9PDC: Porcine Trypsin grown from PEG and

Porcine Trypsin grown from PEG and Complexed with Crystallization Additives II. Determined by X-ray diffraction at 1.27 Å resolution. Released 27 May 2026.

Method: X-ray diffraction
Resolution: 1.27 Å
Organism: Sus scrofa
Chains: 1
Atoms: 2,355
Mol. weight: 30.51 kDa
Ligands: BEN, PG5, PG6, TLA
Released: 27 May 2026

Explore 9PDC in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9PDC contains 9 α-helices and 18 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 9 helices, 18 β-strands

Element	Residues	Length	Sheet
β-strand	2	1	1
β-strand	5-6	2	2
α-helix	7-8	2
β-strand	15-19	5	3
β-strand	23-31	9	3
β-strand	34-37	4	3
α-helix	39-41	3
β-strand	47-50	4	3
β-strand	54	1	4
β-strand	63-72	10	3
β-strand	86-90	5	3
α-helix	93-96	4
β-strand	104	1	2
α-helix	105-106	2
α-helix	109-111	3
β-strand	115-120	6	2
β-strand	134	1	4
β-strand	136-142	7	2
α-helix	143-144	2
α-helix	145-151	7
β-strand	160-163	4	2
β-strand	171	1	1
β-strand	180-183	4	2
β-strand	186-193	8	2
β-strand	204-208	5	2
α-helix	209-211	3
α-helix	213-222	10

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Trypsin	A	protein	231	Sus scrofa	P00761 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>9PDC_1 Trypsin (chains A)
FPTDDDDKIVGGYTCAANSIPYQVSLNSGSHFCGGSLINSQWVVSAAHCYKSRIQVRLGE
HNIDVLEGNEQFINAAKIITHPNFNGNTLDNDIMLIKLSSPATLNSRVATVSLPRSCAAA
GTECLISGWGNTKSSGSSYPSLLQCLKAPVLSDSSCKSSYPGQITGNMICVGFLEGGKDS
CQGDSGGPVVCNGQLQGIVSWGYGCAQKNKPGVYTKVCNYVNWIQQTIAAN

Ligands and cofactors

ID	Name	Formula	Copies
BEN	Benzamidine	C7 H8 N2	1
PG5	1-methoxy-2-[2-(2-methoxy-ethoxy]-ethane	C8 H18 O4	1
PG6	1-(2-methoxy-ethoxy)-2-{2-[2-(2-methoxy-ethoxy]-ethoxy}-ethane	C12 H26 O6	2
TLA	L(+)-tartaric acid	C4 H6 O6	2
CA	Calcium ion	Ca	1

Water and common crystallization additives (PG4, PEG) are not listed.

Primary citation

X-ray Diffraction Analyses of Trypsin Crystals Grown in the Presence of Additives. McPherson, A. Cryst Growth Des (2026) 26:352-364. DOI 10.1021/acs.cgd.5c01305

Other PDB entries of the same protein (UniProt P00761 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9PDA 1.18 Å, Structure of Porcine Trypsin Crystals Grown From PEG and Complexed With Crystallization…
1S83 1.25 Å, Porcine trypsin complexed with 4-amino propanol
2A31 1.25 Å, Trypsin in complex with borate
9PD9 1.28 Å, The Structure of Porcine Trypsin in Complex with Crystallization Additives I
1S5S 1.4 Å, Porcine trypsin complexed with guanidine-3-propanol inhibitor
9PCT 1.41 Å, Structure of Porcine Trypsin Crystals Grown from PEG Complexed with Crystallization…
1S6H 1.45 Å, Porcine trypsin complexed with guanidine-3-propanol inhibitor
1H9H 1.5 Å, Complex of eeti-II with porcine trypsin
2A32 1.5 Å, Trypsin in complex with benzene boronic acid
1FNI 1.6 Å, Crystal structure of porcine beta trypsin with 0.01% polydocanol
1MCT 1.6 Å, The refined 1.6 Å resolution crystal structure of the complex formed between porcine…
1QQU 1.63 Å, Crystal structure of porcine beta trypsin with bound acetate ion

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