9SA6: Apolipoprotein E

Human Apolipoprotein E4 (ApoE4) N-terminal domain (space group P212121). Determined by X-ray diffraction at 1.89 Å resolution. Released 19 Aug 2026.

Method: X-ray diffraction
Resolution: 1.89 Å
Organism: Homo sapiens
Chains: 1
Atoms: 1,322
Mol. weight: 23.98 kDa
Released: 19 Aug 2026

Explore 9SA6 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9SA6 contains 6 α-helices and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 6 helices, 0 β-strands

Element	Residues	Length
α-helix	25-42	18
α-helix	45-52	8
α-helix	55-78	24
α-helix	82-84	3
α-helix	88-124	37
α-helix	131-164	34

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Apolipoprotein E	A	protein	207	Homo sapiens	P02649 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>9SA6_1 Apolipoprotein E (chains A)
GPHMKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQV
TQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVRGRLV
QYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSA
IRERLGPLVEQGRVRAATVGSLAGQPL

Primary citation

Human Apolipoprotein E4 (ApoE4) N-terminal domain. Marek, M., Snajdarova, K. To be published.

Other PDB entries of the same protein (UniProt P02649 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7FCR 1.4 Å, Crystal structure of the N-terminal domain of mutants of Human Apolipoprotein-E (ApoE)
8AX9 1.55 Å, Human Apolipoprotein E4 (ApoE4) N-terminal domain (space group P212121)
8AX8 1.55 Å, Human Apolipoprotein E4 (ApoE4) N-terminal domain (space group P3121)
7FCS 1.6 Å, Crystal structure of the N-terminal domain of mutants of Human Apolipoprotein-E (ApoE)
1GS9 1.7 Å, Apolipoprotein E4, 22k domain
6NCO 1.71 Å, Fragment-based Discovery of an apoE4 Stabilizer
1OR3 1.73 Å, Apolipoprotein E3 (APOE3), trigonal truncation mutant 165
8CE0 1.75 Å, N-terminal domain of human apolipoprotein E
1NFN 1.8 Å, Apolipoprotein E3 (APOE3)
6NCN 1.82 Å, Fragment-based Discovery of an apoE4 Stabilizer
1BZ4 1.85 Å, Apolipoprotein E3 (apo-E3), truncation mutant 165
1H7I 1.9 Å, Apolipoprotein E3 22kD fragment LYS146GLN mutant

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