9F45: Human LST2

cryo-EM structure of human LST2 bound to human mTOR complex 1. Determined by electron microscopy at 3.74 Å resolution. Released 14 Aug 2024.

Method: Electron microscopy
Resolution: 3.74 Å
Organism: Homo sapiens
Chains: 8
Atoms: 56,848
Mol. weight: 1150.39 kDa
Ligands: IHP
Released: 14 Aug 2024

Explore 9F45 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9F45 contains 392 α-helices and 165 β-strands across 6 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 145 helices, 12 β-strands

Element	Residues	Length	Sheet
α-helix	19-29	11
α-helix	38-52	15
α-helix	61-73	13
α-helix	83-97	15
α-helix	101-114	14
α-helix	122-134	13
α-helix	140-155	16
α-helix	165-178	14
α-helix	180-183	4
α-helix	188-197	10
α-helix	204-222	19
α-helix	234-245	12
α-helix	259-275	17
α-helix	278-288	11
α-helix	309-311	3
α-helix	314-316	3
α-helix	362-375	14
α-helix	387-402	16
α-helix	411-425	15
α-helix	430-443	14
α-helix	447-451	5
α-helix	452-462	11
α-helix	479-490	12
α-helix	500-511	12
α-helix	515-527	13
α-helix	532-547	16
α-helix	579-591	13
α-helix	601-611	11
α-helix	616-629	14
α-helix	646-665	20
α-helix	669-678	10
α-helix	681-683	3
α-helix	684-687	4
α-helix	690-700	11
α-helix	705-717	13
α-helix	723-743	21
α-helix	747-763	17
α-helix	765-768	4
α-helix	769-771	3
α-helix	772-783	12
α-helix	792-809	18
α-helix	817-828	12
α-helix	837-851	15
α-helix	856-860	5
α-helix	864-874	11
α-helix	878-891	14
α-helix	896-902	7
α-helix	934-940	7
α-helix	943-959	17
α-helix	964-982	19
α-helix	983-989	7
α-helix	990-1003	14
α-helix	1008-1023	16
α-helix	1024-1027	4
α-helix	1028-1040	13
α-helix	1046-1063	18
α-helix	1065-1069	5
α-helix	1071-1083	13
α-helix	1088-1090	3
α-helix	1091-1103	13
α-helix	1104-1107	4
α-helix	1111-1123	13
α-helix	1129-1145	17
α-helix	1152-1165	14
α-helix	1167-1169	3
α-helix	1170-1184	15
α-helix	1185-1190	6
α-helix	1192-1202	11
α-helix	1207-1218	12
α-helix	1263-1269	7
α-helix	1277-1294	18
α-helix	1298-1302	5
α-helix	1304-1309	6
α-helix	1311-1316	6
α-helix	1318-1328	11
α-helix	1333-1346	14
α-helix	1351-1366	16
α-helix	1377-1379	3
α-helix	1380-1389	10
α-helix	1393-1406	14
α-helix	1410-1422	13
α-helix	1426-1440	15
α-helix	1447-1453	7
α-helix	1456-1469	14
α-helix	1471-1472	2
α-helix	1474-1487	14
α-helix	1490-1499	10
α-helix	1506-1523	18
α-helix	1526-1535	10
α-helix	1541-1553	13
α-helix	1557-1580	24
α-helix	1587-1607	21
α-helix	1612-1625	14
α-helix	1630-1640	11
α-helix	1646-1648	3
α-helix	1650-1662	13
α-helix	1666-1677	12
α-helix	1688-1690	3
α-helix	1694-1706	13
α-helix	1710-1731	22
α-helix	1738-1761	24
α-helix	1768-1782	15
α-helix	1787-1808	22
α-helix	1809-1813	5
α-helix	1868-1895	28
α-helix	1900-1913	14
α-helix	1917-1929	13
α-helix	1933-1936	4
α-helix	1939-1944	6
α-helix	1951-1966	16
α-helix	1970-1980	11
α-helix	1985-1999	15
α-helix	2005-2020	16
α-helix	2023-2036	14
α-helix	2037-2041	5
α-helix	2044-2058	15
α-helix	2065-2070	6
α-helix	2071-2075	5
α-helix	2076-2091	16
α-helix	2094-2114	21
α-helix	2115-2117	3
β-strand	2120-2122	3	1
α-helix	2123-2126	4
α-helix	2128-2132	5
β-strand	2139	1	2
α-helix	2140	1
α-helix	2149-2150	2
β-strand	2152	1	2
β-strand	2153-2156	4	3
β-strand	2159-2161	3	1
β-strand	2170-2176	7	3
β-strand	2181-2187	7	3
α-helix	2193-2211	19
α-helix	2213-2218	6
β-strand	2227-2229	3	3
β-strand	2235-2238	4	3
α-helix	2239-2240	2
β-strand	2243-2245	3	4
α-helix	2246-2256	11
α-helix	2263-2271	9
α-helix	2275-2277	3
α-helix	2280-2292	13
α-helix	2298-2306	9
α-helix	2310-2334	25
α-helix	2341-2343	3
β-strand	2344-2347	4	4
β-strand	2353-2355	3	4
α-helix	2364-2367	4
α-helix	2381-2386	6
α-helix	2395-2409	15
α-helix	2411-2422	12
α-helix	2425-2427	3
α-helix	2429-2434	6
α-helix	2493-2509	17
α-helix	2521-2533	13
α-helix	2535-2539	5
α-helix	2543-2545	3

Chain B: 144 helices, 13 β-strands

Element	Residues	Length	Sheet
α-helix	19-29	11
α-helix	38-52	15
α-helix	61-73	13
α-helix	83-97	15
α-helix	101-114	14
α-helix	122-134	13
α-helix	139-155	17
α-helix	165-178	14
α-helix	180-183	4
α-helix	188-197	10
α-helix	204-222	19
α-helix	234-245	12
α-helix	259-275	17
α-helix	278-288	11
α-helix	309-311	3
α-helix	314-316	3
α-helix	362-375	14
α-helix	387-402	16
α-helix	411-425	15
α-helix	430-443	14
α-helix	447-451	5
α-helix	452-462	11
α-helix	479-490	12
α-helix	500-511	12
α-helix	515-527	13
α-helix	532-548	17
α-helix	579-591	13
α-helix	601-611	11
α-helix	616-629	14
α-helix	646-665	20
α-helix	669-678	10
α-helix	681-683	3
α-helix	684-687	4
α-helix	690-700	11
α-helix	705-717	13
α-helix	723-743	21
α-helix	747-763	17
α-helix	765-768	4
α-helix	769-771	3
α-helix	772-783	12
α-helix	792-809	18
α-helix	817-828	12
α-helix	837-851	15
α-helix	856-860	5
α-helix	864-874	11
α-helix	878-891	14
α-helix	896-902	7
α-helix	934-940	7
α-helix	943-959	17
α-helix	964-982	19
α-helix	983-989	7
α-helix	990-1003	14
α-helix	1008-1023	16
α-helix	1024-1027	4
α-helix	1028-1041	14
α-helix	1046-1063	18
α-helix	1065-1069	5
α-helix	1071-1083	13
α-helix	1088-1090	3
α-helix	1091-1103	13
α-helix	1104-1107	4
α-helix	1111-1123	13
α-helix	1129-1145	17
α-helix	1152-1165	14
α-helix	1170-1184	15
α-helix	1185-1190	6
α-helix	1192-1202	11
α-helix	1207-1218	12
α-helix	1263-1269	7
α-helix	1277-1294	18
α-helix	1298-1301	4
α-helix	1304-1309	6
α-helix	1311-1316	6
α-helix	1318-1328	11
α-helix	1333-1346	14
α-helix	1351-1366	16
α-helix	1377-1379	3
α-helix	1380-1389	10
α-helix	1393-1406	14
α-helix	1410-1422	13
α-helix	1426-1440	15
α-helix	1447-1453	7
α-helix	1456-1469	14
α-helix	1471-1472	2
α-helix	1474-1487	14
α-helix	1490-1499	10
α-helix	1506-1523	18
α-helix	1526-1535	10
α-helix	1541-1553	13
α-helix	1557-1580	24
α-helix	1587-1607	21
α-helix	1612-1625	14
α-helix	1630-1640	11
α-helix	1646-1648	3
α-helix	1650-1662	13
α-helix	1666-1677	12
α-helix	1688-1690	3
α-helix	1694-1706	13
α-helix	1710-1731	22
α-helix	1738-1761	24
α-helix	1768-1782	15
α-helix	1787-1808	22
α-helix	1809-1813	5
α-helix	1868-1895	28
α-helix	1900-1913	14
α-helix	1917-1929	13
α-helix	1932-1936	5
α-helix	1939-1944	6
α-helix	1951-1966	16
α-helix	1969-1971	3
α-helix	1973-1980	8
α-helix	1985-1999	15
α-helix	2005-2020	16
α-helix	2023-2036	14
α-helix	2037-2041	5
α-helix	2044-2060	17
α-helix	2065-2070	6
α-helix	2071-2075	5
α-helix	2076-2091	16
α-helix	2094-2117	24
β-strand	2120-2122	3	5
α-helix	2123-2126	4
α-helix	2128-2132	5
β-strand	2134	1	6
β-strand	2139	1	7
α-helix	2140	1
α-helix	2149-2150	2
β-strand	2152	1	7
β-strand	2153-2156	4	6
β-strand	2159-2161	3	5
β-strand	2170-2176	7	6
β-strand	2181-2187	7	6
α-helix	2193-2211	19
α-helix	2213-2218	6
β-strand	2227-2229	3	6
β-strand	2235-2238	4	6
α-helix	2239-2240	2
β-strand	2243-2245	3	8
α-helix	2246-2256	11
α-helix	2263-2271	9
α-helix	2275-2277	3
α-helix	2280-2292	13
α-helix	2298-2306	9
α-helix	2310-2334	25
α-helix	2341-2343	3
β-strand	2344-2347	4	8
β-strand	2353-2355	3	8
α-helix	2364-2367	4
α-helix	2381-2386	6
α-helix	2395-2409	15
α-helix	2411-2422	12
α-helix	2425-2427	3
α-helix	2429-2434	6
α-helix	2493-2509	17
α-helix	2521-2533	13
α-helix	2535-2538	4
α-helix	2543-2545	3

Chain C: 3 helices, 30 β-strands

Element	Residues	Length	Sheet
β-strand	14-19	6	9
β-strand	23-27	5	9
β-strand	36-39	4	9
β-strand	47-50	4	10
β-strand	56-60	5	10
β-strand	65-69	5	10
β-strand	79-81	3	10
β-strand	90-91	2	11
β-strand	99-103	5	11
β-strand	108-113	6	11
β-strand	124-126	3	11
α-helix	130-131	2
β-strand	134-136	3	12
β-strand	142-145	4	12
β-strand	152-156	5	12
α-helix	162	1
β-strand	163-165	3	12
β-strand	173-178	6	13
β-strand	184-189	6	13
β-strand	194-199	6	13
α-helix	200	1
β-strand	210-216	7	13
β-strand	226-228	3	14
β-strand	234-237	4	14
β-strand	239	1	15
β-strand	243-248	6	14
β-strand	254-259	6	14
β-strand	273	1	15
β-strand	277-278	2	16
β-strand	284-287	4	16
β-strand	294-298	5	16
β-strand	304-308	5	16
β-strand	315-321	7	9

Chain D: 3 helices, 31 β-strands

Element	Residues	Length	Sheet
β-strand	14	1	17
β-strand	15-19	5	18
β-strand	23-27	5	18
β-strand	36-39	4	18
β-strand	47-50	4	19
β-strand	56-60	5	19
β-strand	65-69	5	19
β-strand	79-81	3	19
β-strand	88-91	4	20
β-strand	99-104	6	20
β-strand	108-113	6	20
β-strand	123-126	4	20
α-helix	130-131	2
β-strand	134-136	3	21
β-strand	142-145	4	21
β-strand	152-156	5	21
α-helix	162	1
β-strand	163-165	3	21
β-strand	173-178	6	22
β-strand	184-189	6	22
β-strand	194-199	6	22
α-helix	200	1
β-strand	210-216	7	22
β-strand	223-228	6	23
β-strand	234-239	6	23
β-strand	243-248	6	23
β-strand	254-259	6	23
β-strand	273	1	23
β-strand	277-278	2	24
β-strand	284-287	4	24
β-strand	294-298	5	24
β-strand	304-308	5	24
β-strand	315-317	3	18
β-strand	321	1	17

Chain E: 48 helices, 41 β-strands

Element	Residues	Length	Sheet
α-helix	20-24	5
α-helix	33-36	4
α-helix	41-45	5
β-strand	59-64	6	25
β-strand	85	1	26
β-strand	88	1	26
α-helix	95-113	19
β-strand	118-123	6	25
α-helix	127-140	14
β-strand	147-151	5	25
α-helix	156-158	3
β-strand	159	1	27
β-strand	163-167	5	27
β-strand	174-178	5	27
α-helix	179-185	7
β-strand	191-195	5	25
α-helix	199-218	20
β-strand	241-244	4	25
α-helix	262-268	7
α-helix	270-278	9
α-helix	282-286	5
α-helix	292-296	5
α-helix	308-327	20
α-helix	330-337	8
α-helix	341-358	18
β-strand	365-366	2	25
α-helix	370-372	3
α-helix	378-390	13
α-helix	393-394	2
α-helix	395-399	5
α-helix	404-406	3
α-helix	408-422	15
α-helix	429-430	2
α-helix	433-441	9
α-helix	446-457	12
α-helix	461-470	10
α-helix	473-478	6
α-helix	479-481	3
α-helix	487-501	15
α-helix	505-512	8
α-helix	515-522	8
α-helix	529-542	14
α-helix	547-555	9
α-helix	558-564	7
α-helix	571-584	14
α-helix	589-598	10
α-helix	600-604	5
α-helix	605-609	5
α-helix	613-628	16
α-helix	635-649	15
α-helix	650-652	3
α-helix	657-673	17
α-helix	675-684	10
α-helix	808-819	12
α-helix	824-838	15
α-helix	951-953	3
α-helix	959-968	10
α-helix	974-975	2
α-helix	983-1007	25
β-strand	1015-1021	7	28
β-strand	1028-1031	4	29
β-strand	1038-1041	4	29
β-strand	1046-1049	4	29
β-strand	1056-1060	5	29
β-strand	1070	1	30
β-strand	1074	1	31
β-strand	1084-1087	4	31
β-strand	1088	1	30
β-strand	1092-1097	6	31
β-strand	1107-1113	7	31
β-strand	1128-1129	2	32
β-strand	1137-1141	5	32
β-strand	1146-1151	6	32
β-strand	1156-1162	7	32
β-strand	1169-1173	5	33
β-strand	1181-1185	5	33
β-strand	1190-1193	4	33
β-strand	1203-1207	5	33
β-strand	1214-1219	6	34
β-strand	1227-1231	5	34
β-strand	1235-1239	5	34
β-strand	1248-1251	4	34
β-strand	1259-1261	3	35
β-strand	1268-1270	3	35
β-strand	1276-1280	5	35
β-strand	1286-1291	6	35
β-strand	1306-1309	4	28
β-strand	1316-1319	4	28
β-strand	1324-1329	6	28

Chain F: 49 helices, 38 β-strands

Element	Residues	Length	Sheet
α-helix	20-24	5
α-helix	33-36	4
α-helix	38-39	2
α-helix	41-45	5
β-strand	59-64	6	36
β-strand	85	1	37
β-strand	88	1	37
α-helix	95-113	19
β-strand	118-123	6	36
α-helix	127-140	14
β-strand	146-151	6	36
α-helix	156-159	4
β-strand	163-167	5	38
β-strand	174-178	5	38
α-helix	179-185	7
β-strand	190-195	6	36
α-helix	199-218	20
β-strand	240-244	5	36
α-helix	262-268	7
α-helix	270-278	9
α-helix	282-286	5
α-helix	292-296	5
α-helix	308-327	20
α-helix	330-337	8
α-helix	341-358	18
β-strand	365-366	2	36
α-helix	370-372	3
α-helix	378-390	13
α-helix	393-394	2
α-helix	395-399	5
α-helix	404-406	3
α-helix	408-422	15
α-helix	429-430	2
α-helix	433-441	9
α-helix	446-457	12
α-helix	461-470	10
α-helix	473-478	6
α-helix	479-481	3
α-helix	487-501	15
α-helix	505-512	8
α-helix	515-522	8
α-helix	529-542	14
α-helix	547-555	9
α-helix	558-564	7
α-helix	571-584	14
α-helix	589-598	10
α-helix	600-604	5
α-helix	605-609	5
α-helix	613-628	16
α-helix	635-649	15
α-helix	650-652	3
α-helix	657-673	17
α-helix	675-685	11
α-helix	808-819	12
α-helix	824-838	15
α-helix	951-953	3
α-helix	959-968	10
α-helix	974-975	2
α-helix	983-1007	25
β-strand	1015-1021	7	39
β-strand	1028-1031	4	40
β-strand	1038-1041	4	40
β-strand	1046-1049	4	40
β-strand	1058-1060	3	40
β-strand	1070-1076	7	41
β-strand	1083-1088	6	41
β-strand	1092-1097	6	41
β-strand	1107-1113	7	41
β-strand	1127-1129	3	42
β-strand	1137-1142	6	42
β-strand	1146-1151	6	42
β-strand	1156-1162	7	42
β-strand	1172-1173	2	43
β-strand	1181-1184	4	43
β-strand	1190-1193	4	43
β-strand	1203-1207	5	43
β-strand	1214-1219	6	44
β-strand	1227-1231	5	44
β-strand	1235-1239	5	44
β-strand	1248-1251	4	44
β-strand	1259-1261	3	45
β-strand	1267-1270	4	45
β-strand	1276-1281	6	45
β-strand	1286-1291	6	45
β-strand	1306-1309	4	39
β-strand	1316-1319	4	39
β-strand	1324-1329	6	39

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Serine/threonine-protein kinase mTOR	A, B	protein	2549	Homo sapiens	P42345 (AlphaFold model)
Target of rapamycin complex subunit LST8	C, D	protein	326	Homo sapiens	Q9BVC4 (AlphaFold model)
Regulatory-associated protein of mTOR	E, F	protein	1363	Homo sapiens	Q8N122 (AlphaFold model)
Lateral signaling target protein 2 homolog	G, H	protein	887	Homo sapiens	Q9HCC9 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>9F45_1 Serine/threonine-protein kinase mTOR (chains A, B)
MLGTGPAAATTAATTSSNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEES
TRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSNDP
VVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVP
TFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWYRHTFEE
AEKGFDETLAKEKGMNRDDRIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKYC
KDLMGFGTKPRHITPFTSFQAVQPQQSNALVGLLGYSSHQGLMGFGTSPSPAKSTLVESR
CCRDLMEEKFDQVCQWVLKCRNSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHV
LSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKAMQVDA
TVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLL
KMLSLVLMHKPLRHPGMPKGLAHQLASPGLTTLPEASDVGSITLALRTLGSFEFEGHSLT
QFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLL
VVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSS
MNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALI
LKLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVA
LWTLGQLVASTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHK
VNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFR
DQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLV
SFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLR
VFMHDNSPGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPEAPLPSRKAALETVD
RLTESLDFTDYASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLV
RHRINHQRYDVLICRIVKGYTLADEEEDPLIYQHRMLRSGQGDALASGPVETGPMKKLHV
STINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNA
AFVSCWSELNEDQQDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGI
VLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHF
GELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEK
WTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLA
QQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEVIQYKLVPERREIIRQIWW
ERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLCGKSGRLALAHKTLVLLLGVD
PSRQLDHPLPTVHPQVTYAYMKNMWKSARKIDAFQHMQHFVQTMQQQAQHAIATEDQQHK
QELHKLMARCFLKLGEWQLNLQGINESTIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEA
VLHYKHQNQARDEKKKLRHASGANITNATTAATTAATATTTASTEGSNSESEAESTENSP
TPSPLQKKVTEDLSKTLLMYTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDVN
EALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVAS
KSTTTARHNAANKILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFG
ERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQA
WDLYYHVFRRISKQLPQLTSLELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSL
QVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNL
SIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLTL
MQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRH
PSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITC
HTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILDG
VELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDDTLD
VPTQVELLIKQATSHENLCQCYIGWCPFW

Sequence of entity 2 (C, D), FASTA

>9F45_2 Target of rapamycin complex subunit LST8 (chains C, D)
MNTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAA
GYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQ
CQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP
DASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSA
DQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVE
TGEIKREYGGHQKAVVCLAFNDSVLG

Sequence of entity 3 (E, F), FASTA

>9F45_3 Regulatory-associated protein of mTOR (chains E, F)
HHHHHHHHHHEQKLISEEDLDYKDDDDKMESEMLQSPLLGLGEEDEADLTDWNLPLAFMK
KRHCEKIEGSKSLAQSWRMKDRMKTVSVALVLCLNVGVDPPDVVKTTPCARLECWIDPLS
MGPQKALETIGANLQKQYENWQPRARYKQSLDPTVDEVKKLCTSLRRNAKEERVLFHYNG
HGVPRPTVNGEVWVFNKNYTQYIPLSIYDLQTWMGSPSIFVYDCSNAGLIVKSFKQFALQ
REQELEVAAINPNHPLAQMPLPPSMKNCIQLAACEATELLPMIPDLPADLFTSCLTTPIK
IALRWFCMQKCVSLVPGVTLDLIEKIPGRLNDRRTPLGELNWIFTAITDTIAWNVLPRDL
FQKLFRQDLLVASLFRNFLLAERIMRSYNCTPVSSPRLPPTYMHAMWQAWDLAVDICLSQ
LPTIIEEGTAFRHSPFFAEQLTAFQVWLTMGVENRNPPEQLPIVLQVLLSQVHRLRALDL
LGRFLDLGPWAVSLALSVGIFPYVLKLLQSSARELRPLLVFIWAKILAVDSSCQADLVKD
NGHKYFLSVLADPYMPAEHRTMTAFILAVIVNSYHTGQEACLQGNLIAICLEQLNDPHPL
LRQWVAICLGRIWQNFDSARWCGVRDSAHEKLYSLLSDPIPEVRCAAVFALGTFVGNSAE
RTDHSTTIDHNVAMMLAQLVSDGSPMVRKELVVALSHLVVQYESNFCTVALQFIEEEKNY
ALPSPATTEGGSLTPVRDSPCTPRLRSVSSYGNIRAVATARSLNKSLQNLSLTEESGGAV
AFSPGNLSTSSSASSTLGSPENEEHILSFETIDKMRRASSYSSLNSLIGVSFNSVYTQIW
RVLLHLAADPYPEVSDVAMKVLNSIAYKATVNARPQRVLDTSSLTQSAPASPTNKGVHIH
QAGGSPPASSTSSSSLTNDVAKQPVSRDLPSGRPGTTGPAGAQYTPHSHQFPRTRKMFDK
GPEQTADDADDAAGHKSFISATVQTGFCDWSARYFAQPVMKIPEEHDLESQIRKEREWRF
LRNSRVRRQAQQVIQKGITRLDDQIFLNRNPGVPSVVKFHPFTPCIAVADKDSICFWDWE
KGEKLDYFHNGNPRYTRVTAMEYLNGQDCSLLLTATDDGAIRVWKNFADLEKNPEMVTAW
QGLSDMLPTTRGAGMVVDWEQETGLLMSSGDVRIVRIWDTDREMKVQDIPTGADSCVTSL
SCDSHRSLIVAGLGDGSIRVYDRRMALSECRVMTYREHTAWVVKASLQKRPDGHIVSVSV
NGDVRIFDPRMPESVNVLQIVKGLTALDIHPQADLIACGSVNQFTAIYNSSGELINNIKY
YDGFMGQRVGAISCLAFHPHWPHLAVGSNDYYISVYSVEKRVR

Sequence of entity 4 (G, H), FASTA

>9F45_4 Lateral signaling target protein 2 homolog (chains G, H)
MMNRFRKWLYKPKRSDPQLLARFYYADEELNQVAAELDSLDGRKDPQRCTLLVSQFRSCQ
DNVLNIINQIMDECIPQDRAPRDFCVKFPEEIRHDNLAGQLWFGAECLAAGSIIMNRELE
SMAMRPLAKELTRSLEDVRGALRDQALRDLNTYTEKMREALRHFDVLFAEFELSYVSAMV
PVKSPREYYVQQEVIVLFCETVERALDFGYLTQDMIDDYEPALMFSIPRLAIVCGLVVYA
DGPLNLDRKVEDMSELFRPFHTLLRKIRDLLQTLTEEELHTLERNLCISQDVEFPIRADV
QGPAALAPALSAPLPPEGPLSAKAKDPDAELACSMQYDDQELEQLSRMVHRAGDEMSSLL
SPPIACQSPAHRPGAEGSPGGEASPGRPRLRSGSDEEERVFFMDDVEGTAEALARPESPA
GPFGWAGSTWADPQEKGQGGPGGAAGISLPASEKEEDLSNNNLEAEGTDGASLAGTSSCS
CLDSRLHLDGWEVGADDAETAEMIAHRTGGMKLSATVIFNPKSPTSLDSAVATQEAASEP
VAEGMDGGPHKLSTGATNCLLHSCVCCGSCGDSREDVVERLREKCSPGGVIGASYAAGLA
KASDRAPERQEEAPPPSEDASNGREPKAPTSDKCLPHTSGSQVDTASGLQGEAGVAGQQE
PEARELHAGSPSAHEAPQALSGSSSSTAGSCSSDKMGPEAAPAATHAAPQATREKIRSRF
HGSHDLIHRLFVCISGVADQLQTNYASDLRSILKTLFEVMATKPETDDKEKLRKVTQTLR
SAALEDCALCQETLSSSELAAKTRDGDFEDPPEWVPDEACGFCTACKAPFTVIRRKHHCR
SCGKIFCSRCSSHSAPLPRYGQVKPVRVCTHCYMFHVTPFYSDKAGL

Ligands and cofactors

ID	Name	Formula	Copies
IHP	Inositol hexakisphosphate	C6 H18 O24 P6	2

Primary citation

mTORC1 phosphorylates and stabilizes LST2 to negatively regulate EGFR. Battaglioni, S., Craigie, L.M., Filippini, S. et al. Proc Natl Acad Sci U S A (2024) 121:e2405959121-e2405959121. DOI 10.1073/pnas.2405959121 · PubMed

Other PDB entries of the same protein (UniProt P42345 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4DRI 1.45 Å, Co-crystal structure of the PPIase domain of FKBP51, Rapamycin and the FRB fragment of…
9DBO 1.55 Å, Crystal structure of a synthetic Fab (R3E9) in complex with the FRB domain of mTOR
5GPG 1.67 Å, Co-crystal structure of the FK506 binding domain of human FKBP25, Rapamycin and the FRB…
5WBH 1.75 Å, Structure of the FRB domain of mTOR bound to a substrate recruitment peptide of S6K1
4DRJ 1.8 Å, o-crystal structure of the PPIase domain of FKBP52, Rapamycin and the FRB fragment of mTOR
3FAP 1.85 Å, Atomic structures of the rapamycin analogs in complex with both human FKBP12 and frb…
8PPZ 1.85 Å, Co-crystal structure of FKBP12, compound 7 and the FRB fragment of mTOR
8XI9 1.85 Å, Crystal structure of FRB-FKBP fusion protein in complex with rapamycin
9PIW 1.9 Å, Crystal structure of a synthetic Fab (1A) in complex with the FRB domain of mTOR
9DL0 2.0 Å, Crystal structure of a synthetic Fab (R3H8) in complex with the FRB domain of mTOR
9PJ1 2.05 Å, Crystal structure of a synthetic Fab (4R) in complex with the ternary assembly of…
9PIU 2.18 Å, Crystal structure of a synthetic Fab (2C) in complex with the FRB domain of mTOR

Browse structure collections

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