9T2C: Human Single Domain TCR-like Antibody A10

Human Single Domain TCR-like Antibody A10 in complex with NY-ESO-1(C165V):HLA-A0201. Determined by X-ray diffraction at 2.89 Å resolution. Released 30 Sept 2026.

Method: X-ray diffraction
Resolution: 2.89 Å
Organism: Homo sapiens
Chains: 8
Atoms: 7,749
Mol. weight: 122.17 kDa
Released: 30 Sept 2026

Explore 9T2C in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9T2C contains 28 α-helices and 77 β-strands across 6 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 11 helices, 19 β-strands

Element	Residues	Length	Sheet
β-strand	3-12	10	1
α-helix	20	1
β-strand	21-28	8	1
β-strand	31-37	7	1
α-helix	45	1
β-strand	46-47	2	1
α-helix	50-53	4
α-helix	57-84	28
β-strand	94-103	10	1
β-strand	109-118	10	1
β-strand	121-126	6	1
β-strand	133-135	3	1
α-helix	138-150	13
α-helix	152-158	7
α-helix	159-164	6
α-helix	165-174	10
α-helix	176-179	4
β-strand	186-193	8	2
β-strand	198-208	11	2
β-strand	213-214	2	3
β-strand	217-219	3	4
β-strand	222-223	2	4
β-strand	228-230	3	2
α-helix	231-233	3
β-strand	234-235	2	2
β-strand	241-250	10	2
α-helix	254-256	3
β-strand	257-261	5	4
β-strand	262-263	2	3
β-strand	270-272	3	4

Chain B: 2 helices, 10 β-strands

Element	Residues	Length	Sheet
β-strand	1-3	3	5
α-helix	4-5	2
β-strand	6-11	6	6
β-strand	21-28	8	6
β-strand	36-41	6	7
β-strand	44-45	2	7
α-helix	46	1
β-strand	50-51	2	6
β-strand	55-56	2	6
β-strand	62-70	9	6
β-strand	78-83	6	7
β-strand	91-94	4	7

Chain D: 8 helices, 13 β-strands

Element	Residues	Length	Sheet
β-strand	3-12	10	8
α-helix	20	1
β-strand	21-28	8	8
β-strand	31-37	7	8
β-strand	46-47	2	8
α-helix	57-84	28
β-strand	94-103	10	8
β-strand	109-118	10	8
β-strand	121-126	6	8
β-strand	133-135	3	8
α-helix	138-150	13
α-helix	152-158	7
α-helix	159-163	5
α-helix	164-174	11
α-helix	176-179	4
β-strand	186-189	4	9
β-strand	201-208	8	9
β-strand	230	1	9
α-helix	231-233	3
β-strand	234-235	2	9
β-strand	241-247	7	9

Chain E: 3 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	1-3	3	5
α-helix	4-5	2
β-strand	6-11	6	10
β-strand	21-30	10	10
β-strand	31	1	5
β-strand	36-41	6	11
β-strand	44-45	2	11
α-helix	46	1
β-strand	50-51	2	10
α-helix	52-54	3
β-strand	55-56	2	10
β-strand	62-70	9	10
β-strand	78-83	6	11
β-strand	91-94	4	11

Chain G: 2 helices, 12 β-strands

Element	Residues	Length	Sheet
β-strand	4-7	4	12
β-strand	11-12	2	13
β-strand	18-24	7	12
β-strand	34-40	7	14
β-strand	47-53	7	14
β-strand	58-60	3	14
α-helix	65-67	3
β-strand	68-71	4	12
β-strand	79-83	5	12
α-helix	88-90	3
β-strand	92-99	8	14
β-strand	109-110	2	14
β-strand	114-116	3	14
β-strand	117-118	2	13

Chain H: 2 helices, 12 β-strands

Element	Residues	Length	Sheet
β-strand	3-7	5	15
β-strand	11-12	2	16
β-strand	18-25	8	15
β-strand	34-40	7	17
β-strand	47-53	7	17
β-strand	58-60	3	17
α-helix	65-67	3
β-strand	68-73	6	15
β-strand	78-83	6	15
α-helix	88-90	3
β-strand	92-99	8	17
β-strand	108-110	3	17
β-strand	114-116	3	17
β-strand	117-118	2	16

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
MHC class I antigen	A, D	protein	276	Homo sapiens	A5I8L1 (AlphaFold model)
Beta-2-microglobulin	B, E	protein	100	Homo sapiens	P61769 (AlphaFold model)
Cancer/testis antigen 1	C, F	protein	9	Homo sapiens	P78358 (AlphaFold model)
A10 single-domain antibody	G, H	protein	147	Homo sapiens

Sequence of entity 1 (A, D), FASTA

>9T2C_1 MHC class I antigen (chains A, D)
MGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEY
WDGETRKVKAHSQTHRVDLGTLRGYYNQSEAGSHTVQRMYGCDVGSDWRFLRGYHQYAYD
GKDYIALKEDLRSWTAADMAAQTTKHKWEAAHVAEQLRAYLEGTCVEWLRRYLENGKETL
QRTDAPKTHMTHHAVSDHEATLRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDG
TFQKWAAVVVPSGQEQRYTCHVQHEGLPKPLTLRWE

Sequence of entity 2 (B, E), FASTA

>9T2C_2 Beta-2-microglobulin (chains B, E)
MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKD
WSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM

Sequence of entity 3 (C, F), FASTA

>9T2C_3 Cancer/testis antigen 1 (chains C, F)
SLLMWITQV

Sequence of entity 4 (G, H), FASTA

>9T2C_4 A10 single-domain antibody (chains G, H)
QVQLQESGPGLVKPSETLSLTCAVSGYSISSGYYWGWYRQPPGKERELIGSIYHSGSTYY
NPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARERDGSGGPFDYWGQGTQVTVSS
GSASASTSEQKLISEFELNGHHHHHHH

Primary citation

Human Single Domain TCR-like Antibody A10 in complex with NY-ESO-1(C165V):HLA-A0201. Cmunt, D., Didelot, G., Lani, R. et al. To be published.

Other PDB entries of the same protein (UniProt A5I8L1 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9SKO 1.49 Å, Crystal structure of HLA-A0201 in complex with peptide LLWNGPMAVS
9SL0 1.6 Å, Crystal structure of HLA-A0201 in complex with peptide LLWNGPMAV
9SKP 1.89 Å, Crystal structure of HLA-A0201 in complex with peptide SLLWNGPMAV
9NMV 1.97 Å, TCR156 S32Halpha bound to HLA A*02:01-PAP
9NMY 2.01 Å, TCR156 S32Qalpha bound to HLA A*02:01-PAP
9T2A 2.04 Å, Human Single Domain TCR-like Antibody 6K23 in complex with NY-ESO-1(C165V):HLA-A0201
9NMU 2.1 Å, TCR156 bound to HLA A*02:01-PAP
9NMW 2.11 Å, TCR156 S30Ealpha S32Qalpha bound to HLA A*02:01-PAP
9NMX 2.19 Å, TCR156 S32Malpha variant bound to HLA A*02:01-PAP
9O5S 2.27 Å, minibinder-antigen complex BXMart1-3-MART1-HLA*A02
9T2B 2.34 Å, Human Single Domain TCR-like Antibody 5F17 in complex with NY-ESO-1(C165V):HLA-A0201
9YTD 2.5 Å, Designed antibody vAB66 targeting PAP-HLA A*02:01

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