9O6G: PDB entry 9O6G

Wildtype rabbit TRPV5 in nanodics in the presence of Menthol and PI(4,5)P2. Determined by electron microscopy at 3.37 Å resolution. Released 22 Apr 2026.

Method
Electron microscopy
Resolution
3.37 Å
Organism
Oryctolagus cuniculus
Chains
4
Atoms
20,263
Mol. weight
353.58 kDa
Ligands
ERG, CPL, PIO, IT9
Released
22 Apr 2026

Explore 9O6G in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9O6G contains 148 α-helices and 32 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 37 helices, 8 β-strands

ElementResiduesLengthSheet
α-helix30-4617
α-helix48-558
α-helix58-669
α-helix82-887
α-helix92-987
α-helix103-1053
α-helix108-1103
α-helix113-1153
α-helix120-1267
α-helix130-1389
α-helix166-1738
α-helix176-1849
α-helix199-2046
α-helix210-22112
α-helix232-2343
α-helix243-2497
α-helix253-2608
β-strand265-27061
β-strand273-27971
α-helix292-2976
α-helix302-3065
α-helix311-32010
α-helix321-3255
α-helix326-34823
β-strand352-35432
β-strand36613
β-strand368-37032
α-helix380-41031
α-helix412-4165
α-helix423-44422
α-helix453-46311
α-helix465-4695
α-helix476-4849
α-helix485-4895
α-helix490-51122
β-strand51514
α-helix526-53712
α-helix542-5443
α-helix553-56210
α-helix563-5708
α-helix571-58616
α-helix589-60719
α-helix614-6163
β-strand61811
β-strand630-63671
Chain B: 36 helices, 8 β-strands
ElementResiduesLengthSheet
α-helix30-4617
α-helix48-558
α-helix58-669
α-helix82-887
α-helix92-1009
α-helix103-1075
α-helix113-1153
α-helix120-1267
α-helix131-1399
α-helix166-1738
α-helix177-1848
α-helix199-2057
α-helix209-22113
α-helix243-2497
α-helix253-2608
β-strand266-27055
β-strand273-27975
α-helix292-2987
α-helix302-3065
α-helix311-32010
α-helix321-3255
α-helix326-34823
β-strand352-35436
β-strand36614
β-strand368-37036
α-helix371-3722
α-helix380-41031
α-helix412-4176
α-helix423-44422
α-helix451-46313
α-helix464-4718
α-helix477-4848
α-helix485-4895
α-helix490-51122
β-strand51517
α-helix526-53712
α-helix542-5443
α-helix553-56412
α-helix565-5706
α-helix571-58616
α-helix589-60719
α-helix614-6163
β-strand618-61925
β-strand629-63575
Chain C: 37 helices, 8 β-strands
ElementResiduesLengthSheet
α-helix30-4617
α-helix48-558
α-helix58-658
α-helix82-887
α-helix92-10110
α-helix105-1073
α-helix108-1103
α-helix120-1278
α-helix130-13910
α-helix166-1738
α-helix177-1848
α-helix199-2057
α-helix213-2219
α-helix243-2497
α-helix253-2608
β-strand265-27068
β-strand273-27978
α-helix292-2976
α-helix302-3076
α-helix311-32010
α-helix321-3255
α-helix326-34823
β-strand352-35439
β-strand36617
β-strand368-37039
α-helix371-3722
α-helix380-41031
α-helix412-4176
α-helix423-44422
α-helix451-46313
α-helix464-4718
α-helix476-4849
α-helix485-4906
α-helix491-4922
α-helix494-51118
β-strand515110
α-helix526-53712
α-helix542-5443
α-helix553-56210
α-helix563-5708
α-helix571-58616
α-helix589-60719
α-helix614-6163
β-strand61818
β-strand630-63678
Chain D: 38 helices, 8 β-strands
ElementResiduesLengthSheet
α-helix30-4617
α-helix48-558
α-helix58-6811
α-helix82-887
α-helix92-10110
α-helix103-1075
α-helix113-1153
α-helix120-1267
α-helix130-13910
α-helix166-1738
α-helix176-18510
α-helix199-2046
α-helix209-22113
α-helix232-2343
α-helix243-2508
α-helix253-2608
β-strand265-270611
β-strand273-279711
α-helix292-2976
α-helix304-3074
α-helix311-32010
α-helix321-3255
α-helix326-34823
β-strand352-354312
β-strand366110
β-strand368-370312
α-helix371-3722
α-helix380-41031
α-helix412-4165
α-helix423-44422
α-helix451-46111
α-helix465-4717
α-helix476-4849
α-helix485-4906
α-helix491-51121
β-strand51513
α-helix526-53712
α-helix542-5443
α-helix553-56210
α-helix563-5708
α-helix571-58717
α-helix589-60719
α-helix610-6123
α-helix614-6152
β-strand618111
β-strand630-636711

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Transient receptor potential cation channel subfamily V member 5A, B, C, Dprotein739Oryctolagus cuniculusQ9XSM3 (AlphaFold model)
Sequence of entity 1 (A, B, C, D), FASTA
>9O6G_1 Transient receptor potential cation channel subfamily V member 5 (chains A, B, C, D)
MGACPPKAKGPWAQLQKLLISWPVGEQDWEQYRDRVNMLQQERIRDSPLLQAAKENDLRL
LKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTA
LHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVR
LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQG
LTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDSWGEELSFLELVVSSK
KREARQILEQTPVKELVSFKWKKYGRPYFCVLASLYILYMICFTTCCIYRPLKLRDDNRT
DPRDITILQQKLLQEAYVTHQDNIRLVGELVTVTGAVIILLLEIPDIFRVGASRYFGQTI
LGGPFHVIIITYASLVLLTMVMRLTNMNGEVVPLSFALVLGWCSVMYFARGFQMLGPFTI
MIQKMIFGDLMRFCWLMAVVILGFASAFHITFQTEDPNNLGEFSDYPTALFSTFELFLTI
IDGPANYSVDLPFMYCITYAAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVAT
TVMLERKMPRFLWPRSGICGYEYGLGDRWFLRVENHHDQNPLRVLRYVEAFKCSDKEDGQ
EQLSEKRPSTVESGMLSRASVAFQTPSLSRTTSQSSNSHRGWEILRRNTLGHLNLGLDLG
EGDGEEVYHFTETSQVAPA

Ligands and cofactors

IDNameFormulaCopies
ERGErgosterolC28 H44 O8
CPL1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholineC42 H80 N O8 P16
PIO[(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-d…C25 H49 O19 P34
IT9(-)-IsopiperitenoneC10 H14 O1

Primary citation

Molecular mechanism of action of menthol, a novel inhibitor of TRPV5 channels. Mendez-Resendiz, A., De Jesus-Perez, J.J., Rangel-Yescas, G.E. et al. To be published.

Other PDB entries of the same protein (UniProt Q9XSM3 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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