9UK2: Human OXGR1-miniGq complex

Human OXGR1-miniGq complex (conformation 1). Determined by electron microscopy at 2.9 Å resolution. Released 22 Apr 2026.

Method: Electron microscopy
Resolution: 2.9 Å
Organism: Homo sapiens
Chains: 5
Atoms: 8,999
Mol. weight: 142.32 kDa
Released: 22 Apr 2026

Explore 9UK2 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9UK2 contains 37 α-helices and 62 β-strands across 5 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 18 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	29-34	6
α-helix	36-61	26
α-helix	63	1
α-helix	65	1
α-helix	67-84	18
α-helix	86-94	9
α-helix	106-136	31
α-helix	143-145	3
α-helix	147-165	19
α-helix	166-170	5
β-strand	174-175	2	1
β-strand	182-183	2	1
α-helix	193-202	10
α-helix	203-208	6
α-helix	209-226	18
α-helix	236-267	32
α-helix	274-287	14
α-helix	294-299	6
α-helix	300-304	5
α-helix	307-322	16

Chain B: 8 helices, 6 β-strands

Element	Residues	Length	Sheet
α-helix	7-30	24
β-strand	33-40	8	2
α-helix	46-56	11
β-strand	70-75	6	2
β-strand	80-85	6	2
α-helix	96-100	5
β-strand	105-111	7	2
α-helix	118-129	12
β-strand	138-144	7	2
α-helix	146-155	10
α-helix	165-168	4
α-helix	184-202	19
β-strand	211-215	5	2
α-helix	223-242	20

Chain C: 3 helices, 28 β-strands

Element	Residues	Length	Sheet
α-helix	7-24	18
α-helix	30-34	5
β-strand	47-51	5	3
β-strand	58-63	6	4
β-strand	69-74	6	4
β-strand	78-83	6	4
β-strand	88-94	7	4
β-strand	100-105	6	5
β-strand	111-116	6	5
β-strand	120-125	6	5
β-strand	134-140	7	5
β-strand	146-153	8	6
β-strand	156-161	6	6
β-strand	165-170	6	6
β-strand	175-181	7	6
β-strand	187-192	6	7
β-strand	198-203	6	7
β-strand	207-212	6	7
β-strand	218-223	6	7
β-strand	229-234	6	8
β-strand	240-245	6	8
β-strand	250-254	5	8
β-strand	259-264	6	8
α-helix	272	1
β-strand	273-278	6	9
β-strand	284-289	6	9
β-strand	294-298	5	9
β-strand	303-308	6	9
β-strand	315-320	6	3
β-strand	327-331	5	3
β-strand	335-339	5	3

Chain D: 3 helices, 0 β-strands

Element	Residues	Length
α-helix	12-24	13
α-helix	30-43	14
α-helix	56-58	3

Chain E: 5 helices, 26 β-strands

Element	Residues	Length	Sheet
β-strand	41-45	5	10
β-strand	48-50	3	11
β-strand	56-63	8	10
α-helix	67-69	3
β-strand	71-77	7	11
β-strand	83-89	7	11
β-strand	96-98	3	11
β-strand	103	1	10
β-strand	106-111	6	10
β-strand	116-121	6	10
α-helix	126-128	3
β-strand	130-137	8	11
β-strand	148-149	2	11
β-strand	153-157	5	11
α-helix	176-177	2
β-strand	178-179	2	12
β-strand	184-185	2	13
β-strand	193-197	5	14
β-strand	198-199	2	12
β-strand	204	1	15
β-strand	210	1	15
β-strand	212-217	6	13
β-strand	224-228	5	13
β-strand	232-233	2	13
α-helix	234	1
β-strand	241-245	5	14
β-strand	250-254	5	14
α-helix	259-261	3
β-strand	264-269	6	13
β-strand	277	1	13
β-strand	281-283	3	13

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
2-oxoglutarate receptor 1	A	protein	337	Homo sapiens	Q96P68 (AlphaFold model)
mini Gq	B	protein	246	Homo sapiens
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	C	protein	340	Homo sapiens	P62873 (AlphaFold model)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	D	protein	71	Homo sapiens	P59768 (AlphaFold model)
scFV16	E	protein	286	Homo sapiens

Sequence of entity 1 (A), FASTA

>9UK2_1 2-oxoglutarate receptor 1 (chains A)
MNEPLDYLANASDFPDYAAAFGNCTDENIPLKMHYLPVIYGIIFLVGFPGNAVVISTYIF
KMRPWKSSTIIMLNLACTDLLYLTSLPFLIHYYASGENWIFGDFMCKFIRFSFHFNLYSS
ILFLTCFSIFRYCVIIHPMSCFSIHKTRCAVVACAVVWIISLVAVIPMTFLITSTNRTNR
SACLDLTSSDELNTIKWYNLILTATTFCLPLVIVTLCYTTIIHTLTHGLQTDSCLKQKAR
RLTILLLLAFYVCFLPFHILRVIRIESRLLSISCSIENQIHEAYIVSRPLAALNTFGNLL
LYVVVSDNFQQAVCSTVRCKVSGNLEQAKKISYSNNP

Sequence of entity 2 (B), FASTA

>9UK2_2 mini Gq (chains B)
MGSTVSAEDKAAAERSKMIDKNLREDGEKARRTLRLLLLGADNSGKSTIVKQMRILHGGS
GGSGGTSGIFETKFQVDKVNFHMFDVGAQRDERRKWIQCFNDVTAIIFVVDSSDYNRLQE
ALNDFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEP
GEDPRVTRAKYFIRKEFVDISTASGDGRHICYPHFTCSVDTENARRIFNDCKDIILQMNL
REYNLV

Sequence of entity 3 (C), FASTA

>9UK2_3 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (chains C)
MSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYA
MHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNI
CSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTF
TGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA
FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL
KADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN

Sequence of entity 4 (D), FASTA

>9UK2_4 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (chains D)
MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENP
FREKKFFCAIL

Sequence of entity 5 (E), FASTA

>9UK2_5 scFV16 (chains E)
MVSAIVLYVLLAAAAHSAFADVQLVESGGGLVQPGGSRKLSCSASGFAFSSFGMHWVRQA
PEKGLEWVAYISSGSGTIYYADTVKGRFTISRDDPKNTLFLQMTSLRSEDTAMYYCVRSI
YYYGSSPFDFWGQGTTLTVSSGGGGSGGGGSGGGGSDIVMTQATSSVPVTPGESVSISCR
SSKSLLHSNGNTYLYWFLQRPGQSPQLLIYRMSNLASGVPDRFSGSGSGTAFTLTISRLE
AEDVGVYYCMQHLEYPLTFGAGTKLELKAAAENLYFQGHHHHHHHH

Primary citation

Structural basis of the a GPCR complex. Liu, H., Wang, C. To be published.

Other PDB entries of the same protein (UniProt Q96P68 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9VUS 2.37 Å, The structure of akg bound OXGR1
9VMO 2.4 Å, Cryo-EM structure of the ITA-OXGR1-Gq complex
9VMP 2.5 Å, Cryo-EM structure of the A-1-OXGR1-Gq complex
9VMN 2.6 Å, Cryo-EM structure of the a-KG-OXGR1-Gq complex
9VV6 2.62 Å, The structure of ITN bound OXGR1
9M1U 2.64 Å, Cryo-EM structure of Succinic Acid bound OXGR1-Gq complex
9M1S 2.65 Å, Cryo-EM structure of Itaconic acid bound OXGR1-Gq complex
9M1R 2.66 Å, Cryo-EM structure of AKG bound OXGR1-Gq complex
9UXN 2.7 Å, Local refinement of Succinate bound OXGR1
9VO2 2.7 Å, Cryo-EM structure of the OXGR1(CA)-Gq complex
26XH 2.82 Å, Cryo-EM structure of Maleic Acid bound OXGR1-Gq complex
8YYX 2.84 Å, Cryo-EM structure of OXGR1 bound to leukotriene E4 and Gq proteins

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