9DGS: Alpha-centractin
Dynactin and dynein tail region of dynein-dynactin complex on microtubules. Determined by electron microscopy at 3.9 Å resolution. Released 10 Sept 2025.
- Method
- Electron microscopy
- Resolution
- 3.9 Å
- Organism
- Sus scrofa
- Chains
- 31
- Atoms
- 85,480
- Mol. weight
- 3501.91 kDa
- Ligands
- ZN, ATP, ADP
- Released
- 10 Sept 2025
Explore 9DGS in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
9DGS contains 520 α-helices and 496 β-strands across 31 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 24 helices, 22 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 10-11 | 2 | |
| β-strand | 12-16 | 5 | 1 |
| β-strand | 20-25 | 6 | 1 |
| β-strand | 33-36 | 4 | 1 |
| β-strand | 39-42 | 4 | 2 |
| β-strand | 45-46 | 2 | 3 |
| α-helix | 51-53 | 3 | |
| β-strand | 57 | 1 | 2 |
| α-helix | 60-64 | 5 | |
| β-strand | 69-72 | 4 | 2 |
| β-strand | 75-76 | 2 | 4 |
| β-strand | 79-80 | 2 | 4 |
| α-helix | 83-94 | 12 | |
| β-strand | 108-112 | 5 | 1 |
| α-helix | 113 | 1 | |
| α-helix | 118-130 | 13 | |
| β-strand | 136-141 | 6 | 1 |
| α-helix | 142-150 | 9 | |
| β-strand | 155-160 | 6 | 5 |
| β-strand | 165-171 | 7 | 5 |
| β-strand | 174-175 | 2 | 5 |
| α-helix | 177-179 | 3 | |
| β-strand | 181-183 | 3 | 5 |
| α-helix | 187-201 | 15 | |
| α-helix | 208-220 | 13 | |
| β-strand | 223 | 1 | 6 |
| α-helix | 228-233 | 6 | |
| α-helix | 235-237 | 3 | |
| β-strand | 240-242 | 3 | 7 |
| β-strand | 248-250 | 3 | 7 |
| α-helix | 254-257 | 4 | |
| α-helix | 258-261 | 4 | |
| α-helix | 265-267 | 3 | |
| α-helix | 275-285 | 11 | |
| α-helix | 288-296 | 9 | |
| β-strand | 298-301 | 4 | 5 |
| α-helix | 303-306 | 4 | |
| β-strand | 308 | 1 | 6 |
| α-helix | 310-321 | 12 | |
| α-helix | 323 | 1 | |
| β-strand | 330-331 | 2 | 5 |
| α-helix | 339-349 | 11 | |
| α-helix | 352-356 | 5 | |
| β-strand | 358-359 | 2 | 1 |
| α-helix | 360-366 | 7 | |
| α-helix | 368-374 | 7 | |
Chain B: 21 helices, 22 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 12-15 | 4 | 17 |
| β-strand | 20-25 | 6 | 17 |
| β-strand | 33-36 | 4 | 17 |
| β-strand | 39-42 | 4 | 18 |
| β-strand | 45-46 | 2 | 19 |
| β-strand | 57 | 1 | 18 |
| α-helix | 60-64 | 5 | |
| β-strand | 69-72 | 4 | 18 |
| β-strand | 75-76 | 2 | 20 |
| β-strand | 79-80 | 2 | 20 |
| α-helix | 83-93 | 11 | |
| α-helix | 103-105 | 3 | |
| β-strand | 108-111 | 4 | 17 |
| α-helix | 118-130 | 13 | |
| β-strand | 136-140 | 5 | 17 |
| α-helix | 143-150 | 8 | |
| β-strand | 155-160 | 6 | 21 |
| β-strand | 165-171 | 7 | 21 |
| β-strand | 174-175 | 2 | 21 |
| β-strand | 181-183 | 3 | 21 |
| α-helix | 187-201 | 15 | |
| α-helix | 208-220 | 13 | |
| β-strand | 223 | 1 | 22 |
| α-helix | 228-233 | 6 | |
| α-helix | 235-236 | 2 | |
| β-strand | 240-242 | 3 | 23 |
| β-strand | 248-250 | 3 | 23 |
| α-helix | 254-257 | 4 | |
| α-helix | 259-262 | 4 | |
| α-helix | 265-267 | 3 | |
| α-helix | 275-285 | 11 | |
| α-helix | 288-296 | 9 | |
| β-strand | 298-301 | 4 | 21 |
| α-helix | 303-306 | 4 | |
| β-strand | 308 | 1 | 22 |
| α-helix | 310-321 | 12 | |
| α-helix | 323 | 1 | |
| β-strand | 328-331 | 4 | 21 |
| α-helix | 339-349 | 11 | |
| α-helix | 353-356 | 4 | |
| β-strand | 358-359 | 2 | 17 |
| α-helix | 360-366 | 7 | |
| α-helix | 368-373 | 6 | |
Chain C: 22 helices, 22 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 10-11 | 2 | |
| β-strand | 12-15 | 4 | 27 |
| β-strand | 20-25 | 6 | 27 |
| β-strand | 33-36 | 4 | 27 |
| β-strand | 39-42 | 4 | 28 |
| β-strand | 45-46 | 2 | 29 |
| β-strand | 57 | 1 | 28 |
| α-helix | 60-64 | 5 | |
| β-strand | 69-72 | 4 | 28 |
| β-strand | 75-76 | 2 | 30 |
| β-strand | 79-80 | 2 | 30 |
| α-helix | 83-93 | 11 | |
| α-helix | 103-105 | 3 | |
| β-strand | 108-111 | 4 | 27 |
| α-helix | 118-126 | 9 | |
| α-helix | 127-131 | 5 | |
| β-strand | 136-140 | 5 | 27 |
| α-helix | 142-150 | 9 | |
| β-strand | 155-160 | 6 | 3 |
| β-strand | 165-171 | 7 | 3 |
| β-strand | 174-175 | 2 | 3 |
| β-strand | 181-183 | 3 | 3 |
| α-helix | 187-201 | 15 | |
| α-helix | 208-220 | 13 | |
| β-strand | 223 | 1 | 31 |
| α-helix | 228-233 | 6 | |
| β-strand | 240-242 | 3 | 32 |
| β-strand | 248-250 | 3 | 32 |
| α-helix | 254-257 | 4 | |
| α-helix | 259-262 | 4 | |
| α-helix | 265-267 | 3 | |
| α-helix | 275-285 | 11 | |
| α-helix | 291-296 | 6 | |
| β-strand | 298-301 | 4 | 3 |
| α-helix | 303-306 | 4 | |
| β-strand | 308 | 1 | 31 |
| α-helix | 310-321 | 12 | |
| α-helix | 323 | 1 | |
| β-strand | 330-333 | 4 | 3 |
| α-helix | 339-349 | 11 | |
| α-helix | 352-356 | 5 | |
| β-strand | 358-359 | 2 | 27 |
| α-helix | 360-366 | 7 | |
| α-helix | 368-372 | 5 | |
Chain D: 21 helices, 22 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 12-16 | 5 | 38 |
| β-strand | 20-25 | 6 | 38 |
| β-strand | 33-36 | 4 | 38 |
| β-strand | 39-42 | 4 | 39 |
| β-strand | 45-46 | 2 | 40 |
| β-strand | 57 | 1 | 39 |
| α-helix | 60-64 | 5 | |
| β-strand | 69-72 | 4 | 39 |
| β-strand | 75-76 | 2 | 41 |
| β-strand | 79-80 | 2 | 41 |
| α-helix | 83-93 | 11 | |
| α-helix | 103-105 | 3 | |
| β-strand | 108-112 | 5 | 38 |
| α-helix | 118-130 | 13 | |
| β-strand | 136-141 | 6 | 38 |
| α-helix | 142-150 | 9 | |
| β-strand | 155-160 | 6 | 19 |
| β-strand | 165-171 | 7 | 19 |
| β-strand | 174-175 | 2 | 19 |
| α-helix | 177-179 | 3 | |
| β-strand | 181-183 | 3 | 19 |
| α-helix | 187-201 | 15 | |
| α-helix | 208-220 | 13 | |
| β-strand | 223 | 1 | 42 |
| α-helix | 228-234 | 7 | |
| β-strand | 240-242 | 3 | 43 |
| β-strand | 248-250 | 3 | 43 |
| α-helix | 254-257 | 4 | |
| α-helix | 259-263 | 5 | |
| α-helix | 265-267 | 3 | |
| α-helix | 275-285 | 11 | |
| α-helix | 291-296 | 6 | |
| β-strand | 298-301 | 4 | 19 |
| α-helix | 303-306 | 4 | |
| β-strand | 308 | 1 | 42 |
| α-helix | 310-321 | 12 | |
| α-helix | 323 | 1 | |
| β-strand | 329-331 | 3 | 19 |
| α-helix | 339-349 | 11 | |
| α-helix | 352-356 | 5 | |
| β-strand | 358-359 | 2 | 38 |
| α-helix | 360-366 | 7 | |
| α-helix | 368-373 | 6 | |
Chain e: 39 helices, 10 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 29-42 | 14 | |
| α-helix | 50-56 | 7 | |
| α-helix | 59-70 | 12 | |
| α-helix | 72-74 | 3 | |
| β-strand | 77-81 | 5 | 127 |
| β-strand | 83-86 | 4 | 128 |
| α-helix | 87-88 | 2 | |
| α-helix | 94-95 | 2 | |
| β-strand | 96-99 | 4 | 128 |
| β-strand | 102-104 | 3 | 127 |
| β-strand | 114-118 | 5 | 127 |
| α-helix | 131-134 | 4 | |
| β-strand | 138 | 1 | 127 |
| α-helix | 145-151 | 7 | |
| α-helix | 152-157 | 6 | |
| α-helix | 158-166 | 9 | |
| α-helix | 178-198 | 21 | |
| α-helix | 202-205 | 4 | |
| α-helix | 213-222 | 10 | |
| α-helix | 233-235 | 3 | |
| α-helix | 239-261 | 23 | |
| α-helix | 271-293 | 23 | |
| α-helix | 295-306 | 12 | |
| α-helix | 310-320 | 11 | |
| α-helix | 322-337 | 16 | |
| α-helix | 341-346 | 6 | |
| α-helix | 350-366 | 17 | |
| α-helix | 374-399 | 26 | |
| α-helix | 401-404 | 4 | |
| α-helix | 406-435 | 30 | |
| α-helix | 455-482 | 28 | |
| α-helix | 514-530 | 17 | |
| α-helix | 540-572 | 33 | |
| α-helix | 578-587 | 10 | |
| α-helix | 595-622 | 28 | |
| α-helix | 632-638 | 7 | |
| α-helix | 643-669 | 27 | |
| α-helix | 677-693 | 17 | |
| α-helix | 696-709 | 14 | |
| β-strand | 719 | 1 | 129 |
| β-strand | 724-725 | 2 | 130 |
| β-strand | 728-731 | 4 | 130 |
| α-helix | 735 | 1 | |
| β-strand | 736 | 1 | 129 |
| α-helix | 741-756 | 16 | |
| α-helix | 762-797 | 36 | |
| α-helix | 799-801 | 3 | |
| α-helix | 806-820 | 15 | |
| α-helix | 829-848 | 20 | |
Chain E: 22 helices, 22 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 9-11 | 3 | |
| β-strand | 12-15 | 4 | 53 |
| β-strand | 20-25 | 6 | 53 |
| β-strand | 33-36 | 4 | 53 |
| β-strand | 39-42 | 4 | 54 |
| β-strand | 45-46 | 2 | 55 |
| β-strand | 57 | 1 | 54 |
| α-helix | 60-64 | 5 | |
| β-strand | 69-72 | 4 | 54 |
| β-strand | 75-76 | 2 | 56 |
| β-strand | 79-80 | 2 | 56 |
| α-helix | 83-93 | 11 | |
| β-strand | 108-112 | 5 | 53 |
| α-helix | 113 | 1 | |
| α-helix | 118-130 | 13 | |
| β-strand | 136-141 | 6 | 53 |
| α-helix | 142-150 | 9 | |
| β-strand | 155-160 | 6 | 29 |
| β-strand | 165-171 | 7 | 29 |
| β-strand | 174-175 | 2 | 29 |
| β-strand | 181-183 | 3 | 29 |
| α-helix | 187-201 | 15 | |
| α-helix | 208-220 | 13 | |
| β-strand | 223 | 1 | 57 |
| α-helix | 228-233 | 6 | |
| α-helix | 235-236 | 2 | |
| β-strand | 240-242 | 3 | 58 |
| β-strand | 248-250 | 3 | 58 |
| α-helix | 254-257 | 4 | |
| α-helix | 259-261 | 3 | |
| α-helix | 265-268 | 4 | |
| α-helix | 275-285 | 11 | |
| α-helix | 290-296 | 7 | |
| β-strand | 298-301 | 4 | 29 |
| α-helix | 303-306 | 4 | |
| β-strand | 308 | 1 | 57 |
| α-helix | 310-321 | 12 | |
| α-helix | 323 | 1 | |
| β-strand | 329-331 | 3 | 29 |
| α-helix | 339-349 | 11 | |
| α-helix | 352-356 | 5 | |
| β-strand | 358-359 | 2 | 53 |
| α-helix | 360-366 | 7 | |
| α-helix | 368-373 | 6 | |
Chain f: 40 helices, 9 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 23-26 | 4 | |
| α-helix | 29-36 | 8 | |
| α-helix | 50-55 | 6 | |
| α-helix | 59-69 | 11 | |
| β-strand | 77-79 | 3 | 131 |
| β-strand | 85-86 | 2 | 132 |
| β-strand | 96-97 | 2 | 132 |
| β-strand | 103-104 | 2 | 131 |
| β-strand | 117-118 | 2 | 131 |
| α-helix | 145-152 | 8 | |
| α-helix | 157-167 | 11 | |
| α-helix | 178-194 | 17 | |
| α-helix | 211-222 | 12 | |
| α-helix | 225-227 | 3 | |
| α-helix | 229-232 | 4 | |
| α-helix | 234-237 | 4 | |
| α-helix | 239-261 | 23 | |
| α-helix | 271-292 | 22 | |
| α-helix | 295-306 | 12 | |
| α-helix | 310-314 | 5 | |
| α-helix | 315-319 | 5 | |
| α-helix | 322-336 | 15 | |
| α-helix | 341-345 | 5 | |
| α-helix | 350-363 | 14 | |
| α-helix | 364-368 | 5 | |
| α-helix | 374-399 | 26 | |
| α-helix | 406-440 | 35 | |
| α-helix | 455-482 | 28 | |
| α-helix | 514-532 | 19 | |
| α-helix | 540-574 | 35 | |
| α-helix | 578-587 | 10 | |
| α-helix | 589-591 | 3 | |
| α-helix | 595-624 | 30 | |
| α-helix | 632-638 | 7 | |
| α-helix | 643-668 | 26 | |
| α-helix | 677-692 | 16 | |
| α-helix | 695-709 | 15 | |
| β-strand | 716 | 1 | 133 |
| β-strand | 718-723 | 6 | 134 |
| β-strand | 732-737 | 6 | 134 |
| α-helix | 741-749 | 9 | |
| α-helix | 750-754 | 5 | |
| α-helix | 755-756 | 2 | |
| α-helix | 762-773 | 12 | |
| α-helix | 775-797 | 23 | |
| α-helix | 799-801 | 3 | |
| α-helix | 806-821 | 16 | |
| β-strand | 823 | 1 | 133 |
| α-helix | 829-849 | 21 | |
Chain F: 22 helices, 22 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 9-11 | 3 | |
| β-strand | 12-15 | 4 | 68 |
| β-strand | 20-25 | 6 | 68 |
| β-strand | 33-36 | 4 | 68 |
| β-strand | 39-42 | 4 | 69 |
| β-strand | 45-46 | 2 | 70 |
| β-strand | 57 | 1 | 69 |
| α-helix | 60-64 | 5 | |
| β-strand | 69-72 | 4 | 69 |
| β-strand | 75-76 | 2 | 71 |
| β-strand | 79-80 | 2 | 71 |
| α-helix | 83-94 | 12 | |
| α-helix | 103-105 | 3 | |
| β-strand | 108-112 | 5 | 68 |
| α-helix | 118-130 | 13 | |
| β-strand | 136-141 | 6 | 68 |
| α-helix | 142-150 | 9 | |
| β-strand | 155-160 | 6 | 40 |
| β-strand | 165-171 | 7 | 40 |
| β-strand | 174-175 | 2 | 40 |
| α-helix | 177-179 | 3 | |
| β-strand | 181-183 | 3 | 40 |
| α-helix | 187-201 | 15 | |
| α-helix | 208-220 | 13 | |
| β-strand | 223 | 1 | 72 |
| α-helix | 228-233 | 6 | |
| β-strand | 240-242 | 3 | 73 |
| β-strand | 248-250 | 3 | 73 |
| α-helix | 254-257 | 4 | |
| α-helix | 258-262 | 5 | |
| α-helix | 265-268 | 4 | |
| α-helix | 275-285 | 11 | |
| α-helix | 290-296 | 7 | |
| β-strand | 298-301 | 4 | 40 |
| α-helix | 303-306 | 4 | |
| β-strand | 308 | 1 | 72 |
| α-helix | 310-321 | 12 | |
| α-helix | 323 | 1 | |
| β-strand | 329-331 | 3 | 40 |
| α-helix | 339-349 | 11 | |
| α-helix | 352-356 | 5 | |
| β-strand | 358-359 | 2 | 68 |
| α-helix | 360-366 | 7 | |
| α-helix | 368-373 | 6 | |
22 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Alpha-centractin | A, B, C, D, E, F, G, I | protein | 376 | Sus scrofa | A0A8D1PMN0 (AlphaFold model) |
| Actin, cytoplasmic 1 | H | protein | 375 | Sus scrofa | Q6QAQ1 (AlphaFold model) |
| Actin-related protein 10 | J | protein | 417 | Sus scrofa | I3LHK5 (AlphaFold model) |
| F-actin-capping protein subunit alpha-1 | K | protein | 286 | Sus scrofa | A0PFK5 (AlphaFold model) |
| F-actin-capping protein subunit beta | L | protein | 272 | Sus scrofa | A0PFK7 |
| Dynactin subunit 2 | M, N, P, Q | protein | 405 | Sus scrofa | A0A5G2QD80 |
| Dynactin subunit 3 | O, R | protein | 186 | Sus scrofa | F1SEC0 |
| Dynactin subunit 6 | U | protein | 190 | Sus scrofa | D0G6S1 |
| Dynactin subunit 5 | V | protein | 182 | Sus scrofa | A0A286ZK88 |
| Dynactin subunit 1 | W, Z | protein | 1281 | Sus scrofa | A0A287B8J2 |
| Dynactin subunit 4 | Y | protein | 467 | Sus scrofa | A0A4X1TB62 |
| Cytoplasmic dynein 1 heavy chain 1 | e, f, m, n | protein | 4646 | Sus scrofa | A0A480I0V8 |
1 more molecules are not listed.
Sequence of entity 1 (A, B, C, D, E, F, G, I), FASTA
>9DGS_1 Alpha-centractin (chains A, B, C, D, E, F, G, I)
MESYDVIANQPVVIDNGSGVIKAGFAGDQIPKYCFPNYVGRPKHVRVMAGALEGDIFIGP
KAEEHRGLLSIRYPMEHGIVKDWNDMERIWQYVYSKDQLQTFSEEHPVLLTEAPLNPRKN
RERAAEVFFETFNVPALFISMQAVLSLYATGRTTGVVLDSGDGVTHAVPIYEGFAMPHSI
MRIDIAGRDVSRFLRLYLRKEGYDFHSSSEFEIVKAIKERACYLSINPQKDETLETEKAQ
YYLPDGSTIEIGPSRFRAPELLFRPDLIGEESEGIHEVLVFAIQKSDMDLRRTLFSNIVL
SGGSTLFKGFGDRLLSEVKKLAPKDVKIRISAPQERLYSTWIGGSILASLDTFKKMWVSK
KEYEEDGARSIHRKTF
Sequence of entity 2 (H), FASTA
>9DGS_2 Actin, cytoplasmic 1 (chains H)
MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQS
KRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMT
QIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDL
AGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSY
ELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLS
GGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQ
EYDESGPSIVHRKCF
Sequence of entity 3 (J), FASTA
>9DGS_3 Actin-related protein 10 (chains J)
MPLYEGLGSGGEKTAVVIDLGEAFTKCGFAGETGPRCIIPSVIKKAGMPKPIKVVQYNIN
TEELYSYLKEFIHILYFRHLLVNPRDRRVVVIESVLCPSHFRETLTRVLFKYFEVPSVLL
APSHLMALLTLGINSAMVLDCGYRESLVLPIYEGIPVLNCWGALPLGGKALHKELETQLL
EQCTVDTGAAKEQSLPSVMGSIPEGVLEDIKVRTCFVSDLTRGLKIQAAKFNIDGNTERP
SPPPNVDYPLDGEKILHVLGSIRDSVVEILFEQDNEEKSVATLILDSLMQCPIDTRKQLA
ENLVIIGGTSMLPGFLHRLLAEIRYLVEKPKYKKTLGTKTFRIHTPPAKANCVAWLGGAI
FGALQDILGSRSVSKEYYNQTGRIPDWCSLNNPPLEMVFDVGKSQPPLMKRAFSTEK
Sequence of entity 4 (K), FASTA
>9DGS_4 F-actin-capping protein subunit alpha-1 (chains K)
MADFEDRVSDEEKVRIAAKFITHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNMD
QFTPVKIEGYEDQVLITEHGDLGNSRFLDPRNKISFKFDHLRKEASDPQPEEVDGSLKSW
RESCDSALRAYVKDHYSNGFCTVYAKNIDGQQTIIACIESHQFQPKNFWNGRWRSEWKFT
ITPPTAQVVGVLKIQVHYYEDGNVQLVSHKDVQDSVTVSNEAQTAKEFIKIIEHAENEYQ
TAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILSYKIGKEMQNA
Sequence of entity 5 (L), FASTA
>9DGS_5 F-actin-capping protein subunit beta (chains L)
MSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYL
LCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVY
LWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTN
KSGSGTMNLGGSLTRQMEKDETVSDCSPHIANIGRLVEDMENKIRSTLNEIYFGKTKDIV
NGLRSVQTFADKSKQEALKNDLVEALKRKQQC
Sequence of entity 6 (M, N, P, Q), FASTA
>9DGS_6 Dynactin subunit 2 (chains M, N, P, Q)
MADPKYADLPGIARNEPDVYETSDLPEDDQAEFDAELEELTSTSVEHIIVNPNAAYDKFK
DKRVGTKGLDFSDRIGKTKRTGYESGEYEMLGEGLGVKETPQQKYQRLLHEVQELTTEVE
KIKMTVKESATEEKLTPVVLAKQLAALKQQLVASHLEKLLGPDAAINLTDPDGALAKRLL
LQLEATKNTKGAGSGGKTTSGSPPDSSLVTYELHSRPEQDKFSQAAKVAELEKRLTELEA
TVRCDQDAQNPLSAGLQGACLMETVELLQAKVSALDLAVLDQVEARLQSVLGKVNEIAKH
KASVEDADTQSKVHQLYETIQRWSPIASTLPELVQRLVTIKQLHEQAMQFGQLLTHLDTT
QQMIACSLKDNATLLTQVQTTMRENLSTVEGNFANIDERMKKLGK
Sequence of entity 7 (O, R), FASTA
>9DGS_7 Dynactin subunit 3 (chains O, R)
MAGVTDVQRLQARLEELERWVYGPGGSRGSRKVADGLVKVQVALGNIASKRERVKILYKK
IEDLIKYLDPEYMDRIAIPDASKLQFILAEEQFILSQVALLEQVEALVPMLDSAHIKAVP
EHAARLQRLAQIHIQQQDQCVEITEESKALLEEYNKTTMLLSKQFVQWDELLCQLEAAKQ
VKPAEE
Sequence of entity 8 (U), FASTA
>9DGS_8 Dynactin subunit 6 (chains U)
MAEKTQKSVKIAPGAVVCVESEIRGDVTIGPRTVIHPKARIIAEAGPIVIGEGNLIEEQA
LIINAHPDNITPDAEDSEPKPMIIGTNNVFEVGCYSQAMKMGDNNVIESKAYVGRNVILT
SGCIIGACCNLNTFEVIPENTVIYGADCLRRVQTERPQPQTLQLDFLMKILPNYHHLKKT
MKGSSTPVKN
Sequence of entity 9 (V), FASTA
>9DGS_9 Dynactin subunit 5 (chains V)
MELGELLYNKSEYIETASGNKVSRQSVLCGSQNIVLNGKTIVMNDCIIRGDLANVRVGRH
CVVKSRSVIRPPFKKFSKGVAFFPLHIGDHVFIEEDCVVNAAQIGSYVHVGKNCVIGRRC
VLKDCCKILDNTVLPPETVVPPFTVFSGCPGLFSGELPECTQELMIDVTKSYYQKFLPLT
QV
Sequence of entity 10 (W, Z), FASTA
>9DGS_10 Dynactin subunit 1 (chains W, Z)
MAQSKRHVYSRTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGV
ILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLRRE
GTDSNAKTSKLRGPKPKKAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSS
SEPSTPAQTPLAAPIIPTPALTSPGAAPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAE
DKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADT
ADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQL
KQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAE
STIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARE
TELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEA
SVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPG
GDHDCVLVLLLMPRLICKAELIRKQAQEKFDLSENCSERPGLRGAAGEQLSFAAGLVYSL
SLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPL
TKAIKYYQHLYSIHLAEQPEDSTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEASDI
ALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGAQVSDTLLDCRKHLTWVVAV
LQEVAAAAAQLIAPLAENEGLPVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTM
NKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLK
IKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQ
ADIDQLEAEKAELKQRLNSQSKRTIEGIRGPPPSGIATLVSGIAGEEQQRGGAPGQAPGI
VPGPGLVKDSPLLLQQISAMRLHISQLQHENSVLKGAQMKASLAALPPLHVAKLSLPPHE
GPGSELAAGALYRKTNQLLETLNQLSTHTHVVDITRSSPAAKSPSAQLLEQVTQLKSLSD
TIEKLKDEVLKETVSQRPGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGLG
QRHRLVLTQEQLHQLHDRLIS
Sequence of entity 11 (Y), FASTA
>9DGS_11 Dynactin subunit 4 (chains Y)
MASLLQSERVLYLVQGEKKVRAPLSQLYFCRYCSELRSLECVSHEVDSHYCPSCLENMPS
AEAKLKKNRCANCFDCPGCMHTLSTRATSISTQLPDDPAKTAVKKAYYLACGFCRWTSRD
VGMADKSVASGGWQEPDHPHTQRMNKLIEYYQQLAQKEKVERDRKKLARRRNYMPLAFSQ
HTIHVVDKYGLGTRLQRPRAGTTITALAGLSLKEGEDQKEIKIEPAQAVDEVEPLPEDYY
TRPVNLTEVTTLQQRLLQPDFQPICASQLYPRHKHLLIKRSLRCRQCEHNLSKPEFNPTS
IKFKIQLVAVNYIPEVRIMSIPNLRYMKESQVLLTLTNPVENLTHVTLLECEEGDPDDTN
STAKVSVPPTELVLAGKDAAAEYDELAEPQDFPDDPDVVAFRKANKVGVFIKVTPQREEG
DVTVCFKLKHDFKNLAAPIRPVEEADPGAEVSWLTQHVELSLGPLLP
Sequence of entity 12 (e, f, m, n), FASTA
>9DGS_12 Cytoplasmic dynein 1 heavy chain 1 (chains e, f, m, n)
MSEPGGGGGEDGSAGLEVSAVQNVADVSVLQKHLRKLVPLLLEDGGEAPAALEAALEEKS
ALEQMRKFLSDPQVHTVLVERSTLKEDVGDEGEEEKEFISYNINIDIHYGVKSNSLAFIK
RAPVIDADKPVSSQLRVLTLSEDSPYETLHSFISNAVAPFFKSYIRESGKADRDGDKMAP
SVEKKIAELEMGLLHLQQNIEIPEISLPIHPIITNVAKQCYERGEKPKVTDFGDKVEDPT
FLNQLQSGVNRWIREIQKVTKLDRDPASGTALQEISFWLNLERALYRIQEKRESPEVLLT
LDILKHGKRFHATVSFDTDTGLKQALETVNDYNPLMKDFPLNDLLSATELDKIRQALVAI
FTHLRKIRNTKYPIQRALRLVEAISRDLSSQLLKVLGTRKLMHVAYEEFEKVMVACFEVF
QTWDDEYEKLQVLLRDIVKRKREENLKMVWRINPAHRKLQARLDQMRKFRRQHEQLRAVI
VRVLRPQVTAVAQQNQGEAPEPQDMKVAEVLFDAADANAIEEVNLAYENVKEVDGLDVSK
EGTEAWEAAMKRYDERIDRVETRITARLRDQLGTAKNANEMFRIFSRFNALFVRPHIRGA
IREYQTQLIQRVKDDIESLHDKFKVQYPQSQACKMSHVRDLPPVSGSIIWAKQIDRQLTA
YMKRVEDVLGKGWENHVEGQKLKQDGDSFRMKLNTQEIFDDWARKVQQRNLGVSGRIFAI
ESTRVRGRSGNVLKLKVNFLPEIITLSKEVRNLKWLGFRVPLAIVNKAHQANQLYPFAIS
LIESVRTYERTCEKVEERNTISLLVAGLKKEVQALIAEGIALVWESYKLDPYVQRLAETV
FNFQEKVDDLLIIEEKIDLEVRSLETCVYDHKTFSEILNRVQKAVDDLNLHSYSNLPIWV
NKLDMEIERILGVRLQAGLRAWTQVLLGQAEDKAEVDMDTDAPQVSHKPGGEPKIKNVVH
ELRITNQVIYLNPPIEECRYKLYQEMFAWKMVVLSLPRIQSQRYQVGVHYELTEEEKFYR
NALTRMPDGPVALEESYSAVMGIVTEVEQYVKVWLQYQCLWDMQAENIYNRLGEDLNKWQ
ALLVQIRKARGTFDNAETKKEFGPVVIDYGKVQSKVNLKYDSWHKEVLSKFGQMLGSNMT
EFHSQISKSRQELEQHSVDTASTSDAVTFITYVQSLKRKIKQFEKQVELYRNGQRLLEKQ
RFQFPPSWLYIDNIEGEWGAFNDIMRRKDSAIQQQVANLQMKIVQEDRAVESRTTDLLAD
WEKTKPVTGNLRPEEALQALTIYEGKFGRLKDDREKCAKAKEALELTETGLLSGSEERVQ
VALEELQDLKGVWSELSKIWEQIDQMKEQPWVSVQPRKLRQNLDGLLNQLKNFPARLRQY
ASYEFVQRLLKGYLKINMLVIELKSEALKDRHWKQLMKRLHVNWVVSELTLGQIWDVDLQ
KNEAVVKDVLLVAQGEMALEEFLKQIREVWNTYELDLVNYQNKCRLIRGWDDLFNKVKEH
INSVSAMKLSPYYKVFEEDALSWEDKLNRIMALFDVWIDVQRRWVYLEGIFTGSADIKHL
LPVETQRFQSISTEFLALMKKVSKSPLVMDVLNIQGVQRSLERLADLLGKIQKALGEYLE
RERSSFPRFYFVGDEDLLEIIGNSKNVAKLQKHFKKMFAGVSSIILSEDNSVVLGISSRE
GEEVTFKTPVSITEHPKINEWLTLVEKEMRVTLAKLLAESVTEVEIFGKATSIDPNTYIT
WIDKYQAQLVVLSAQIAWSENVEAALSSIGGSGDSAPLQSVLSNVEVTLNVLADSVLMEQ
PPLRRRKLEHLITELVHQRDVTRSLIKSKIDNAKSFEWLSQMRFYFDPKQTDVLQQLSIQ
MANAKFNYGFEYLGVQDKLVQTPLTDRCYLTMTQALEARLGGSPFGPAGTGKTESVKALG
HQLGRFVLVFNCDETFDFQAMGRIFVGLCQVGAWGCFDEFNRLEERMLSAVSQQVQCIQE
ALREHSSPNHDKASAPITCELLNKQVKVSPDMAIFITMNPGYAGRSNLPDNLKKLFRSLA
MTKPDRQLIAQVMLYSQGFRTAEVLANKIVPFFKLCDEQLSSQSHYDFGLRALKSVLVSA
GNVKRERIQKIKREKEERGEAVDEGEIAENLPEQEILIQSVCETMVPKLVAEDIPLLFSL
LSDVFPGVQYHRGEMTALREELKKVCQEMYLTYGDGEEVGGMWVEKVLQLYQITQINHGL
MMVGPSGSGKSMAWRVLLKALERLEGVEGVAHIIDPKAISKDHLYGTLDPNTREWTDGLF
THVLRKIIDNVRGELQKRQWIVFDGDVDPEWVENLNSVLDDNKLLTLPNGERLSLPPNVR
IMFEVQDLKYATLATVSRCGMVWFSEDVLSTDMIFNNFLARLRSIPLDEGEDEAQRRRKG
KEDEGEEAASPMLQIQRDAATTLQPYFTPNGLVTKALEHAFKLEHIMDLTRLRCLGSLFS
MLHQACRNVAQYNANHPDFPMQMEQLERYIQRYLVYAILWSLSGDSRLKMRAELGEYIRR
ITTVPLPAAPNIPIIDYEVSISGEWSPWQAKVPQIEVETHKVAAPDVVVPTLDTVRHEAL
LYTWLAEHKPLVLCGPPGSGKTMTLFSALRALPDMEVVGLNFSSATTPELLLKTFDHYCE
YRRTPNGVVLAPVQLGKWLVLFCDEINLPDMDKYGTQRVISFIRQMVEHGGFYRTSDQTW
VKLERIQFVGACNPPTDPGRKPLSHRFLRHVPVVYVDYPGPASLTQIYGTFNRAMLRLVP
SLRTYAEPLTAAMVEFYTMSQERFTQDTQPHYIYSPREMTRWVRGIFEALRPLETLPVEG
LIRIWAHEALRLFQDRLVEDEERRWTDENIDLVALKHFPNIDKEKAMSRPILYSNWLSKD
YIPVDQEELRDYVKARLKVFYEEELDVPLVLFNEVLDHVLRIDRIFRQPQGHLLLIGVSG
AGKTTLSRFVAWMNGLSVYQIKVHRKYTGEDFDEDLRTVLRRSGCKNEKIAFIMDESNVL
DSGFLERMNTLLANGEVPGLFEGDEYATLMTQCKEGAQKEGLMLDSHEELYKWFTSQVIR
NLHVVFTMNPSSEGLKDRAATSPALFNRCVLNWFGDWSTEALYQVGKEFTSKMDLEKPNY
VVPDYMPVVYDKLPQPPSHREAIVNSCVFVHQTLHQANARLAKRGGRTMAITPRHYLDFI
NHYANLFHEKRSELEEQQMHLNVGLRKIKETVDQVEELRRDLRIKSQELEVKNAAANDKL
KKMVKDQQEAEKKKVMSQEIQEQLHKQQEVIADKQMSVKEDLDKVEPAVIEAQNAVKSIK
KQHLVEVRSMANPPAAVKLALESICLLLGESTTDWKQIRSIIMRENFIPTIVNFSAEEIS
DAIREKMKKNYMSNPSYNYEIVNRASLACGPMVKWAIAQLNYADMLKRVEPLRNELQKLE
DDAKDNQQKANEVEQMIRDLEASIARYKEEYAVLISEAQAIKADLAAVEAKVNRSTALLK
SLSAERERWEKTSETFKNQMSTIAGDCLLSAAFIAYAGYFDQQMRQNLFTTWSHHLQQAN
IQFRTDIARTEYLSNADERLRWQASSLPADDLCTENAIMLKRFNRYPLIIDPSGQATEFI
MNEYKDRKITRTSFLDDAFRKNLESALRFGNPLLVQDVESYDPVLNPVLNREVRRTGGRV
LITLGDQDIDLSPSFVIFLSTRDPTVEFPPDLCSRVTFVNFTVTRSSLQSQCLNEVLKAE
RPDVDEKRSDLLKLQGEFQLRLRQLEKSLLQALNEVKGRILDDDTIITTLENLKREAAEV
TRKVEETDIVMQEVETVSQQYLPLSTACSSIYFTMESLKQIHFLYQYSLQFFLDIYHNVL
YENPNLKGVTDHTQRLCIITKDLFQVAFNRVARGMLHQDHITFAMLLARIKLKGTVGEPT
YEAEFQHFLRGKEIVLSAGSTPKIPGLTVEQAEAVVRLSCLPAFKDLIAKVQADEQFSIW
LDSSSPEQTVPHLWSEENPATPIGQAIHRLLLIQAFRPDRLLAMAHVFVSTNLGESFMSI
MEQPLDLTHIVDTEVKPNTPVLMCSVPGYDASGHVEDLAAEQNTQITSIAIGSAEGFNQA
DKAINTAVKSGRWVMLKNVHLAPGWLMQLEKKLHSLQPHACFRLFLTMEINPKVPVNLLR
AGRIFVFEPPPGVKANMLRTFSSVPVSRICKSPNERARLYFLLAWFHAIIQERLRYAPLG
WSKKYEFGESDLRSACDTVDTWLDDTAKGRQNISPDKIPWSALKTLMAQSIYGGRVDNEF
DQRLLNTFLERLFTTRSFDSEFKLACKVDGHKDIQMPDGIRREEFVQWVELLPDTQTPSW
LGLPNNAERVLLTTQGVDMISKMLKMQMLEDEDDLAYAETEKKTRTDSTADGRPAWMRTL
HTTASNWLHLIPQTLSHLKRTVDNIKDPLFRFFEREVKMGARLLQDVRQDLADVVQVCEG
KKKQTNYLRTLINELVKGILPRSWSHYTVPAGMTVIQWVSDFSERIKQLQSVSQAAASGG
AKELKNIHVCLGGLFVPEAYITATRQYVAQANSWSLEELCLEVIVTTSQSATLDACSFGV
TGLKLQGATCSNNKLSLSNAISTVLPLTQLRWVKQTNAEKKANVVTLPVYLNFTRADLIF
TVDFEIATKEDPRSFYERGVAVLCTE
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ZN | Zinc ion | Zn | 3 |
| ATP | Adenosine-5'-triphosphate | C10 H16 N5 O13 P3 | 1 |
| ADP | Adenosine-5'-diphosphate | C10 H15 N5 O10 P2 | 9 |
Primary citation
Roles of microtubules and LIS1 in dynein transport machinery assembly. Rao, Q., Yang, J., Chai, P. et al. Nature (2026) 652:1384-1392. DOI 10.1038/s41586-026-10153-y · PubMed
Other PDB entries of the same protein (UniProt A0A8D1PMN0 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 7Z8M 3.37 Å, The pointed end complex of dynactin bound to BICDR1
- 9YNG 4.07 Å, Dynactin and dynein-1 tail region of dynein-dynactin complex on microtubule in the…
- 9DGU 7.1 Å, structure of dynactin, dynein tail with two BICDR from dynein-dynactin-BICDR on…
- 9DGT 7.2 Å, structure of dynactin, dynein tail with one BICDR from dynein-dynactin-BICDR on…
- 9DGV 8.8 Å, structure of dynactin, dynein tail with TRAK2 from dynein-dynactin-TRAK2 on microtubules
- 9DGR 15.0 Å, Composite structure of dynein-dynactin on microtubules
Browse structure collections
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