHDALNIIDMALSEYPENFILLFSKVKLQSLCRGPD
EALLTCKHMLQIWKSCYNLTNPSDSGRGSSLLDRTIADRRQLNTITLPDFSDPETGSVHA
TSVAASRVEQALSEVASSLQSSAPKQGPLHPWMTLAQIWLHAAEVYIGIGKPAEATACTQ
EAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRY
SLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALELEASSPAVPFTIIP
RVL
Sequence of entity 3 (E, G), FASTA
>9B9G_3 Hyccin (chains E, G)
MFTSEKGVVEEWLSEFKTLPETSLPNYATNLKDKSSLVSSLYKVIQEPQSELLEPVCHQL
FEFYRSGEEQLLQFTLQFLPELIWCYLAVSASRNVHSSGCIEALLLGVYNLEIVDKQGHT
KVLSFTIPSLSKPSVYHEPSSIGSMALTESALSQHGLSKVVYSGPHPQREMLTAQNRFEV
LTFLLLCYNAALTYMPSVSLQSLCQICSRICVCGYPRQHVRKYKGISSRIPVSSGFMVQM
LTGIYFAFYNGEWDLAQKALDDIIYRAQLELYPEPLLVANAIKASLPHGPMKSNKEGTRC
IQVEITPT
Sequence of entity 4 (H, J), FASTA
>9B9G_4 Calcineurin subunit B type 1 (chains H, J)
MGNEASYPLEMCSHFDADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQQNPLVQRVID
IFDTDGNGEVDFKEFIEGVSQFSVKGDKEQKLRFAFRIYDMDKDGYISNGELFQVLKMMV
GNNLKDTQLQQIVDKTIINADKDGDGRISFEEFCAVVGGLDIHKKMVVDV
Sequence of entity 5 (I, K), FASTA
>9B9G_5 Protein phosphatase 3 catalytic subunit alpha (chains I, K)
SEPKAIDPKLSTTDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESVA
LRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVD
RGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDA
FDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPPENFGN
EKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFPS
LITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKV
TEMLVNVLNICSDDELGSEEDGFDGATAAAFKQECKIKYSERVYDACMDAFDCLPLAALM
NQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPPEDFGNEKTQEHFTHN
TVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNY
LDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNI
CSDDELGSEEDGFDGATAAA
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| CA | Calcium ion | Ca | 8 |
Primary citation
Structure of calcineurin bound to PI4KA reveals dual interface in both PI4KA and FAM126A. Shaw, A.L., Suresh, S., Parson, M.A.H. et al. Structure (2024) 32:1973. DOI 10.1016/j.str.2024.08.007 · PubMed
Other PDB entries of the same protein (UniProt P42356 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 9OT6 3.54 Å, Cryo-EM structure of the PI4KA complex bound to an EFR3 interfering nanobody (F3IN)
- 6BQ1 3.6 Å, Human PI4KIIIa lipid kinase complex
- 9BAX 3.65 Å, PI4KA complex bound to C-terminus of EFR3A
Browse structure collections
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