9V86: KICSTOR CCC complex

Cryo-EM structure of KICSTOR CCC complex (state 3). Determined by electron microscopy at 3.04 Å resolution. Released 12 Nov 2025.

Method
Electron microscopy
Resolution
3.04 Å
Organism
Homo sapiens
Chains
4
Atoms
14,073
Mol. weight
526.42 kDa
Released
12 Nov 2025

Explore 9V86 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9V86 contains 67 α-helices and 103 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 34 helices, 34 β-strands

ElementResiduesLengthSheet
β-strand222211
α-helix2228-22303
α-helix2234-224815
β-strand225011
β-strand2278-228141
β-strand2294-230291
α-helix2330-23334
β-strand2354-236291
α-helix2367-239024
α-helix2500-251112
α-helix2521-25255
α-helix2526-25327
α-helix2555-256814
β-strand2574-257742
β-strand2578-257923
β-strand2588-258923
β-strand260814
β-strand2609-261242
β-strand263015
β-strand264916
β-strand265112
β-strand2653-265424
β-strand2659-266024
β-strand266416
β-strand266615
α-helix2668-268720
α-helix26911
α-helix2692-26965
α-helix2698-27003
α-helix2729-27313
α-helix2764-27663
α-helix2790-27934
α-helix2795-281319
α-helix2816-28227
α-helix2834-28429
β-strand2845-285397
α-helix2858-28603
α-helix2908-292518
β-strand2930-293127
β-strand2981-298667
β-strand2990-2999107
β-strand3002-3011107
α-helix3028-303811
α-helix3042-305918
α-helix30661
α-helix3071-308111
β-strand3092-310098
α-helix3107-311610
α-helix3118-31214
β-strand312418
β-strand3127-312829
β-strand3138-313929
β-strand3141-314778
β-strand3163-317088
α-helix3181-31844
β-strand3187-3197118
α-helix3203-32042
α-helix3249-328234
α-helix3301-33088
β-strand3312-3315410
α-helix3316-33183
α-helix3321-33288
α-helix3331-334414
β-strand3349-3352410
β-strand3360-3364510
β-strand3374-3378510
β-strand3386-3391610
α-helix3410-342920
Chain B: 4 helices, 33 β-strands
ElementResiduesLengthSheet
β-strand2-3211
β-strand10-13412
β-strand23-26413
β-strand35-39513
β-strand44-48513
β-strand57-60413
β-strand65-71714
β-strand80-85614
β-strand89-93514
β-strand119-122414
β-strand127-133715
β-strand142-147615
β-strand151-158815
β-strand170-178915
α-helix182-1832
β-strand186-187216
β-strand190117
β-strand196117
β-strand199-202416
β-strand206-210516
α-helix211-2133
β-strand240-244516
β-strand256-259418
β-strand275-280618
β-strand284-289618
β-strand296-302718
β-strand307119
β-strand311-313311
β-strand322-325411
β-strand327119
β-strand331-335511
β-strand341-345511
β-strand350-3591012
β-strand365-373912
β-strand377-381512
α-helix402-41110
α-helix418-43013
Chain C: 6 helices, 29 β-strands
ElementResiduesLengthSheet
β-strand14-21820
β-strand31-32221
β-strand41-44421
β-strand50-58921
β-strand61-68821
β-strand79-87922
β-strand95-103922
β-strand110-116722
α-helix127-1304
β-strand135-138422
β-strand145-153923
β-strand156-164923
β-strand170-175623
β-strand182-185423
β-strand201-208824
β-strand214-221824
β-strand225-232824
β-strand237-245924
β-strand250-257825
β-strand273-279725
β-strand285-286225
α-helix290-2934
β-strand299-300225
α-helix3011
β-strand310-316726
β-strand325-330626
β-strand334-340726
α-helix343-3453
α-helix348-3503
β-strand354-358526
β-strand361126
β-strand366-372720
β-strand381-386620
β-strand389-395720
α-helix397-41822
Chain D: 23 helices, 7 β-strands
ElementResiduesLengthSheet
α-helix13-2311
α-helix30-389
α-helix39-435
α-helix51-7020
α-helix92-954
α-helix99-1035
α-helix119-1213
α-helix122-14928
α-helix157-17115
α-helix181-20525
α-helix209-22618
α-helix250-2523
α-helix253-27220
α-helix274-2763
α-helix287-2904
α-helix298-30710
β-strand312-317627
α-helix338-3403
β-strand348-351427
α-helix356-3572
α-helix358-3603
α-helix364-3707
α-helix374-3774
β-strand382127
β-strand385128
β-strand392128
β-strand395-396227
β-strand402-407627
α-helix417-43014
α-helix433-4375

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
KICSTOR complex protein SZT2Aprotein3432Homo sapiensQ5T011 (AlphaFold model)
KICSTOR complex protein ITFG2Bprotein447Homo sapiensQ969R8 (AlphaFold model)
KICSTOR complex protein kaptinCprotein436Homo sapiensQ9Y664 (AlphaFold model)
KICSTOR subunit 2Dprotein445Homo sapiensQ96MD2 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>9V86_1 KICSTOR complex protein SZT2 (chains A)
MASERPEPEVEEAGQVFLLMKKDYRISRNVRLAWFLSHLHQTVQATPQEMLLQSEQELEV
LSVLPPGWQPDEPVVPRPFLLVPSTRVTFLAWQYRFVIELDLSPSTGIVDDSTGEILFDE
VFHALSRCLGGLLRPFRVPGSCIDFQPEIYVTIQAYSSIIGLQSHQVLVQGCLLDPSQRE
VFLQQIYEQLCLFEDKVATMLQQQYDPQSQAEDQSPDSGDLLGRKVGVSMVTADLGLVSM
IRQGILALQLLPSNSSAGIIVITDGVTSVPDVAVCETLLNQLRSGTVACSFVQVGGVYSY
DCSFGHVPNVELMKFIAMATFGSYLSTCPEPEPGNLGLTVYHRAFLLYSFLRSGEALNPE
YYCGSQHRLFNEHLVSASSNPALALRRKKHTEKEVPADLVSTVSVRLREGYSVREVTLAK
GGSQLEVKLVLLWKHNMRIEYVAMAPWPLEPEGPRVTRVEVTMEGGYDILHDVSCALRQP
IRSLYRTHVIRRFWNTLQSINQTDQMLAHLQSFSSVPEHFTLPDSTKSGVPLFYIPPGST
TPVLSLQPSGSDSSHAQFAAYWKPVLSMDANSWQRWLHMHRLVLILEHDTPIPKHLHTPG
SNGRYSTIQCRISHSSLTSLLRDWSSFVLVEGYSYVKLLSSAPDQPPNSFYMVRIISKAP
CMVLRLGFPIGTPAPARHKIVSGLREEILRLRFPHRVQSKEPTPKVKRKGLGGAGGGSSP
SKSPPVLGPQQALSDRPCLVVLHKPLDKLLIRYEKLPLDYRAPFLLTLEPPGPLPLVSGR
SASSSLASLSRYLYHQRWLWSVPSGLAPALPLSAIAQLLSILTEVRLSEGFHFACSGEGI
INMVLELPIQNEPPGQAAAEEKHTCVVQYILFPPHSTSTKDSFSTDDDNDVEVEALEGDS
ELNLVTEVWVEPQYGRVGPGPGIWKHLQDLTYSEIPQALHPRDAACIGSMLSFEYLIQLC
QSKEWGPLPPEPRVSDGLDQGGDTCVHEIPFHFDLMGLLPQCQQLQMFFLLLAREPEGVP
FAEGSCPANDMVLCLLHSCLGQELSDREIPLTPVDQAAFLSEVLRRTCHVPGAEGPLLGV
HGIPKEQAVGSTQATGDSAFTSLSVGLPETLKPLISAQPPQWRCYARLVNPQHVFLTFLP
ATFSDVQRLAACGLEGPPQEETKPKFGDWSGAPSLKDLGGTGIKATKSHVPVLSVTLASD
NAQNQGELSPPFRRDLQAYAGRQASQTESADGPRTRCPVYIYSCSLEALREQMVGMQPPQ
APRDLIFRTQFLDHPSPSSAWMEPRYKEAANHCALLQEHAQRCYVRGLFRSLQQAQSVTS
QDLLTAVDACEELLQEIDITPFLLALCGHTWGLPHAPPSPGPLSPGPFSSSMEEGAEPRE
RAILASESSIETEDLSEPEFQSTRVPGIPDPGPEISLTDVCQLRGEAHGALHSVIQEKFL
EISRLHFRTVPSNPHYFFYCPPSSRREDEGPRDTVDRKISDLEFSEAELMGEEGDTSACC
VVTESDPELEVEYRESRESDLGPAGLDSASLSDVDTVNPDEDSFSILGGDSPTGPESFLH
DLPPLFLHLTCSVRLRGQHSSVPVCSLPTCLGQVLSSLEGPPVGGRVPLRDLSVTLDVFM
LTLPLEVELPTASDPQHHRSTSESSASFPRSPGQPSSLRSDDGLGPPLPPPEEERHPGLS
NLATPHRLAIETTMNEIRWLLEDEMVGALRRGGIPQSPALHRAAAHIHSSPGRSTCLRQT
LPLSFVFGPERSLTQFKEEFRRLHLPGHVLLEDPDSGFFFVAAGQQPGGSHGEPSSAAWA
WHSHEDRAEGIEGETLTASPQAPGSPEDSEGVPLISLPRVPQGGSQPGPSRGLSLMSSQG
SVDSDHLGYDGGSSGSDSEGPNDTLGEKAPFTLRTPPGPAPPQPSLSGLPGPCLPDFWLI
VRVLQDRVEVYAHARSLIREDGGPGTECRHLQQLLVRRVGEICREVNQRLLLQDLHDSHV
CNSLLVAESEEDLWRSETPFHSRQRAPLPSDDYAADESCAPRGYLAATMQFVPGHFSCDV
VWGTVIRVHSRLKMGPSMGVSRAIQALRSVLNAFSVVNRKNMFVYQERATKAVYYLRLLE
TSCSDRPWKGDALPPSLALSRSQEPIYSEEASGPRSPLDMVSSRSSDAARPVGQVDRHIQ
LLVHGVGQAGPEITDELVRVLCRRLDEATLDVITVMLVRNCKLTPADVEFIQPPGSLPSE
VLHLALPTSCRPWLPALAWYLRQNLLIFLHSPKYTDSNSRNHFQHPLPPQGGLPDLDIYL
YNKPGGQGTGGKGVACITLAFVDEGGAPLSLALWPPSSPGPPDPLREEEFEQLTQVIRCP
VVVDSSSAQNGAPRLRLDVWEKGNISIVQLEEKLRGAARQALADAIIELQLLPASLCTED
TPTGSLRNGSLETKSSAGRASTFPPAPVPGEPVTPPSKAGRRSFWDMLSKTECGDLGSPK
TTDDIVLDRPEDTRGRRRHKTESVRTPGGAERAPGSDSGAQRQKRRTTQLEEGEVGTLHP
VFARVAQRWMEFMVQIGCASVSRSSAHMVSRFLLPSILSEFTALVTSMAGDTSVRIFEQH
LGSEPEIFGPCSPGQLGPSPRPAAERHLLLLGRNFLQWRRPTQQAAKAMQRFEPGGDGSS
GRNAPRQRLLLLEVVDKKLQLLTYNWAPDLGAALGRALVRLVQWQNARAHLIFCLLSQKL
GLFHHYGQLDFPVRDEKEPNPFLLPTMEVETLIRSASPPLSREQGRLSGSSRGGGPLPLD
TFPFDEALRDITAARPSSVLGPVPRPPDPVTYHGQQFLEIKMAERRELERQMKMENLFVT
WQQRSTPATMPISAGELETLKQSSRLVHYCATAMLFDPAAWLHGPPETSGPPDGQRRHRP
ESGSGSREAPTSCESLDVSPPGAREEPWLKELSLAFLQQYVQYLQSIGFVLVPLRPPSPA
RSTSRPRAMAILGTEGRGSFSCPKTKTDGSPKSTSSPVTTYHLQRALPGGIILMELAFQG
CYFCVKQFALECSRIPMGQAVNSQLSMLFTEECDKVRDLMHVHSFSYDFHLRLVHQHVLG
AHLVLRHGYHLTTFLRHFLAHHPDGPHFGRNHIYQGTLELPTPLIAAHQLYNYVADHASS
YHMKPLRMARPGGPEHNEYALVSAWHSSGSYLDSEGLRHQDDFDVSLLVCHCAAPFEEQG
EAERHVLRLQFFVVLTSQRELFPRLTADMRRFRKPPRLPPEPEAPGSSAGSPGEASGLIL
APGPAPLFPPLAAEVGMARARLAQLVRLAGGHCRRDTLWKRLFLLEPPGPDRLRLGGRLA
LAELEELLEAVHAKSIGDIDPQLDCFLSMTVSWYQSLIKVLLSRFPQSCRHFQSPDLGTQ
YLVVLNQKFTDCFVLVFLDSHLGKTSLTVVFREPFPVQPQDSESPPAQLVSTYHHLESVI
NTACFTLWTRLL
Sequence of entity 2 (B), FASTA
>9V86_2 KICSTOR complex protein ITFG2 (chains B)
MRSVSYVQRVALEFSGSLFPHAICLGDVDNDTLNELVVGDTSGKVSVYKNDDSRPWLTCS
CQGMLTCVGVGDVCNKGKNLLVAVSAEGWFHLFDLTPAKVLDASGHHETLIGEEQRPVFK
QHIPANTKVMLISDIDGDGCRELVVGYTDRVVRAFRWEELGEGPEHLTGQLVSLKKWMLE
GQVDSLSVTLGPLGLPELMVSQPGCAYAILLCTWKKDTGSPPASEGPTDGSRETPAARDV
VLHQTSGRIHNKNVSTHLIGNIKQGHGTESSGSGLFALCTLDGTLKLMEEMEEADKLLWS
VQVDHQLFALEKLDVTGNGHEEVVACAWDGQTYIIDHNRTVVRFQVDENIRAFCAGLYAC
KEGRNSPCLVYVTFNQKIYVYWEVQLERMESTNLVKLLETKPEYHSLLQELGVDPDDLPV
TRALLHQTLYHPDQPPQCAPSSLQDPT
Sequence of entity 3 (C), FASTA
>9V86_3 KICSTOR complex protein kaptin (chains C)
MMGEAAVAAGPCPLREDSFTRFSSQSNVYGLAGGAGGRGELLAATLKGKVLGFRYQDLRQ
KIRPVAKELQFNYIPVDAEIVSIDTFNKSPPKRGLVVGITFIKDSGDKGSPFLNIYCDYE
PGSEYNLDSIAQSCLNLELQFTPFQLCHAEVQVGDQLETVFLLSGNDPAIHLYKENEGLH
QFEEQPVENLFPELTNLTSSVLWLDVHNFPGTSRRLSALGCQSGYVRVAHVDQRSREVLQ
MWSVLQDGPISRVIVFSLSAAKETKDRPLQDEYSVLVASMLEPAVVYRDLLNRGLEDQLL
LPGSDQFDSVLCSLVTDVDLDGRPEVLVATYGQELLCYKYRGPESGLPEAQHGFHLLWQR
SFSSPLLAMAHVDLTGDGLQELAVVSLKGVHILQHSLIQASELVLTRLRHQVEQRRRRLQ
GLEDGAGAGPAENAAS
Sequence of entity 4 (D), FASTA
>9V86_4 KICSTOR subunit 2 (chains D)
MGESIPLAAPVPVEQAVLETFFSHLGIFSYDKAKDNVEKEREANKSAGGSWLSLLAALAH
LAAAEKVYHSLTYLGQKLGGQSFFSRKDSIRTIYTSLHNELKKVVTGRGALGGTAPHVEE
LLSHLSEQLCFFVQARMEIADFYEKMYTLSTQKFINAEELVGLLDAIMKKYSSRFHHPIL
SPLESSFQLEVDVLCHLLKAQAQVSEWKFLPSLVNLHSAHTKLQTWGQIFEKQRETKKHL
FGGQSQKAVQPPHLFLWLMKLKNMLLAKFSFYFHEALSRQTTASEMKTLTAKANPDFFGK
ISSFIRKYDAANVSLIFDNRGSESFQGHGYHHPHSYREAPKGVDQYPAVVSLPSDRPVMH
WPNVIMIMTDRTSDLNSLEKVVHFYDDKVQSTYFLTRPEPHFTIVIIFESKKSERDSHFI
SFLNEVSLALKNPKVFASLKPGAKG

Primary citation

Architecture of the human KICSTOR and GATOR1-KICSTOR complexes. Teng, F., Zeng, H., Mai, X. et al. Nat Struct Mol Biol (2025) 32:2587-2600. DOI 10.1038/s41594-025-01693-4 · PubMed

Other PDB entries of the same protein (UniProt Q5T011 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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