9W0W: T2R46

CryoEM structure of the T2R46 in complex with strychine and heterotrimeric G protein complex. Determined by electron microscopy at 3.2 Å resolution. Released 22 Apr 2026.

Method: Electron microscopy
Resolution: 3.2 Å
Organism: Homo sapiens
Chains: 4
Atoms: 6,651
Mol. weight: 128.96 kDa
Ligands: SY9
Released: 22 Apr 2026

Explore 9W0W in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9W0W contains 30 α-helices and 34 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 9 helices, 6 β-strands

Element	Residues	Length	Sheet
α-helix	7-32	26
β-strand	34-40	7	1
α-helix	47-51	5
β-strand	185-190	6	1
β-strand	195-200	6	1
α-helix	208-210	3
α-helix	212-215	4
β-strand	220-226	7	1
α-helix	242-254	13
β-strand	263-269	7	1
α-helix	271-280	10
α-helix	283-285	3
α-helix	296-308	13
β-strand	319-323	5	1
α-helix	328-349	22

Chain B: 5 helices, 28 β-strands

Element	Residues	Length	Sheet
α-helix	6-25	20
α-helix	30-33	4
α-helix	38-39	2
β-strand	47-51	5	2
β-strand	58-62	5	3
β-strand	69-74	6	3
β-strand	78-83	6	3
β-strand	91-94	4	3
β-strand	100-105	6	4
β-strand	111-116	6	4
β-strand	121-125	5	4
β-strand	134-139	6	4
α-helix	145	1
β-strand	146-151	6	5
β-strand	156-161	6	5
β-strand	166-170	5	5
β-strand	175-180	6	5
α-helix	186	1
β-strand	187-192	6	6
β-strand	198-203	6	6
β-strand	207-212	6	6
β-strand	217-223	7	6
β-strand	229-234	6	7
β-strand	240-245	6	7
β-strand	249-254	6	7
β-strand	260-264	5	7
β-strand	273-278	6	8
β-strand	284-289	6	8
β-strand	294-298	5	8
β-strand	304-308	5	8
β-strand	315-320	6	2
β-strand	327-331	5	2
β-strand	336-339	4	2

Chain C: 4 helices, 0 β-strands

Element	Residues	Length
α-helix	10-23	14
α-helix	30-44	15
α-helix	53-55	3
α-helix	56-58	3

Chain R: 12 helices, 0 β-strands

Element	Residues	Length
α-helix	9-37	29
α-helix	43-66	24
α-helix	67-71	5
α-helix	73-75	3
α-helix	78-110	33
α-helix	116-123	8
α-helix	126-133	8
α-helix	137-152	16
α-helix	173-210	38
α-helix	218-251	34
α-helix	258-283	26
α-helix	285-300	16

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Taste receptor type 2 member 46	R	protein	363	Homo sapiens	P59540 (AlphaFold model)
Guanine nucleotide-binding protein G(i) subunit alpha-1	A	protein	354	Homo sapiens	P63096 (AlphaFold model)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	B	protein	351	Homo sapiens	P62873 (AlphaFold model)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	C	protein	71	Homo sapiens	P59768 (AlphaFold model)

Sequence of entity 1 (R), FASTA

>9W0W_1 Taste receptor type 2 member 46 (chains R)
MKTIIALSYIFCLVFADYKDDDMITFLPIIFSILIVVTFVIGNFANGFIALVNSIEWFKR
QKISFADQILTALAVSRVGLLWVLLLNWYATELNPAFNSIEVRITAYNVWAVINHFSNWL
ATSLSIFYLLKIANFSNLIFLHLKRRVKSVVLVILLGPLLFLVCHLFVINMNQIIWTKEY
EGNMTWKIKLRSAMYLSNTTVTILANLVPFTLTLISFLLLICSLCKHLKKMQLHGKGSQD
PSMKVHIKALQTVTSFLLLCAIYFLSIIMSVWSFESLENKPVFMFCEAIAFSYPSTHPFI
LIWGNKKLKQTFLSVLWHVRYWVKGEFLEVLFQGPWSHPQFEKGGGSGGGSGGSAWSHPQ
FEK

Sequence of entity 2 (A), FASTA

>9W0W_2 Guanine nucleotide-binding protein G(i) subunit alpha-1 (chains A)
MGCTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKNTIVKQMKIIHEAG
YSEEECKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLAGAAEEGFMT
AELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLDRIAQPNYIPTQQDVLRTRVK
TTGIVETHFTFKDLHFKMFDVTAQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEM
NRMHASMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTICYPEYAGSNTYEEAA
AYIQCQFEDLNKRKDTKEIYTHFTCSTDTKNVQFVFDAVTDVIIKNNLKDCGLF

Sequence of entity 3 (B), FASTA

>9W0W_3 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (chains B)
MHHHHHHGSLLQSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRR
TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG
NYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALW
DIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDI
NAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGY
DDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN

Sequence of entity 4 (C), FASTA

>9W0W_4 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (chains C)
MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENP
FREKKFFCAIL

Ligands and cofactors

ID	Name	Formula	Copies
SY9	Strychnine	C21 H22 N2 O2	1

Primary citation

Ligand binding modes of the bitter taste receptor T2R14 and T2R46. Tan, Q., Yu, Y., Han, X. et al. Nat Struct Mol Biol (2026) 33:691-700. DOI 10.1038/s41594-026-01786-8 · PubMed

Other PDB entries of the same protein (UniProt P59540 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9W0R 2.7 Å, Cryo-EM structure of apo-T2R46 in complex with heterotrimeric G protein
9W0U 2.9 Å, CryoEM structure of the T2R46 in complex with tangeretin and heterotrimeric G protein…
7XP4 3.01 Å, Cryo-EM structure of a class T GPCR in apo state
7XP6 3.01 Å, Cryo-EM structure of a class T GPCR in active state
7XP5 3.08 Å, Cryo-EM structure of a class T GPCR in ligand-free state
9W0S 3.3 Å, CryoEM structure of T2R46 in complex with Arteminisin and heterotrimeric G protein complex
9W0T 3.3 Å, CryoEM structure of the T2R46 in complex with Denatomium benozate and heterotrimeric G…

Browse structure collections

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