9CPB: Armadillo repeat containing 4
Atomic model of bovine Fallopian tube cilia doublet microtubule (48-nm periodicity). Determined by electron microscopy at 3.52 Å resolution. Released 30 Oct 2024.
- Method
- Electron microscopy
- Resolution
- 3.52 Å
- Organism
- Bos taurus
- Chains
- 395
- Atoms
- 1,132,145
- Mol. weight
- 19409.02 kDa
- Ligands
- GDP, MG, GTP
- Released
- 30 Oct 2024
Explore 9CPB in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
9CPB contains 5,469 α-helices and 3,297 β-strands across 388 chains. Residue ranges use sequence positions (label_seq_id) from RCSB, which can differ from the residue numbers in the file. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain 1A: 41 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 535-546 | 12 | |
| α-helix | 549-561 | 13 | |
| α-helix | 567-569 | 3 | |
| α-helix | 570-576 | 7 | |
| α-helix | 579-586 | 8 | |
| α-helix | 608-612 | 5 | |
| α-helix | 621-632 | 12 | |
| α-helix | 633-643 | 11 | |
| α-helix | 648-657 | 10 | |
| α-helix | 657-662 | 6 | |
| α-helix | 662-671 | 10 | |
| α-helix | 674-683 | 10 | |
| α-helix | 689-698 | 10 | |
| α-helix | 705-712 | 8 | |
| α-helix | 719-725 | 7 | |
| α-helix | 728-741 | 14 | |
| α-helix | 745-756 | 12 | |
| α-helix | 756-766 | 11 | |
| α-helix | 772-779 | 8 | |
| α-helix | 779-784 | 6 | |
| α-helix | 786-796 | 11 | |
| α-helix | 798-805 | 8 | |
| α-helix | 810-817 | 8 | |
| α-helix | 817-827 | 11 | |
| α-helix | 827-838 | 12 | |
| α-helix | 839-848 | 10 | |
| α-helix | 851-855 | 5 | |
| α-helix | 856-866 | 11 | |
| α-helix | 871-879 | 9 | |
| α-helix | 882-888 | 7 | |
| α-helix | 894-909 | 16 | |
| α-helix | 911-922 | 12 | |
| α-helix | 925-931 | 7 | |
| α-helix | 936-950 | 15 | |
| α-helix | 954-960 | 7 | |
| α-helix | 964-972 | 9 | |
| α-helix | 976-990 | 15 | |
| α-helix | 993-1004 | 12 | |
| α-helix | 1004-1011 | 8 | |
| α-helix | 1017-1022 | 6 | |
| α-helix | 1023-1043 | 21 | |
Chain 1D: 5 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 112-134 | 23 | |
| α-helix | 145-176 | 32 | |
| α-helix | 180-184 | 5 | |
| α-helix | 186-220 | 35 | |
| α-helix | 221-251 | 31 | |
Chain 1E: 5 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 29-35 | 7 | |
| α-helix | 38-84 | 47 | |
| α-helix | 87-127 | 41 | |
| α-helix | 143-172 | 30 | |
| α-helix | 174-223 | 50 | |
Chain 1F: 4 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 29-39 | 11 | |
| α-helix | 44-75 | 32 | |
| α-helix | 77-84 | 8 | |
| α-helix | 85-107 | 23 | |
Chain 1H: 2 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 413-477 | 65 | |
| α-helix | 484-492 | 9 | |
Chain 1I: 8 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 45-54 | 10 | |
| α-helix | 58-85 | 28 | |
| α-helix | 92-142 | 51 | |
| α-helix | 143-169 | 27 | |
| α-helix | 179-190 | 12 | |
| α-helix | 193-330 | 138 | |
| α-helix | 337-399 | 63 | |
| α-helix | 401-411 | 11 | |
Chain 1K: 7 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 49-55 | 7 | |
| α-helix | 65-77 | 13 | |
| α-helix | 78-81 | 4 | |
| α-helix | 99-104 | 6 | |
| α-helix | 125-129 | 5 | |
| α-helix | 143-152 | 10 | |
| α-helix | 162-168 | 7 | |
Chain 1L: 1 helix, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 32-37 | 6 | |
380 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Armadillo repeat containing 4 | 1A | protein | 1044 | Bos taurus | E1B8W3 (AlphaFold model) |
| Coiled-coil domain containing 114 | 1D, 1E, 1F | protein | 687 | Bos taurus | F1N2N9 (AlphaFold model) |
| Coiled-coil domain containing 173 | 1H, 1I | protein | 547 | Bos taurus | E1BJL9 (AlphaFold model) |
| Uncharacterized protein C1orf158 homolog | 1K, 1L | protein | 196 | Bos taurus | Q2TA11 (AlphaFold model) |
| Protein Flattop | 1N, 1O, 1P | protein | 196 | Bos taurus | Q3SZT6 |
| CFAP141 | 1R | protein | 101 | Bos taurus | Q32L75 |
| Cilia and flagella associated protein 161 | 1T, 1U | protein | 321 | Bos taurus | F6RJC2 |
| Cilia- and flagella-associated protein 20 | 1W, 1X, 1Y, 1Z, 2A, 2B | protein | 193 | Bos taurus | Q6B857 |
| EF-hand domain family member B | 2D, 2E | protein | 877 | Bos taurus | F1MMV1 |
| CFAP276 | 2F, 2G, 2H | protein | 170 | Bos taurus | E1B9I5 |
| Cilia and flagella associated protein 45 | 2J, 2K, 2L, 2M | protein | 549 | Bos taurus | Q32LN4 |
| Cilia and flagella associated protein 52 | 2O, 2P, 2Q | protein | 623 | Bos taurus | E1BKF9 |
30 more molecules are not listed.
Sequence of entity 1 (1A), FASTA
>9CPB_1 Armadillo repeat containing 4 (chains 1A)
MGVALTRSAQWTAAGHGAKTLEVTPLNEAIVKEIIMFVESFIYKYPQEANYVFVEPLEWK
TNLDPSAFGSGYAVSGTTVKSEEADKNGEPLLYLSVPQIKIRSFGQLSRMLYIAKNMKLK
EAQACIEANRNPVAKILGLDYNIISEKIGNSFVSNILDKITKDDDSESEIKMKIALQLKQ
LDLHLLNHSLKHISLEIRLNPGTVKNDIELLKQFSGKGKQTVLESIEYTSDYEFSNGCRA
PPWRQIKGEICYVLVKPHDAETLCVTCSKEGVFLNGGKTDDEGQINYERKGEIYKDLVTL
LKEKSAIFSENMSKQEIKFSEQPQKDQPNEAPKEEVAITHKASVTSRKSTQEKNRINLGR
SQLTKRLEPSLNWRTSVSSKDRNTLRDTQVEKHGGKLEKSRSSVSPGRAQLIRKSVEKIE
EIISDSSSESEEDEEQPDHRQEANADLPSEYWQIQKLVKYLKGGNQTATVIALCSMKDFN
LAQETCQLAIRDVGGLEVLINLLETDEVKCKIGSLKILKEISHNPQIRRNIVDLGGLPVM
VNILDSPHKSLKCLAAETIANVAKFRRARRVVRRHGGITKLVALLDCGKHSGEPAQSSLY
ETRDVEVARCGALALWSCSKSYANKEAIRKAGGIPLLARLLKTSHENMLIPVVGTLQECA
SEENYRAAIKAERIIENLVKNLNSENEQLQEHCAMAIYQCAEDEETRDLVRLHGGLKPLA
SLLNNTDNKERLAAVTGAIWKCSISKENVTKFREYKAIETLVGLLTDQPEEVLVNVVGAL
GECCQEHENRVIIRRCGGIQPLVNLLVGINQALLVNVTKAVGACAVEPESMMIIDRLDGV
RLLWSLLKNPHPDVKASAAWALCPCIQNAKDAGEMVRSFVGGLELVVNLLKSDNKEVLAS
VCAVITNIAKDQENLAVITDHGVVPLLSKLANTNNDKLRRHLAETISRCCMWGRNRVAFG
EHKAVAPLVRYLKSNDTNVHRATAQALYQLSEDADNCVTMHENGAVKLLLDMVGSPDEEL
QEAAAGCISNIRRLALAIEKARYS
Sequence of entity 2 (1D, 1E, 1F), FASTA
>9CPB_2 Coiled-coil domain containing 114 (chains 1D, 1E, 1F)
MPFGLSAGSTRSEDGSEAFLEGMVDWELSRLQRQCKVMEDERRAYSKEVHQRINKQLEEI
QRLEGVRHKLRVQISIAQSQVRRLRDSERLESMGHLLKCQVRVQAEVKELQAQNQALDRE
IQEWESRNSAHSKNARSPGCVQHDKVKSQRRIKSLENQLDKVICRFDIQLAQNATLREEL
DLLRIERNRYLNVDRKLQKEIQLLKDSVRNLMVSSTSAYTVREEAKAKLGMLRERAEKEV
AQNETEVQILQRQIAHLEQLHHFLKLKNGDRQPDSAIVEKREQRAREVAEGLRKTSQEKL
VLRYEDALNKLSQMTGESDPDLLVEKYLELEERNFAEFNFINEQNSELEHLQEEIKEMQE
ALVSGRRSEEDRRAQQEQQRAELQQRVDDVHSEADDLEARYHNFREQLEKLKTNIQHLFT
RAQCDSTLINDLLGIKTHMRDRDISLFLSLIEKRLVQLLTVQAFLETQVVVMFNAALMVL
GQSSEDFPKKVAPPQPPDNLEDPPGFEAKDDYPLSKEELLSSVMKAEQHLKELVESIKVE
STPSMTSSTQKVSSSSRLVTQRPSQVPGSIMSHRTSGILVSSGGRATSSNVGHVTFGDSS
ATTGGLMSSRGSIPGRVTFRSPNSSSYLGSTGYVGSSRDHDSFEASKGPGSESSGGLGSS
PGPASSPGPASSTGQASSTSKDSQSNY
Sequence of entity 3 (1H, 1I), FASTA
>9CPB_3 Coiled-coil domain containing 173 (chains 1H, 1I)
MLVRFGRRSGQAKESAEMKNCEEDPVLYPPLLPTKVDLRQVTIIPHNEWERIRDSLDSLT
REAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDIEE
AIYKQGERKKAIELAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFQKSKIKSDKKWE
EQVKLNVEKAFKEEREKAEKQRRERVALAKDHLKQIKEHEEEEERRRKEEEKDAEEIKRQ
NSLYEIEMKKKQGKKKEEINESRRLFFEHLNDKHIIKAVEQQQQEEEDEKIRKFIKAKKR
LTQMGKEKEAETHRLMEERRKRINNFLSKLMKEKFDNEDLIIARDIAEAEAEWEKREREK
YEKNKAELKAIAEHRALVMKNKEEEERQRKIEATEQMLAILKADQIFWEHEKEKKQKADK
ERREVQDAHIQQMAKHKFNALQAKQAESEYCRLTEALVAEKEKEFQDYAREVIESESEST
KKYIYPLVKAVQEGPGGGRGPVLVDRGGLRPSYQANDTTGVQLPFYNSPGSKYNNFQKSK
GRLGFTW
Sequence of entity 4 (1K, 1L), FASTA
>9CPB_4 Uncharacterized protein C1orf158 homolog (chains 1K, 1L)
MQFLTAVSPQSSSTPSWKIETKYSTRVLTGNWTEERRKFIKATEKTPQTIYRKEYVPFPG
HRPDQISRWYSKRTVEGLPYKYLITHHQEPSQRYLISTYDDHYNRHNYHPGLPELRTWNR
HKLLWLPEKADFPLLGPPTNYGLYEQLKQKWLPPPEATLRESIYTSSYPRPPAGAMSRRE
HAIPVPPPRLQPVPHF
Sequence of entity 5 (1N, 1O, 1P), FASTA
>9CPB_5 Protein Flattop (chains 1N, 1O, 1P)
MATNYSANQYEKPFSPKYLQNWSLAKPTKERISSHEGYTQIIANDRGHLLPSVPRSKASP
WGSFMGTWQMPLKVPPARATLTSRTAAGAASLTRWIQKNPDLLKASNGLRPEIFGKPHDP
DSQKKLRKSITKTVQQAPSPTIIPSSPASNLSSPDQLQSSHPSAGHTPGPQSPLNSPKCP
PGSPCLPHAGRNLAEV
Sequence of entity 6 (1R), FASTA
>9CPB_6 CFAP141 (chains 1R)
MSMEKMGKVEEHFQRALELKKMVHRWRNSHTHCLWQITLSQRRNPYAILRMQDTMVQELA
LANKQLLMVRQAALHQLFEKEHQQYQQELNEKGKAFYMERL
Sequence of entity 7 (1T, 1U), FASTA
>9CPB_7 Cilia and flagella associated protein 161 (chains 1T, 1U)
MAQNLYGPRVRIGNWNEDVYLEEEIMKDFLAKRDKGQLLIQRNRRLKENLLRPMQLSVSE
DGYIHYGDKVMLVSPDHPETEADLFLPGDLSLCMTPDEIKAHLSNELEVPCGLSAAQTKI
PVGRNTFTILCAAGEVIGQVLRYGQNFRLGITGGFDDRMLYLSSDHRTLLKSSKRSWLQE
VFLTHEDSYLNCWQAAFPHPQLRLEYEGSPVPANTKILITHCHTNRGLVAHRHLFLRTYF
GQEAEVAAHTYLDSHRVEKPKNHWMLVTGAPRKDLSTMLDLPKPPAEDTRALEQEREQVS
DPGARSTPDARGCVPQCTLPM
Sequence of entity 8 (1W, 1X, 1Y, 1Z, 2A, 2B), FASTA
>9CPB_8 Cilia- and flagella-associated protein 20 (chains 1W, 1X, 1Y, 1Z, 2A, 2B)
MFKNTFQSGFLSILYSIGSKPLQIWDKKVRNGHIKRITDNDIQSLVLEIEGTNVSTTYIT
CPADPKKTLGIKLPFLVMIIKNLKKYFTFEVQVLDDKNVRRRFRASNYQSTTRVKPFICT
MPMRLDDGWNQIQFNLSDFTRRAYGTNYIETLRVQIHANCRIRRVYFSDRLYSEDELPAE
FKLYLPVQNKAKQ
Sequence of entity 9 (2D, 2E), FASTA
>9CPB_9 EF-hand domain family member B (chains 2D, 2E)
MCSFLRVPSPKGLEPSKGLGAPLQPGTAYPSEMSALGPGMTVSGRKSPLSMEVGLAPEGK
DDLEERRVFMGTTSPTELGLRVGLRKDFPCSKTYEERMASPEIRSPSSKGLELRLKRQNI
SRTVMDGSNLGVHRVSASQETKPPLSALPGRVGLEKERFLAGYCPGRVTQPPLGQGCESP
QASGGRRCPVTGDPEGFGASVSKLPALGMECRGELGGESACVVMKPRAETEPPVEVDMGL
TRLEEPAEMESPEPQMGLVMEPPAWQLAQQPEEQREAENTEPGVEPPDRIRPIYSGKFFD
RMPCWPSAGKVLPIGYRAATCLTERFPRLMTPPEAKKFFNFRYPPAGAERVFYGRANDPQ
IAPSLTHGIRSKISIPAKVLINPQPITTFQQKMKDKKESVYFSNQRAPLGKSHDQTPGLP
KGLDILNTTFGTAIVRETSARDMVNPPKPYKEVFEEAQAGHDLYVVSHNDYFVGEAKNRK
YDPSSFHRFNLYGIPTPHFNDGRNMAKTLHWLHELQMKRGAKIVSKRVDDFKEKFQHRLG
RVLDPIAETMNVPPDYTFGAFLRPEDYGVGDLIHRRLPGEYLRGKDRQRGLVAAVRHHLK
KVNYQNFDTLLAAFRHYDKKGDGVIDRAELQEACDQACLHLDEKLLDQLFEYCDVDKDGL
INYLEFANFLTWKDKTPLKEYEERVLIKGRKADCANPAEANVEESEPALLLKPEDIVLKE
PGSSEKTLRTLLRPSDKVSNHYKTTSSEISAVVGAVPSTCYPTYGVPTIRSDIPAPLIRR
VSDRTSYGEEGNAYSLLHPTIFAQKGVFERDFFKTRSKQEISEILCNIGVKLSEDEFENV
WNLASKKHHRGEVCVENIRSVLDELQHADGAKCKAAT
Sequence of entity 10 (2F, 2G, 2H), FASTA
>9CPB_10 CFAP276 (chains 2F, 2G, 2H)
MPLTRDPFQNPALDKDDSYLGKSRASKKLPYKNPTHLAQQQEPWCRLSSTPTITSMKRDG
FFFYSEIPKDDLDFRLAALYNHHTGTFKNKSEILTHQETIQDTRRIKTQFPGEFLPAPQP
PLITSRANIRHWINPKKESIHSIQGSIVSPHTAATNGGYSRKNDGGFFST
Sequence of entity 11 (2J, 2K, 2L, 2M), FASTA
>9CPB_11 Cilia and flagella associated protein 45 (chains 2J, 2K, 2L, 2M)
MPLSTAGVLSSASTASNRSRNRPRYRTKALSSEVDESLFGAIKPLTRSDSPIVLLRDKHA
IRKTLTALGLDHKPETIQLITRDMVRELIIPTKDPSGQSLIMSPEEFERIKWASHVLTKE
ELEAREQAFKKEKEAIVDTVTTRKKIMKQKEMVWRNNRKLSDLEEVAKERAQNLLQRANQ
LRMEQEEELKDMKKIILNAKCHAIRDAQILEKQLIQKELDAEEKRLDQMMEVERQKSVQR
QEELDRKRREERIRGRRHIVEQMEKNQEERSLLAEQREQEKEQMLEYMEKLQEEDLRDLE
QRHQQKLKMQAEIKRINDENQRQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIR
REKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKENAQKKMETEAKLRK
SRLEQVAFKEHTLAVQVQRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQV
RENQQKQVQARIATFDEGRRLKEEAQKRRERIEDIKRKKLEELRATGLPEKYCIEAERKA
NIPVNTSVN
Sequence of entity 12 (2O, 2P, 2Q), FASTA
>9CPB_12 Cilia and flagella associated protein 52 (chains 2O, 2P, 2Q)
METQASPKDEVAEAVELELEAVIGFNGHVPTGLKCHPDQEHLVYPLGCTILIQAINTQEQ
NFLHGHGNNVSCVAISKSGLYIASGQVTFMGFKADIILWDYKKRELMARLSLHKGKIEAL
AFSPNDMYLVSLGGPDDGSVVVWSIAKREAICGSPAAGLNVGNATTVIFSKCRDEMFVTA
GNGTIRVWELDLPNRKIWPTECQTGQMKRIVMSISMANDDSFFYLGTTTGDILKMNPRTK
LLADTGPAKDKFSLGVSAICCLKMGGLLVGSGDGLLVFCKSPSYKPIKKIQLQGGITSIT
LRGEGHQFFVGTEESHIYRVNFTNFKETLITTCHFESVEDIVFPFGTAELFATCAKKDIR
VWHTLTNRELLRITVPNMTCHGIDFMRDGKSIISAWDDGRIRAFAPETGRLMYVINNAHR
IGVTAIATTSDCKRVISGGGEGEVRVWHIGHQTQKLEEALKEHKSSVSCIRVKKSNEECV
TASTDGTCIIWDLVRLRRNQMILANTLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGSVI
RELDGSLSGAVNGMDITVEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISP
GNQYIVSVSADGAILRWKYPFPS
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| GDP | Guanosine-5'-diphosphate | C10 H15 N5 O11 P2 | 130 |
| MG | Magnesium ion | Mg | 106 |
| GTP | Guanosine-5'-triphosphate | C10 H16 N5 O14 P3 | 134 |
Primary citation
Structural diversity of axonemes across mammalian motile cilia. Leung, M.R., Sun, C., Zeng, J. et al. Nature (2025) 637:1170-1177. DOI 10.1038/s41586-024-08337-5 · PubMed
Other PDB entries of the same protein (UniProt E1B8W3 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 7RRO 3.4 Å, Structure of the 48-nm repeat doublet microtubule from bovine tracheal cilia
- 9FQR 5.0 Å, 96-nm repeat of axonemal doublet microtubules from bovine sperm
Browse structure collections
About this viewer
MolViewer shows 9CPB directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.