9IM6: Importin-5

Structure of influenza A virus RNA polymerase PB1 and nuclear import host factor RanBP5 complex. Determined by electron microscopy at 3.21 Å resolution. Released 27 Nov 2024.

Method
Electron microscopy
Resolution
3.21 Å
Organisms
Homo sapiens, Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)
Chains
2
Atoms
8,982
Mol. weight
132.67 kDa
Released
27 Nov 2024

Explore 9IM6 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9IM6 contains 71 α-helices and 3 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 71 helices, 3 β-strands

ElementResiduesLengthSheet
α-helix22-3716
α-helix40-5112
α-helix56-6813
α-helix74-9118
α-helix92-943
α-helix101-11717
α-helix121-13717
α-helix148-15811
α-helix163-17513
α-helix183-1875
α-helix188-19811
α-helix205-22117
α-helix226-2316
α-helix233-2353
α-helix236-24712
α-helix253-26412
α-helix266-2727
α-helix273-28513
α-helix291-30717
α-helix309-3124
α-helix316-32914
α-helix353-36816
α-helix370-38415
α-helix392-40211
α-helix408-4114
α-helix415-4239
α-helix431-44717
α-helix451-46919
α-helix474-49017
α-helix493-4953
α-helix497-4993
α-helix500-5045
α-helix508-52013
α-helix525-54117
α-helix542-5454
α-helix546-56116
α-helix569-59123
α-helix595-60915
α-helix617-6193
α-helix621-63212
α-helix636-6405
α-helix641-65212
α-helix654-6574
β-strand658-66141
α-helix663-6664
α-helix667-6693
β-strand675-68061
β-strand684-68961
α-helix693-71018
α-helix711-7177
α-helix718-7258
α-helix727-7304
α-helix735-75218
α-helix753-7553
α-helix757-77519
α-helix781-79717
α-helix805-83228
α-helix840-87132
α-helix872-8754
α-helix876-88914
α-helix896-91217
α-helix916-9205
α-helix921-93010
α-helix931-9333
α-helix937-95216
α-helix959-97416
α-helix984-100017
α-helix1002-10043
α-helix1007-101711
α-helix1024-104017
α-helix1053-106311
α-helix1074-108613
α-helix1090-10978
α-helix1102-111413

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Importin-5Aprotein1118Homo sapiensO00410 (AlphaFold model)
RNA-directed RNA polymerase catalytic subunitBprotein53Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)P03431 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>9IM6_1 Importin-5 (chains A)
MRGSHHHHHHGSENLYFQGGSMAAAAAEQQQFYLLLGNLLSPDNVVRKQAEETYENIPGQ
SKITFLLQAIRNTTAAEEARQMAAVLLRRLLSSAFDEVYPALPSDVQTAIKSELLMIIQM
ETQSSMRKKVCDIAAELARNLIDEDGNNQWPEGLKFLFDSVSSQNVGLREAALHIFWNFP
GIFGNQQQHYLDVIKRMLVQCMQDQEHPSIRTLSARATAAFILANEHNVALFKHFADLLP
GFLQAVNDSCYQNDDSVLKSLVEIADTVPKYLRPHLEATLQLSLKLCGDTSLNNMQRQLA
LEVIVTLSETAAAMLRKHTNIVAQTIPQMLAMMVDLEEDEDWANADELEDDDFDSNAVAG
ESALDRMACGLGGKLVLPMIKEHIMQMLQNPDWKYRHAGLMALSAIGEGCHQQMEGILNE
IVNFVLLFLQDPHPRVRYAACNAVGQMATDFAPGFQKKFHEKVIAALLQTMEDQGNQRVQ
AHAAAALINFTEDCPKSLLIPYLDNLVKHLHSIMVLKLQELIQKGTKLVLEQVVTSIASV
ADTAEEKFVPYYDLFMPSLKHIVENAVQKELRLLRGKTIECISLIGLAVGKEKFMQDASD
VMQLLLKTQTDFNDMEDDDPQISYMISAWARMCKILGKEFQQYLPVVMGPLMKTASIKPE
VALLDTQDMENMSDDDGWEFVNLGDQQSFGIKTAGLEEKSTACQMLVCYAKELKEGFVEY
TEQVVKLMVPLLKFYFHDGVRVAAAESMPLLLECARVRGPEYLTQMWHFMCDALIKAIGT
EPDSDVLSEIMHSFAKCIEVMGDGCLNNEHFEELGGILKAKLEEHFKNQELRQVKRQDED
YDEQVEESLQDEDDNDVYILTKVSDILHSIFSSYKEKVLPWFEQLLPLIVNLICPHRPWP
DRQWGLCIFDDVIEHCSPASFKYAEYFLRPMLQYVCDNSPEVRQAAAYGLGVMAQYGGDN
YRPFCTEALPLLVRVIQSADSKTKENVNATENCISAVGKIMKFKPDCVNVEEVLPHWLSW
LPLHEDKEEAVQTFNYLCDLIESNHPIVLGPNNTNLPKIFSIIAEGEMHEAIKHEDPCAK
RLANVVRQVQTSGGLWTECIAQLSPEQQAAIQELLNSA
Sequence of entity 2 (B), FASTA
>9IM6_2 RNA-directed RNA polymerase catalytic subunit (chains B)
HHHHHHGSENLYFQGGSTTHFQRKRRVRDNMTKKMITQRTIGKKKQRLNKRSY

Primary citation

Structural insights into Influenza A virus RNA polymerase PB1 binding to nuclear import host factor RanBP5. Uchikubo-Kamo, T., Ishimoto, N., Umezawa, H. et al. Biochem Biophys Res Commun (2024) 739:150952-150952. DOI 10.1016/j.bbrc.2024.150952 · PubMed

Other PDB entries of the same protein (UniProt O00410 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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