9F44: LST2 TOS peptide

cryo-EM structure of LST2 TOS peptide bound to human mTOR complex 1. Determined by electron microscopy at 3.68 Å resolution. Released 14 Aug 2024.

Method: Electron microscopy
Resolution: 3.68 Å
Organism: Homo sapiens
Chains: 8
Atoms: 56,848
Mol. weight: 960.51 kDa
Ligands: IHP
Released: 14 Aug 2024

Explore 9F44 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9F44 contains 397 α-helices and 178 β-strands across 6 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 147 helices, 13 β-strands

Element	Residues	Length	Sheet
α-helix	19-29	11
α-helix	38-52	15
α-helix	61-73	13
α-helix	83-97	15
α-helix	101-114	14
α-helix	122-134	13
α-helix	140-155	16
α-helix	165-178	14
α-helix	180-183	4
α-helix	188-197	10
α-helix	204-222	19
α-helix	234-245	12
α-helix	259-275	17
α-helix	277-288	12
α-helix	308-311	4
α-helix	314-316	3
α-helix	362-370	9
α-helix	372-375	4
α-helix	387-402	16
α-helix	411-425	15
α-helix	430-443	14
α-helix	447-451	5
α-helix	452-462	11
α-helix	479-490	12
α-helix	500-511	12
α-helix	515-527	13
α-helix	532-548	17
α-helix	579-591	13
α-helix	601-611	11
α-helix	616-629	14
α-helix	646-665	20
α-helix	669-678	10
α-helix	681-683	3
α-helix	684-687	4
α-helix	690-700	11
α-helix	705-717	13
α-helix	723-743	21
α-helix	747-763	17
α-helix	765-768	4
α-helix	769-771	3
α-helix	772-783	12
α-helix	792-809	18
α-helix	814-816	3
α-helix	817-828	12
α-helix	837-851	15
α-helix	856-860	5
α-helix	864-874	11
α-helix	878-891	14
α-helix	896-902	7
α-helix	934-940	7
α-helix	943-959	17
α-helix	964-982	19
α-helix	983-989	7
α-helix	990-1003	14
α-helix	1008-1023	16
α-helix	1024-1027	4
α-helix	1028-1041	14
α-helix	1046-1063	18
α-helix	1067-1083	17
α-helix	1088-1090	3
α-helix	1091-1103	13
α-helix	1104-1107	4
α-helix	1111-1123	13
α-helix	1129-1145	17
α-helix	1152-1165	14
α-helix	1170-1184	15
α-helix	1185-1190	6
α-helix	1192-1202	11
α-helix	1207-1218	12
α-helix	1263-1269	7
α-helix	1277-1294	18
α-helix	1298-1301	4
α-helix	1304-1309	6
α-helix	1311-1316	6
α-helix	1318-1328	11
α-helix	1332-1346	15
α-helix	1351-1366	16
α-helix	1377-1379	3
α-helix	1380-1389	10
α-helix	1393-1406	14
α-helix	1410-1422	13
α-helix	1426-1440	15
α-helix	1447-1453	7
α-helix	1456-1469	14
α-helix	1471-1472	2
α-helix	1474-1487	14
α-helix	1490-1499	10
α-helix	1506-1523	18
α-helix	1526-1535	10
α-helix	1541-1553	13
α-helix	1557-1580	24
α-helix	1583-1607	25
α-helix	1609-1611	3
α-helix	1612-1625	14
α-helix	1630-1640	11
α-helix	1646-1648	3
α-helix	1650-1662	13
α-helix	1666-1677	12
α-helix	1688-1690	3
α-helix	1694-1706	13
α-helix	1710-1731	22
α-helix	1738-1761	24
α-helix	1768-1782	15
α-helix	1787-1808	22
α-helix	1809-1813	5
α-helix	1868-1895	28
α-helix	1900-1913	14
α-helix	1917-1929	13
α-helix	1933-1938	6
α-helix	1939-1944	6
α-helix	1951-1966	16
α-helix	1969-1971	3
α-helix	1973-1980	8
α-helix	1985-2001	17
α-helix	2004-2020	17
α-helix	2023-2035	13
α-helix	2036-2041	6
α-helix	2044-2058	15
α-helix	2065-2070	6
α-helix	2071-2075	5
α-helix	2076-2091	16
α-helix	2094-2114	21
α-helix	2115-2117	3
β-strand	2120-2122	3	1
α-helix	2123-2126	4
α-helix	2128-2132	5
β-strand	2134	1	2
β-strand	2139	1	3
α-helix	2140	1
α-helix	2149-2150	2
β-strand	2152	1	3
β-strand	2153-2156	4	2
β-strand	2159-2161	3	1
β-strand	2170-2176	7	2
β-strand	2181-2187	7	2
α-helix	2193-2211	19
α-helix	2213-2218	6
β-strand	2227-2229	3	2
β-strand	2235-2238	4	2
α-helix	2239-2240	2
β-strand	2243-2245	3	4
α-helix	2246-2256	11
α-helix	2263-2271	9
α-helix	2275-2277	3
α-helix	2280-2292	13
α-helix	2298-2306	9
α-helix	2310-2334	25
α-helix	2341-2343	3
β-strand	2344-2347	4	4
β-strand	2353-2355	3	4
α-helix	2364-2367	4
α-helix	2381-2386	6
α-helix	2395-2409	15
α-helix	2411-2422	12
α-helix	2425-2427	3
α-helix	2428-2434	7
α-helix	2493-2509	17
α-helix	2521-2533	13
α-helix	2535-2538	4
α-helix	2543-2545	3

Chain B: 148 helices, 13 β-strands

Element	Residues	Length	Sheet
α-helix	19-29	11
α-helix	38-52	15
α-helix	61-73	13
α-helix	83-97	15
α-helix	101-114	14
α-helix	122-134	13
α-helix	140-155	16
α-helix	165-178	14
α-helix	180-183	4
α-helix	188-197	10
α-helix	204-222	19
α-helix	234-245	12
α-helix	259-275	17
α-helix	277-288	12
α-helix	308-311	4
α-helix	314-316	3
α-helix	362-370	9
α-helix	372-375	4
α-helix	387-402	16
α-helix	411-425	15
α-helix	430-443	14
α-helix	447-451	5
α-helix	452-462	11
α-helix	479-490	12
α-helix	500-511	12
α-helix	515-527	13
α-helix	532-548	17
α-helix	579-591	13
α-helix	601-611	11
α-helix	616-629	14
α-helix	646-665	20
α-helix	669-678	10
α-helix	681-683	3
α-helix	684-687	4
α-helix	690-700	11
α-helix	705-717	13
α-helix	723-743	21
α-helix	747-763	17
α-helix	765-768	4
α-helix	769-771	3
α-helix	772-783	12
α-helix	792-809	18
α-helix	814-816	3
α-helix	817-828	12
α-helix	837-851	15
α-helix	856-860	5
α-helix	864-874	11
α-helix	878-891	14
α-helix	896-902	7
α-helix	934-940	7
α-helix	943-959	17
α-helix	964-982	19
α-helix	983-989	7
α-helix	990-1003	14
α-helix	1008-1023	16
α-helix	1024-1027	4
α-helix	1028-1041	14
α-helix	1046-1063	18
α-helix	1067-1083	17
α-helix	1088-1090	3
α-helix	1091-1103	13
α-helix	1104-1107	4
α-helix	1111-1123	13
α-helix	1129-1145	17
α-helix	1152-1165	14
α-helix	1167-1169	3
α-helix	1170-1184	15
α-helix	1185-1190	6
α-helix	1192-1202	11
α-helix	1207-1218	12
α-helix	1263-1269	7
α-helix	1277-1294	18
α-helix	1298-1301	4
α-helix	1304-1309	6
α-helix	1311-1316	6
α-helix	1318-1328	11
α-helix	1332-1346	15
α-helix	1351-1366	16
α-helix	1377-1379	3
α-helix	1380-1389	10
α-helix	1393-1406	14
α-helix	1410-1422	13
α-helix	1426-1440	15
α-helix	1447-1453	7
α-helix	1456-1469	14
α-helix	1471-1472	2
α-helix	1474-1487	14
α-helix	1490-1499	10
α-helix	1506-1523	18
α-helix	1526-1535	10
α-helix	1541-1553	13
α-helix	1557-1580	24
α-helix	1583-1607	25
α-helix	1609-1611	3
α-helix	1612-1625	14
α-helix	1630-1640	11
α-helix	1646-1648	3
α-helix	1650-1662	13
α-helix	1666-1677	12
α-helix	1688-1690	3
α-helix	1694-1706	13
α-helix	1710-1731	22
α-helix	1738-1761	24
α-helix	1768-1782	15
α-helix	1787-1808	22
α-helix	1809-1813	5
α-helix	1868-1895	28
α-helix	1900-1913	14
α-helix	1917-1929	13
α-helix	1933-1938	6
α-helix	1939-1944	6
α-helix	1951-1966	16
α-helix	1969-1971	3
α-helix	1973-1980	8
α-helix	1985-2001	17
α-helix	2004-2020	17
α-helix	2023-2035	13
α-helix	2036-2041	6
α-helix	2044-2058	15
α-helix	2065-2070	6
α-helix	2071-2075	5
α-helix	2076-2091	16
α-helix	2094-2114	21
α-helix	2115-2117	3
β-strand	2120-2122	3	5
α-helix	2123-2126	4
α-helix	2128-2132	5
β-strand	2134	1	6
β-strand	2139	1	7
α-helix	2140	1
α-helix	2149-2150	2
β-strand	2152	1	7
β-strand	2153-2156	4	6
β-strand	2159-2161	3	5
β-strand	2170-2176	7	6
β-strand	2181-2187	7	6
α-helix	2193-2211	19
α-helix	2213-2218	6
β-strand	2227-2229	3	6
β-strand	2235-2238	4	6
α-helix	2239-2240	2
β-strand	2243-2245	3	8
α-helix	2246-2256	11
α-helix	2263-2271	9
α-helix	2275-2277	3
α-helix	2280-2292	13
α-helix	2298-2306	9
α-helix	2310-2334	25
α-helix	2341-2343	3
β-strand	2344-2347	4	8
β-strand	2353-2355	3	8
α-helix	2364-2367	4
α-helix	2381-2386	6
α-helix	2395-2409	15
α-helix	2411-2422	12
α-helix	2425-2427	3
α-helix	2428-2434	7
α-helix	2493-2509	17
α-helix	2521-2533	13
α-helix	2535-2538	4
α-helix	2543-2545	3

Chains C and D: 2 helices, 35 β-strands

Element	Residues	Length	Sheet
β-strand	14	1	9
β-strand	15-18	4	10
β-strand	19	1	11
β-strand	23-27	5	10
β-strand	37-39	3	10
β-strand	47-50	4	12
β-strand	56	1	13
β-strand	57-60	4	12
β-strand	65-67	3	12
β-strand	69	1	13
β-strand	79-81	3	12
β-strand	88-91	4	14
β-strand	99-104	6	14
β-strand	108-113	6	14
β-strand	123-126	4	14
α-helix	130-131	2
β-strand	134-136	3	15
β-strand	142-145	4	15
β-strand	152-156	5	15
β-strand	162-165	4	15
β-strand	173-178	6	16
β-strand	184-189	6	16
β-strand	194-199	6	16
α-helix	200	1
β-strand	210-216	7	16
β-strand	226-228	3	17
β-strand	234-237	4	17
β-strand	239	1	18
β-strand	243-248	6	17
β-strand	254-259	6	17
β-strand	273	1	18
β-strand	277-278	2	19
β-strand	284-287	4	19
β-strand	294-298	5	19
β-strand	304-308	5	19
β-strand	315	1	11
β-strand	321	1	9

Chains E and F: 49 helices, 41 β-strands

Element	Residues	Length	Sheet
α-helix	20-24	5
α-helix	33-36	4
α-helix	38-39	2
α-helix	41-45	5
β-strand	59-64	6	31
β-strand	85	1	32
β-strand	88	1	32
α-helix	95-113	19
β-strand	118-123	6	31
α-helix	127-140	14
β-strand	146-151	6	31
α-helix	156-158	3
β-strand	159	1	33
β-strand	163	1	33
β-strand	166-167	2	34
β-strand	174-175	2	34
β-strand	178	1	33
α-helix	179-185	7
β-strand	191-195	5	31
α-helix	199-218	20
β-strand	241-244	4	31
α-helix	262-268	7
α-helix	270-278	9
α-helix	282-286	5
α-helix	292-296	5
α-helix	308-327	20
α-helix	330-337	8
α-helix	341-358	18
β-strand	365-366	2	31
α-helix	370-372	3
α-helix	378-390	13
α-helix	393-394	2
α-helix	395-399	5
α-helix	404-406	3
α-helix	408-421	14
α-helix	429-430	2
α-helix	433-440	8
α-helix	446-457	12
α-helix	461-469	9
α-helix	473-478	6
α-helix	479-481	3
α-helix	487-501	15
α-helix	505-512	8
α-helix	515-522	8
α-helix	529-542	14
α-helix	547-555	9
α-helix	558-564	7
α-helix	571-584	14
α-helix	589-597	9
α-helix	600-604	5
α-helix	605-609	5
α-helix	613-628	16
α-helix	635-649	15
α-helix	657-673	17
α-helix	675-685	11
α-helix	808-819	12
α-helix	824-838	15
α-helix	951-953	3
α-helix	959-968	10
α-helix	974-975	2
α-helix	983-1007	25
β-strand	1015-1021	7	35
β-strand	1028-1031	4	36
β-strand	1038-1041	4	36
β-strand	1046-1049	4	36
β-strand	1056-1060	5	36
β-strand	1070-1074	5	37
β-strand	1084-1088	5	37
β-strand	1092-1097	6	37
β-strand	1107-1113	7	37
β-strand	1127-1129	3	38
β-strand	1137-1142	6	38
β-strand	1146-1151	6	38
β-strand	1156-1162	7	38
β-strand	1169-1173	5	39
β-strand	1181-1185	5	39
β-strand	1190-1193	4	39
α-helix	1199-1201	3
β-strand	1203-1207	5	39
β-strand	1214-1219	6	40
β-strand	1227-1231	5	40
β-strand	1235-1239	5	40
β-strand	1248-1251	4	40
β-strand	1259-1261	3	41
β-strand	1267-1270	4	41
β-strand	1276-1281	6	41
β-strand	1286-1291	6	41
β-strand	1306-1309	4	35
β-strand	1316-1319	4	35
β-strand	1324-1329	6	35

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Serine/threonine-protein kinase mTOR	A, B	protein	2549	Homo sapiens	P42345 (AlphaFold model)
Target of rapamycin complex subunit LST8	C, D	protein	326	Homo sapiens	Q9BVC4 (AlphaFold model)
Regulatory-associated protein of mTOR	E, F	protein	1363	Homo sapiens	Q8N122 (AlphaFold model)
Lateral signaling target protein 2 homolog	G, H	protein	13	Homo sapiens	Q9HCC9 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>9F44_1 Serine/threonine-protein kinase mTOR (chains A, B)
MLGTGPAAATTAATTSSNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEES
TRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSNDP
VVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVP
TFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWYRHTFEE
AEKGFDETLAKEKGMNRDDRIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKYC
KDLMGFGTKPRHITPFTSFQAVQPQQSNALVGLLGYSSHQGLMGFGTSPSPAKSTLVESR
CCRDLMEEKFDQVCQWVLKCRNSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHV
LSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKAMQVDA
TVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLL
KMLSLVLMHKPLRHPGMPKGLAHQLASPGLTTLPEASDVGSITLALRTLGSFEFEGHSLT
QFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLL
VVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSS
MNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALI
LKLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVA
LWTLGQLVASTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHK
VNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFR
DQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLV
SFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLR
VFMHDNSPGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPEAPLPSRKAALETVD
RLTESLDFTDYASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLV
RHRINHQRYDVLICRIVKGYTLADEEEDPLIYQHRMLRSGQGDALASGPVETGPMKKLHV
STINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNA
AFVSCWSELNEDQQDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGI
VLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHF
GELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEK
WTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLA
QQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEVIQYKLVPERREIIRQIWW
ERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLCGKSGRLALAHKTLVLLLGVD
PSRQLDHPLPTVHPQVTYAYMKNMWKSARKIDAFQHMQHFVQTMQQQAQHAIATEDQQHK
QELHKLMARCFLKLGEWQLNLQGINESTIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEA
VLHYKHQNQARDEKKKLRHASGANITNATTAATTAATATTTASTEGSNSESEAESTENSP
TPSPLQKKVTEDLSKTLLMYTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDVN
EALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVAS
KSTTTARHNAANKILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFG
ERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQA
WDLYYHVFRRISKQLPQLTSLELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSL
QVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNL
SIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLTL
MQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRH
PSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITC
HTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILDG
VELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDDTLD
VPTQVELLIKQATSHENLCQCYIGWCPFW

Sequence of entity 2 (C, D), FASTA

>9F44_2 Target of rapamycin complex subunit LST8 (chains C, D)
MNTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAA
GYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQ
CQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP
DASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSA
DQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVE
TGEIKREYGGHQKAVVCLAFNDSVLG

Sequence of entity 3 (E, F), FASTA

>9F44_3 Regulatory-associated protein of mTOR (chains E, F)
HHHHHHHHHHEQKLISEEDLDYKDDDDKMESEMLQSPLLGLGEEDEADLTDWNLPLAFMK
KRHCEKIEGSKSLAQSWRMKDRMKTVSVALVLCLNVGVDPPDVVKTTPCARLECWIDPLS
MGPQKALETIGANLQKQYENWQPRARYKQSLDPTVDEVKKLCTSLRRNAKEERVLFHYNG
HGVPRPTVNGEVWVFNKNYTQYIPLSIYDLQTWMGSPSIFVYDCSNAGLIVKSFKQFALQ
REQELEVAAINPNHPLAQMPLPPSMKNCIQLAACEATELLPMIPDLPADLFTSCLTTPIK
IALRWFCMQKCVSLVPGVTLDLIEKIPGRLNDRRTPLGELNWIFTAITDTIAWNVLPRDL
FQKLFRQDLLVASLFRNFLLAERIMRSYNCTPVSSPRLPPTYMHAMWQAWDLAVDICLSQ
LPTIIEEGTAFRHSPFFAEQLTAFQVWLTMGVENRNPPEQLPIVLQVLLSQVHRLRALDL
LGRFLDLGPWAVSLALSVGIFPYVLKLLQSSARELRPLLVFIWAKILAVDSSCQADLVKD
NGHKYFLSVLADPYMPAEHRTMTAFILAVIVNSYHTGQEACLQGNLIAICLEQLNDPHPL
LRQWVAICLGRIWQNFDSARWCGVRDSAHEKLYSLLSDPIPEVRCAAVFALGTFVGNSAE
RTDHSTTIDHNVAMMLAQLVSDGSPMVRKELVVALSHLVVQYESNFCTVALQFIEEEKNY
ALPSPATTEGGSLTPVRDSPCTPRLRSVSSYGNIRAVATARSLNKSLQNLSLTEESGGAV
AFSPGNLSTSSSASSTLGSPENEEHILSFETIDKMRRASSYSSLNSLIGVSFNSVYTQIW
RVLLHLAADPYPEVSDVAMKVLNSIAYKATVNARPQRVLDTSSLTQSAPASPTNKGVHIH
QAGGSPPASSTSSSSLTNDVAKQPVSRDLPSGRPGTTGPAGAQYTPHSHQFPRTRKMFDK
GPEQTADDADDAAGHKSFISATVQTGFCDWSARYFAQPVMKIPEEHDLESQIRKEREWRF
LRNSRVRRQAQQVIQKGITRLDDQIFLNRNPGVPSVVKFHPFTPCIAVADKDSICFWDWE
KGEKLDYFHNGNPRYTRVTAMEYLNGQDCSLLLTATDDGAIRVWKNFADLEKNPEMVTAW
QGLSDMLPTTRGAGMVVDWEQETGLLMSSGDVRIVRIWDTDREMKVQDIPTGADSCVTSL
SCDSHRSLIVAGLGDGSIRVYDRRMALSECRVMTYREHTAWVVKASLQKRPDGHIVSVSV
NGDVRIFDPRMPESVNVLQIVKGLTALDIHPQADLIACGSVNQFTAIYNSSGELINNIKY
YDGFMGQRVGAISCLAFHPHWPHLAVGSNDYYISVYSVEKRVR

Sequence of entity 4 (G, H), FASTA

>9F44_4 Lateral signaling target protein 2 homolog (chains G, H)
DEEERVFFMDDVE

Ligands and cofactors

ID	Name	Formula	Copies
IHP	Inositol hexakisphosphate	C6 H18 O24 P6	2

Primary citation

mTORC1 phosphorylates and stabilizes LST2 to negatively regulate EGFR. Battaglioni, S., Craigie, L.M., Filippini, S. et al. Proc Natl Acad Sci U S A (2024) 121:e2405959121-e2405959121. DOI 10.1073/pnas.2405959121 · PubMed

Other PDB entries of the same protein (UniProt P42345 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4DRI 1.45 Å, Co-crystal structure of the PPIase domain of FKBP51, Rapamycin and the FRB fragment of…
9DBO 1.55 Å, Crystal structure of a synthetic Fab (R3E9) in complex with the FRB domain of mTOR
5GPG 1.67 Å, Co-crystal structure of the FK506 binding domain of human FKBP25, Rapamycin and the FRB…
5WBH 1.75 Å, Structure of the FRB domain of mTOR bound to a substrate recruitment peptide of S6K1
4DRJ 1.8 Å, o-crystal structure of the PPIase domain of FKBP52, Rapamycin and the FRB fragment of mTOR
3FAP 1.85 Å, Atomic structures of the rapamycin analogs in complex with both human FKBP12 and frb…
8PPZ 1.85 Å, Co-crystal structure of FKBP12, compound 7 and the FRB fragment of mTOR
8XI9 1.85 Å, Crystal structure of FRB-FKBP fusion protein in complex with rapamycin
9PIW 1.9 Å, Crystal structure of a synthetic Fab (1A) in complex with the FRB domain of mTOR
9DL0 2.0 Å, Crystal structure of a synthetic Fab (R3H8) in complex with the FRB domain of mTOR
9PJ1 2.05 Å, Crystal structure of a synthetic Fab (4R) in complex with the ternary assembly of…
9PIU 2.18 Å, Crystal structure of a synthetic Fab (2C) in complex with the FRB domain of mTOR

Browse structure collections

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