Cryo-EM structure of the beta3 homomeric GABA(A) receptor in the long-lived desensitised state (C5) sprayed with PBS. Determined by electron microscopy at 2.5 Å resolution. Released 23 Jul 2025.
Explore 9G2E in 3D Show helices and sheets RCSB PDB PDBe
9G2E contains 55 α-helices and 65 β-strands across 5 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 9-20 | 12 | |
| α-helix | 35 | 1 | |
| β-strand | 36-51 | 16 | 1 |
| β-strand | 56-68 | 13 | 1 |
| α-helix | 70-72 | 3 | |
| β-strand | 81-83 | 3 | 1 |
| α-helix | 85-90 | 6 | |
| β-strand | 96-98 | 3 | 2 |
| β-strand | 101-106 | 6 | 1 |
| β-strand | 110 | 1 | 3 |
| β-strand | 114-118 | 5 | 1 |
| β-strand | 123-135 | 13 | 1 |
| β-strand | 147-156 | 10 | 2 |
| β-strand | 164-168 | 5 | 1 |
| α-helix | 171-173 | 3 | |
| β-strand | 175-176 | 2 | 1 |
| β-strand | 186-199 | 14 | 2 |
| β-strand | 204-216 | 13 | 2 |
| α-helix | 219-221 | 3 | |
| α-helix | 222-226 | 5 | |
| α-helix | 227-241 | 15 | |
| α-helix | 247-271 | 25 | |
| α-helix | 280-305 | 26 | |
| α-helix | 310-446 | 30 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Gamma-aminobutyric acid receptor subunit beta-3 | A, B, C, D, E | protein | 395 | Homo sapiens | P28472 (AlphaFold model) |
>9G2E_1 Gamma-aminobutyric acid receptor subunit beta-3 (chains A, B, C, D, E) MDEKTTGWRGGHVVEGLAGELEQLRARLEHHPQGQREPDYDIPTTENLYFQGTGQSVNDP GNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQY WRDKRLAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLY GLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQF SIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDA SAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIF FSQPARAAAIDRWSRIVFPFTFSLFNLVYWLYYVN
Water and common crystallization additives (CL) are not listed.
Cryo-EM structure of the beta3 homomeric GABA(A) receptor in the long-lived desensitised state (C5) sprayed with PBS. Mihaylov, D.B., Malinauskas, T., Aricescu, A.R. To be published.
Other PDB entries of the same protein (UniProt P28472 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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