9S2F: Human debranched intron spliceosome
Human debranched intron spliceosome (DIS). Determined by electron microscopy at 3.14 Å resolution. Released 29 Jul 2026.
- Method
- Electron microscopy
- Resolution
- 3.14 Å
- Organism
- Homo sapiens
- Chains
- 37
- Atoms
- 77,158
- Mol. weight
- 2174.49 kDa
- Ligands
- IHP, GTP, MG, ZN
- Released
- 29 Jul 2026
Explore 9S2F in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
9S2F contains 552 α-helices and 425 β-strands across 34 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain 35: 40 helices, 29 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 47-53 | 7 | |
| α-helix | 55-58 | 4 | |
| α-helix | 60-69 | 10 | |
| β-strand | 72-76 | 5 | 1 |
| α-helix | 83-93 | 11 | |
| α-helix | 98-100 | 3 | |
| β-strand | 102-107 | 6 | 1 |
| α-helix | 110-124 | 15 | |
| α-helix | 126-127 | 2 | |
| β-strand | 128 | 1 | 1 |
| β-strand | 132-136 | 5 | 1 |
| β-strand | 139-141 | 3 | 1 |
| β-strand | 149-153 | 5 | 1 |
| α-helix | 154-163 | 10 | |
| β-strand | 170-175 | 6 | 1 |
| α-helix | 178-180 | 3 | |
| α-helix | 183-198 | 16 | |
| β-strand | 203-208 | 6 | 1 |
| α-helix | 214-220 | 7 | |
| α-helix | 228-230 | 3 | |
| β-strand | 233-237 | 5 | 1 |
| α-helix | 242-244 | 3 | |
| β-strand | 245-250 | 6 | 2 |
| α-helix | 257-271 | 15 | |
| β-strand | 276-280 | 5 | 2 |
| α-helix | 284-303 | 20 | |
| β-strand | 309-315 | 7 | 2 |
| α-helix | 321-324 | 4 | |
| α-helix | 325-328 | 4 | |
| β-strand | 335-341 | 7 | 2 |
| α-helix | 344-347 | 4 | |
| β-strand | 354-359 | 6 | 2 |
| β-strand | 362-369 | 8 | 3 |
| β-strand | 374-381 | 8 | 3 |
| α-helix | 382-383 | 2 | |
| α-helix | 384-392 | 9 | |
| α-helix | 393-395 | 3 | |
| β-strand | 400-404 | 5 | 2 |
| α-helix | 408-412 | 5 | |
| α-helix | 418-420 | 3 | |
| α-helix | 421-424 | 4 | |
| α-helix | 428-437 | 10 | |
| α-helix | 450-452 | 3 | |
| α-helix | 453-465 | 13 | |
| β-strand | 469 | 1 | 4 |
| β-strand | 475 | 1 | 4 |
| α-helix | 479-485 | 7 | |
| α-helix | 490-502 | 13 | |
| α-helix | 505-514 | 10 | |
| β-strand | 521 | 1 | 5 |
| α-helix | 525-527 | 3 | |
| α-helix | 528-535 | 8 | |
| α-helix | 536-538 | 3 | |
| β-strand | 540 | 1 | 6 |
| β-strand | 543 | 1 | 3 |
| α-helix | 544-557 | 14 | |
| α-helix | 562-567 | 6 | |
| β-strand | 570 | 1 | 5 |
| α-helix | 572-591 | 20 | |
| α-helix | 603-614 | 12 | |
| β-strand | 618-621 | 4 | 3 |
| β-strand | 627-629 | 3 | 3 |
| β-strand | 635-638 | 4 | 3 |
| α-helix | 648-650 | 3 | |
| β-strand | 652-660 | 9 | 3 |
| β-strand | 664-671 | 8 | 3 |
| α-helix | 674-680 | 7 | |
| β-strand | 685-689 | 5 | 7 |
| α-helix | 690-694 | 5 | |
Chain a: 3 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 5-12 | 8 | |
| β-strand | 17-22 | 6 | 8 |
| β-strand | 27-35 | 9 | 8 |
| β-strand | 41-49 | 9 | 8 |
| β-strand | 55-63 | 9 | 8 |
| α-helix | 65-67 | 3 | |
| β-strand | 68-73 | 6 | 8 |
| α-helix | 75-79 | 5 | |
Chain A: 115 helices, 57 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 27-44 | 18 | |
| α-helix | 47-49 | 3 | |
| α-helix | 55-57 | 3 | |
| α-helix | 59-62 | 4 | |
| α-helix | 63-73 | 11 | |
| α-helix | 79-84 | 6 | |
| α-helix | 85-90 | 6 | |
| α-helix | 91-94 | 4 | |
| α-helix | 95-104 | 10 | |
| α-helix | 106-108 | 3 | |
| β-strand | 115-121 | 7 | 9 |
| β-strand | 127-129 | 3 | 9 |
| β-strand | 134-135 | 2 | 10 |
| α-helix | 137-157 | 21 | |
| α-helix | 163-165 | 3 | |
| α-helix | 174-177 | 4 | |
| α-helix | 178-181 | 4 | |
| α-helix | 185-189 | 5 | |
| α-helix | 201-204 | 4 | |
| β-strand | 220 | 1 | 11 |
| β-strand | 227-229 | 3 | 11 |
| α-helix | 232-241 | 10 | |
| α-helix | 242-244 | 3 | |
| α-helix | 252-255 | 4 | |
| α-helix | 260-268 | 9 | |
| α-helix | 299-301 | 3 | |
| α-helix | 310-315 | 6 | |
| α-helix | 329-331 | 3 | |
| α-helix | 357-358 | 2 | |
| α-helix | 361-363 | 3 | |
| α-helix | 371-373 | 3 | |
| α-helix | 396-404 | 9 | |
| β-strand | 415-417 | 3 | 11 |
| β-strand | 419-420 | 2 | 10 |
| α-helix | 428-431 | 4 | |
| α-helix | 441-459 | 19 | |
| α-helix | 463-466 | 4 | |
| α-helix | 472-477 | 6 | |
| β-strand | 482-488 | 7 | 9 |
| α-helix | 489-510 | 22 | |
| β-strand | 516-518 | 3 | 12 |
| β-strand | 524-526 | 3 | 12 |
| α-helix | 529-531 | 3 | |
| α-helix | 532-537 | 6 | |
| α-helix | 542-565 | 24 | |
| α-helix | 571-583 | 13 | |
| α-helix | 585-589 | 5 | |
| α-helix | 591-593 | 3 | |
| α-helix | 596-598 | 3 | |
| α-helix | 599-616 | 18 | |
| α-helix | 631-661 | 31 | |
| α-helix | 677-679 | 3 | |
| α-helix | 681-696 | 16 | |
| α-helix | 706-721 | 16 | |
| α-helix | 733-763 | 31 | |
| α-helix | 769-797 | 29 | |
| α-helix | 803-820 | 18 | |
| α-helix | 824 | 1 | |
| β-strand | 825 | 1 | 13 |
| α-helix | 826-829 | 4 | |
| α-helix | 835-850 | 16 | |
| α-helix | 858-872 | 15 | |
| α-helix | 874-887 | 14 | |
| β-strand | 894-900 | 7 | 14 |
| β-strand | 905-910 | 6 | 14 |
| α-helix | 913-933 | 21 | |
| β-strand | 940 | 1 | 15 |
| α-helix | 948-960 | 13 | |
| β-strand | 973-980 | 8 | 15 |
| α-helix | 985-987 | 3 | |
| α-helix | 990-997 | 8 | |
| β-strand | 1001 | 1 | 13 |
| α-helix | 1003-1012 | 10 | |
| β-strand | 1016-1019 | 4 | 14 |
| β-strand | 1022-1025 | 4 | 14 |
| α-helix | 1037-1053 | 17 | |
| α-helix | 1055-1062 | 8 | |
| α-helix | 1077-1080 | 4 | |
| β-strand | 1085-1091 | 7 | 15 |
| β-strand | 1094-1101 | 8 | 15 |
| α-helix | 1103-1116 | 14 | |
| α-helix | 1123-1125 | 3 | |
| α-helix | 1140-1141 | 2 | |
| α-helix | 1144-1158 | 15 | |
| β-strand | 1174-1178 | 5 | 15 |
| β-strand | 1179 | 1 | 16 |
| β-strand | 1182 | 1 | 16 |
| β-strand | 1185-1189 | 5 | 17 |
| β-strand | 1192-1198 | 7 | 17 |
| α-helix | 1199-1201 | 3 | |
| α-helix | 1207-1208 | 2 | |
| β-strand | 1213-1217 | 5 | 17 |
| α-helix | 1218 | 1 | |
| β-strand | 1224-1232 | 9 | 17 |
| α-helix | 1234-1248 | 15 | |
| α-helix | 1256-1274 | 19 | |
| α-helix | 1275-1277 | 3 | |
| α-helix | 1282-1303 | 22 | |
| α-helix | 1307-1308 | 2 | |
| α-helix | 1314-1317 | 4 | |
| α-helix | 1320-1322 | 3 | |
| β-strand | 1332 | 1 | 18 |
| β-strand | 1334-1335 | 2 | 19 |
| α-helix | 1336 | 1 | |
| α-helix | 1337-1340 | 4 | |
| β-strand | 1344-1345 | 2 | 20 |
| β-strand | 1350-1351 | 2 | 20 |
| β-strand | 1363-1364 | 2 | 19 |
| α-helix | 1365-1367 | 3 | |
| α-helix | 1368-1371 | 4 | |
| α-helix | 1375-1398 | 24 | |
| β-strand | 1404 | 1 | 21 |
| α-helix | 1405-1411 | 7 | |
| α-helix | 1419-1422 | 4 | |
| β-strand | 1424 | 1 | 22 |
| α-helix | 1427-1430 | 4 | |
| α-helix | 1436-1442 | 7 | |
| α-helix | 1443-1445 | 3 | |
| α-helix | 1458-1461 | 4 | |
| α-helix | 1468-1477 | 10 | |
| α-helix | 1480-1485 | 6 | |
| α-helix | 1490-1493 | 4 | |
| β-strand | 1502 | 1 | 23 |
| β-strand | 1503 | 1 | 24 |
| α-helix | 1508-1513 | 6 | |
| α-helix | 1520-1527 | 8 | |
| α-helix | 1529-1537 | 9 | |
| α-helix | 1539-1542 | 4 | |
| β-strand | 1552-1554 | 3 | 25 |
| α-helix | 1555 | 1 | |
| β-strand | 1561-1563 | 3 | 25 |
| α-helix | 1567-1576 | 10 | |
| α-helix | 1581-1599 | 19 | |
| α-helix | 1601-1604 | 4 | |
| β-strand | 1608-1611 | 4 | 26 |
| α-helix | 1616-1620 | 5 | |
| β-strand | 1626 | 1 | 27 |
| β-strand | 1629-1631 | 3 | 26 |
| α-helix | 1636 | 1 | |
| β-strand | 1637-1639 | 3 | 28 |
| α-helix | 1640-1642 | 3 | |
| β-strand | 1643-1644 | 2 | 26 |
| β-strand | 1655-1657 | 3 | 28 |
| β-strand | 1660-1667 | 8 | 26 |
| α-helix | 1676-1689 | 14 | |
| β-strand | 1694 | 1 | 27 |
| β-strand | 1700-1706 | 7 | 26 |
| β-strand | 1711-1716 | 6 | 26 |
| α-helix | 1722-1736 | 15 | |
| α-helix | 1738-1751 | 14 | |
| β-strand | 1753 | 1 | 24 |
| β-strand | 1777-1781 | 5 | 29 |
| β-strand | 1788-1792 | 5 | 30 |
| β-strand | 1798-1802 | 5 | 30 |
| β-strand | 1805-1810 | 6 | 29 |
| β-strand | 1816-1822 | 7 | 29 |
| α-helix | 1824-1827 | 4 | |
| α-helix | 1835-1851 | 17 | |
| β-strand | 1860-1863 | 4 | 29 |
| α-helix | 1866-1868 | 3 | |
| α-helix | 1869-1875 | 7 | |
| α-helix | 1876-1878 | 3 | |
| β-strand | 1883-1886 | 4 | 29 |
| α-helix | 1894-1897 | 4 | |
| α-helix | 1900-1908 | 9 | |
| β-strand | 1914-1918 | 5 | 29 |
| α-helix | 1923-1925 | 3 | |
| α-helix | 1929-1945 | 17 | |
| α-helix | 1947-1954 | 8 | |
| α-helix | 1973-1995 | 23 | |
| α-helix | 1999-2001 | 3 | |
| α-helix | 2004-2011 | 8 | |
Chain b: 3 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 9-12 | 4 | |
| β-strand | 16-21 | 6 | 8 |
| β-strand | 26-34 | 9 | 8 |
| β-strand | 40-50 | 11 | 8 |
| β-strand | 62-72 | 11 | 8 |
| α-helix | 74-76 | 3 | |
| β-strand | 77-84 | 8 | 8 |
| α-helix | 85-87 | 3 | |
| β-strand | 106-109 | 4 | 46 |
Chain B: 0 helices, 1 β-strand
| Element | Residues | Length | Sheet |
|---|
| β-strand | 41 | 1 | 18 |
Chain c: 4 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 4-8 | 5 | |
| β-strand | 14-19 | 6 | 8 |
| β-strand | 24-32 | 9 | 8 |
| β-strand | 38-46 | 9 | 8 |
| β-strand | 53-60 | 8 | 8 |
| α-helix | 62-64 | 3 | |
| β-strand | 65-69 | 5 | 8 |
| α-helix | 70-71 | 2 | |
| α-helix | 76-79 | 4 | |
Chain C: 47 helices, 43 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 60-62 | 3 | |
| α-helix | 69-73 | 5 | |
| β-strand | 78-81 | 4 | 33 |
| α-helix | 109-111 | 3 | |
| α-helix | 116-123 | 8 | |
| β-strand | 129-135 | 7 | 34 |
| α-helix | 142-153 | 12 | |
| β-strand | 160 | 1 | 35 |
| β-strand | 163 | 1 | 35 |
| α-helix | 172-177 | 6 | |
| β-strand | 184-191 | 8 | 34 |
| β-strand | 197-204 | 8 | 34 |
| α-helix | 212-221 | 10 | |
| β-strand | 224-230 | 7 | 34 |
| α-helix | 237-248 | 12 | |
| β-strand | 252-258 | 7 | 34 |
| α-helix | 261 | 1 | |
| α-helix | 262-267 | 6 | |
| α-helix | 271-292 | 22 | |
| α-helix | 302-304 | 3 | |
| β-strand | 307-311 | 5 | 34 |
| α-helix | 312-314 | 3 | |
| β-strand | 316-318 | 3 | 34 |
| α-helix | 320-331 | 12 | |
| α-helix | 336-340 | 5 | |
| β-strand | 348-350 | 3 | 36 |
| β-strand | 355-357 | 3 | 36 |
| α-helix | 365-366 | 2 | |
| β-strand | 367 | 1 | 36 |
| α-helix | 368-369 | 2 | |
| α-helix | 370-374 | 5 | |
| α-helix | 375-384 | 10 | |
| α-helix | 392-399 | 8 | |
| α-helix | 407-409 | 3 | |
| α-helix | 412-424 | 13 | |
| α-helix | 428-437 | 10 | |
| α-helix | 441-452 | 12 | |
| β-strand | 453 | 1 | 37 |
| α-helix | 460-466 | 7 | |
| β-strand | 475-483 | 9 | 38 |
| α-helix | 484 | 1 | |
| β-strand | 490-498 | 9 | 38 |
| β-strand | 501-502 | 2 | 39 |
| β-strand | 506-510 | 5 | 38 |
| β-strand | 515 | 1 | 40 |
| β-strand | 518 | 1 | 40 |
| β-strand | 522-526 | 5 | 38 |
| β-strand | 530-533 | 4 | 38 |
| β-strand | 538-541 | 4 | 38 |
| β-strand | 543-544 | 2 | 39 |
| β-strand | 549-553 | 5 | 38 |
| β-strand | 563-566 | 4 | 38 |
| α-helix | 575-576 | 2 | |
| β-strand | 577 | 1 | 37 |
| α-helix | 578-580 | 3 | |
| β-strand | 588-594 | 7 | 41 |
| α-helix | 597-599 | 3 | |
| α-helix | 600-613 | 14 | |
| β-strand | 618-621 | 4 | 41 |
| β-strand | 627-631 | 5 | 41 |
| α-helix | 634-642 | 9 | |
| α-helix | 643-649 | 7 | |
| β-strand | 653-655 | 3 | 41 |
| α-helix | 656-658 | 3 | |
| β-strand | 659-660 | 2 | 41 |
| β-strand | 663-666 | 4 | 42 |
| β-strand | 674-677 | 4 | 43 |
| β-strand | 684-691 | 8 | 43 |
| α-helix | 692-693 | 2 | |
| α-helix | 696-701 | 6 | |
| α-helix | 711-722 | 12 | |
| α-helix | 726-730 | 5 | |
| β-strand | 732-736 | 5 | 43 |
| β-strand | 743-747 | 5 | 43 |
| α-helix | 756-776 | 21 | |
| β-strand | 784 | 1 | 42 |
| β-strand | 787-795 | 9 | 43 |
| α-helix | 805-821 | 17 | |
| β-strand | 825-839 | 15 | 42 |
| α-helix | 840-842 | 3 | |
| α-helix | 843-852 | 10 | |
| β-strand | 856-862 | 7 | 42 |
| α-helix | 863 | 1 | |
| β-strand | 868-876 | 9 | 42 |
| α-helix | 877-880 | 4 | |
| α-helix | 883-890 | 8 | |
| β-strand | 896-906 | 11 | 42 |
| α-helix | 907 | 1 | |
| α-helix | 926-928 | 3 | |
| α-helix | 929-941 | 13 | |
Chain d: 3 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 18-26 | 9 | |
| α-helix | 30-37 | 8 | |
| β-strand | 41-46 | 6 | 8 |
| β-strand | 51-59 | 9 | 8 |
| β-strand | 65-75 | 11 | 8 |
| β-strand | 91-101 | 11 | 8 |
| α-helix | 103-105 | 3 | |
| β-strand | 106-111 | 6 | 8 |
26 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Probable ATP-dependent RNA helicase DHX35 | 35 | protein | 703 | Homo sapiens | Q9H5Z1 (AlphaFold model) |
| U5 snRNA | 5 | RNA | 116 | Homo sapiens | |
| Pre-mRNA-processing-splicing factor 8 | A | protein | 2335 | Homo sapiens | Q6P2Q9 (AlphaFold model) |
| U5 small nuclear ribonucleoprotein 200 kDa helicase | B | protein | 2136 | Homo sapiens | O75643 (AlphaFold model) |
| 116 kDa U5 small nuclear ribonucleoprotein component | C | protein | 972 | Homo sapiens | Q15029 (AlphaFold model) |
| U5 small nuclear ribonucleoprotein 40 kDa protein | E | protein | 357 | Homo sapiens | Q96DI7 |
| G patch domain-containing protein 1 | GP | protein | 931 | Homo sapiens | Q9BRR8 |
| Pre-mRNA-splicing factor SYF1 | I | protein | 855 | Homo sapiens | Q9HCS7 |
| Crooked neck-like protein 1 | J | protein | 848 | Homo sapiens | Q9BZJ0 |
| Pre-mRNA-splicing factor SPF27 | K | protein | 225 | Homo sapiens | O75934 |
| Cell division cycle 5-like protein | L | protein | 802 | Homo sapiens | Q99459 |
| Pre-mRNA-splicing factor SYF2 | M | protein | 243 | Homo sapiens | O95926 |
22 more molecules are not listed.
Sequence of entity 1 (35), FASTA
>9S2F_1 Probable ATP-dependent RNA helicase DHX35 (chains 35)
MAAPVGPVKFWRPGTEGPGVSISEERQSLAENSGTTVVYNPYAALSIEQQRQKLPVFKLR
NHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTVAGRV
AEERGAVLGHEVGYCIRFDDCTDQLATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHE
RTLYTDIAIGLLKKIQKKRGDLRLIVASATLDADKFRDFFNQNETSDPARDTCVILTVEG
RTFPVDIFYLQSPVPDYIKSTVETVVKIHQTEGDGDVLAFLTGQEEVETVVSMLIEQARA
LARTGMKRHLRVLPMYAGLPSFEQMKVFERVSRSVRKVIVATNVAETSITISGIVYVIDC
GFVKLRAYNPRTAIECLVVVPVSQASANQRAGRGGRSRSGKCYRLYTEEAFDKLPQSTVP
EMQRSNLAPVILQLKALGIDNVLRFHFMSPPPAQSMVQALELLYALGGLDKDCRLTEPLG
MRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNIFVVPPNQKSHAIRVHRKFAV
EEGDHLTMLNIYEAFIKHNKDSKWCQEHFLNYKGLVRAATVREQLKKLLVKFQVPRKSSE
GDPDLVLRCIVSGFFANAARFHSTGAYRTIRDDHELHIHPASVLYAEKPPRWVIYNEVIQ
TSKYYMRDVTAIESAWLLELAPHFYQQGTHLSLKAKRAKVQDP
Sequence of entity 2 (5), FASTA
>9S2F_2 U5 snRNA (chains 5)
AUACUCUGGUUUCUCUUCAGAUCGCAUAAAUCUUUCGCCUUUUACUAAAGAUUUCCGUGG
AGAGGAACAACUCUGAGUCUUAACCCAAUUUUUUGAGCCUUGCCUUGGCAAGGCUA
Sequence of entity 3 (A), FASTA
>9S2F_3 Pre-mRNA-processing-splicing factor 8 (chains A)
MAGVFPYRGPGNPVPGPLAPLPDYMSEEKLQEKARKWQQLQAKRYAEKRKFGFVDAQKED
MPPEHVRKIIRDHGDMTNRKFRHDKRVYLGALKYMPHAVLKLLENMPMPWEQIRDVPVLY
HITGAISFVNEIPWVIEPVYISQWGSMWIMMRREKRDRRHFKRMRFPPFDDEEPPLDYAD
NILDVEPLEAIQLELDPEEDAPVLDWFYDHQPLRDSRKYVNGSTYQRWQFTLPMMSTLYR
LANQLLTDLVDDNYFYLFDLKAFFTSKALNMAIPGGPKFEPLVRDINLQDEDWNEFNDIN
KIIIRQPIRTEYKIAFPYLYNNLPHHVHLTWYHTPNVVFIKTEDPDLPAFYFDPLINPIS
HRHSVKSQEPLPDDDEEFELPEFVEPFLKDTPLYTDNTANGIALLWAPRPFNLRSGRTRR
ALDIPLVKNWYREHCPAGQPVKVRVSYQKLLKYYVLNALKHRPPKAQKKRYLFRSFKATK
FFQSTKLDWVEVGLQVCRQGYNMLNLLIHRKNLNYLHLDYNFNLKPVKTLTTKERKKSRF
GNAFHLCREVLRLTKLVVDSHVQYRLGNVDAFQLADGLQYIFAHVGQLTGMYRYKYKLMR
QIRMCKDLKHLIYYRFNTGPVGKGPGCGFWAAGWRVWLFFMRGITPLLERWLGNLLARQF
EGRHSKGVAKTVTKQRVESHFDLELRAAVMHDILDMMPEGIKQNKARTILQHLSEAWRCW
KANIPWKVPGLPTPIENMILRYVKAKADWWTNTAHYNRERIRRGATVDKTVCKKNLGRLT
RLYLKAEQERQHNYLKDGPYITAEEAVAVYTTTVHWLESRRFSPIPFPPLSYKHDTKLLI
LALERLKEAYSVKSRLNQSQREELGLIEQAYDNPHEALSRIKRHLLTQRAFKEVGIEFMD
LYSHLVPVYDVEPLEKITDAYLDQYLWYEADKRRLFPPWIKPADTEPPPLLVYKWCQGIN
NLQDVWETSEGECNVMLESRFEKMYEKIDLTLLNRLLRLIVDHNIADYMTAKNNVVINYK
DMNHTNSYGIIRGLQFASFIVQYYGLVMDLLVLGLHRASEMAGPPQMPNDFLSFQDIATE
AAHPIRLFCRYIDRIHIFFRFTADEARDLIQRYLTEHPDPNNENIVGYNNKKCWPRDARM
RLMKHDVNLGRAVFWDIKNRLPRSVTTVQWENSFVSVYSKDNPNLLFNMCGFECRILPKC
RTSYEEFTHKDGVWNLQNEVTKERTAQCFLRVDDESMQRFHNRVRQILMASGSTTFTKIV
NKWNTALIGLMTYFREAVVNTQELLDLLVKCENKIQTRIKIGLNSKMPSRFPPVVFYTPK
ELGGLGMLSMGHVLIPQSDLRWSKQTDVGITHFRSGMSHEEDQLIPNLYRYIQPWESEFI
DSQRVWAEYALKRQEAIAQNRRLTLEDLEDSWDRGIPRINTLFQKDRHTLAYDKGWRVRT
DFKQYQVLKQNPFWWTHQRHDGKLWNLNNYRTDMIQALGGVEGILEHTLFKGTYFPTWEG
LFWEKASGFEESMKWKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGI
FMHGKIPTLKISLIQIFRAHLWQKIHESIVMDLCQVFDQELDALEIETVQKETIHPRKSY
KMNSSCADILLFASYKWNVSRPSLLADSKDVMDSTTTQKYWIDIQLRWGDYDSHDIERYA
RAKFLDYTTDNMSIYPSPTGVLIAIDLAYNLHSAYGNWFPGSKPLIQQAMAKIMKANPAL
YVLRERIRKGLQLYSSEPTEPYLSSQNYGELFSNQIIWFVDDTNVYRVTIHKTFEGNLTT
KPINGAIFIFNPRTGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQ
IIVTRKGMLDPLEVHLLDFPNIVIKGSELQLPFQACLKVEKFGDLILKATEPQMVLFNLY
DDWLKTISSYTAFSRLILILRALHVNNDRAKVILKPDKTTITEPHHIWPTLTDEEWIKVE
VQLKDLILADYGKKNNVNVASLTQSEIRDIILGMEISAPSQQRQQIAEIEKQTKEQSQLT
ATQTRTVNKHGDEIITSTTSNYETQTFSSKTEWRVRAISAANLHLRTNHIYVSSDDIKET
GYTYILPKNVLKKFICISDLRAQIAGYLYGVSPPDNPQVKEIRCIVMVPQWGTHQTVHLP
GQLPQHEYLKEMEPLGWIHTQPNESPQLSPQDVTTHAKIMADNPSWDGEKTIIITCSFTP
GSCTLTAYKLTPSGYEWGRQNTDKGNNPKGYLPSHYERVQMLLSDRFLGFFMVPAQSSWN
YNFMGVRHDPNMKYELQLANPKEFYHEVHRPSHFLNFALLQEGEVYSADREDLYA
Sequence of entity 4 (B), FASTA
>9S2F_4 U5 small nuclear ribonucleoprotein 200 kDa helicase (chains B)
MADVTARSLQYEYKANSNLVLQADRSLIDRTRRDEPTGEVLSLVGKLEGTRMGDKAQRTK
PQMQEERRAKRRKRDEDRHDINKMKGYTLLSEGIDEMVGIIYKPKTKETRETYEVLLSFI
QAALGDQPRDILCGAADEVLAVLKNEKLRDKERRKEIDLLLGQTDDTRYHVLVNLGKKIT
DYGGDKEIQNMDDNIDETYGVNVQFESDEEEGDEDVYGEVREEASDDDMEGDEAVVRCTL
SANLVASGELMSSKKKDLHPRDIDAFWLQRQLSRFYDDAIVSQKKADEVLEILKTASDDR
ECENQLVLLLGFNTFDFIKVLRQHRMMILYCTLLASAQSEAEKERIMGKMEADPELSKFL
YQLHETEKEDLIREERSRRERVRQSRMDTDLETMDLDQGGEALAPRQVLDLEDLVFTQGS
HFMANKRCQLPDGSFRRQRKGYEEVHVPALKPKPFGSEEQLLPVEKLPKYAQAGFEGFKT
LNRIQSKLYRAALETDENLLLCAPTGAGKTNVALMCMLREIGKHINMDGTINVDDFKIIY
IAPMRSLVQEMVGSFGKRLATYGITVAELTGDHQLCKEEISATQIIVCTPEKWDIITRKG
GERTYTQLVRLIILDEIHLLHDDRGPVLEALVARAIRNIEMTQEDVRLIGLSATLPNYED
VATFLRVDPAKGLFYFDNSFRPVPLEQTYVGITEKKAIKRFQIMNEIVYEKIMEHAGKNQ
VLVFVHSRKETGKTARAIRDMCLEKDTLGLFLREGSASTEVLRTEAEQCKNLELKDLLPY
GFAIHHAGMTRVDRTLVEDLFADKHIQVLVSTATLAWGVNLPAHTVIIKGTQVYSPEKGR
WTELGALDILQMLGRAGRPQYDTKGEGILITSHGELQYYLSLLNQQLPIESQMVSKLPDM
LNAEIVLGNVQNAKDAVNWLGYAYLYIRMLRSPTLYGISHDDLKGDPLLDQRRLDLVHTA
ALMLDKNNLVKYDKKTGNFQVTELGRIASHYYITNDTVQTYNQLLKPTLSEIELFRVFSL
SSEFKNITVREEEKLELQKLLERVPIPVKESIEEPSAKINVLLQAFISQLKLEGFALMAD
MVYVTQSAGRLMRAIFEIVLNRGWAQLTDKTLNLCKMIDKRMWQSMCPLRQFRKLPEEVV
KKIEKKNFPFERLYDLNHNEIGELIRMPKMGKTIHKYVHLFPKLELSVHLQPITRSTLKV
ELTITPDFQWDEKVHGSSEAFWILVEDVDSEVILHHEYFLLKAKYAQDEHLITFFVPVFE
PLPPQYFIRVVSDRWLSCETQLPVSFRHLILPEKYPPPTELLDLQPLPVSALRNSAFESL
YQDKFPFFNPIQTQVFNTVYNSDDNVFVGAPTGSGKTICAEFAILRMLLQSSEGRCVYIT
PMEALAEQVYMDWYEKFQDRLNKKVVLLTGETSTDLKLLGKGNIIISTPEKWDILSRRWK
QRKNVQNINLFVVDEVHLIGGENGPVLEVICSRMRYISSQIERPIRIVALSSSLSNAKDV
AHWLGCSATSTFNFHPNVRPVPLELHIQGFNISHTQTRLLSMAKPVYHAITKHSPKKPVI
VFVPSRKQTRLTAIDILTTCAADIQRQRFLHCTEKDLIPYLEKLSDSTLKETLLNGVGYL
HEGLSPMERRLVEQLFSSGAIQVVVASRSLCWGMNVAAHLVIIMDTQYYNGKIHAYVDYP
IYDVLQMVGHANRPLQDDEGRCVIMCQGSKKDFFKKFLYEPLPVESHLDHCMHDHFNAEI
VTKTIENKQDAVDYLTWTFLYRRMTQNPNYYNLQGISHRHLSDHLSELVEQTLSDLEQSK
CISIEDEMDVAPLNLGMIAAYYYINYTTIELFSMSLNAKTKVRGLIEIISNAAEYENIPI
RHHEDNLLRQLAQKVPHKLNNPKFNDPHVKTNLLLQAHLSRMQLSAELQSDTEEILSKAI
RLIQACVDVLSSNGWLSPALAAMELAQMVTQAMWSKDSYLKQLPHFTSEHIKRCTDKGVE
SVFDIMEMEDEERNALLQLTDSQIADVARFCNRYPNIELSYEVVDKDSIRSGGPVVVLVQ
LEREEEVTGPVIAPLFPQKREEGWWVVIGDAKSNSLISIKRLTLQQKAKVKLDFVAPATG
AHNYTLYFMSDAYMGCDQEYKFSVDVKEAETDSDSD
Sequence of entity 5 (C), FASTA
>9S2F_5 116 kDa U5 small nuclear ribonucleoprotein component (chains C)
MDTDLYDEFGNYIGPELDSDEDDDELGRETKDLDEMDDDDDDDDVGDHDDDHPGMEVVLH
EDKKYYPTAEEVYGPEVETIVQEEDTQPLTEPIIKPVKTKKFTLMEQTLPVTVYEMDFLA
DLMDNSELIRNVTLCGHLHHGKTCFVDCLIEQTHPEIRKRYDQDLCYTDILFTEQERGVG
IKSTPVTVVLPDTKGKSYLFNIMDTPGHVNFSDEVTAGLRISDGVVLFIDAAEGVMLNTE
RLIKHAVQERLAVTVCINKIDRLILELKLPPTDAYYKLRHIVDEVNGLISMYSTDENLIL
SPLLGNVCFSSSQYSICFTLGSFAKIYADTFGDINYQEFAKRLWGDIYFNPKTRKFTKKA
PTSSSQRSFVEFILEPLYKILAQVVGDVDTSLPRTLDELGIHLTKEELKLNIRPLLRLVC
KKFFGEFTGFVDMCVQHIPSPKVGAKPKIEHTYTGGVDSDLGEAMSDCDPDGPLMCHTTK
MYSTDDGVQFHAFGRVLSGTIHAGQPVKVLGENYTLEDEEDSQICTVGRLWISVARYHIE
VNRVPAGNWVLIEGVDQPIVKTATITEPRGNEEAQIFRPLKFNTTSVIKIAVEPVNPSEL
PKMLDGLRKVNKSYPSLTTKVEESGEHVILGTGELYLDCVMHDLRKMYSEIDIKVADPVV
TFCETVVETSSLKCFAETPNKKNKITMIAEPLEKGLAEDIENEVVQITWNRKKLGEFFQT
KYDWDLLAARSIWAFGPDATGPNILVDDTLPSEVDKALLGSVKDSIVQGFQWGTREGPLC
DELIRNVKFKILDAVVAQEPLHRGGGQIIPTARRVVYSAFLMATPRLMEPYYFVEVQAPA
DCVSAVYTVLARRRGHVTQDAPIPGSPLYTIKAFIPAIDSFGFETDLRTHTQGQAFSLSV
FHHWQIVPGDPLDKSIVIRPLEPQPAPHLAREFMIKTRRRKGLSEDVSISKFFDDPMLLE
LAKQDVVLNYPM
Sequence of entity 6 (E), FASTA
>9S2F_6 U5 small nuclear ribonucleoprotein 40 kDa protein (chains E)
MIEQQKRKGPELPLVPVKRQRHELLLGAGSGPGAGQQQATPGALLQAGPPRCSSLQAPIM
LLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTD
GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD
IRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTG
LSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKI
AAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ
Sequence of entity 7 (GP), FASTA
>9S2F_7 G patch domain-containing protein 1 (chains GP)
MAARDSDSEEDLVSYGTGLEPLEEGERPKKPIPLQDQTVRDEKGRYKRFHGAFSGGFSAG
YFNTVGSKEGWTPSTFVSSRQNRADKSVLGPEDFMDEEDLSEFGIAPKAIVTTDDFASKT
KDRIREKARQLAAATAPIPGATLLDDLITPAKLSVGFELLRKMGWKEGQGVGPRVKRRPR
RQKPDPGVKIYGCALPPGSSEGSEGEDDDYLPDNVTFAPKDVTPVDFTPKDNVHGLAYKG
LDPHQALFGTSGEHFNLFSGGSERAGDLGEIGLNKGRKLGISGQAFGVGALEEEDDDIYA
TETLSKYDTVLKDEEPGDGLYGWTAPRQYKNQKESEKDLRYVGKILDGFSLASKPLSSKK
IYPPPELPRDYRPVHYFRPMVAATSENSHLLQVLSESAGKATPDPGTHSKHQLNASKRAE
LLGETPIQGSATSVLEFLSQKDKERIKEMKQATDLKAAQLKARSLAQNAQSSRAQLSPAA
AAGHCSWNMALGGGTATLKASNFKPFAKDPEKQKRYDEFLVHMKQGQKDALERCLDPSMT
EWERGRERDEFARAALLYASSHSTLSSRFTHAKEEDDSDQVEVPRDQENDVGDKQSAVKM
KMFGKLTRDTFEWHPDKLLCKRFNVPDPYPDSTLVGLPRVKRDKYSVFNFLTLPETASLP
TTQASSEKVSQHRGPDKSRKPSRWDTSKHEKKEDSISEFLSLARSKAEPPKQQSSPLVNK
EEEHAPELSANQTVNKDVDAQAEGEGSRPSMDLFRAIFASSSDEKSSSSEDEQGDSEDDQ
AGSGEANFQSSQDTDLGETSSVAHALVPAPQEPPPSFPIQKMQIDEREEFGPRLPPVFCP
NARQTLEVPQKEKHKKNKDKHKAKKEHRRKKEKKKKHRKHKHKGKQKNKKPEKSSSSESS
DSSDSQSDEETADVSPQELLRRLKSLPLRRQ
Sequence of entity 8 (I), FASTA
>9S2F_8 Pre-mRNA-splicing factor SYF1 (chains I)
MVVMARLSRPERPDLVFEEEDLPYEEEIMRNQFSVKCWLRYIEFKQGAPKPRLNQLYERA
LKLLPCSYKLWYRYLKARRAQVKHRCVTDPAYEDVNNCHERAFVFMHKMPRLWLDYCQFL
MDQGRVTHTRRTFDRALRALPITQHSRIWPLYLRFLRSHPLPETAVRGYRRFLKLSPESA
EEYIEYLKSSDRLDEAAQRLATVVNDERFVSKAGKSNYQLWHELCDLISQNPDKVQSLNV
DAIIRGGLTRFTDQLGKLWCSLADYYIRSGHFEKARDVYEEAIRTVMTVRDFTQVFDSYA
QFEESMIAAKMETASELGREEEDDVDLELRLARFEQLISRRPLLLNSVLLRQNPHHVHEW
HKRVALHQGRPREIINTYTEAVQTVDPFKATGKPHTLWVAFAKFYEDNGQLDDARVILEK
ATKVNFKQVDDLASVWCQCGELELRHENYDEALRLLRKATALPARRAEYFDGSEPVQNRV
YKSLKVWSMLADLEESLGTFQSTKAVYDRILDLRIATPQIVINYAMFLEEHKYFEESFKA
YERGISLFKWPNVSDIWSTYLTKFIARYGGRKLERARDLFEQALDGCPPKYAKTLYLLYA
QLEEEWGLARHAMAVYERATRAVEPAQQYDMFNIYIKRAAEIYGVTHTRGIYQKAIEVLS
DEHAREMCLRFADMECKLGEIDRARAIYSFCSQICDPRTTGAFWQTWKDFEVRHGNEDTI
KEMLRIRRSVQATYNTQVNFMASQMLKVSGSATGTVSDLAPGQSGMDDMKLLEQRAEQLA
AEAERDQPLRAQSKILFVRSDASREELAELAQQVNPEEIQLGEDEDEDEMDLEPNEVRLE
QQSVPAAVFGSLKED
Sequence of entity 9 (J), FASTA
>9S2F_9 Crooked neck-like protein 1 (chains J)
MTATVENLTFQKDTLGNAVDKNTSRLELRSYSLAGRHGSTEPLVLAWSSQFRRLTWGCAL
DALHRSPCVAASQHGVTHLIRSSRTPHSTRCRKEDAQPGHHGNGAASVTAQARGQRSVLQ
VPLPVPRSCLFSESFVVSVSSQSRFLASVPGTGVQRSTAADMAASTAAGKQRIPKVAKVK
NKAPAEVQITAEQLLREAKERELELLPPPPQQKITDEEELNDYKLRKRKTFEDNIRKNRT
VISNWIKYAQWEESLKEIQRARSIYERALDVDYRNITLWLKYAEMEMKNRQVNHARNIWD
RAITTLPRVNQFWYKYTYMEEMLGNVAGARQVFERWMEWQPEEQAWHSYINFELRYKEVD
RARTIYERFVLVHPDVKNWIKYARFEEKHAYFAHARKVYERAVEFFGDEHMDEHLYVAFA
KFEENQKEFERVRVIYKYALDRISKQDAQELFKNYTIFEKKFGDRRGIEDIIVSKRRFQY
EEEVKANPHNYDAWFDYLRLVESDAEAEAVREVYERAIANVPPIQEKRHWKRYIYLWINY
ALYEELEAKDPERTRQVYQASLELIPHKKFTFAKMWILYAQFEIRQKNLSLARRALGTSI
GKCPKNKLFKVYIELELQLREFDRCRKLYEKFLEFGPENCTSWIKFAELETILGDIDRAR
AIYELAISQPRLDMPEVLWKSYIDFEIEQEETERTRNLYRRLLQRTQHVKVWISFAQFEL
SSGKEGSLTKCRQIYEEANKTMRNCEEKEERLMLLESWRSFEEEFGTASDKERVDKLMPE
KVKKRRKVQTDDGSDAGWEEYFDYIFPEDAANQPNLKLLAMAKLWKKQQQEKEDAEHHPD
EDVDESES
Sequence of entity 10 (K), FASTA
>9S2F_10 Pre-mRNA-splicing factor SPF27 (chains K)
MAGTGLVAGEVVVDALPYFDQGYEAPGVREAAAALVEEETRRYRPTKNYLSYLTAPDYSA
FETDIMRNEFERLAARQPIELLSMKRYELPAPSSGQKNDITAWQECVNNSMAQLEHQAVR
IENLELMSQHGCNAWKVYNENLVHMIEHAQKELQKLRKHIQDLNWQRKNMQLTAGSKLRE
MESNWVSLVSKNYEIERTIVQLENEIYQIKQQHGEANKENIRQDF
Sequence of entity 11 (L), FASTA
>9S2F_11 Cell division cycle 5-like protein (chains L)
MPRIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKK
TEWSREEEEKLLHLAKLMPTQWRTIAPIIGRTAAQCLEHYEFLLDKAAQRDNEEETTDDP
RKLKPGEIDPNPETKPARPDPIDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEAR
RLAALQKRRELRAAGIEIQKKRKRKRGVDYNAEIPFEKKPALGFYDTSEENYQALDADFR
KLRQQDLDGELRSEKEGRDRKKDKQHLKRKKESDLPSAILQTSGVSEFTKKRSKLVLPAP
QISDAELQEVVKVGQASEIARQTAEESGITNSASSTLLSEYNVTNNSVALRTPRTPASQD
RILQEAQNLMALTNVDTPLKGGLNTPLHESDFSGVTPQRQVVQTPNTVLSTPFRTPSNGA
EGLTPRSGTTPKPVINSTPGRTPLRDKLNINPEDGMADYSDPSYVKQMERESREHLRLGL
LGLPAPKNDFEIVLPENAEKELEEREIDDTYIEDAADVDARKQAIRDAERVKEMKRMHKA
VQKDLPRPSEVNETILRPLNVEPPLTDLQKSEELIKKEMITMLHYDLLHHPYEPSGNKKG
KTVGFGTNNSEHITYLEHNPYEKFSKEELKKAQDVLVQEMEVVKQGMSHGELSSEAYNQV
WEECYSQVLYLPGQSRYTRANLASKKDRIESLEKRLEINRGHMTTEAKRAAKMEKKMKIL
LGGYQSRAMGLMKQLNDLWDQIEQAHLELRTFEELKKHEDSAIPRRLECLKEDVQRQQER
EKELQHRYADLLLEKETLKSKF
Sequence of entity 12 (M), FASTA
>9S2F_12 Pre-mRNA-splicing factor SYF2 (chains M)
MAAIAASEVLVDSAEEGSLAAAAELAAQKREQRLRKFRELHLMRNEARKLNHQEVVEEDK
RLKLPANWEAKKARLEWELKEEEKKKECAARGEDYEKVKLLEISAEDAERWERKKKRKNP
DLGFSDYAAAQLRQYHRLTKQIKPDMETYERLREKHGEEFFPTSNSLLHGTHVPSTEEID
RMVIDLEKQIEKRDKYSRRRPYNDDADIDYINERNAKFNKKAERFYGKYTAEIKQNLERG
TAV
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| IHP | Inositol hexakisphosphate | C6 H18 O24 P6 | 1 |
| GTP | Guanosine-5'-triphosphate | C10 H16 N5 O14 P3 | 1 |
| MG | Magnesium ion | Mg | 1 |
| ZN | Zinc ion | Zn | 3 |
Primary citation
Mechanisms of spliceosome termination. Boreikaite, V., Vorlaender, M.K., Phillips, A.W. et al. To be published.
Browse structure collections
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