9J38: Human KCNQ5-CaM in apo state

human KCNQ5-CaM in apo state. Determined by electron microscopy at 2.4 Å resolution. Released 16 Apr 2025.

Method: Electron microscopy
Resolution: 2.4 Å
Organism: Homo sapiens
Chains: 8
Atoms: 15,596
Mol. weight: 342.52 kDa
Released: 16 Apr 2025

Explore 9J38 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9J38 contains 112 α-helices and 8 β-strands across 8 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A, B, C and D: 20 helices, 0 β-strands

Element	Residues	Length
α-helix	104-120	17
α-helix	126-147	22
α-helix	153-181	29
α-helix	182-184	3
α-helix	186-188	3
α-helix	190-198	9
α-helix	201-222	22
α-helix	225-234	10
α-helix	235-238	4
α-helix	239-244	6
α-helix	250-261	12
α-helix	263-288	26
α-helix	293-295	3
α-helix	298-309	12
α-helix	322-339	18
α-helix	341-362	22
α-helix	367-383	17
α-helix	516-539	24
α-helix	543-544	2
α-helix	546-575	30

Chains E, F, G and H: 8 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	7-21	15
α-helix	30-39	10
α-helix	46-54	9
α-helix	66-74	9
α-helix	80-92	13
β-strand	100-102	3	1
α-helix	103-112	10
α-helix	119-128	10
β-strand	136-138	3	1
α-helix	140-147	8

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Potassium voltage-gated channel subfamily KQT member 5	A, B, C, D	protein	610	Homo sapiens	Q9NR82 (AlphaFold model)
Calmodulin-1	E, F, G, H	protein	149	Homo sapiens	P0DP23 (AlphaFold model)

Sequence of entity 1 (A, B, C, D), FASTA

>9J38_1 Potassium voltage-gated channel subfamily KQT member 5 (chains A, B, C, D)
MLGKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLLVFGCLILSVFST
IPEHTKLASSCLLILEFVMIVVFGLEFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDTI
VLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELIT
AWYIGFLVLIFSSFLVYLVEKDANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLS
AGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAANLIQCVWRSYAADEKSV
SIATWKPHLKALHTCSPTKKEQGEASSSQKLSFKERVRMASPRGQSIKSRQASVGDRRSP
STDITAEGSPTKVQKSWSFNDRTRFRPSLRLKSSQPKPVIDADTALGTDDVYDEKGCQCD
VSVEDLTPPLKTVIRAIRIMKFHVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQ
TRVDQILGKGQITSDKKSREKITAEHETTDDLSMLGRVVKVEKQVQSIESKLDCLLDIYQ
QVLRKGSASALALASFQIPPFECEQTSDYQSPVDSKDLSGSAQNSGCLSRSTSANISRGL
QFILTPNEFS

Sequence of entity 2 (E, F, G, H), FASTA

>9J38_2 Calmodulin-1 (chains E, F, G, H)
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG
NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE
EVDEMIREADIDGDGQVNYEEFVQMMTAK

Primary citation

Phosphatidylinositol 4,5-bisphosphate activation mechanism of human KCNQ5. Yang, Z., Zheng, Y., Ma, D. et al. Proc Natl Acad Sci U S A (2025) 122:e2416738122-e2416738122. DOI 10.1073/pnas.2416738122 · PubMed

Other PDB entries of the same protein (UniProt Q9NR82 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6B8Q 2.6 Å, Crystal Structure of the Mg2+/CaM:Kv7.5 (KCNQ5) AB domain complex
9LJ5 2.9 Å, Human KCNQ5-CaM-PIP2-HN37 complex in an open conformation.
9LIZ 3.1 Å, Human KCNQ5-CaM in complex with PIP2
9LJ1 3.2 Å, Human KCNQ5-CaM-PIP2-HN37 complex in a closed conformation.

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