9TAX: Human inner kinetochore CCAN
Structure of the human inner kinetochore CCAN bound to a mono-CENP-A nucleosome. Determined by electron microscopy at 4.5 Å resolution. Released 20 May 2026.
- Method
- Electron microscopy
- Resolution
- 4.5 Å
- Organism
- Homo sapiens
- Chains
- 27
- Atoms
- 40,202
- Mol. weight
- 922.82 kDa
- Released
- 20 May 2026
Explore 9TAX in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
9TAX contains 203 α-helices and 106 β-strands across 25 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain a: 0 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 516-517 | 2 | 25 |
| β-strand | 523-524 | 2 | 25 |
Chain b: 5 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 258-261 | 4 | |
| α-helix | 262-271 | 10 | |
| α-helix | 272-274 | 3 | |
| α-helix | 298-302 | 5 | |
| β-strand | 304-305 | 2 | 11 |
| β-strand | 516-517 | 2 | 26 |
| α-helix | 519-521 | 3 | |
| β-strand | 523-524 | 2 | 26 |
Chain c: 6 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 47-56 | 10 | |
| α-helix | 64-76 | 13 | |
| α-helix | 84 | 1 | |
| β-strand | 85-86 | 2 | 27 |
| α-helix | 87 | 1 | |
| α-helix | 88-115 | 28 | |
| β-strand | 120-121 | 2 | 28 |
| α-helix | 123-133 | 11 | |
Chain d: 3 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 31-40 | 10 | |
| β-strand | 45-46 | 2 | 28 |
| α-helix | 50-75 | 26 | |
| β-strand | 80-81 | 2 | 27 |
| α-helix | 83-92 | 10 | |
| β-strand | 96-98 | 3 | 29 |
Chain e: 7 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 12-14 | 3 | |
| α-helix | 17-21 | 5 | |
| α-helix | 28-36 | 9 | |
| β-strand | 42-43 | 2 | 30 |
| α-helix | 46-72 | 27 | |
| β-strand | 77-78 | 2 | 31 |
| α-helix | 80-88 | 9 | |
| α-helix | 91-96 | 6 | |
| β-strand | 100-102 | 3 | 32 |
| α-helix | 113-115 | 3 | |
Chain f: 4 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 38-48 | 11 | |
| β-strand | 53-54 | 2 | 31 |
| α-helix | 56-83 | 28 | |
| β-strand | 88-89 | 2 | 30 |
| α-helix | 91-101 | 11 | |
| α-helix | 105-123 | 19 | |
Chain g: 4 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 47-56 | 10 | |
| α-helix | 64-79 | 16 | |
| β-strand | 85-86 | 2 | 33 |
| α-helix | 90-115 | 26 | |
| β-strand | 120-121 | 2 | 34 |
| α-helix | 123-133 | 11 | |
Chain h: 4 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 26-28 | 3 | |
| α-helix | 31-40 | 10 | |
| β-strand | 45-46 | 2 | 34 |
| α-helix | 50-75 | 26 | |
| β-strand | 80-81 | 2 | 33 |
| α-helix | 83-91 | 9 | |
| β-strand | 96-98 | 3 | 32 |
17 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Centromere protein H | H | protein | 247 | Homo sapiens | Q9H3R5 (AlphaFold model) |
| Centromere protein I | I | protein | 762 | Homo sapiens | A0A8C8KX99 (AlphaFold model) |
| Centromere protein K | K | protein | 269 | Homo sapiens | Q9BS16 (AlphaFold model) |
| Centromere protein M | M | protein | 180 | Homo sapiens | Q9NSP4 (AlphaFold model) |
| Centromere protein L | L | protein | 348 | Homo sapiens | Q8N0S6 |
| Isoform 3 of Centromere protein N | N | protein | 347 | Homo sapiens | Q96H22 |
| Centromere protein O | O | protein | 300 | Homo sapiens | Q9BU64 |
| Centromere protein P | P | protein | 288 | Homo sapiens | Q6IPU0 |
| Centromere protein Q | Q | protein | 215 | Homo sapiens | Q7L2Z9 |
| Centromere protein U | U | protein | 211 | Homo sapiens | Q71F23 |
| Centromere protein R | R | protein | 177 | Homo sapiens | Q13352 |
| Centromere protein T | T | protein | 777 | Homo sapiens | Q96BT3 |
10 more molecules are not listed.
Sequence of entity 1 (H), FASTA
>9TAX_1 Centromere protein H (chains H)
MEEQPQMQDADEPADSGGEGRAGGPPQVAGAQAACSEDRMTLLLRLRAQTKQQLLEYKSM
VDASEEKTPEQIMQEKQIEAKIEDLENEIEEVKVAFEIKKLALDRMRLSTALKKNLEKIS
RQSSVLMDNMKHLLELNKLIMKSQQESWDLEEKLLDIRKKRLQLKQASESKLLEIQTEKN
KQKIDLDSMENSERIKIIRQNLQMEIKITTVIQHVFQNLILGSKVNWAEDPALKEIVLQL
EKNVDMM
Sequence of entity 2 (I), FASTA
>9TAX_2 Centromere protein I (chains I)
MSPQKRVKNVQAQNRTSQGSSSFQTTLSAWKVKQDPSNSKNISKHGQNNPVGDYEHADDQ
AEEDALQMAVGYFEKGPIKASQNKDKTLEKHLKTVENVAWKNGLASEEIDILLNIALSGK
FGNAVNTRILKCMIPATVISEDSVVKAVSWLCVGKCSGSTKVLFYRWLVAMFDFIDRKEQ
INLLYGFFFASLQDDALCPYVCHLLYLLTKKENVKPFRVRKLLDLQAKMGMQPHLQALLS
LYKFFAPALISVSLPVRKKIYFKNSENLWKTALLAVKQRNRGPSPEPLKLMLGPANVRPL
KRKWNSLSVIPVLNSSSYTKECGKKEMSLSDCLNRSGSFPLEQLQSFPQLLQNIHCLELP
SQMGSVLNNSLLLHYINCVRDEPVLLRFYYWLSQTLQEECIWYKVNNYEHGKEFTNFLDT
IIRAECFLQEGFYSCEAFLYKSLPLWDGLCCRSQFLQLVSWIPFSSFSEVKPLLFDHLAQ
LFFTSTIYFKCSVLQSLKELLQNWLLWLSMDIHMKPVTNSPLETTLGGSMNSVSKLIHYV
GWLSTTAMRLESNNTFLLHFILDFYEKVCDIYINYNLPLVVLFPPGIFYSALLSLDTSIL
NQLCFIMHRYRKNLTAAKKNELVQKTKSEFNFSSKTYQEFNHYLTSMVGCLWTSKPFGKG
IYIDPEILEKTGVAEYKNSLNVVHHPSFLSYAVSFLLQESPEERTVNVSSIRGKKWSWYL
DYLFSQGLQGLKLFIRSSVHHSSIPRAEGINCNNQYENLYFQ
Sequence of entity 3 (K), FASTA
>9TAX_3 Centromere protein K (chains K)
MNQEDLDPDSTTDVGDVTNTEEELIRECEEMWKDMEECQNKLSLIGTETLTDSNAQLSLL
IMQVKCLTAELSQWQKKTPETIPLTEDVLITLGKEEFQKLRQDLEMVLSTKESKNEKLKE
DLEREQRWLDEQQQIMESLNVLHSELKNKVETFSESRIFNELKTKMLNIKEYKEKLLSTL
GEFLEDHFPLPDRSVKKKKKNIQESSVNLITLHEMLEILINRLFDVPHDPYVKISDSFWP
PYVELLLRNGIALRHPEDPTRIRLEAFHQ
Sequence of entity 4 (M), FASTA
>9TAX_4 Centromere protein M (chains M)
MSVLRPLDKLPGLNTATILLVGTEDALLQQLADSMLKEDCASELKVHLAKSLPLPSSVNR
PRIDLIVFVVNLHSKYSLQNTEESLRHVDASFFLGKVCFLATGAGRESHCSIHRHTVVKL
AHTYQSPLLYCDLEVEGFRATMAQRLVRVLQICAGHVPGVSALNLLSLLRSSEGPSLEDL
Sequence of entity 5 (L), FASTA
>9TAX_5 Centromere protein L (chains L)
GPLGMDSYSAPESTPSASSRPEDYFIGATPLQKRLESVRKQSSFILTPPRRKIPQCSQLQ
EDVDPQKVAFLLHKQWTLYSLTPLYKFSYSNLKEYSRLLNAFIVAEKQKGLAVEVGEDFN
IKVIFSTLLGMKGTQRDPEAFLVQIVSKSQLPSENREGKVLWTGWFCCVFGDSLLETVSE
DFTCLPLFLANGAESNTAIIGTWFQKTFDCYFSPLAINAFNLSWMAAMWTACKMDHYVAT
TEFLWSVPCSPQSLDISFAIHPEDAKALWDSVHKTPGEVTQEEVDLFMDCLYSHFHRHFK
IHLSATRLVRVSTSVASAHTDGKIKILCHKYLIGVLAYLTELAIFQIE
Sequence of entity 6 (N), FASTA
>9TAX_6 Isoform 3 of Centromere protein N (chains N)
MDETVAEFIKRTILKIPMNELTTILKAWDFLSENQLQTVNFRQRKESVVQHLIHLCEEKR
ASISDAALLDIIYMQFHQHQKVWEVFQMSKGPGEDVDLFDMKQFKNSFKKILQRALKNVT
VSFRETEENAVWIRIAWGTQYTKPNQYKPTYVVYYSQTPYAFTSSSMLRRNTPLLGQALT
IASKHHQIVKMDLRSRYLDSLKAIVFKQYNQTFETHNSTTPLQERSLGLDINMDSRIIHE
NIVEKERVQRITQETFGDYPQPQLEFAQYKLETKFKSGLNGSILAERKEPLRCLIKFSSP
HLLEALKSLAPAGIADAPLSPLLTCIPNKRMNYFKIRDKSDLEVLFQ
Sequence of entity 7 (O), FASTA
>9TAX_7 Centromere protein O (chains O)
MEQANPLRPDGESKGGVLAHLERLETQVSRSRKQSEELQSVQAQEGALGTKIHKLRRLRD
ELRAVVRHRRASVKACIANVEPNQTVEINEQEALEEKLENVKAILQAYHFTGLSGKLTSR
GVCVCISTAFEGNLLDSYFVDLVIQKPLRIHHHSVPVFIPLEEIAAKYLQTNIQHFLFSL
CEYLNAYSGRKYQADRLQSDFAALLTGPLQRNPLCNLLSFTYKLDPGGQSFPFCARLLYK
DLTATLPTDVTVTCQGVEVLSTSWEEQRASHETLFCTKPLHQVFASFTRKGEKLDMSLVS
Sequence of entity 8 (P), FASTA
>9TAX_8 Centromere protein P (chains P)
MDAELAEVRALQAEIAALRRACEDPPAPWEEKSRVQKSFQAIHQFNLEGWKSSKDLKNQL
GHLESELSFLSTLTGINIRNHSKQTEDLTSTEMTEKSIRKVLQRHRLSGNCHMVTFQLEF
QILEIQNKERLSSAVTDLNIIMEPTECSELSEFVSRAEERKDLFMFFRSLHFFVEWFEYR
KRTFKHLKEKYPDAVYLSEGPSSCSMGIRSASRPGFELVIVWRIQIDEDGKVFPKLDLLT
KVPQRALELDKNRAIETAPLSFRTLVGLLGIEAALESLIKSLCAEENN
Sequence of entity 9 (Q), FASTA
>9TAX_9 Centromere protein Q (chains Q)
MTKHTNLKHGKTAASKRKTWQPLSKSTRDHLQTMMESVIMTILSNSIKEKEEIQYHLNFL
KKRLLQQCETLKVPPKKMEDLTNVSSLLNMERARDKANEEGLALLQEEIDKMVETTELMT
GNIQSLKNKIQILASEVEEEEERVKQMHQINSSGVLSLPELSQKTLKAPTLQKEILALIP
NQNALLKDLDILHNSSQMKSMSTFIEEAYKKLDAS
Sequence of entity 10 (U), FASTA
>9TAX_10 Centromere protein U (chains U)
MKTSDIKELNIVLPEFEKTHLEHQQRIESKVCKAAIATFYVNVKEQFIKMLKESQMLTNL
KRKNAKMISDIEKKRQRMIEVQDELLRLEPQLKQLQTKYDELKERKSSLRNAAYFLSNLK
QLYQDYSDVQAQEPNVKETYDSSSLPALLFKARTLLGAESHLRNINHQLEKLLDQGENLY
FQSWSHPQFEKGGGSGGGSGGGSWSHPQFEK
Sequence of entity 11 (R), FASTA
>9TAX_11 Centromere protein R (chains R)
MPVKRSLKLDGLLEENSFDPSKITRKKSVITYSPTTGTCQMSLFASPTSSEEQKHRNGLS
NEKRKKLNHPSLTESKESTTKDNDEFMMLLSKVEKLSEEIMEIMQNLSSIQALEGSRELE
NLIGISCASHFLKREMQKTKELMTKVNKQKLFEKSTGLPHKASRHLDSYEFLKAILN
Sequence of entity 12 (T), FASTA
>9TAX_12 Centromere protein T (chains T)
MSYYHHHHHHDYDIPTTENLYFQGMDKDCEMKRTTLDSPLGKLELSGCEQGLHRIIFLGK
GTSAADAVEVPAPAAVLGGPEPLMQATAWLNAYFHQPEAIEEFPVPALHHPVFQQESFTR
QVLWKLLKVVKFGEVISYSHLAALAGNPAATAAVKTALSGNPVPILIPCHRVVQGDLDVG
GYEGGLAVKEWLLAHEGHRLGKPGLGSDLEVLFQGPMADHNPDSDSTPRTLLRRVLDTAD
PRTPRRPRSARAGARRALLETASPRKLSGQTRTIARGRSHGARSVGRSAHIQASGHLEEQ
TPRTLLKNILLTAPESSILMPESVVKPVPAPQAVQPSRQESSCGSLELQLPELEPPTTLA
PGLLAPGRRKQRLRLSVFQQGVDQGLSLSQEPQGNADASSLTRSLNLTFATPLQPQSVQR
PGLARRPPARRAVDVGAFLRDLRDTSLAPPNIVLEDTQPFSQPMVGSPNVYHSLPCTPHT
GAEDAEQAAGRKTQSSGPGLQKNSPGKPAQFLAGEAEEVNAFALGFLSTSSGVSGEDEVE
PLHDGVEEAEKKMEEEGVSVSEMEATGAQGPSRVEEAEGHTEVTEAEGSQGTAEADGPGA
SSGDEDASGRAASPESASSTPESLQARRHHQFLEPAPAPGAAVLSSEPAEPLLVRHPPRP
RTTGPRPRQDPHKAGLSHYVKLFSFYAKMPMERKALEMVEKCLDKYFQHLCDDLEVFAAH
AGRKTVKPEDLELLMRRQGLVTDQVSLHVLVERHLPLEYRQLLIPCAYSGNSVFPAQ
Primary citation
Models for the architecture of the human inner kinetochore on centromeric alpha-satellite CENP-A nucleosome arrays. Yu, C., Muir, K.W., Yang, J. et al. Nat Commun (2026) 17. DOI 10.1038/s41467-026-72856-0 · PubMed
Other PDB entries of the same protein (UniProt Q9H3R5 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 7PB4 2.49 Å, Cenp-HIK 3-protein complex
- 28OP 2.7 Å, Structure of the human inner kinetochore CCAN and CENP-C bound to DNA
- 7R5S 2.83 Å, Structure of the human CCAN bound to alpha satellite DNA
- 7PKN 3.2 Å, Structure of the human CCAN deltaCT complex
- 7XHO 3.29 Å, Structure of human inner kinetochore CCAN complex
- 9TAW 3.54 Å, Structure of the human inner kinetochore CCAN bound to DNA
- 7XHN 3.71 Å, Structure of human inner kinetochore CCAN-DNA complex
- 7R5V 4.55 Å, Structure of the human CCAN CENP-A alpha-satellite complex
- 7QOO 4.6 Å, Structure of the human inner kinetochore CCAN complex
- 7YYH 8.9 Å, Structure of the human CCANdeltaT CENP-A alpha-satellite complex
- 7YWX 12.0 Å, Structure of the human CCAN CENP-A alpha-satellite complex
- 9TAY 15.5 Å, Structure of the human inner kinetochore CCAN bound to a di-CENP-A nucleosome
Browse structure collections
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