Cryo-EM structure of LGR4. Determined by electron microscopy at 3.53 Å resolution. Released 15 Oct 2025.
Explore 9KB6 in 3D Show helices and sheets RCSB PDB PDBe
9KB6 contains 19 α-helices and 31 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 34-35 | 2 | 1 |
| β-strand | 40-42 | 3 | 1 |
| β-strand | 61-63 | 3 | 1 |
| β-strand | 71-72 | 2 | 2 |
| β-strand | 85-87 | 3 | 1 |
| β-strand | 95-96 | 2 | 2 |
| β-strand | 109-111 | 3 | 1 |
| β-strand | 119 | 1 | 3 |
| β-strand | 133-135 | 3 | 1 |
| β-strand | 143 | 1 | 3 |
| β-strand | 157-159 | 3 | 1 |
| α-helix | 170-173 | 4 | |
| β-strand | 181-183 | 3 | 1 |
| β-strand | 191-192 | 2 | 4 |
| β-strand | 205-207 | 3 | 1 |
| β-strand | 215-216 | 2 | 4 |
| β-strand | 229-231 | 3 | 1 |
| α-helix | 243-246 | 4 | |
| β-strand | 252-254 | 3 | 1 |
| β-strand | 262-263 | 2 | 5 |
| β-strand | 276-278 | 3 | 1 |
| β-strand | 286-287 | 2 | 5 |
| β-strand | 300-304 | 5 | 6 |
| β-strand | 323-327 | 5 | 6 |
| α-helix | 338-341 | 4 | |
| β-strand | 347-349 | 3 | 6 |
| β-strand | 369-371 | 3 | 6 |
| β-strand | 379-380 | 2 | 7 |
| α-helix | 382-385 | 4 | |
| β-strand | 393-395 | 3 | 6 |
| β-strand | 403-404 | 2 | 7 |
| β-strand | 417-419 | 3 | 6 |
| β-strand | 438-440 | 3 | 6 |
| α-helix | 449-452 | 4 | |
| α-helix | 453-455 | 3 | |
| β-strand | 461-463 | 3 | 6 |
| α-helix | 467-470 | 4 | |
| β-strand | 521-523 | 3 | 6 |
| α-helix | 539-564 | 26 | |
| α-helix | 572-600 | 29 | |
| α-helix | 605-614 | 10 | |
| α-helix | 616-652 | 37 | |
| α-helix | 659-682 | 24 | |
| α-helix | 704-731 | 28 | |
| α-helix | 734-737 | 4 | |
| α-helix | 741-758 | 18 | |
| α-helix | 761-767 | 7 | |
| α-helix | 779-788 | 10 | |
| α-helix | 792-804 | 13 | |
| α-helix | 806-821 | 16 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Leucine-rich repeat-containing G-protein coupled receptor 4 | A | protein | 845 | Homo sapiens | Q9BXB1 (AlphaFold model) |
>9KB6_1 Leucine-rich repeat-containing G-protein coupled receptor 4 (chains A) MPGPLGLLCFLALGLLGSAGPSGAAPPLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQ ALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTV PSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQ ALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEF PQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHS LVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPS FNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDV SFNELTSFPTEGLNGLNQLKLVGNFKLKEALAAKDFVNLRSLSVPYAYQCCAFWGCDSYA NLNTEDNSLQDHSVAQEKGTADAANVTSTLENEEHSQIIIHCTPSTGAFKPCEYLLGSWM IRLTVWFIFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNLFMGIYTGILTFLDAV SWGRFAEFGIWWETGSGCKVAGFLAVFSSESAIFLLMLATVERSLSAKDIMKNGKSNHLK QFRVAALLAFLGATVAGCFPLFHRGEYSASPLCLPFPTGETPSLGFTVTLVLLNSLAFLL MAVIYTKLYCNLEKEDLSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISISPE IMKSVTLIFFPLPACLNPVLYVFFNPKFKEDWKLLKRRVTKKENLYFQGDYKDDDDKHHH HHHHH
| ID | Name | Formula | Copies |
|---|---|---|---|
| NAG | 2-acetamido-2-deoxy-beta-D-glucopyranose | C8 H15 N O6 | 4 |
Structural insights into Wnt/ beta-catenin signaling regulation by LGR4, R-spondin, and ZNRF3. Peng, Y., Fujimura, A., Asami, J. et al. Nat Commun (2025) 16:8337-8337. DOI 10.1038/s41467-025-64129-z · PubMed
Other PDB entries of the same protein (UniProt Q9BXB1 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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