9VWP: Human OSM

human OSM in complex with Nb3.43. Determined by X-ray diffraction at 3.03 Å resolution. Released 22 Jul 2026.

Method: X-ray diffraction
Resolution: 3.03 Å
Organisms: Homo sapiens, Vicugna pacos
Chains: 4
Atoms: 4,182
Mol. weight: 67.49 kDa
Released: 22 Jul 2026

Explore 9VWP in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9VWP contains 22 α-helices and 27 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 10 helices, 0 β-strands

Element	Residues	Length
α-helix	10-24	15
α-helix	27-29	3
α-helix	31-37	7
α-helix	43-46	4
α-helix	51-52	2
α-helix	59-62	4
α-helix	67-89	23
α-helix	105-111	7
α-helix	114-131	18
α-helix	161-186	26

Chain B: 10 helices, 0 β-strands

Element	Residues	Length
α-helix	10-24	15
α-helix	27-29	3
α-helix	31-37	7
α-helix	43-46	4
α-helix	51-52	2
α-helix	59-63	5
α-helix	67-89	23
α-helix	105-111	7
α-helix	114-131	18
α-helix	161-184	24

Chain C: 1 helix, 14 β-strands

Element	Residues	Length	Sheet
β-strand	3	1	1
β-strand	6-7	2	2
β-strand	10-11	2	3
β-strand	17-23	7	2
β-strand	25	1	1
β-strand	33-39	7	3
β-strand	45-52	8	3
β-strand	57-59	3	3
β-strand	64	1	2
β-strand	67-71	5	2
β-strand	77-83	7	2
α-helix	87-89	3
β-strand	91-98	8	3
β-strand	104-106	3	3
β-strand	110-113	4	3

Chain D: 1 helix, 13 β-strands

Element	Residues	Length	Sheet
β-strand	3	1	4
β-strand	6-7	2	5
β-strand	10-11	2	6
β-strand	18-23	6	5
β-strand	25	1	4
β-strand	33-39	7	6
β-strand	45-52	8	6
β-strand	57-59	3	6
β-strand	67-71	5	5
β-strand	77-82	6	5
α-helix	87-89	3
β-strand	91-97	7	6
β-strand	105-106	2	6
β-strand	110-113	4	6

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Oncostatin-M	A, B	protein	187	Homo sapiens	P13725 (AlphaFold model)
Nb3.43	C, D	protein	116	Vicugna pacos

Sequence of entity 1 (A, B), FASTA

>9VWP_1 Oncostatin-M (chains A, B)
AAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEE
TLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILG
LRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSV
GRVFSKW

Sequence of entity 2 (C, D), FASTA

>9VWP_2 Nb3.43 (chains C, D)
QVQLQESGGGLVQPGGSLRLSCTASGIIFGWNTMAWYRQAPGTERELVARITSGGGTDYA
DSVKGRFTISRDRAKKTVFLQMNSLKPEDTAVYYCNVDLDGLKIHWGQGTQVTVSS

Primary citation

human OSM in complex with Nb3.30. Wen, Y. To be published.

Other PDB entries of the same protein (UniProt P13725 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1EVS 2.2 Å, Crystal structure of human oncostatin M
9VWO 2.45 Å, human OSM in complex with Nb3.30
8V2A 3.59 Å, Cryo-EM structure of human type I OSM receptor complex: model for assembly core region
8V29 3.99 Å, Cryo-EM structure of human type I OSM receptor complex: model for full extracellular…

Browse structure collections

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