9QQP: Mouse Ribosome rotated-2 PRE state

Name: PDB 9QQP: Mouse Ribosome rotated-2 PRE state
Published: 2026-04-15
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: ribosome

Mouse Ribosome rotated-2 PRE state. Determined by electron microscopy at 2.8 Å resolution. Released 15 Apr 2026.

Method: Electron microscopy
Resolution: 2.8 Å
Organism: Mus musculus
Chains: 82
Atoms: 206,901
Mol. weight: 3284.67 kDa
Ligands: ZN, MG
Released: 15 Apr 2026

Explore 9QQP in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9QQP contains 483 α-helices and 526 β-strands across 74 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A1: 13 helices, 11 β-strands

Element	Residues	Length	Sheet
α-helix	50-100	51
β-strand	103-105	3	1
α-helix	106-109	4
β-strand	111-116	6	2
α-helix	125-133	9
β-strand	141-146	6	2
α-helix	149-157	9
α-helix	159-161	3
β-strand	162-165	4	2
α-helix	169-178	10
β-strand	181-183	3	3
β-strand	188-190	3	3
α-helix	194-201	8
α-helix	202-204	3
α-helix	209-217	9
α-helix	223-229	7
β-strand	230	1	3
α-helix	231-232	2
β-strand	233-234	2	2
β-strand	248	1	4
α-helix	249-251	3
β-strand	255	1	4
β-strand	256-257	2	2
α-helix	262-269	8

Chain a2: 7 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	16-18	3
β-strand	20-24	5	49
β-strand	30-34	5	49
α-helix	35-39	5
α-helix	41-42	2
β-strand	43	1	50
α-helix	44	1
β-strand	52	1	50
α-helix	53	1
α-helix	70-72	3
α-helix	84-107	24

Chain A3: 9 helices, 5 β-strands

Element	Residues	Length	Sheet
β-strand	13	1	14
β-strand	21	1	14
α-helix	26-29	4
α-helix	30-32	3
α-helix	38-47	10
α-helix	56-58	3
α-helix	61-72	12
α-helix	74-77	4
α-helix	81-83	3
β-strand	86	1	15
β-strand	91	1	16
β-strand	96	1	15
α-helix	101-117	17
α-helix	120-126	7

Chain B1: 16 helices, 7 β-strands

Element	Residues	Length	Sheet
α-helix	45-47	3
α-helix	52-54	3
β-strand	56	1	32
α-helix	59-73	15
β-strand	75-76	2	33
α-helix	78-81	4
α-helix	89-100	12
α-helix	103-105	3
α-helix	107-115	9
β-strand	136-138	3	34
α-helix	140-148	9
β-strand	154-158	5	34
α-helix	164-166	3
α-helix	170-177	8
β-strand	181-184	4	34
α-helix	188-193	6
β-strand	201-204	4	34
α-helix	209-211	3
α-helix	212-222	11
α-helix	223-227	5
α-helix	231-234	4
β-strand	238-239	2	33
α-helix	244-258	15

Chain b2: 7 helices, 1 β-strand

Element	Residues	Length	Sheet
α-helix	6-10	5
α-helix	14-36	23
α-helix	41-73	33
α-helix	89-93	5
α-helix	95-96	2
α-helix	105-113	9
α-helix	115-118	4
β-strand	119-121	3	115

Chain B3: 8 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	12-24	13
α-helix	33-36	4
α-helix	38-39	2
α-helix	52-66	15
α-helix	72-79	8
β-strand	82-83	2	46
α-helix	89-90	2
β-strand	91-92	2	46
α-helix	97-109	13
α-helix	125-143	19

Chain C1: 4 helices, 13 β-strands

Element	Residues	Length	Sheet
β-strand	3-11	9	58
β-strand	17-21	5	59
β-strand	24-29	6	59
β-strand	32-37	6	59
β-strand	44-48	5	58
β-strand	54-62	9	58
α-helix	64-67	4
α-helix	69-85	17
β-strand	88-95	8	60
β-strand	102-106	5	61
β-strand	111-115	5	61
β-strand	124-127	4	61
α-helix	128-129	2
β-strand	133-136	4	60
β-strand	143-148	6	60
α-helix	151-164	14
β-strand	178-185	8	60

Chain c2: 7 helices, 0 β-strands

Element	Residues	Length
α-helix	18-21	4
α-helix	23-25	3
α-helix	26-29	4
α-helix	35-48	14
α-helix	52-61	10
α-helix	66-77	12
α-helix	80-102	23

66 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Large ribosomal subunit protein uL30	A1	protein	270	Mus musculus	P14148 (AlphaFold model)
28S ribosomal RNA	A2	RNA	3615	Mus musculus
Small ribosomal subunit protein uS13	A3	protein	152	Mus musculus	P62270 (AlphaFold model)
Large ribosomal subunit protein eL8	B1	protein	266	Mus musculus	P12970 (AlphaFold model)
5S ribosomal RNA	B2	RNA	121	Mus musculus
40S ribosomal protein S19 (eS19)	B3	protein	145	Mus musculus
transfer RNA	Bv	RNA	76	Mus musculus
messenger RNA	Bx	RNA	10	Mus musculus
Nascent protein chain	By	protein	22	Mus musculus
Large ribosomal subunit protein uL6	C1	protein	192	Mus musculus	P51410 (AlphaFold model)
5.8S ribosomal RNA	C2	RNA	156	Mus musculus
Small ribosomal subunit protein uS10	C3	protein	119	Mus musculus	P60867

70 more molecules are not listed.

Sequence of entity 1 (A1), FASTA

>9QQP_1 Large ribosomal subunit protein uL30 (chains A1)
MEAVPEKKKKVATVPGTLKKKVPAGPKTLKKKVPAVPETLKKKRRNFAELKVKRLRKKFA
LKTLRKARRKLIYEKAKHYHKEYRQMYRTEIRMARMARKAGNFYVPAEPKLAFVIRIRGI
NGVSPKVRKVLQLLRLRQIFNGTFVKLNKASINMLRIVEPYIAWGYPNLKSVNELIYKRG
YGKINKKRIALTDNSLIARSLGKFGIICMEDLIHEIYTVGKRFKEANNFLWPFKLSSPRG
GMKKKTTHFVEGGDAGNREDQINRLIRRMN

Sequence of entity 2 (A2), FASTA

>9QQP_2 28S ribosomal RNA (chains A2)
CGCGACCUCAGAUCAGACGUGGCGACCCGCUGAAUUUAAGCAUAUUAGUCAGCGGAGGAA
AAGAAACUAACCAGGAUUCCCUCAGUAACGGCGAGUGAACAGGGAAGAGCCCAGCGCCGA
AUCCCCGCCGCGCGUCGCGGCGUGGGAAAUGUGGCGUACGGAAGACCCACUCCCCGGCGC
CGCUCGUGGGGGGCCCAAGUCCUUCUGAUCGAGGCCCAGCCCGUGGACGGUGUGAGGCCG
GUAGCGGCCCCCGGCGCGCCGGGCUCGGGUCUUCCCGGAGUCGGGUUGCUUGGGAAUGCA
GCCCAAAGCGGGUGGUAAACUCCAUCUAAGGCUAAAUACCGGCACGAGACCGAUAGUCAA
CAAGUACCGUAAGGGAAAGUUGAAAAGAACUUUGAAGAGAGAGUUCAAGAGGGCGUGAAA
CCGUUAAGAGGUAAACGGGUGGGGUCCGCGCAGUCCGCCCGGAGGAUUCAACCCGGCGGC
GUCCGGCCGUGCCGGUGGGCGGAUCUUUCCCGCGCGGGGGACCGCCCCCGGCCGGCGACC
GGCCGCCGCCGGGCGCACUUCCACCGUGGCGGUGCGCCGCGACCGGCUCCGGGACGGCCG
GGAAGGCCCGGUGGGGAAGGUGGCUCGGGGGGGGCUCACCCCGAGUGUUACAGCCCUCCG
GCCGCGCUUUUCGCCGAAUCCCGGGGCCGAGGAAGACCGUCGCCGCGCUCUCCCUCUCCC
GGGUGGGGGCCGGGCCGCCCCUCCCACGGCGCGACCGCUCCGGGGCGGACUGUCCCCAGU
GCGCCCCGGGCGUCGUCGCGCCGUCGGGUCCCGGGGGCGUCGGUCACGCGUGACGAAGCC
GAGCGCACGGGGUCGGCGGCGAUGUCGGCUACCCACCCGACCCGUCUUGAAACACGGACC
AAGGAGUCUAACGCGUGCGCGAGUCAGGGGCUCGUCCGAAAGCCGCCGUGGCGCAAUGAA
GGUGAAGGGCCCCGCCCGGGGGCCCGAGGUGGGAUCCCGAGGCCUCUCCAGUCCGCCGAG
GGCGCACCACCGGCCCGUCUCGCCCGCCGCGCCGGGGAGGUGGAGCACGAGCGUACGCGU
UAGGACCCGAAAGAUGGUGAACUAUGCUUGGGCAGGGCGAAGCCAGAGGAAACUCUGGUG
GAGGUCCGUAGCGGUCCUGACGUGCAAAUCGGUCGUCCGACCUGGGUAUAGGGGCGAAAG
ACUAAUCGAACCAUCUAGUAGCUGGUUCCCUCCGAAGUUUCCCUCAGGAUAGCUGGCGCU
CUCGCUACGCAGUUUUAUCCGGUAAAGCGAAUGAUUAGAGGUCUUGGGGCAUCUCAACCU
AUUCUCAAACUUUAAAUGGGUAAGAAGCCCGGCUCGCUGGCGUGGAGCCGGGCGUGGAAU
GCGAGUGCCUAGUGGGCCACUUUUGGGAAGCAGAACUGGCGCUGCGGGAUGAACCGAACG
CCGGGUUAAGGCGCCCGAUGCCGACGCUCAUCAGACCCCAGAAAAGGUGUUGGUUGAUAU
AGACAGCAGGACCUGCCGAAUCAACUAGCCCUGAAAAUGGAUGGCGCUGGAGCGUCGGGC
CCAUACCCGGCCGUCGCCGGCAGUCGGAACGGAACGGGACGGGAGCGUCGGGCCCCGCGG
AGCCUACGCCGCGACGAGUAGGAGGGCCGCUGCGGUGAGCCUUGAAGCCUAGGGCGCGGG
CCCGGGUGGAGCCGCCGCAGGUGCAGAUCUUGGUGGUAGUAGCAAAUAUUCAAACGAGAA
CUUUGAAGGCCGAAGUGGAGAAGGGUUCCAUGUGAACAGCAGUUGAACAUGGGUCAGUCG
GUCCUGAGAGAUGGGCGAGUGCCGUUCCGAAGGGACGGGCGAUGGCCUCCGUUGCCCUCG
GCCGAUCGAAAGGGAGUCGGGUUCAGAUCCCCGAAUCCGGAGUGGCGGAGAUGGGCGCCG
CGAGGCGUCCAGUGCGGUAACGCGACCGAUCCCGGAGAAGCCGGCGGGAGCCUCGGGGAG
AGUUCUCUUUUCUUUGUGAAGGGCAGGGCGCCCUGGAAUGGGUUCGCCCCGAGAGAGGGG
CCCGUGCCUUGGAAAGCGUCGCGGUUCCGGCGGCGUCCGGUGAGCUCUCGCUGGCCCUUG
AAAAUCCGGGGGAGAGGGUGUAAAUCUCGCGCCGGGCCGUACCCAUAUCCGCAGCAGGUC
UCCAAGGUGAACAGCCUCUGGCAUGUUGGAACAAUGUAGGUAAGGGAAGUCGGCAAGCCG
GAUCCGUAACUUCGGGAUAAGGAUUGGCUCUAAGGGCUGGGCGGCCGGCGCCUAGCAGCC
GACUUAGAACUGGUGCGGACCAGGGGAAUCCGACUGUUUAAUUAAAACAAAGCAUCGCGA
AGGCCCGCGGCGGGUGUUGACGCGAUGUGAUUUCUGCCCAGUGCUCUGAAUGUCAAAGUG
AAGAAAUUCAAUGAAGCGCGGGUAAACGGCGGGAGUAACUAUGACUCUCUUAAGGUAGCC
AAAUGCCUCGUCAUCUAAUUAGUGACGCGCAUGAAUGGAUGAACGAGAUUCCCACUGUCC
CUACCUACUAUCCAGCGAAACCACAGCCAAGGGAACGGGCUUGGCGGAAUCAGCGGGGAA
AGAAGACCCUGUUGAGCUUGACUCUAGUCUGGCACGGUGAAGAGACAUGAGAGGUGUAGA
AUAAGUGGGAGGCCCGGCCGCCGGUGAAAUACCACUACUCUCAUCGUUUUUUCACUGACC
CGGUGAGGCGGGGGGGCGAGCCCGGCUCUCGCUUCUGGCGCCAAGCGUCCGUCCCGGCGG
GCGGGCGCGACCCGCUCCGGGGACAGUGCCAGGUGGGGAGUUUGACUGGGGCGGUACACC
UGUCAAACGGUAACGCAGGUGUCCUAAGGCGAGCUCAGGGAGGACAGAAACCUCCCGUGG
AGCAGAAGGGCAAAAGCUCGCUUGAUCUUGAUUUUCAGUACGAAUACAGACCGUGAAAGC
GGGGCCUCACGAUCCUUCUGACCUUUUGGGUUUUAAGCAGGAGGUGUCAGAAAAGUUACC
ACAGGGAUAACUGGCUUGUGGCGGCCAAGCGUUCAUAGCGACGUCGCUUUUUGAUCCUUC
GAUGUCGGCUCUUCCUAUCAUUGUGAAGCAGAAUUCACCAAGCGUUGGAUUGUUCACCCA
CUAAUAGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUACCCUACUG
AUGAUGUGUUGUUGCCAUGGUAAUCCUGCUCAGUACGAGAGGAACCGCAGAUUCAGACAU
UUGGUGUAUGUGCUUGGCUGAGGAGCCAAUGGGGCGAAGCUACCAUCUGUGGGAUUAUGA
CUGAACGCCUCUAAGUCAGAAUCCCGCCCAGGCGGAACGAUACGGCAGCGCCGAGGAGCC
UCGGUUGGCCCCGGAUAGCCGGGUCCCCGUCCGUCCCGGCGUCGGGACCGGGGUCCGGUG
CGGAGAGCCGUUCGUCUUGGGAAACGGGGUGCGGCCGGAAAGGGGGCCGCCCUCUCGCCC
GUCACGUUGACGCACGUUCGUGUGGAACCUGGCGCUAAACCAUUCGUAGACGACCUGCUU
CUGGGUCGGGGUUUCGUACGUAGCAGAGCAGCUGCUGCGAUCUAUUGAAAGUCAGCCCUC
GACACAAGGGUUUGU

Sequence of entity 3 (A3), FASTA

>9QQP_3 Small ribosomal subunit protein uS13 (chains A3)
MSLVIPEKFQHILRVLNTNIDGRRKIAFAITAIKGVGRRYAHVVLRKADIDLTKRAGELT
EDEVERVITIMQNPRQYKIPDWFLNRQKDVKDGKYSQVLANGLDNKLREDLERLKKIRAH
RGLRHFWGLRVRGQHTKTTGRRGRTVGVSKKK

Sequence of entity 4 (B1), FASTA

>9QQP_4 Large ribosomal subunit protein eL8 (chains B1)
MPKGKKAKGKKVAPAPAVVKKQEAKKVVNPLFEKRPKNFGIGQDIQPKRDLTRFVKWPRY
IRLQRQRAILYKRLKVPPAINQFTQALDRQTATQLLKLAHKYRPETKQEKKQRLLARAEK
KAAGKGDVPTKRPPVLRAGVNTVTTLVENKKAQLVVIAHDVDPIELVVFLPALCRKMGVP
YCIIKGKARLGHLVHRKTCTTVAFTQVNSEDKGALAKLVEAIRTNYNDRYDEIRRHWGGN
VLGPKSVARIAKLEKAKAKELATKLG

Sequence of entity 5 (B2), FASTA

>9QQP_5 5S ribosomal RNA (chains B2)
GUCUACGGCCAUACCACCCUGAACGCGCCCGAUCUCGUCUGAUCUCGGAAGCUAAGCAGG
GUCGGGCCUGGUUAGUACUUGGAUGGGAGACCGCCUGGGAAUACCGGGUGCUGUAGGCUU
U

Sequence of entity 6 (B3), FASTA

>9QQP_6 40S ribosomal protein S19 (eS19) (chains B3)
MPGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENWFYTRAAST
ARHLYLRGGAGVGSMTKIYGGRQRNGVMPSHFSRGSKSVARRVLQALEGLKMVEKDQDGG
RKLTPQGQRDLDRIAGQVAAANKKH

Sequence of entity 7 (Bv), FASTA

>9QQP_7 transfer RNA (chains Bv)
GCCCGGAUAGCUCAGUCGGUAGAGCAGGGGAUUGAAAAUCCCCGUGCCCUUGGUUCGAUU
CCGAGUCCGGGCACCA

Sequence of entity 8 (Bx), FASTA

>9QQP_8 messenger RNA (chains Bx)
UUUUUUUUUU

Sequence of entity 9 (By), FASTA

>9QQP_9 Nascent protein chain (chains By)
XXXXXXXXXXXXXXXXXXXXXX

Sequence of entity 10 (C1), FASTA

>9QQP_10 Large ribosomal subunit protein uL6 (chains C1)
MKTILSNQTVDIPENVEITLKGRTVIVKGPRGTLRRDFNHINVELSLLGKKKKRLRVDKW
WGNRKELATVRTICSHVQNMIKGVTLGFRYKMRSVYAHFPINVVIQENGSLVEIRNFLGE
KYIRRVRMRTGVACSVSQAQKDELILEGNDIELVSNSAALIQQATTVKNKDIRKFLDGIY
VSEKGTVQQADE

Sequence of entity 11 (C2), FASTA

>9QQP_11 5.8S ribosomal RNA (chains C2)
CGACUCUUAGCGGUGGAUCACUCGGCUCGUGCGUCGAUGAAGAACGCAGCUAGCUGCGAG
AAUUAAUGUGAAUUGCAGGACACAUUGAUCAUCGACACUUCGAACGCACUUGCGGCCCCG
GGUUCCUCCCGGGGCUACGCCUGUCUGAGCGUCGCU

Sequence of entity 12 (C3), FASTA

>9QQP_12 Small ribosomal subunit protein uS10 (chains C3)
MAFKDTGKTPVEPEVAIHRIRITLTSRNVKSLEKVCADLIRGAKEKNLKVKGPVRMPTKT
LRITTRKTPCGEGSKTWDRFQMRIHKRLIDLHSPSEIVKQITSISIEPGVEVEVTIADA

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	6
MG	Magnesium ion	Mg	123

Primary citation

A RiboCancer cell line panel reveals that CLL-associated Rps15 mutations translationally rewire transcription through codon-specific tRNA accommodation defects. Astier, A., Caruso, M., Vereecke, S. et al. Hemasphere (2026) 10:e70377-e70377. DOI 10.1002/hem3.70377 · PubMed

Other PDB entries of the same protein (UniProt P14148 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9H4N 2.46 Å, RPL13 (eL13)-mutant 80S ribosome from mouse
31FX 2.54 Å, Mouse 80S ribosome, sgRNA control
31FY 2.57 Å, Mouse 80S ribosome, Gm10076 KO
9KDT 2.63 Å, Cryo-EM structure of 80S ribosome
9KDW 2.67 Å, Cryo-EM structure of 80S ribosome
9QOH 2.78 Å, Mouse Ribosome POST translocation state
7CPU 2.82 Å, Cryo-EM structure of 80S ribosome from mouse kidney
31FZ 2.89 Å, Mouse 80S ribosome, eL41 KO
9KDU 2.96 Å, Cryo-EM structure of 80S ribosome
7CPV 3.03 Å, Cryo-EM structure of 80S ribosome from mouse testis
9QQL 3.09 Å, Mouse RPS15 P131 Mutant Ribosome POST translocation state
6SWA 3.1 Å, Mus musculus brain neocortex ribosome 60S bound to Ebp1

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