Enhancer of polycomb homolog 1 (EPC1) is a 836-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9H2F5.
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The mean pLDDT of this model is 56.7 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 11% |
| 70 to 90 | Confident: backbone generally right | 22% |
| 50 to 70 | Low: treat with caution | 18% |
| Below 50 | Very low: often disordered regions | 49% |
What pLDDT means and how to read it
Component of the NuA4 histone acetyltransferase (HAT) complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:14966270). The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR) (PubMed:27153538). The NuA4 complex is also required for spermatid development by promoting acetylation of histones: histone acetylation is required for histone replacement during the transition from round to elongating spermatids (By similarity). In the NuA4 complex, EPC1 is required to recruit MBTD1 into the complex (PubMed:32209463)
Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6 (PubMed:12963728, PubMed:14966270, PubMed:27153538, PubMed:32209463). KAT5/TIP60, EPC1, and ING3 together…
Nucleus, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6NFX | X-ray | 1.95 Å | A=644-671 |
| 8QR1 | EM | 2.4 Å | C=1-836 |
| 9C57 | EM | 2.75 Å | H=1-836 |
| 9CAE | EM | 3.07 Å | C=359-620 |
| 8XVT | EM | 3.2 Å | M=1-836 |
| 9C6N | EM | 3.29 Å | H=1-836 |
| 9CAC | EM | 3.43 Å | C=1-836 |
| 9C62 | EM | 5.28 Å | H=1-836 |
| 8XVG | EM | 9.4 Å | M=1-836 |
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