9C57: RuvB-like 1

Reconstituted P400 Subcomplex of the human TIP60 complex. Determined by electron microscopy at 2.75 Å resolution. Released 21 Aug 2024.

Method: Electron microscopy
Resolution: 2.75 Å
Organism: Homo sapiens
Chains: 13
Atoms: 38,368
Mol. weight: 976.74 kDa
Ligands: AGS, ATP
Released: 21 Aug 2024

Explore 9C57 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9C57 contains 263 α-helices and 265 β-strands across 13 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 22 helices, 27 β-strands

Element	Residues	Length	Sheet
α-helix	13-14	2
β-strand	15	1	24
β-strand	26	1	81
α-helix	31	1
β-strand	32	1	81
α-helix	33	1
β-strand	35-36	2	82
β-strand	39-40	2	82
α-helix	43-58	16
β-strand	61	1	48
β-strand	65-69	5	56
α-helix	76-87	12
β-strand	93-97	5	56
α-helix	98-101	4
α-helix	108-118	11
β-strand	120-131	12	83
β-strand	138	1	84
β-strand	157-163	7	84
β-strand	166-172	7	84
α-helix	174-182	9
β-strand	191-194	4	83
β-strand	200-202	3	83
β-strand	229-239	11	83
α-helix	240-246	7
α-helix	273-288	16
β-strand	292-296	5	83
β-strand	298-302	5	56
α-helix	304-306	3
β-strand	308	1	85
α-helix	309-320	12
β-strand	326-331	6	56
β-strand	333	1	57
α-helix	336	1
β-strand	337	1	86
α-helix	338	1
β-strand	339	1	85
β-strand	345	1	86
α-helix	352-355	4
β-strand	358-362	5	56
α-helix	365-367	3
α-helix	368-381	14
β-strand	385-386	2	87
α-helix	388-400	13
α-helix	403-408	6
α-helix	410-419	10
β-strand	424-425	2	87
α-helix	427-436	10
β-strand	438	1	25
α-helix	440-447	8

Chain B: 21 helices, 26 β-strands

Element	Residues	Length	Sheet
β-strand	22	1	21
β-strand	33	1	22
α-helix	38	1
β-strand	39	1	22
α-helix	40	1
β-strand	42-43	2	23
β-strand	46-47	2	23
α-helix	50-65	16
β-strand	68	1	24
β-strand	72-77	6	25
α-helix	83-94	12
β-strand	100-104	5	25
α-helix	105-108	4
α-helix	115-124	10
β-strand	127-134	8	26
β-strand	162-165	4	27
β-strand	168-171	4	27
α-helix	179-183	5
β-strand	194-195	2	28
β-strand	202-203	2	28
β-strand	237-243	7	26
α-helix	244-250	7
α-helix	256-258	3
α-helix	259-262	4
α-helix	270-286	17
β-strand	289-293	5	26
β-strand	295-299	5	25
α-helix	301-303	3
β-strand	305	1	29
α-helix	306-315	10
β-strand	323-328	6	25
β-strand	333-334	2	30
α-helix	335	1
β-strand	336	1	29
β-strand	341-342	2	30
α-helix	348-352	5
β-strand	354-359	6	25
α-helix	360-362	3
α-helix	364-378	15
β-strand	382	1	31
α-helix	384-396	13
α-helix	399-415	17
β-strand	421	1	31
α-helix	423-432	10
β-strand	434	1	32
α-helix	436-445	10
β-strand	451	1	33

Chain C: 24 helices, 26 β-strands

Element	Residues	Length	Sheet
α-helix	13-14	2
β-strand	15	1	34
β-strand	26	1	35
α-helix	31	1
β-strand	32	1	35
α-helix	33	1
β-strand	35-36	2	36
β-strand	39-40	2	36
α-helix	43-58	16
β-strand	61	1	21
β-strand	65-69	5	32
α-helix	76-87	12
β-strand	93-97	5	32
α-helix	98-101	4
α-helix	108-118	11
β-strand	120-141	22	37
β-strand	156-162	7	37
β-strand	167-172	6	37
α-helix	174-183	10
β-strand	189-194	6	37
β-strand	199-206	8	37
α-helix	207-212	6
β-strand	215	1	38
β-strand	220-221	2	37
α-helix	222-224	3
β-strand	229-239	11	37
α-helix	240-248	9
α-helix	256-261	6
α-helix	273-289	17
β-strand	292-296	5	37
β-strand	298-302	5	32
α-helix	304-306	3
α-helix	309-318	10
β-strand	326-331	6	32
β-strand	333	1	33
α-helix	336	1
β-strand	337	1	39
α-helix	338	1
β-strand	345	1	39
α-helix	352-355	4
β-strand	358-362	5	32
α-helix	364-367	4
α-helix	368-381	14
β-strand	386	1	40
α-helix	388-400	13
α-helix	403-420	18
β-strand	425	1	40
α-helix	427-436	10
β-strand	438	1	41
α-helix	440-446	7

Chain D: 22 helices, 30 β-strands

Element	Residues	Length	Sheet
β-strand	22	1	4
β-strand	33	1	42
α-helix	38	1
β-strand	39	1	42
α-helix	40	1
β-strand	42-43	2	43
β-strand	46-47	2	43
α-helix	50-65	16
β-strand	68	1	34
β-strand	71-77	7	41
α-helix	83-94	12
β-strand	100-104	5	41
α-helix	105-108	4
α-helix	115-125	11
β-strand	127-134	8	44
β-strand	137-149	13	7
β-strand	158-164	7	7
β-strand	169-173	5	7
β-strand	174	1	38
α-helix	175	1
α-helix	176-185	10
β-strand	191-196	6	7
β-strand	202-207	6	7
β-strand	224	1	7
α-helix	226-229	4
β-strand	233	1	7
β-strand	237-243	7	44
α-helix	244-250	7
α-helix	259-262	4
α-helix	270-285	16
β-strand	289-293	5	44
β-strand	295-299	5	41
α-helix	301-303	3
β-strand	305	1	45
α-helix	306-315	10
β-strand	323-328	6	41
β-strand	333-334	2	46
α-helix	335	1
β-strand	336	1	45
β-strand	341-342	2	46
α-helix	348-351	4
β-strand	354-359	6	41
α-helix	360-362	3
α-helix	364-378	15
β-strand	381-382	2	47
α-helix	384-396	13
α-helix	399-416	18
β-strand	420-421	2	47
α-helix	423-432	10
β-strand	434	1	5
α-helix	436-445	10
β-strand	451	1	10

Chain E: 26 helices, 30 β-strands

Element	Residues	Length	Sheet
β-strand	15	1	1
β-strand	26	1	2
α-helix	31	1
β-strand	32	1	2
α-helix	33	1
β-strand	35-36	2	3
β-strand	39-40	2	3
α-helix	43-58	16
β-strand	61	1	4
β-strand	65-69	5	5
α-helix	76-87	12
β-strand	93-97	5	5
α-helix	98-101	4
α-helix	108-118	11
β-strand	120-127	8	6
β-strand	130-143	14	7
β-strand	152-162	11	7
β-strand	167-172	6	7
α-helix	176-182	7
β-strand	189-194	6	7
β-strand	202-206	5	7
α-helix	207-209	3
β-strand	214	1	8
β-strand	220-221	2	7
α-helix	222-225	4
β-strand	229	1	7
β-strand	233-239	7	6
α-helix	240-248	9
α-helix	256	1
α-helix	257-261	5
α-helix	262-263	2
α-helix	273-288	16
β-strand	292-296	5	6
β-strand	298-302	5	5
α-helix	304-306	3
β-strand	308	1	9
α-helix	309-318	10
β-strand	326-331	6	5
β-strand	333	1	10
β-strand	336-337	2	11
α-helix	338	1
β-strand	339	1	9
β-strand	345-346	2	11
α-helix	352-355	4
β-strand	359-362	4	5
α-helix	363	1
α-helix	365-367	3
α-helix	368-381	14
β-strand	385-386	2	12
α-helix	388-400	13
α-helix	403-408	6
α-helix	410-419	10
β-strand	424-425	2	12
α-helix	427-436	10
β-strand	438	1	13
α-helix	440-447	8

Chain F: 20 helices, 30 β-strands

Element	Residues	Length	Sheet
β-strand	22	1	48
β-strand	33	1	49
β-strand	39	1	49
β-strand	42-43	2	50
β-strand	46-47	2	50
α-helix	50-65	16
β-strand	68	1	1
β-strand	72-77	6	13
α-helix	83-94	12
β-strand	100-104	5	13
α-helix	105-108	4
α-helix	115-124	10
β-strand	127-134	8	51
β-strand	137-145	9	8
β-strand	159-164	6	8
β-strand	169-174	6	8
α-helix	176-184	9
β-strand	191-196	6	8
β-strand	201-207	7	8
β-strand	224	1	8
β-strand	225	1	52
α-helix	226-228	3
β-strand	233-234	2	8
β-strand	237-243	7	51
α-helix	244-252	9
α-helix	256-258	3
α-helix	259-262	4
α-helix	270-286	17
β-strand	289-293	5	51
β-strand	295-299	5	13
α-helix	301-303	3
β-strand	305	1	53
α-helix	306-315	10
β-strand	323-328	6	13
β-strand	333-334	2	54
α-helix	335	1
β-strand	336	1	53
β-strand	341-342	2	54
α-helix	348-352	5
β-strand	354-359	6	13
α-helix	360-362	3
α-helix	364-378	15
β-strand	382	1	55
α-helix	384-396	13
α-helix	399-415	17
β-strand	421	1	55
α-helix	423-432	10
β-strand	434	1	56
α-helix	436-445	10
β-strand	451	1	57

Chain G: 50 helices, 21 β-strands

Element	Residues	Length	Sheet
α-helix	783-792	10
α-helix	811-907	97
α-helix	1058-1067	10
α-helix	1071-1075	5
α-helix	1090-1092	3
α-helix	1093-1107	15
β-strand	1112-1114	3	58
α-helix	1116-1117	2
α-helix	1122-1132	11
α-helix	1133-1137	5
β-strand	1145-1147	3	58
α-helix	1151-1162	12
β-strand	1168-1170	3	58
α-helix	1175-1186	12
β-strand	1193-1197	5	58
α-helix	1198-1203	6
α-helix	1207-1210	4
β-strand	1212-1218	7	58
α-helix	1221-1223	3
α-helix	1229-1237	9
β-strand	1239-1246	8	58
α-helix	1313-1315	3
β-strand	1320-1326	7	59
α-helix	1327-1329	3
α-helix	1330-1341	12
α-helix	1343-1351	9
α-helix	1354-1369	16
α-helix	1371-1373	3
α-helix	1376-1379	4
β-strand	1380-1381	2	60
β-strand	1383-1385	3	61
α-helix	1386-1388	3
β-strand	1389-1391	3	62
α-helix	1394-1397	4
α-helix	1411-1413	3
α-helix	1417-1420	4
α-helix	1424-1433	10
β-strand	1434	1	52
α-helix	1435-1436	2
α-helix	1437-1445	9
α-helix	1447-1448	2
β-strand	1467-1468	2	63
α-helix	1472-1473	2
α-helix	1740-1762	23
α-helix	1763-1765	3
α-helix	1769-1774	6
α-helix	1825-1831	7
β-strand	1838-1840	3	61
α-helix	1841-1843	3
β-strand	1844-1846	3	62
α-helix	1852-1865	14
α-helix	1870-1872	3
α-helix	1873-1878	6
β-strand	1885-1886	2	60
α-helix	1887-1889	3
α-helix	1898-1913	16
β-strand	1917-1921	5	59
α-helix	1924-1936	13
β-strand	1941-1944	4	59
α-helix	1950-1962	13
β-strand	1968-1972	5	59
β-strand	1987-1990	4	59
α-helix	1997-2010	14
β-strand	2017-2023	7	59
α-helix	2027-2031	5
α-helix	2150-2156	7
α-helix	2161-2173	13
α-helix	2183-2216	34
β-strand	2222-2224	3	64
α-helix	2249	1
α-helix	2251-2254	4

Chain H: 1 helix, 4 β-strands

Element	Residues	Length	Sheet
β-strand	441-444	4	14
β-strand	451-455	5	14
β-strand	457-459	3	15
β-strand	465-467	3	15
α-helix	475-478	4

5 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
RuvB-like 1	A, C, E	protein	456	Homo sapiens	Q9Y265 (AlphaFold model)
Enhancer of polycomb homolog 1	H	protein	836	Homo sapiens	Q9H2F5 (AlphaFold model)
Actin-like protein 6A	L, M	protein	429	Homo sapiens	O96019 (AlphaFold model)
RuvB-like 2	B, D, F	protein	463	Homo sapiens	Q9Y230 (AlphaFold model)
E1A-binding protein p400	G	protein	3159	Homo sapiens	Q96L91
DNA methyltransferase 1-associated protein 1	I	protein	467	Homo sapiens	Q9NPF5
Actin, cytoplasmic 1	J	protein	375	Homo sapiens	P60709
Vacuolar protein sorting-associated protein 72 homolog	K	protein	364	Homo sapiens	Q15906

Sequence of entity 1 (A, C, E), FASTA

>9C57_1 RuvB-like 1 (chains A, C, E)
MKIEEVKSTTKTQRIASHSHVKGLGLDESGLAKQAASGLVGQENAREACGVIVELIKSKK
MAGRAVLLAGPPGTGKTALALAIAQELGSKVPFCPMVGSEVYSTEIKKTEVLMENFRRAI
GLRIKETKEVYEGEVTELTPCETENPMGGYGKTISHVIIGLKTAKGTKQLKLDPSIFESL
QKERVEAGDVIYIEANSGAVKRQGRCDTYATEFDLEAEEYVPLPKGDVHKKKEIIQDVTL
HDLDVANARPQGGQDILSMMGQLMKPKKTEITDKLRGEINKVVNKYIDQGIAELVPGVLF
VDEVHMLDIECFTYLHRALESSIAPIVIFASNRGNCVIRGTEDITSPHGIPLDLLDRVMI
IRTMLYTPQEMKQIIKIRAQTEGINISEEALNHLGEIGTKTTLRYSVQLLTPANLLAKIN
GKDSIEKEHVEEISELFYDAKSSAKILADQQDKYMK

Sequence of entity 2 (H), FASTA

>9C57_2 Enhancer of polycomb homolog 1 (chains H)
MSKLSFRARALDASKPLPVFRCEDLPDLHEYASINRAVPQMPTGMEKEEESEHHLQRAIS
AQQVYGEKRDNMVIPVPEAESNIAYYESIYPGEFKMPKQLIHIQPFSLDAEQPDYDLDSE
DEVFVNKLKKKMDICPLQFEEMIDRLEKGSGQQPVSLQEAKLLLKEDDELIREVYEYWIK
KRKNCRGPSLIPSVKQEKRDGSSTNDPYVAFRRRTEKMQTRKNRKNDEASYEKMLKLRRD
LSRAVTILEMIKRREKSKRELLHLTLEIMEKRYNLGDYNGEIMSEVMAQRQPMKPTYAIP
IIPITNSSQFKHQEAMDVKEFKVNKQDKADLIRPKRKYEKKPKVLPSSAAATPQQTSPAA
LPVFNAKDLNQYDFPSSDEEPLSQVLSGSSEAEEDNDPDGPFAFRRKAGCQYYAPHLDQT
GNWPWTSPKDGGLGDVRYRYCLTTLTVPQRCIGFARRRVGRGGRVLLDRAHSDYDSVFHH
LDLEMLSSPQHSPVNQFANTSETNTSDKSFSKDLSQILVNIKSCRWRHFRPRTPSLHDSD
NDELSCRKLYRSINRTGTAQPGTQTCSTSTQSKSSSGSAHFAFTAEQYQQHQQQLALMQK
QQLAQIQQQQANSNSSTNTSQNLASNQQKSGFRLNIQGLERTLQGFVSKTLDSASAQFAA
SALVTSEQLMGFKMKDDVVLGIGVNGVLPASGVYKGLHLSSTTPTALVHTSPSTAGSALL
QPSNITQTSSSHSALSHQVTAANSATTQVLIGNNIRLTVPSSVATVNSIAPINARHIPRT
LSAVPSSALKLAAAANCQVSKVPSSSSVDSVPRENHESEKPALNNIADNTVAMEVT

Sequence of entity 3 (L, M), FASTA

>9C57_3 Actin-like protein 6A (chains L, M)
MSGGVYGGDEVGALVFDIGSYTVRAGYAGEDCPKVDFPTAIGMVVERDDGSTLMEIDGDK
GKQGGPTYYIDTNALRVPRENMEAISPLKNGMVEDWDSFQAILDHTYKMHVKSEASLHPV
LMSEAPWNTRAKREKLTELMFEHYNIPAFFLCKTAVLTAFANGRSTGLILDSGATHTTAI
PVHDGYVLQQGIVKSPLAGDFITMQCRELFQEMNIELVPPYMIASKEAVREGSPANWKRK
EKLPQVTRSWHNYMCNCVIQDFQASVLQVSDSTYDEQVAAQMPTVHYEFPNGYNCDFGAE
RLKIPEGLFDPSNVKGLSGNTMLGVSHVVTTSVGMCDIDIRPGLYGSVIVAGGNTLIQSF
TDRLNRELSQKTPPSMRLKLIANNTTVERRFSSWIGGSILASLGTFQQMWISKQEYEEGG
KQCVERKCP

Sequence of entity 4 (B, D, F), FASTA

>9C57_4 RuvB-like 2 (chains B, D, F)
MATVTATTKVPEIRDVTRIERIGAHSHIRGLGLDDALEPRQASQGMVGQLAARRAAGVVL
EMIREGKIAGRAVLIAGQPGTGKTAIAMGMAQALGPDTPFTAIAGSEIFSLEMSKTEALT
QAFRRSIGVRIKEETEIIEGEVVEIQIDRPATGTGSKVGKLTLKTTEMETIYDLGTKMIE
SLTKDKVQAGDVITIDKATGKISKLGRSFTRARDYDAMGSQTKFVQCPDGELQKRKEVVH
TVSLHEIDVINSRTQGFLALFSGDTGEIKSEVREQINAKVAEWREEGKAEIIPGVLFIDE
VHMLDIESFSFLNRALESDMAPVLIMATNRGITRIRGTSYQSPHGIPIDLLDRLLIVSTT
PYSEKDTKQILRIRCEEEDVEMSEDAYTVLTRIGLETSLRYAIQLITAASLVCRKRKGTE
VQVDDIKRVYSLFLDESRSTQYMKEYQDAFLFNELKGETMDTS

Sequence of entity 5 (G), FASTA

>9C57_5 E1A-binding protein p400 (chains G)
MHHGTGPQNVQHQLQRSRACPGSEGEEQPAHPNPPPSPAAPFAPSASPSAPQSPSYQIQQ
LMNRSPATGQNVNITLQSVGPVVGGNQQITLAPLPLPSPTSPGFQFSAQPRRFEHGSPSY
IQVTSPLSQQVQTQSPTQPSPGPGQALQNVRAGAPGPGLGLCSSSPTGGFVDASVLVRQI
SLSPSSGGHFVFQDGSGLTQIAQGAQVQLQHPGTPITVRERRPSQPHTQSGGTIHHLGPQ
SPAAAGGAGLQPLASPSHITTANLPPQISSIIQGQLVQQQQVLQGPPLPRPLGFERTPGV
LLPGAGGAAGFGMTSPPPPTSPSRTAVPPGLSSLPLTSVGNTGMKKVPKKLEEIPPASPE
MAQMRKQCLDYHYQEMQALKEVFKEYLIELFFLQHFQGNMMDFLAFKKKHYAPLQAYLRQ
NDLDIEEEEEEEEEEEEKSEVINDEVKVVTGKDGQTGTPVAIATQLPPKVSAAFSSQQQP
FQQALAGSLVAGAGSTVETDLFKRQQAMPSTGMAEQSKRPRLEVGHQGVVFQHPGADAGV
PLQQLMPTAQGGMPPTPQAAQLAGQRQSQQQYDPSTGPPVQNAASLHTPLPQLPGRLPPA
GVPTAALSSALQFAQQPQVVEAQTQLQIPVKTQQPNVPIPAPPSSQLPIPPSQPAQLALH
VPTPGKVQVQASQLSSLPQMVASTRLPVDPAPPCPRPLPTSSTSSLAPVSGSGPGPSPAR
SSPVNRPSSATNKALSPVTSRTPGVVASAPTKPQSPAQNATSSQDSSQDTLTEQITLENQ
VHQRIAELRKAGLWSQRRLPKLQEAPRPKSHWDYLLEEMQWMATDFAQERRWKVAAAKKL
VRTVVRHHEEKQLREERGKKEEQSRLRRIAASTAREIECFWSNIEQVVEIKLRVELEEKR
KKALNLQKVSRRGKELRPKGFDALQESSLDSGMSGRKRKASISLTDDEVDDEEETIEEEE
ANEGVVDHQTELSNLAKEAELPLLDLMKLYEGAFLPSSQWPRPKPDGEDTSGEEDADDCP
GDRESRKDLVLIDSLFIMDQFKAAERMNIGKPNAKDIADVTAVAEAILPKGSARVTTSVK
FNAPSLLYGALRDYQKIGLDWLAKLYRKNLNGILADEAGLGKTVQIIAFFAHLACNEGNW
GPHLVVVRSCNILKWELELKRWCPGLKILSYIGSHRELKAKRQEWAEPNSFHVCITSYTQ
FFRGLTAFTRVRWKCLVIDEMQRVKGMTERHWEAVFTLQSQQRLLLIDSPLHNTFLELWT
MVHFLVPGISRPYLSSPLRAPSEESQDYYHKVVIRLHRVTQPFILRRTKRDVEKQLTKKY
EHVLKCRLSNRQKALYEDVILQPGTQEALKSGHFVNVLSILVRLQRICNHPGLVEPRHPG
SSYVAGPLEYPSASLILKALERDFWKEADLSMFDLIGLENKITRHEAELLSKKKIPRKLM
EEISTSAAPAARPAAAKLKASRLFQPVQYGQKPEGRTVAFPSTHPPRTAAPTTASAAPQG
PLRGRPPIATFSANPEAKAAAAPFQTSQASASAPRHQPASASSTAASPAHPAKLRAQTTA
QASTPGQPPPQPQAPSHAAGQSALPQRLVLPSQAQARLPSGEVVKIAQLASITGPQSRVA
QPETPVTLQFQGSKFTLSHSQLRQLTAGQPLQLQGSVLQIVSAPGQPYLRAPGPVVMQTV
SQAGAVHGALGSKPPAGGPSPAPLTPQVGVPGRVAVNALAVGEPGTASKPASPIGGPTQE
EKTRLLKERLDQIYLVNERRCSQAPVYGRDLLRICALPSHGRVQWRGSLDGRRGKEAGPA
HSYTSSSESPSELMLTLCRCGESLQDVIDRVAFVIPPVVAAPPSLRVPRPPPLYSHRMRI
LRQGLREHAAPYFQQLRQTTAPRLLQFPELRLVQFDSGKLEALAILLQKLKSEGRRVLIL
SQMILMLDILEMFLNFHYLTYVRIDENASSEQRQELMRSFNRDRRIFCAILSTHSRTTGI
NLVEADTVVFYDNDLNPVMDAKAQEWCDRIGRCKDIHIYRLVSGNSIEEKLLKNGTKDLI
REVAAQGNDYSMAFLTQRTIQELFEVYSPMDDAGFPVKAEEFVVLSQEPSVTETIAPKIA
RPFIEALKSIEYLEEDAQKSAQEGVLGPHTDALSSDSENMPCDEEPSQLEELADFMEQLT
PIEKYALNYLELFHTSIEQEKERNSEDAVMTAVRAWEFWNLKTLQEREARLRLEQEEAEL
LTYTREDAYSMEYVYEDVDGQTEVMPLWTPPTPPQDDSDIYLDSVMCLMYEATPIPEAKL
PPVYVRKERKRHKTDPSAAGRKKKQRHGEAVVPPRSLFDRATPGLLKIRREGKEQKKNIL
LKQQVPFAKPLPTFAKPTAEPGQDNPEWLISEDWALLQAVKQLLELPLNLTIVSPAHTPN
WDLVSDVVNSCSRIYRSSKQCRNRYENVIIPREEGKSKNNRPLRTSQIYAQDENATHTQL
YTSHFDLMKMTAGKRSPPIKPLLGMNPFQKNPKHASVLAESGINYDKPLPPIQVASLRAE
RIAKEKKALADQQKAQQPAVAQPPPPQPQPPPPPQQPPPPLPQPQAAGSQPPAGPPAVQP
QPQPQPQTQPQPVQAPAKAQPAITTGGSAAVLAGTIKTSVTGTSMPTGAVSGNVIVNTIA
GVPAATFQSINKRLASPVAPGALTTPGGSAPAQVVHTQPPPRAVGSPATATPDLVSMATT
QGVRAVTSVTASAVVTTNLTPVQTPARSLVPQVSQATGVQLPGKTITPAHFQLLRQQQQQ
QQQQQQQQQQQQQQQQQQQQQQQQTTTTSQVQVPQIQGQAQSPAQIKAVGKLTPEHLIKM
QKQKLQMPPQPPPPQAQSAPPQPTAQVQVQTSQPPQQQSPQLTTVTAPRPGALLTGTTVA
NLQVARLTRVPTSQLQAQGQMQTQAPQPAQVALAKPPVVSVPAAVVSSPGVTTLPMNVAG
ISVAIGQPQKAAGQTVVAQPVHMQQLLKLKQQAVQQQKAIQPQAAQGPAAVQQKITAQQI
TTPGAQQKVAYAAQPALKTQFLTTPISQAQKLAGAQQVQTQIQVAKLPQVVQQQTPVASI
QQVASASQQASPQTVALTQATAAGQQVQMIPAVTATAQVVQQKLIQQQVVTTASAPLQTP
GAPNPAQVPASSDSPSQQPKLQMRVPAVRLKTPTKPPCQ

Sequence of entity 6 (I), FASTA

>9C57_6 DNA methyltransferase 1-associated protein 1 (chains I)
MATGADVRDILELGGPEGDAASGTISKKDIINPDKKKSKKSSETLTFKRPEGMHREVYAL
LYSDKKDAPPLLPSDTGQGYRTVKAKLGSKKVRPWKWMPFTNPARKDGAMFFHWRRAAEE
GKDYPFARFNKTVQVPVYSEQEYQLYLHDDAWTKAETDHLFDLSRRFDLRFVVIHDRYDH
QQFKKRSVEDLKERYYHICAKLANVRAVPGTDLKIPVFDAGHERRRKEQLERLYNRTPEQ
VAEEEYLLQELRKIEARKKEREKRSQDLQKLITAADTTAEQRRTERKAPKKKLPQKKEAE
KPAVPETAGIKFPDFKSAGVTLRSQRMKLPSSVGQKKIKALEQMLLELGVELSPTPTEEL
VHMFNELRSDLVLLYELKQACANCEYELQMLRHRHEALARAGVLGGPATPASGPGPASAE
PAVTEPGLGPDPKDTIIDVVGAPLTPNSRKRRESASSSSSVKKAKKP

Sequence of entity 7 (J), FASTA

>9C57_7 Actin, cytoplasmic 1 (chains J)
MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQS
KRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMT
QIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDL
AGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSY
ELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLS
GGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQ
EYDESGPSIVHRKCF

Sequence of entity 8 (K), FASTA

>9C57_8 Vacuolar protein sorting-associated protein 72 homolog (chains K)
MSLAGGRAPRKTAGNRLSGLLEAEEEDEFYQTTYGGFTEESGDDEYQGDQSDTEDEVDSD
FDIDEGDEPSSDGEAEEPRRKRRVVTKAYKEPLKSLRPRKVNTPAGSSQKAREEKALLPL
ELQDDGSDSRKSMRQSTAEHTRQTFLRVQERQGQSRRRKGPHCERPLTQEELLREAKITE
ELNLRSLETYERLEADKKKQVHKKRKCPGPIITYHSVTVPLVGEPGPKEENVDIEGLDPA
PSVSALTPHAGTGPVNPPARCSRTFITFSDDATFEEWFPQGRPPKVPVREVCPVTHRPAL
YRDPVTDIPYATARAFKIIREAYKKYITAHGLPPTASALGPGPPPPEPLPGSGPRALRQK
IVIK

Ligands and cofactors

ID	Name	Formula	Copies
AGS	Phosphothiophosphoric acid-adenylate ester	C10 H16 N5 O12 P3 S	7
ATP	Adenosine-5'-triphosphate	C10 H16 N5 O13 P3	1

Primary citation

Structural insights into the human NuA4/TIP60 acetyltransferase and chromatin remodeling complex. Yang, Z., Mameri, A., Cattoglio, C. et al. Science (2024) 385:eadl5816-eadl5816. DOI 10.1126/science.adl5816 · PubMed

Other PDB entries of the same protein (UniProt Q9Y265 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2C9O 2.2 Å, 3D Structure of the human RuvB-like helicase RuvBL1
8QR1 2.4 Å, Cryo-EM structure of the human Tip60 complex
9EMA 2.4 Å, RUVBL1/2 in complex with ATP and CB-6644 inhibitor
6K0R 2.5 Å, Ruvbl1-Ruvbl2 with truncated domain II in complex with phosphorylated Cordycepin
2XSZ 3.0 Å, The dodecameric human RuvBL1:RuvBL2 complex with truncated domains II
9CAE 3.07 Å, Cryo-EM structure of the reconstituted RuvBL lobe of the human TIP60 complex (composite…
7ZI4 3.2 Å, Cryo-EM structure of the human INO80 complex bound to a WT nucleosome
8X15 3.2 Å, Structure of nucleosome-bound SRCAP-C in the apo state
8X19 3.2 Å, Structure of nucleosome-bound SRCAP-C in the ADP-BeFx-bound state
8X1C 3.2 Å, Structure of nucleosome-bound SRCAP-C in the ADP-bound state
8XVT 3.2 Å, The core subcomplex of human NuA4/TIP60 complex
9SN2 3.2 Å, Cryo-EM reconstruction of the RUVBL1-RUVBL2-CCDC103 (R2C) complex

Browse structure collections

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