9I8Q: Glycoprotein G

Cryo-EM structure of VSV-Indiana (MUDD-SUMMERS strain) glycoprotein under its pre-fusion conformation. Determined by electron microscopy at 2.93 Å resolution. Released 22 Oct 2025.

Method: Electron microscopy
Resolution: 2.93 Å
Organism: Vesicular stomatitis Indiana virus strain Mudd-Summers
Chains: 3
Atoms: 10,092
Mol. weight: 167.17 kDa
Released: 22 Oct 2025

Explore 9I8Q in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9I8Q contains 61 α-helices and 110 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 22 helices, 35 β-strands

Element	Residues	Length	Sheet
β-strand	2-7	6	1
β-strand	15-16	2	1
α-helix	17	1
β-strand	23	1	2
α-helix	26-28	3
α-helix	36	1
β-strand	37-45	9	3
α-helix	49-51	3
β-strand	54	1	4
β-strand	56-69	14	5
β-strand	77-85	9	5
α-helix	86-88	3
α-helix	89-101	13
α-helix	110-111	2
β-strand	123-131	9	5
β-strand	134	1	4
β-strand	135-136	2	6
β-strand	143-144	2	6
β-strand	148	1	7
α-helix	149-151	3
β-strand	152-153	2	6
β-strand	157-159	3	5
β-strand	160	1	7
β-strand	165-169	5	5
α-helix	173-175	3
α-helix	176-178	3
α-helix	180-181	2
β-strand	182-190	9	3
α-helix	195-197	3
β-strand	204-206	3	3
α-helix	215-217	3
β-strand	219-223	5	8
β-strand	226-230	5	8
β-strand	236-237	2	8
β-strand	238-239	2	3
α-helix	242-248	7
α-helix	250-253	4
β-strand	263	1	1
α-helix	275-293	19
β-strand	297	1	9
α-helix	299-305	7
β-strand	311-319	9	1
β-strand	322-335	14	1
β-strand	340	1	10
β-strand	344-347	4	1
β-strand	353-355	3	1
β-strand	361-363	3	10
β-strand	366-368	3	10
α-helix	370-372	3
β-strand	374-375	2	10
β-strand	380	1	10
α-helix	383-386	4
α-helix	394-397	4
β-strand	400	1	9
β-strand	403	1	1
α-helix	410-416	7
α-helix	418	1

Chain B: 20 helices, 37 β-strands

Element	Residues	Length	Sheet
β-strand	3-7	5	11
β-strand	15-16	2	11
α-helix	17	1
α-helix	25-28	4
α-helix	36	1
β-strand	37-45	9	12
α-helix	49-51	3
β-strand	53-54	2	13
β-strand	56-69	14	14
β-strand	77-85	9	14
α-helix	86-88	3
α-helix	89-101	13
α-helix	110-111	2
β-strand	122-131	10	14
β-strand	134-136	3	13
β-strand	143-144	2	13
β-strand	148	1	15
α-helix	149-151	3
β-strand	152-153	2	13
β-strand	157-159	3	14
β-strand	160	1	15
β-strand	165-169	5	14
α-helix	176-178	3
α-helix	180-181	2
β-strand	182-190	9	12
α-helix	195-197	3
β-strand	204-206	3	12
β-strand	213-214	2	12
α-helix	215-217	3
β-strand	219-223	5	16
β-strand	226-230	5	16
β-strand	236-237	2	16
β-strand	238-239	2	12
α-helix	242-248	7
α-helix	250-253	4
β-strand	263	1	11
α-helix	275-293	19
β-strand	297	1	17
α-helix	299-304	6
β-strand	311-319	9	11
β-strand	322-334	13	11
β-strand	340	1	18
β-strand	344-345	2	19
β-strand	346-347	2	11
β-strand	354-355	2	19
β-strand	361-363	3	18
β-strand	366-368	3	18
α-helix	370-372	3
β-strand	374-375	2	18
β-strand	380	1	18
α-helix	383-386	4
β-strand	391	1	2
β-strand	400	1	17
β-strand	403	1	11
α-helix	410-416	7
α-helix	418	1
β-strand	425	1	14

Chain C: 19 helices, 38 β-strands

Element	Residues	Length	Sheet
β-strand	2-7	6	20
β-strand	15-16	2	20
α-helix	17	1
α-helix	25-28	4
α-helix	36	1
β-strand	37-45	9	21
α-helix	48-51	4
β-strand	54	1	22
β-strand	56-69	14	23
β-strand	77-82	6	23
β-strand	84	1	23
α-helix	89-101	13
α-helix	110-112	3
β-strand	123-131	9	23
β-strand	134	1	22
β-strand	135-136	2	24
β-strand	143-144	2	24
β-strand	148	1	25
α-helix	149-151	3
β-strand	152-153	2	24
β-strand	157-159	3	23
β-strand	160	1	25
β-strand	166-169	4	23
α-helix	180-181	2
β-strand	182-190	9	21
α-helix	195-197	3
β-strand	204-206	3	21
β-strand	213-214	2	21
α-helix	215-217	3
β-strand	219-223	5	26
β-strand	226-230	5	26
β-strand	236-237	2	26
β-strand	238-239	2	21
α-helix	242-248	7
α-helix	250-253	4
β-strand	263	1	20
α-helix	269-271	3
α-helix	276-293	18
β-strand	297	1	27
α-helix	299-304	6
β-strand	311-319	9	20
β-strand	322-335	14	20
β-strand	340	1	28
β-strand	344-345	2	29
β-strand	346-347	2	20
β-strand	354-355	2	29
β-strand	361-363	3	28
β-strand	366-368	3	28
α-helix	370-372	3
β-strand	374-375	2	28
β-strand	380	1	28
α-helix	383-386	4
α-helix	394-397	4
β-strand	400	1	27
β-strand	403	1	20
α-helix	410-415	6
β-strand	424-425	2	23

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Glycoprotein G	A, B, C	protein	495	Vesicular stomatitis Indiana virus strain Mudd-Summers	B7UCZ5 (AlphaFold model)

Sequence of entity 1 (A, B, C), FASTA

>9I8Q_1 Glycoprotein G (chains A, B, C)
KFTIVFPHNQKGNWKNVPSNYHYCPSSSDLNWHNDLIGTALQVKMPKSHKAIQADGWMCH
ASKWVTTCDFRWYGPKYITHSIRSFTPSVEQCKESIEQTKQGTWLNPGFPPQSCGYATVT
DAEAVIVQVTPHHVLVDEYTGEWVDSQFINGKCSNYICPTVHNSTTWHSDYKVKGLCDSN
LISMDITFFSEDGELSSLGKEGTGFRSNYFAYETGGKACKMQYCKHWGVRLPSGVWFEMA
DKDLFAAARFPECPEGSSISAPSQTSVDVSLIQDVERILDYSLCQETWSKIRAGLPISPV
DLSYLAPKNPGTGPAFTIINGTLKYFETRYIRVDIAAPILSRMVGMISGTTTERELWDDW
APYEDVEIGPNGVLRTSSGYKFPLYMIGHGMLDSDLHLSSKAQVFEHPHIQDAASQLPDD
ESLFFGDTGLSKNPIELVEGWFSSWKSSIASFFFIIGLIIGLFLVLRVGIHLCIKLKHTK
KRQIYTDIEMNRLGK

Primary citation

Cryo-EM structure of VSV-Indiana (MUDD-SUMMERS strain) glycoprotein under its pre-fusion conformation. Albertini, A., Minoves, M.J., OuldAli, M. et al. To be published.

Other PDB entries of the same protein (UniProt B7UCZ5 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6TIT 2.07 Å, Vsv G_440
5OYL 2.25 Å, Vsv G CR2
9HHR 2.81 Å, Cryo-EM structure of VSV-Indiana glycoprotein (MUDD-SUMMERS strain) in its post-fusion…
9HH9 2.93 Å, Cryo-EM structure of VSV-Indiana glycoprotein (MUDD-SUMMERS strain) in its pre-fusion…
9HGN 2.94 Å, Cryo-EM structure of VSV-Indiana (MUDD-SUMMERS strain) glycoprotein under its acidic…

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