9TAW: Human inner kinetochore CCAN
Structure of the human inner kinetochore CCAN bound to DNA. Determined by electron microscopy at 3.54 Å resolution. Released 20 May 2026.
- Method
- Electron microscopy
- Resolution
- 3.54 Å
- Organism
- Homo sapiens
- Chains
- 18
- Atoms
- 28,846
- Mol. weight
- 694.02 kDa
- Released
- 20 May 2026
Explore 9TAW in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
9TAW contains 150 α-helices and 75 β-strands across 16 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain b: 5 helices, 1 β-strand
| Element | Residues | Length | Sheet |
|---|
| α-helix | 258-261 | 4 | |
| α-helix | 262-272 | 11 | |
| α-helix | 297-302 | 6 | |
| α-helix | 304 | 1 | |
| β-strand | 305 | 1 | 8 |
| α-helix | 306 | 1 | |
Chain H: 7 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 36-64 | 29 | |
| α-helix | 76-114 | 39 | |
| α-helix | 117-120 | 4 | |
| α-helix | 125-188 | 64 | |
| α-helix | 195-223 | 29 | |
| α-helix | 227-229 | 3 | |
| α-helix | 231-240 | 10 | |
Chain I: 41 helices, 8 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 62-75 | 14 | |
| α-helix | 83-101 | 19 | |
| β-strand | 104 | 1 | 1 |
| α-helix | 106-118 | 13 | |
| α-helix | 123-131 | 9 | |
| β-strand | 135 | 1 | 1 |
| β-strand | 139 | 1 | 2 |
| α-helix | 142-153 | 12 | |
| α-helix | 158-170 | 13 | |
| α-helix | 172-174 | 3 | |
| β-strand | 175 | 1 | 2 |
| α-helix | 180-184 | 5 | |
| α-helix | 185-190 | 6 | |
| α-helix | 191-193 | 3 | |
| α-helix | 198-208 | 11 | |
| α-helix | 211-213 | 3 | |
| α-helix | 216-229 | 14 | |
| β-strand | 230 | 1 | 3 |
| α-helix | 233-245 | 13 | |
| β-strand | 250-251 | 2 | 4 |
| α-helix | 270-281 | 12 | |
| α-helix | 311-313 | 3 | |
| α-helix | 315-317 | 3 | |
| α-helix | 329-332 | 4 | |
| β-strand | 339 | 1 | 5 |
| α-helix | 341-343 | 3 | |
| α-helix | 347-352 | 6 | |
| β-strand | 357 | 1 | 5 |
| α-helix | 363-368 | 6 | |
| α-helix | 370-379 | 10 | |
| α-helix | 382-399 | 18 | |
| α-helix | 412-427 | 16 | |
| α-helix | 433-442 | 10 | |
| α-helix | 452-459 | 8 | |
| α-helix | 462-464 | 3 | |
| α-helix | 467-470 | 4 | |
| α-helix | 471-475 | 5 | |
| α-helix | 476-483 | 8 | |
| α-helix | 487-513 | 27 | |
| α-helix | 526-550 | 25 | |
| α-helix | 555-575 | 21 | |
| α-helix | 585-592 | 8 | |
| α-helix | 597-624 | 28 | |
| α-helix | 634-651 | 18 | |
| α-helix | 665-671 | 7 | |
| α-helix | 686-688 | 3 | |
| α-helix | 689-696 | 8 | |
| α-helix | 720-726 | 7 | |
| α-helix | 729-739 | 11 | |
Chain K: 6 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 20-43 | 24 | |
| α-helix | 55-76 | 22 | |
| α-helix | 86-148 | 63 | |
| α-helix | 155-187 | 33 | |
| α-helix | 212-225 | 14 | |
| β-strand | 232-233 | 2 | 6 |
| α-helix | 240-249 | 10 | |
| β-strand | 252-254 | 3 | 6 |
| β-strand | 261-264 | 4 | 6 |
Chain L: 14 helices, 17 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 27-36 | 10 | |
| α-helix | 43-44 | 2 | |
| β-strand | 47-48 | 2 | 7 |
| α-helix | 49-50 | 2 | |
| α-helix | 54-56 | 3 | |
| α-helix | 61-67 | 7 | |
| β-strand | 71-77 | 7 | 8 |
| α-helix | 78-79 | 2 | |
| β-strand | 80-81 | 2 | 9 |
| α-helix | 88-103 | 16 | |
| β-strand | 109-110 | 2 | 4 |
| β-strand | 117-123 | 7 | 8 |
| α-helix | 134-136 | 3 | |
| β-strand | 137-143 | 7 | 8 |
| β-strand | 155-163 | 9 | 8 |
| α-helix | 168-171 | 4 | |
| β-strand | 178-179 | 2 | 9 |
| β-strand | 183-188 | 6 | 8 |
| α-helix | 190-204 | 15 | |
| β-strand | 208-210 | 3 | 8 |
| α-helix | 215-227 | 13 | |
| β-strand | 237-243 | 7 | 8 |
| β-strand | 250-256 | 7 | 8 |
| α-helix | 258-268 | 11 | |
| β-strand | 274-275 | 2 | 7 |
| α-helix | 277-295 | 19 | |
| β-strand | 297 | 1 | 10 |
| β-strand | 303-308 | 6 | 8 |
| β-strand | 312-315 | 4 | 8 |
| β-strand | 319-322 | 4 | 8 |
| α-helix | 328-343 | 16 | |
Chain M: 9 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 10-12 | 3 | |
| β-strand | 15-21 | 7 | 11 |
| α-helix | 25-37 | 13 | |
| β-strand | 43-49 | 7 | 11 |
| α-helix | 54-56 | 3 | |
| β-strand | 65-71 | 7 | 11 |
| α-helix | 75-85 | 11 | |
| α-helix | 90-93 | 4 | |
| β-strand | 97-102 | 6 | 11 |
| α-helix | 107-109 | 3 | |
| α-helix | 115-123 | 9 | |
| β-strand | 128-131 | 4 | 11 |
| α-helix | 136-154 | 19 | |
| α-helix | 162-168 | 7 | |
Chain N: 15 helices, 11 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-15 | 13 | |
| α-helix | 21-28 | 8 | |
| α-helix | 33-36 | 4 | |
| α-helix | 45-58 | 14 | |
| α-helix | 63-77 | 15 | |
| β-strand | 83-89 | 7 | 12 |
| α-helix | 94-97 | 4 | |
| α-helix | 101-115 | 15 | |
| β-strand | 120-126 | 7 | 12 |
| β-strand | 130-136 | 7 | 12 |
| β-strand | 150-155 | 6 | 12 |
| β-strand | 160-164 | 5 | 12 |
| α-helix | 167-170 | 4 | |
| α-helix | 172-182 | 11 | |
| β-strand | 187-195 | 9 | 12 |
| α-helix | 198-205 | 8 | |
| β-strand | 237-239 | 3 | 11 |
| α-helix | 242-256 | 15 | |
| α-helix | 260-263 | 4 | |
| β-strand | 264-273 | 10 | 8 |
| β-strand | 291-302 | 12 | 8 |
| α-helix | 309-312 | 4 | |
| β-strand | 315 | 1 | 10 |
| α-helix | 321-324 | 4 | |
| α-helix | 326-329 | 4 | |
| β-strand | 333-336 | 4 | 8 |
Chain O: 9 helices, 9 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 17-26 | 10 | |
| α-helix | 90-108 | 19 | |
| α-helix | 109-111 | 3 | |
| β-strand | 113-117 | 5 | 13 |
| β-strand | 122-130 | 9 | 13 |
| β-strand | 133-143 | 11 | 13 |
| α-helix | 148 | 1 | |
| β-strand | 149-153 | 5 | 13 |
| α-helix | 161-168 | 8 | |
| α-helix | 173-200 | 28 | |
| β-strand | 205 | 1 | 14 |
| α-helix | 208-209 | 2 | |
| β-strand | 210 | 1 | 14 |
| β-strand | 217-224 | 8 | 14 |
| β-strand | 231-238 | 8 | 14 |
| β-strand | 249-253 | 5 | 14 |
| α-helix | 262-277 | 16 | |
| α-helix | 280-288 | 9 | |
8 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| DNA (82-mer) | A | DNA | 171 | Homo sapiens | |
| DNA (80-mer) | B | DNA | 171 | Homo sapiens | |
| Centromere protein H | H | protein | 247 | Homo sapiens | Q9H3R5 (AlphaFold model) |
| Centromere protein I | I | protein | 762 | Homo sapiens | Q92674 (AlphaFold model) |
| Centromere protein K | K | protein | 269 | Homo sapiens | Q9BS16 (AlphaFold model) |
| Centromere protein L | L | protein | 348 | Homo sapiens | Q8N0S6 (AlphaFold model) |
| Centromere protein M | M | protein | 180 | Homo sapiens | Q9NSP4 |
| Centromere protein N | N | protein | 339 | Homo sapiens | Q96H22 |
| Centromere protein O | O | protein | 300 | Homo sapiens | Q9BU64 |
| Centromere protein P | P | protein | 288 | Homo sapiens | Q6IPU0 |
| Centromere protein Q | Q | protein | 215 | Homo sapiens | Q7L2Z9 |
| Centromere protein R | R | protein | 177 | Homo sapiens | Q13352 |
6 more molecules are not listed.
Sequence of entity 1 (A), FASTA
>9TAW_1 DNA (82-MER) (chains A)
TCCAAATGTCCAATTCCAGATACTACAAAAAGAGTGTTTCAAAACTGCTCTATGAAAAGG
AATGTTCAACTCTATGAGTTGAATGCAAACATCACATAGAAGTTTCTGAGAATGCTTCTG
TCTAGTTTTTATGTGAACATATTCCCGTTTCCAACGAAGGCCTCAAAGCGG
Sequence of entity 2 (B), FASTA
>9TAW_2 DNA (80-MER) (chains B)
CCGCTTTGAGGCCTTCGTTGGAAACGGGAATATGTTCACATAAAAACTAGACAGAAGCAT
TCTCAGAAACTTCTATGTGATGTTTGCATTCAACTCATAGAGTTGAACATTCCTTTTCAT
AGAGCAGTTTTGAAACACTCTTTTTGTAGTATCTGGAATTGGACATTTGGA
Sequence of entity 3 (H), FASTA
>9TAW_3 Centromere protein H (chains H)
MEEQPQMQDADEPADSGGEGRAGGPPQVAGAQAACSEDRMTLLLRLRAQTKQQLLEYKSM
VDASEEKTPEQIMQEKQIEAKIEDLENEIEEVKVAFEIKKLALDRMRLSTALKKNLEKIS
RQSSVLMDNMKHLLELNKLIMKSQQESWDLEEKLLDIRKKRLQLKQASESKLLEIQTEKN
KQKIDLDSMENSERIKIIRQNLQMEIKITTVIQHVFQNLILGSKVNWAEDPALKEIVLQL
EKNVDMM
Sequence of entity 4 (I), FASTA
>9TAW_4 Centromere protein I (chains I)
MSPQKRVKNVQAQNRTSQGSSSFQTTLSAWKVKQDPSNSKNISKHGQNNPVGDYEHADDQ
AEEDALQMAVGYFEKGPIKASQNKDKTLEKHLKTVENVAWKNGLASEEIDILLNIALSGK
FGNAVNTRILKCMIPATVISEDSVVKAVSWLCVGKCSGSTKVLFYRWLVAMFDFIDRKEQ
INLLYGFFFASLQDDALCPYVCHLLYLLTKKENVKPFRVRKLLDLQAKMGMQPHLQALLS
LYKFFAPALISVSLPVRKKIYFKNSENLWKTALLAVKQRNRGPSPEPLKLMLGPANVRPL
KRKWNSLSVIPVLNSSSYTKECGKKEMSLSDCLNRSGSFPLEQLQSFPQLLQNIHCLELP
SQMGSVLNNSLLLHYINCVRDEPVLLRFYYWLSQTLQEECIWYKVNNYEHGKEFTNFLDT
IIRAECFLQEGFYSCEAFLYKSLPLWDGLCCRSQFLQLVSWIPFSSFSEVKPLLFDHLAQ
LFFTSTIYFKCSVLQSLKELLQNWLLWLSMDIHMKPVTNSPLETTLGGSMNSVSKLIHYV
GWLSTTAMRLESNNTFLLHFILDFYEKVCDIYINYNLPLVVLFPPGIFYSALLSLDTSIL
NQLCFIMHRYRKNLTAAKKNELVQKTKSEFNFSSKTYQEFNHYLTSMVGCLWTSKPFGKG
IYIDPEILEKTGVAEYKNSLNVVHHPSFLSYAVSFLLQESPEERTVNVSSIRGKKWSWYL
DYLFSQGLQGLKLFIRSSVHHSSIPRAEGINCNNQYENLYFQ
Sequence of entity 5 (K), FASTA
>9TAW_5 Centromere protein K (chains K)
MNQEDLDPDSTTDVGDVTNTEEELIRECEEMWKDMEECQNKLSLIGTETLTDSNAQLSLL
IMQVKCLTAELSQWQKKTPETIPLTEDVLITLGKEEFQKLRQDLEMVLSTKESKNEKLKE
DLEREQRWLDEQQQIMESLNVLHSELKNKVETFSESRIFNELKTKMLNIKEYKEKLLSTL
GEFLEDHFPLPDRSVKKKKKNIQESSVNLITLHEMLEILINRLFDVPHDPYVKISDSFWP
PYVELLLRNGIALRHPEDPTRIRLEAFHQ
Sequence of entity 6 (L), FASTA
>9TAW_6 Centromere protein L (chains L)
GPLGMDSYSAPESTPSASSRPEDYFIGATPLQKRLESVRKQSSFILTPPRRKIPQCSQLQ
EDVDPQKVAFLLHKQWTLYSLTPLYKFSYSNLKEYSRLLNAFIVAEKQKGLAVEVGEDFN
IKVIFSTLLGMKGTQRDPEAFLVQIVSKSQLPSENREGKVLWTGWFCCVFGDSLLETVSE
DFTCLPLFLANGAESNTAIIGTWFQKTFDCYFSPLAINAFNLSWMAAMWTACKMDHYVAT
TEFLWSVPCSPQSLDISFAIHPEDAKALWDSVHKTPGEVTQEEVDLFMDCLYSHFHRHFK
IHLSATRLVRVSTSVASAHTDGKIKILCHKYLIGVLAYLTELAIFQIE
Sequence of entity 7 (M), FASTA
>9TAW_7 Centromere protein M (chains M)
MSVLRPLDKLPGLNTATILLVGTEDALLQQLADSMLKEDCASELKVHLAKSLPLPSSVNR
PRIDLIVFVVNLHSKYSLQNTEESLRHVDASFFLGKVCFLATGAGRESHCSIHRHTVVKL
AHTYQSPLLYCDLEVEGFRATMAQRLVRVLQICAGHVPGVSALNLLSLLRSSEGPSLEDL
Sequence of entity 8 (N), FASTA
>9TAW_8 Centromere protein N (chains N)
MDETVAEFIKRTILKIPMNELTTILKAWDFLSENQLQTVNFRQRKESVVQHLIHLCEEKR
ASISDAALLDIIYMQFHQHQKVWEVFQMSKGPGEDVDLFDMKQFKNSFKKILQRALKNVT
VSFRETEENAVWIRIAWGTQYTKPNQYKPTYVVYYSQTPYAFTSSSMLRRNTPLLGQALT
IASKHHQIVKMDLRSRYLDSLKAIVFKQYNQTFETHNSTTPLQERSLGLDINMDSRIIHE
NIVEKERVQRITQETFGDYPQPQLEFAQYKLETKFKSGLNGSILAEREEPLRCLIKFSSP
HLLEALKSLAPAGIADAPLSPLLTCIPNKRMNYFKIRDK
Sequence of entity 9 (O), FASTA
>9TAW_9 Centromere protein O (chains O)
MEQANPLRPDGESKGGVLAHLERLETQVSRSRKQSEELQSVQAQEGALGTKIHKLRRLRD
ELRAVVRHRRASVKACIANVEPNQTVEINEQEALEEKLENVKAILQAYHFTGLSGKLTSR
GVCVCISTAFEGNLLDSYFVDLVIQKPLRIHHHSVPVFIPLEEIAAKYLQTNIQHFLFSL
CEYLNAYSGRKYQADRLQSDFAALLTGPLQRNPLCNLLSFTYKLDPGGQSFPFCARLLYK
DLTATLPTDVTVTCQGVEVLSTSWEEQRASHETLFCTKPLHQVFASFTRKGEKLDMSLVS
Sequence of entity 10 (P), FASTA
>9TAW_10 Centromere protein P (chains P)
MDAELAEVRALQAEIAALRRACEDPPAPWEEKSRVQKSFQAIHQFNLEGWKSSKDLKNQL
GHLESELSFLSTLTGINIRNHSKQTEDLTSTEMTEKSIRKVLQRHRLSGNCHMVTFQLEF
QILEIQNKERLSSAVTDLNIIMEPTECSELSEFVSRAEERKDLFMFFRSLHFFVEWFEYR
KRTFKHLKEKYPDAVYLSEGPSSCSMGIRSASRPGFELVIVWRIQIDEDGKVFPKLDLLT
KVPQRALELDKNRAIETAPLSFRTLVGLLGIEAALESLIKSLCAEENN
Sequence of entity 11 (Q), FASTA
>9TAW_11 Centromere protein Q (chains Q)
MTKHTNLKHGKTAASKRKTWQPLSKSTRDHLQTMMESVIMTILSNSIKEKEEIQYHLNFL
KKRLLQQCETLKVPPKKMEDLTNVSSLLNMERARDKANEEGLALLQEEIDKMVETTELMT
GNIQSLKNKIQILASEVEEEEERVKQMHQINSSGVLSLPELSQKTLKAPTLQKEILALIP
NQNALLKDLDILHNSSQMKSMSTFIEEAYKKLDAS
Sequence of entity 12 (R), FASTA
>9TAW_12 Centromere protein R (chains R)
MPVKRSLKLDGLLEENSFDPSKITRKKSVITYSPTTGTCQMSLFASPTSSEEQKHRNGLS
NEKRKKLNHPSLTESKESTTKDNDEFMMLLSKVEKLSEEIMEIMQNLSSIQALEGSRELE
NLIGISCASHFLKREMQKTKELMTKVNKQKLFEKSTGLPHKASRHLDSYEFLKAILN
Primary citation
Models for the architecture of the human inner kinetochore on centromeric alpha-satellite CENP-A nucleosome arrays. Yu, C., Muir, K.W., Yang, J. et al. Nat Commun (2026) 17. DOI 10.1038/s41467-026-72856-0 · PubMed
Other PDB entries of the same protein (UniProt Q9H3R5 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 7PB4 2.49 Å, Cenp-HIK 3-protein complex
- 28OP 2.7 Å, Structure of the human inner kinetochore CCAN and CENP-C bound to DNA
- 7R5S 2.83 Å, Structure of the human CCAN bound to alpha satellite DNA
- 7PKN 3.2 Å, Structure of the human CCAN deltaCT complex
- 7XHO 3.29 Å, Structure of human inner kinetochore CCAN complex
- 7XHN 3.71 Å, Structure of human inner kinetochore CCAN-DNA complex
- 9TAX 4.5 Å, Structure of the human inner kinetochore CCAN bound to a mono-CENP-A nucleosome
- 7R5V 4.55 Å, Structure of the human CCAN CENP-A alpha-satellite complex
- 7QOO 4.6 Å, Structure of the human inner kinetochore CCAN complex
- 7YYH 8.9 Å, Structure of the human CCANdeltaT CENP-A alpha-satellite complex
- 7YWX 12.0 Å, Structure of the human CCAN CENP-A alpha-satellite complex
- 9TAY 15.5 Å, Structure of the human inner kinetochore CCAN bound to a di-CENP-A nucleosome
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