9CPB: Armadillo repeat containing 4
Atomic model of bovine Fallopian tube cilia doublet microtubule (48-nm periodicity). Determined by electron microscopy at 3.52 Å resolution. Released 30 Oct 2024.
- Method
- Electron microscopy
- Resolution
- 3.52 Å
- Organism
- Bos taurus
- Chains
- 395
- Atoms
- 1,132,145
- Mol. weight
- 19409.02 kDa
- Ligands
- GDP, MG, GTP
- Released
- 30 Oct 2024
Explore 9CPB in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
9CPB contains 6,438 α-helices and 5,782 β-strands across 393 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain 1A: 43 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 536-545 | 10 | |
| α-helix | 550-560 | 11 | |
| α-helix | 568-570 | 3 | |
| α-helix | 571-575 | 5 | |
| α-helix | 580-585 | 6 | |
| α-helix | 609-611 | 3 | |
| α-helix | 622-631 | 10 | |
| α-helix | 634-642 | 9 | |
| α-helix | 649-656 | 8 | |
| α-helix | 658-661 | 4 | |
| α-helix | 663-670 | 8 | |
| α-helix | 675-682 | 8 | |
| α-helix | 687-691 | 5 | |
| α-helix | 692-697 | 6 | |
| α-helix | 706-711 | 6 | |
| α-helix | 720-724 | 5 | |
| α-helix | 729-740 | 12 | |
| α-helix | 746-755 | 10 | |
| α-helix | 757-765 | 9 | |
| α-helix | 773-778 | 6 | |
| α-helix | 780-783 | 4 | |
| α-helix | 787-795 | 9 | |
| α-helix | 799-804 | 6 | |
| α-helix | 811-816 | 6 | |
| α-helix | 818-826 | 9 | |
| α-helix | 828-837 | 10 | |
| α-helix | 840-847 | 8 | |
| α-helix | 852-854 | 3 | |
| α-helix | 857-865 | 9 | |
| α-helix | 872-878 | 7 | |
| α-helix | 883-887 | 5 | |
| α-helix | 895-908 | 14 | |
| α-helix | 912-918 | 7 | |
| α-helix | 919-923 | 5 | |
| α-helix | 926-930 | 5 | |
| α-helix | 937-949 | 13 | |
| α-helix | 955-959 | 5 | |
| α-helix | 965-971 | 7 | |
| α-helix | 977-989 | 13 | |
| α-helix | 994-1003 | 10 | |
| α-helix | 1005-1010 | 6 | |
| α-helix | 1018-1021 | 4 | |
| α-helix | 1024-1042 | 19 | |
Chain 1D: 5 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 112-133 | 22 | |
| α-helix | 146-175 | 30 | |
| α-helix | 181-183 | 3 | |
| α-helix | 187-219 | 33 | |
| α-helix | 222-250 | 29 | |
Chain 1E: 5 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 29-34 | 6 | |
| α-helix | 39-83 | 45 | |
| α-helix | 88-126 | 39 | |
| α-helix | 143-171 | 29 | |
| α-helix | 175-222 | 48 | |
Chain 1F: 4 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 29-38 | 10 | |
| α-helix | 45-74 | 30 | |
| α-helix | 78-83 | 6 | |
| α-helix | 86-106 | 21 | |
Chain 1H: 2 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 413-476 | 64 | |
| α-helix | 485-491 | 7 | |
Chain 1I: 8 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 46-53 | 8 | |
| α-helix | 59-84 | 26 | |
| α-helix | 93-141 | 49 | |
| α-helix | 144-168 | 25 | |
| α-helix | 180-189 | 10 | |
| α-helix | 194-329 | 136 | |
| α-helix | 338-398 | 61 | |
| α-helix | 402-410 | 9 | |
Chain 1K: 11 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 50-54 | 5 | |
| α-helix | 66-76 | 11 | |
| α-helix | 78-80 | 3 | |
| α-helix | 81-84 | 4 | |
| α-helix | 100-104 | 5 | |
| α-helix | 117-119 | 3 | |
| α-helix | 126-128 | 3 | |
| α-helix | 144-151 | 8 | |
| α-helix | 163-167 | 5 | |
| α-helix | 170-172 | 3 | |
| α-helix | 177-178 | 2 | |
Chain 1L: 2 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 10-11 | 2 | |
| α-helix | 33-36 | 4 | |
385 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Armadillo repeat containing 4 | 1A | protein | 1044 | Bos taurus | E1B8W3 (AlphaFold model) |
| Coiled-coil domain containing 114 | 1D, 1E, 1F | protein | 687 | Bos taurus | F1N2N9 (AlphaFold model) |
| Coiled-coil domain containing 173 | 1H, 1I | protein | 547 | Bos taurus | E1BJL9 (AlphaFold model) |
| Uncharacterized protein C1orf158 homolog | 1K, 1L | protein | 196 | Bos taurus | Q2TA11 (AlphaFold model) |
| Protein Flattop | 1N, 1O, 1P | protein | 196 | Bos taurus | Q3SZT6 |
| CFAP141 | 1R | protein | 101 | Bos taurus | Q32L75 |
| Cilia and flagella associated protein 161 | 1T, 1U | protein | 321 | Bos taurus | F6RJC2 |
| Cilia- and flagella-associated protein 20 | 1W, 1X, 1Y, 1Z, 2A, 2B | protein | 193 | Bos taurus | Q6B857 |
| EF-hand domain family member B | 2D, 2E | protein | 877 | Bos taurus | F1MMV1 |
| CFAP276 | 2F, 2G, 2H | protein | 170 | Bos taurus | E1B9I5 |
| Cilia and flagella associated protein 45 | 2J, 2K, 2L, 2M | protein | 549 | Bos taurus | Q32LN4 |
| Cilia and flagella associated protein 52 | 2O, 2P, 2Q | protein | 623 | Bos taurus | E1BKF9 |
30 more molecules are not listed.
Sequence of entity 1 (1A), FASTA
>9CPB_1 Armadillo repeat containing 4 (chains 1A)
MGVALTRSAQWTAAGHGAKTLEVTPLNEAIVKEIIMFVESFIYKYPQEANYVFVEPLEWK
TNLDPSAFGSGYAVSGTTVKSEEADKNGEPLLYLSVPQIKIRSFGQLSRMLYIAKNMKLK
EAQACIEANRNPVAKILGLDYNIISEKIGNSFVSNILDKITKDDDSESEIKMKIALQLKQ
LDLHLLNHSLKHISLEIRLNPGTVKNDIELLKQFSGKGKQTVLESIEYTSDYEFSNGCRA
PPWRQIKGEICYVLVKPHDAETLCVTCSKEGVFLNGGKTDDEGQINYERKGEIYKDLVTL
LKEKSAIFSENMSKQEIKFSEQPQKDQPNEAPKEEVAITHKASVTSRKSTQEKNRINLGR
SQLTKRLEPSLNWRTSVSSKDRNTLRDTQVEKHGGKLEKSRSSVSPGRAQLIRKSVEKIE
EIISDSSSESEEDEEQPDHRQEANADLPSEYWQIQKLVKYLKGGNQTATVIALCSMKDFN
LAQETCQLAIRDVGGLEVLINLLETDEVKCKIGSLKILKEISHNPQIRRNIVDLGGLPVM
VNILDSPHKSLKCLAAETIANVAKFRRARRVVRRHGGITKLVALLDCGKHSGEPAQSSLY
ETRDVEVARCGALALWSCSKSYANKEAIRKAGGIPLLARLLKTSHENMLIPVVGTLQECA
SEENYRAAIKAERIIENLVKNLNSENEQLQEHCAMAIYQCAEDEETRDLVRLHGGLKPLA
SLLNNTDNKERLAAVTGAIWKCSISKENVTKFREYKAIETLVGLLTDQPEEVLVNVVGAL
GECCQEHENRVIIRRCGGIQPLVNLLVGINQALLVNVTKAVGACAVEPESMMIIDRLDGV
RLLWSLLKNPHPDVKASAAWALCPCIQNAKDAGEMVRSFVGGLELVVNLLKSDNKEVLAS
VCAVITNIAKDQENLAVITDHGVVPLLSKLANTNNDKLRRHLAETISRCCMWGRNRVAFG
EHKAVAPLVRYLKSNDTNVHRATAQALYQLSEDADNCVTMHENGAVKLLLDMVGSPDEEL
QEAAAGCISNIRRLALAIEKARYS
Sequence of entity 2 (1D, 1E, 1F), FASTA
>9CPB_2 Coiled-coil domain containing 114 (chains 1D, 1E, 1F)
MPFGLSAGSTRSEDGSEAFLEGMVDWELSRLQRQCKVMEDERRAYSKEVHQRINKQLEEI
QRLEGVRHKLRVQISIAQSQVRRLRDSERLESMGHLLKCQVRVQAEVKELQAQNQALDRE
IQEWESRNSAHSKNARSPGCVQHDKVKSQRRIKSLENQLDKVICRFDIQLAQNATLREEL
DLLRIERNRYLNVDRKLQKEIQLLKDSVRNLMVSSTSAYTVREEAKAKLGMLRERAEKEV
AQNETEVQILQRQIAHLEQLHHFLKLKNGDRQPDSAIVEKREQRAREVAEGLRKTSQEKL
VLRYEDALNKLSQMTGESDPDLLVEKYLELEERNFAEFNFINEQNSELEHLQEEIKEMQE
ALVSGRRSEEDRRAQQEQQRAELQQRVDDVHSEADDLEARYHNFREQLEKLKTNIQHLFT
RAQCDSTLINDLLGIKTHMRDRDISLFLSLIEKRLVQLLTVQAFLETQVVVMFNAALMVL
GQSSEDFPKKVAPPQPPDNLEDPPGFEAKDDYPLSKEELLSSVMKAEQHLKELVESIKVE
STPSMTSSTQKVSSSSRLVTQRPSQVPGSIMSHRTSGILVSSGGRATSSNVGHVTFGDSS
ATTGGLMSSRGSIPGRVTFRSPNSSSYLGSTGYVGSSRDHDSFEASKGPGSESSGGLGSS
PGPASSPGPASSTGQASSTSKDSQSNY
Sequence of entity 3 (1H, 1I), FASTA
>9CPB_3 Coiled-coil domain containing 173 (chains 1H, 1I)
MLVRFGRRSGQAKESAEMKNCEEDPVLYPPLLPTKVDLRQVTIIPHNEWERIRDSLDSLT
REAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDIEE
AIYKQGERKKAIELAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFQKSKIKSDKKWE
EQVKLNVEKAFKEEREKAEKQRRERVALAKDHLKQIKEHEEEEERRRKEEEKDAEEIKRQ
NSLYEIEMKKKQGKKKEEINESRRLFFEHLNDKHIIKAVEQQQQEEEDEKIRKFIKAKKR
LTQMGKEKEAETHRLMEERRKRINNFLSKLMKEKFDNEDLIIARDIAEAEAEWEKREREK
YEKNKAELKAIAEHRALVMKNKEEEERQRKIEATEQMLAILKADQIFWEHEKEKKQKADK
ERREVQDAHIQQMAKHKFNALQAKQAESEYCRLTEALVAEKEKEFQDYAREVIESESEST
KKYIYPLVKAVQEGPGGGRGPVLVDRGGLRPSYQANDTTGVQLPFYNSPGSKYNNFQKSK
GRLGFTW
Sequence of entity 4 (1K, 1L), FASTA
>9CPB_4 Uncharacterized protein C1orf158 homolog (chains 1K, 1L)
MQFLTAVSPQSSSTPSWKIETKYSTRVLTGNWTEERRKFIKATEKTPQTIYRKEYVPFPG
HRPDQISRWYSKRTVEGLPYKYLITHHQEPSQRYLISTYDDHYNRHNYHPGLPELRTWNR
HKLLWLPEKADFPLLGPPTNYGLYEQLKQKWLPPPEATLRESIYTSSYPRPPAGAMSRRE
HAIPVPPPRLQPVPHF
Sequence of entity 5 (1N, 1O, 1P), FASTA
>9CPB_5 Protein Flattop (chains 1N, 1O, 1P)
MATNYSANQYEKPFSPKYLQNWSLAKPTKERISSHEGYTQIIANDRGHLLPSVPRSKASP
WGSFMGTWQMPLKVPPARATLTSRTAAGAASLTRWIQKNPDLLKASNGLRPEIFGKPHDP
DSQKKLRKSITKTVQQAPSPTIIPSSPASNLSSPDQLQSSHPSAGHTPGPQSPLNSPKCP
PGSPCLPHAGRNLAEV
Sequence of entity 6 (1R), FASTA
>9CPB_6 CFAP141 (chains 1R)
MSMEKMGKVEEHFQRALELKKMVHRWRNSHTHCLWQITLSQRRNPYAILRMQDTMVQELA
LANKQLLMVRQAALHQLFEKEHQQYQQELNEKGKAFYMERL
Sequence of entity 7 (1T, 1U), FASTA
>9CPB_7 Cilia and flagella associated protein 161 (chains 1T, 1U)
MAQNLYGPRVRIGNWNEDVYLEEEIMKDFLAKRDKGQLLIQRNRRLKENLLRPMQLSVSE
DGYIHYGDKVMLVSPDHPETEADLFLPGDLSLCMTPDEIKAHLSNELEVPCGLSAAQTKI
PVGRNTFTILCAAGEVIGQVLRYGQNFRLGITGGFDDRMLYLSSDHRTLLKSSKRSWLQE
VFLTHEDSYLNCWQAAFPHPQLRLEYEGSPVPANTKILITHCHTNRGLVAHRHLFLRTYF
GQEAEVAAHTYLDSHRVEKPKNHWMLVTGAPRKDLSTMLDLPKPPAEDTRALEQEREQVS
DPGARSTPDARGCVPQCTLPM
Sequence of entity 8 (1W, 1X, 1Y, 1Z, 2A, 2B), FASTA
>9CPB_8 Cilia- and flagella-associated protein 20 (chains 1W, 1X, 1Y, 1Z, 2A, 2B)
MFKNTFQSGFLSILYSIGSKPLQIWDKKVRNGHIKRITDNDIQSLVLEIEGTNVSTTYIT
CPADPKKTLGIKLPFLVMIIKNLKKYFTFEVQVLDDKNVRRRFRASNYQSTTRVKPFICT
MPMRLDDGWNQIQFNLSDFTRRAYGTNYIETLRVQIHANCRIRRVYFSDRLYSEDELPAE
FKLYLPVQNKAKQ
Sequence of entity 9 (2D, 2E), FASTA
>9CPB_9 EF-hand domain family member B (chains 2D, 2E)
MCSFLRVPSPKGLEPSKGLGAPLQPGTAYPSEMSALGPGMTVSGRKSPLSMEVGLAPEGK
DDLEERRVFMGTTSPTELGLRVGLRKDFPCSKTYEERMASPEIRSPSSKGLELRLKRQNI
SRTVMDGSNLGVHRVSASQETKPPLSALPGRVGLEKERFLAGYCPGRVTQPPLGQGCESP
QASGGRRCPVTGDPEGFGASVSKLPALGMECRGELGGESACVVMKPRAETEPPVEVDMGL
TRLEEPAEMESPEPQMGLVMEPPAWQLAQQPEEQREAENTEPGVEPPDRIRPIYSGKFFD
RMPCWPSAGKVLPIGYRAATCLTERFPRLMTPPEAKKFFNFRYPPAGAERVFYGRANDPQ
IAPSLTHGIRSKISIPAKVLINPQPITTFQQKMKDKKESVYFSNQRAPLGKSHDQTPGLP
KGLDILNTTFGTAIVRETSARDMVNPPKPYKEVFEEAQAGHDLYVVSHNDYFVGEAKNRK
YDPSSFHRFNLYGIPTPHFNDGRNMAKTLHWLHELQMKRGAKIVSKRVDDFKEKFQHRLG
RVLDPIAETMNVPPDYTFGAFLRPEDYGVGDLIHRRLPGEYLRGKDRQRGLVAAVRHHLK
KVNYQNFDTLLAAFRHYDKKGDGVIDRAELQEACDQACLHLDEKLLDQLFEYCDVDKDGL
INYLEFANFLTWKDKTPLKEYEERVLIKGRKADCANPAEANVEESEPALLLKPEDIVLKE
PGSSEKTLRTLLRPSDKVSNHYKTTSSEISAVVGAVPSTCYPTYGVPTIRSDIPAPLIRR
VSDRTSYGEEGNAYSLLHPTIFAQKGVFERDFFKTRSKQEISEILCNIGVKLSEDEFENV
WNLASKKHHRGEVCVENIRSVLDELQHADGAKCKAAT
Sequence of entity 10 (2F, 2G, 2H), FASTA
>9CPB_10 CFAP276 (chains 2F, 2G, 2H)
MPLTRDPFQNPALDKDDSYLGKSRASKKLPYKNPTHLAQQQEPWCRLSSTPTITSMKRDG
FFFYSEIPKDDLDFRLAALYNHHTGTFKNKSEILTHQETIQDTRRIKTQFPGEFLPAPQP
PLITSRANIRHWINPKKESIHSIQGSIVSPHTAATNGGYSRKNDGGFFST
Sequence of entity 11 (2J, 2K, 2L, 2M), FASTA
>9CPB_11 Cilia and flagella associated protein 45 (chains 2J, 2K, 2L, 2M)
MPLSTAGVLSSASTASNRSRNRPRYRTKALSSEVDESLFGAIKPLTRSDSPIVLLRDKHA
IRKTLTALGLDHKPETIQLITRDMVRELIIPTKDPSGQSLIMSPEEFERIKWASHVLTKE
ELEAREQAFKKEKEAIVDTVTTRKKIMKQKEMVWRNNRKLSDLEEVAKERAQNLLQRANQ
LRMEQEEELKDMKKIILNAKCHAIRDAQILEKQLIQKELDAEEKRLDQMMEVERQKSVQR
QEELDRKRREERIRGRRHIVEQMEKNQEERSLLAEQREQEKEQMLEYMEKLQEEDLRDLE
QRHQQKLKMQAEIKRINDENQRQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIR
REKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKENAQKKMETEAKLRK
SRLEQVAFKEHTLAVQVQRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQV
RENQQKQVQARIATFDEGRRLKEEAQKRRERIEDIKRKKLEELRATGLPEKYCIEAERKA
NIPVNTSVN
Sequence of entity 12 (2O, 2P, 2Q), FASTA
>9CPB_12 Cilia and flagella associated protein 52 (chains 2O, 2P, 2Q)
METQASPKDEVAEAVELELEAVIGFNGHVPTGLKCHPDQEHLVYPLGCTILIQAINTQEQ
NFLHGHGNNVSCVAISKSGLYIASGQVTFMGFKADIILWDYKKRELMARLSLHKGKIEAL
AFSPNDMYLVSLGGPDDGSVVVWSIAKREAICGSPAAGLNVGNATTVIFSKCRDEMFVTA
GNGTIRVWELDLPNRKIWPTECQTGQMKRIVMSISMANDDSFFYLGTTTGDILKMNPRTK
LLADTGPAKDKFSLGVSAICCLKMGGLLVGSGDGLLVFCKSPSYKPIKKIQLQGGITSIT
LRGEGHQFFVGTEESHIYRVNFTNFKETLITTCHFESVEDIVFPFGTAELFATCAKKDIR
VWHTLTNRELLRITVPNMTCHGIDFMRDGKSIISAWDDGRIRAFAPETGRLMYVINNAHR
IGVTAIATTSDCKRVISGGGEGEVRVWHIGHQTQKLEEALKEHKSSVSCIRVKKSNEECV
TASTDGTCIIWDLVRLRRNQMILANTLFQCVCYHPEEFQIITSGTDRKIAYWEVFDGSVI
RELDGSLSGAVNGMDITVEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISP
GNQYIVSVSADGAILRWKYPFPS
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| GDP | Guanosine-5'-diphosphate | C10 H15 N5 O11 P2 | 130 |
| MG | Magnesium ion | Mg | 106 |
| GTP | Guanosine-5'-triphosphate | C10 H16 N5 O14 P3 | 134 |
Primary citation
Structural diversity of axonemes across mammalian motile cilia. Leung, M.R., Sun, C., Zeng, J. et al. Nature (2025) 637:1170-1177. DOI 10.1038/s41586-024-08337-5 · PubMed
Other PDB entries of the same protein (UniProt E1B8W3 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 7RRO 3.4 Å, Structure of the 48-nm repeat doublet microtubule from bovine tracheal cilia
- 9FQR 5.0 Å, 96-nm repeat of axonemal doublet microtubules from bovine sperm
Browse structure collections
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