9FXL: TRPC4

TRPC4 in complex with E-AzPico. Determined by electron microscopy at 3.0 Å resolution. Released 9 Jul 2025.

Method
Electron microscopy
Resolution
3.0 Å
Organism
Danio rerio
Chains
4
Atoms
21,272
Mol. weight
435.64 kDa
Ligands
A1IGW
Released
9 Jul 2025

Explore 9FXL in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9FXL contains 161 α-helices and 10 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 39 helices, 3 β-strands

ElementResiduesLengthSheet
β-strand2011
α-helix33-4210
α-helix45-528
β-strand6612
β-strand7212
α-helix73-808
α-helix83-919
α-helix99-1057
α-helix110-1167
α-helix145-1528
α-helix155-16410
α-helix169-1713
α-helix189-20315
α-helix206-2127
α-helix218-23316
α-helix235-2373
α-helix239-25618
α-helix262-2687
α-helix289-2946
α-helix298-3014
α-helix304-31512
α-helix326-33813
α-helix342-3498
α-helix362-38120
α-helix397-3993
α-helix401-42424
α-helix433-45422
α-helix4691
α-helix473-49018
α-helix491-4966
α-helix502-5109
α-helix516-53823
α-helix539-5413
α-helix564-5729
α-helix581-5844
α-helix591-60515
α-helix606-6127
α-helix613-62715
α-helix631-64313
α-helix700-72021
α-helix722-7254
α-helix733-75220
Chain B: 40 helices, 3 β-strands
ElementResiduesLengthSheet
α-helix33-4210
α-helix45-517
β-strand6613
β-strand7213
α-helix73-797
α-helix83-919
α-helix99-1068
α-helix109-1157
α-helix145-1528
α-helix155-16410
β-strand16714
α-helix168-1703
α-helix189-20315
α-helix206-2127
α-helix216-23015
α-helix235-2373
α-helix238-25619
α-helix262-2687
α-helix287-2948
α-helix298-3014
α-helix304-31512
α-helix326-33813
α-helix345-3495
α-helix362-38120
α-helix382-3843
α-helix397-3993
α-helix401-42121
α-helix433-45826
α-helix465-4673
α-helix468-4692
α-helix473-49018
α-helix491-4988
α-helix502-51110
α-helix513-53826
α-helix564-5707
α-helix581-5844
α-helix591-60616
α-helix607-6126
α-helix617-62711
α-helix631-64414
α-helix655-6573
α-helix699-72123
α-helix732-75221
Chain C: 41 helices, 1 β-strand
ElementResiduesLengthSheet
β-strand2014
α-helix33-4210
α-helix45-528
α-helix73-797
α-helix83-919
α-helix99-1068
α-helix109-1168
α-helix145-1528
α-helix155-16410
α-helix168-1714
α-helix189-20315
α-helix206-2116
α-helix216-22611
α-helix230-2334
α-helix239-25618
α-helix262-2687
α-helix287-2948
α-helix298-3014
α-helix304-31512
α-helix326-33712
α-helix340-34910
α-helix362-38120
α-helix382-3843
α-helix397-3993
α-helix401-42121
α-helix433-45725
α-helix465-4673
α-helix473-48917
α-helix492-4965
α-helix502-5098
α-helix514-53825
α-helix539-5413
α-helix564-5729
α-helix581-5844
α-helix591-60616
α-helix607-6115
α-helix614-62714
α-helix628-6303
α-helix632-64312
α-helix644-6463
α-helix701-72626
α-helix732-75221
Chain D: 41 helices, 3 β-strands
ElementResiduesLengthSheet
α-helix33-419
α-helix46-549
α-helix73-797
α-helix83-919
α-helix99-1057
α-helix109-1168
α-helix145-1528
α-helix155-16410
β-strand16711
α-helix169-1713
α-helix189-1935
α-helix197-2037
α-helix206-2116
α-helix216-23217
α-helix238-25619
α-helix262-2687
α-helix287-2948
α-helix298-3014
α-helix304-31411
α-helix326-33813
α-helix340-34910
α-helix362-38221
β-strand39415
α-helix397-3993
α-helix401-42424
α-helix433-45725
β-strand46215
α-helix465-4673
α-helix468-4692
α-helix473-49018
α-helix491-4988
α-helix502-51110
α-helix513-53826
α-helix539-5413
α-helix564-57310
α-helix574-5763
α-helix581-5844
α-helix591-60515
α-helix606-6105
α-helix615-62713
α-helix632-64413
α-helix702-72524
α-helix733-7353
α-helix736-75217

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Transient receptor potential cation channel subfamily c member 4aA, B, C, Dprotein941Danio rerioU3N7D8 (AlphaFold model)
Sequence of entity 1 (A, B, C, D), FASTA
>9FXL_1 Transient receptor potential cation channel subfamily c member 4a (chains A, B, C, D)
MGHHHHHHHHGGSENLYFQGGSQLYFRRTDNSSYRDRIPLRIVRAESELSTQEKSYLSAV
EKGDYASVKLALEEAEIYFKININCIDPLGRTALLIAIENENLEIIELLLSFNVYVGDAL
LHAIRKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSDFTPDITPIILAAHTNNYEIIKM
LVQKGVSVPQPHEVRCNCVECVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTA
FQLSWELQELSKVENEFKAEYEELSHQCKHFAKDLLDQTRSSRELELILNFRDDMNLLQD
EANNELARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAGKLITCVFIGLMF
PLLSLCYLVAPKSRYGLFIRKPFIKFICHTASYLTFLFLLLLASQHIVSNNPDRQGPKPT
TVEWMILPWVLGFIWTEIKQMWDGGFQDYIHDWWNLMDFVMNSLYLATISLKIVAYVKYS
GCKPRDTWEMWHPTLVAEAVFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFL
FIYCLVLLAFANGLNQLYFYYENSEGMTCKGIRCERQNNAFSTLFETLQSLFWSIFGLIS
LYVTNVKADHKFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQHIADHADIEWKFART
KLWMSYFEEGGTLPPPFNIIPSPKSICYLITWIKVHVFKRRSKRTETFGTLGRRAAENVR
LNHQYQEVLRNLVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRYEVIGMMKGNRKST
RANKSDTSASDVSHPEGSLQYSSALKQNSKLHLYDVTTALQQQNSEEAKASLGCLANGSA
VVLTEPILKDKARSDFPKDFTDFGLFPKKQNPNKIYSLAEEATESDPDILDWGKEDKPLA
GKVEQDVNESKCLMEEDERVLEEQEMEHIASSHEHLEVLFQ

Ligands and cofactors

IDNameFormulaCopies
A1IGW(E)-7-(4-chlorobenzyl)-1-(3-hydroxypropyl)-3-methyl-8-(4-(phenyldiazenyl)-3-(tr…C29 H24 Cl F3 N6 O54

Primary citation

Ideal efficacy photoswitching for chromocontrol of TRPC4/5 channel functions in live tissues. Muller, M., Niemeyer, K., Ojha, N.K. et al. Nat Chem Biol (2026) 22:180-191. DOI 10.1038/s41589-025-02085-x · PubMed

Other PDB entries of the same protein (UniProt U3N7D8 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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