9YNE: Cytoplasmic dynein 1 heavy chain 1
Motor domain of human dynein-1 in pre-power stroke bound to dynactin-p150glued-CC1B-ICD and LIS1. Determined by electron microscopy at 8.46 Å resolution. Released 28 Jan 2026.
- Method
- Electron microscopy
- Resolution
- 8.46 Å
- Organism
- Homo sapiens
- Chains
- 12
- Atoms
- 29,128
- Mol. weight
- 1155.33 kDa
- Ligands
- MG, ATP, ADP
- Released
- 28 Jan 2026
Explore 9YNE in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
9YNE contains 218 α-helices and 179 β-strands across 12 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 138 helices, 73 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 1057-1060 | 4 | |
| α-helix | 1065-1072 | 8 | |
| α-helix | 1077-1092 | 16 | |
| α-helix | 1110-1119 | 10 | |
| α-helix | 1122-1154 | 33 | |
| α-helix | 1163-1177 | 15 | |
| α-helix | 1180-1199 | 20 | |
| α-helix | 1211-1233 | 23 | |
| α-helix | 1236-1263 | 28 | |
| α-helix | 1273-1302 | 30 | |
| α-helix | 1314-1347 | 34 | |
| α-helix | 1356-1372 | 17 | |
| α-helix | 1375-1378 | 4 | |
| α-helix | 1381-1403 | 23 | |
| α-helix | 1410-1419 | 10 | |
| α-helix | 1443-1471 | 29 | |
| β-strand | 1476-1479 | 4 | 1 |
| α-helix | 1480-1482 | 3 | |
| β-strand | 1485-1488 | 4 | 1 |
| α-helix | 1490-1509 | 20 | |
| α-helix | 1517-1553 | 37 | |
| α-helix | 1562-1584 | 23 | |
| α-helix | 1588-1593 | 6 | |
| α-helix | 1597-1614 | 18 | |
| α-helix | 1616-1625 | 10 | |
| α-helix | 1627-1630 | 4 | |
| α-helix | 1634-1642 | 9 | |
| α-helix | 1650-1652 | 3 | |
| α-helix | 1654-1657 | 4 | |
| β-strand | 1661-1663 | 3 | 2 |
| β-strand | 1677-1678 | 2 | 2 |
| α-helix | 1698-1727 | 30 | |
| α-helix | 1735-1744 | 10 | |
| α-helix | 1747-1765 | 19 | |
| α-helix | 1776-1797 | 22 | |
| α-helix | 1799-1801 | 3 | |
| α-helix | 1802-1826 | 25 | |
| α-helix | 1836-1839 | 4 | |
| β-strand | 1843-1846 | 4 | 3 |
| β-strand | 1857-1861 | 5 | 3 |
| β-strand | 1864-1865 | 2 | 3 |
| α-helix | 1878-1880 | 3 | |
| α-helix | 1883-1897 | 15 | |
| β-strand | 1902-1903 | 2 | 4 |
| α-helix | 1914-1922 | 9 | |
| β-strand | 1926-1931 | 6 | 5 |
| α-helix | 1938-1951 | 14 | |
| β-strand | 1953-1958 | 6 | 5 |
| α-helix | 1965-1985 | 21 | |
| β-strand | 1998-2001 | 4 | 6 |
| β-strand | 2004-2007 | 4 | 6 |
| α-helix | 2025-2029 | 5 | |
| α-helix | 2030-2035 | 6 | |
| β-strand | 2037-2038 | 2 | 4 |
| α-helix | 2046-2057 | 12 | |
| α-helix | 2062-2078 | 17 | |
| α-helix | 2090-2113 | 24 | |
| α-helix | 2133-2148 | 16 | |
| α-helix | 2154-2164 | 11 | |
| α-helix | 2176-2188 | 13 | |
| α-helix | 2201-2216 | 16 | |
| β-strand | 2220-2221 | 2 | 7 |
| α-helix | 2230-2244 | 15 | |
| β-strand | 2254 | 1 | 8 |
| α-helix | 2261-2265 | 5 | |
| β-strand | 2268 | 1 | 9 |
| β-strand | 2275 | 1 | 9 |
| α-helix | 2279-2289 | 11 | |
| β-strand | 2302 | 1 | 7 |
| β-strand | 2303 | 1 | 8 |
| α-helix | 2313-2315 | 3 | |
| β-strand | 2324-2325 | 2 | 10 |
| β-strand | 2333-2334 | 2 | 10 |
| β-strand | 2342 | 1 | 7 |
| α-helix | 2353-2356 | 4 | |
| β-strand | 2360-2361 | 2 | 7 |
| α-helix | 2366-2368 | 3 | |
| α-helix | 2371-2383 | 13 | |
| α-helix | 2411-2427 | 17 | |
| α-helix | 2433-2442 | 10 | |
| α-helix | 2451-2475 | 25 | |
| α-helix | 2483-2498 | 16 | |
| α-helix | 2499-2503 | 5 | |
| α-helix | 2508-2520 | 13 | |
| β-strand | 2538-2539 | 2 | 11 |
| β-strand | 2545-2546 | 2 | 11 |
| α-helix | 2569-2571 | 3 | |
| α-helix | 2572-2585 | 14 | |
| β-strand | 2592-2594 | 3 | 12 |
| α-helix | 2603-2609 | 7 | |
| β-strand | 2617 | 1 | 13 |
| β-strand | 2620 | 1 | 14 |
| α-helix | 2628-2638 | 11 | |
| β-strand | 2640 | 1 | 15 |
| β-strand | 2643-2644 | 2 | 16 |
| β-strand | 2647-2648 | 2 | 16 |
| β-strand | 2651 | 1 | 15 |
| β-strand | 2660 | 1 | 13 |
| β-strand | 2662 | 1 | 17 |
| β-strand | 2663 | 1 | 14 |
| α-helix | 2678-2687 | 10 | |
| β-strand | 2691-2694 | 4 | 16 |
| β-strand | 2699-2702 | 4 | 16 |
| β-strand | 2709 | 1 | 17 |
| β-strand | 2710-2712 | 3 | 12 |
| α-helix | 2725-2730 | 6 | |
| β-strand | 2733-2735 | 3 | 12 |
| α-helix | 2740-2755 | 16 | |
| α-helix | 2760-2763 | 4 | |
| α-helix | 2766-2783 | 18 | |
| α-helix | 2796-2810 | 15 | |
| α-helix | 2818-2828 | 11 | |
| α-helix | 2829-2833 | 5 | |
| α-helix | 2840-2857 | 18 | |
| α-helix | 2863-2866 | 4 | |
| β-strand | 2874 | 1 | 18 |
| β-strand | 2882 | 1 | 18 |
| α-helix | 2887-2903 | 17 | |
| α-helix | 2913-2927 | 15 | |
| β-strand | 2932 | 1 | 19 |
| β-strand | 2933 | 1 | 20 |
| β-strand | 2935-2936 | 2 | 21 |
| α-helix | 2943-2953 | 11 | |
| α-helix | 2956 | 1 | |
| β-strand | 2957-2958 | 2 | 22 |
| α-helix | 2969-2980 | 12 | |
| α-helix | 2981-2985 | 5 | |
| β-strand | 2990-2991 | 2 | 22 |
| β-strand | 2992-2993 | 2 | 19 |
| α-helix | 3002-3014 | 13 | |
| α-helix | 3024-3039 | 16 | |
| α-helix | 3048-3061 | 14 | |
| β-strand | 3064-3065 | 2 | 19 |
| β-strand | 3067-3068 | 2 | 21 |
| α-helix | 3073-3080 | 8 | |
| α-helix | 3083-3087 | 5 | |
| β-strand | 3090 | 1 | 20 |
| α-helix | 3099-3109 | 11 | |
| α-helix | 3139-3164 | 26 | |
| α-helix | 3173-3233 | 61 | |
| α-helix | 3458-3515 | 58 | |
| α-helix | 3522-3538 | 17 | |
| α-helix | 3549-3553 | 5 | |
| α-helix | 3556-3564 | 9 | |
| α-helix | 3571-3580 | 10 | |
| β-strand | 3586-3590 | 5 | 23 |
| α-helix | 3595-3603 | 9 | |
| β-strand | 3610-3613 | 4 | 23 |
| α-helix | 3619-3628 | 10 | |
| β-strand | 3633-3636 | 4 | 23 |
| α-helix | 3643-3645 | 3 | |
| α-helix | 3646-3649 | 4 | |
| β-strand | 3654-3656 | 3 | 24 |
| β-strand | 3659-3664 | 6 | 24 |
| β-strand | 3667-3670 | 4 | 24 |
| β-strand | 3679-3680 | 2 | 23 |
| α-helix | 3687-3689 | 3 | |
| α-helix | 3690-3695 | 6 | |
| β-strand | 3696-3700 | 5 | 23 |
| α-helix | 3705-3720 | 16 | |
| α-helix | 3722-3753 | 32 | |
| α-helix | 3765-3816 | 52 | |
| α-helix | 3819-3822 | 4 | |
| α-helix | 3829-3841 | 13 | |
| α-helix | 3852-3872 | 21 | |
| α-helix | 3879-3894 | 16 | |
| α-helix | 3902-3910 | 9 | |
| α-helix | 3915-3917 | 3 | |
| α-helix | 3930-3940 | 11 | |
| α-helix | 3943-3946 | 4 | |
| α-helix | 3947-3952 | 6 | |
| α-helix | 3982-3996 | 15 | |
| α-helix | 3999-4008 | 10 | |
| α-helix | 4009-4013 | 5 | |
| α-helix | 4019-4022 | 4 | |
| α-helix | 4024-4025 | 2 | |
| α-helix | 4027-4029 | 3 | |
| α-helix | 4030-4034 | 5 | |
| β-strand | 4041-4042 | 2 | 25 |
| α-helix | 4052-4061 | 10 | |
| α-helix | 4074-4090 | 17 | |
| α-helix | 4103-4114 | 12 | |
| β-strand | 4125-4126 | 2 | 25 |
| α-helix | 4136-4141 | 6 | |
| α-helix | 4153-4163 | 11 | |
| α-helix | 4166-4170 | 5 | |
| α-helix | 4174-4195 | 22 | |
| α-helix | 4209-4226 | 18 | |
| α-helix | 4240-4249 | 10 | |
| α-helix | 4259-4272 | 14 | |
| α-helix | 4302-4310 | 9 | |
| α-helix | 4329-4349 | 21 | |
| α-helix | 4380-4394 | 15 | |
| α-helix | 4408-4438 | 31 | |
| α-helix | 4446-4456 | 11 | |
| α-helix | 4459-4461 | 3 | |
| α-helix | 4475-4496 | 22 | |
| β-strand | 4508 | 1 | 26 |
| α-helix | 4517-4531 | 15 | |
| β-strand | 4558 | 1 | 27 |
| β-strand | 4559 | 1 | 26 |
| β-strand | 4565 | 1 | 28 |
| β-strand | 4570-4571 | 2 | 29 |
| β-strand | 4574-4575 | 2 | 29 |
| β-strand | 4590 | 1 | 27 |
| β-strand | 4604-4607 | 4 | 30 |
| β-strand | 4609-4610 | 2 | 28 |
| β-strand | 4618 | 1 | 28 |
| β-strand | 4622-4625 | 4 | 30 |
| α-helix | 4632-4637 | 6 | |
| β-strand | 4642-4643 | 2 | 28 |
Chain B: 6 helices, 30 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 5-20 | 16 | |
| α-helix | 25-34 | 10 | |
| α-helix | 43-46 | 4 | |
| α-helix | 50-79 | 30 | |
| α-helix | 100 | 1 | |
| β-strand | 102-104 | 3 | 31 |
| β-strand | 113-116 | 4 | 32 |
| β-strand | 123-126 | 4 | 32 |
| β-strand | 132-134 | 3 | 32 |
| β-strand | 146 | 1 | 32 |
| β-strand | 166-168 | 3 | 33 |
| β-strand | 173-176 | 4 | 33 |
| β-strand | 188-189 | 2 | 33 |
| β-strand | 198-200 | 3 | 34 |
| β-strand | 206-209 | 4 | 34 |
| β-strand | 217-220 | 4 | 34 |
| β-strand | 226-229 | 4 | 34 |
| β-strand | 239 | 1 | 35 |
| β-strand | 242 | 1 | 35 |
| β-strand | 249-252 | 4 | 35 |
| β-strand | 258-261 | 4 | 35 |
| β-strand | 271-272 | 2 | 35 |
| β-strand | 279-284 | 6 | 36 |
| α-helix | 287-297 | 11 | |
| β-strand | 311-315 | 5 | 36 |
| β-strand | 320 | 1 | 37 |
| β-strand | 324 | 1 | 38 |
| β-strand | 329 | 1 | 38 |
| β-strand | 334 | 1 | 37 |
| β-strand | 341-344 | 4 | 39 |
| β-strand | 355-357 | 3 | 39 |
| β-strand | 361-366 | 6 | 40 |
| β-strand | 371-377 | 7 | 40 |
| β-strand | 394-395 | 2 | 41 |
| β-strand | 404-406 | 3 | 31 |
| β-strand | 407-408 | 2 | 41 |
Chain C: 8 helices, 38 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 5-20 | 16 | |
| α-helix | 25-34 | 10 | |
| α-helix | 44-47 | 4 | |
| α-helix | 50-56 | 7 | |
| α-helix | 60-79 | 20 | |
| β-strand | 96 | 1 | 42 |
| β-strand | 103-104 | 2 | 43 |
| β-strand | 113-116 | 4 | 44 |
| β-strand | 123-126 | 4 | 44 |
| β-strand | 131-132 | 2 | 45 |
| β-strand | 146-147 | 2 | 45 |
| β-strand | 158 | 1 | 46 |
| β-strand | 164-165 | 2 | 46 |
| β-strand | 174-178 | 5 | 46 |
| β-strand | 183-188 | 6 | 46 |
| β-strand | 206-207 | 2 | 47 |
| β-strand | 217-220 | 4 | 47 |
| β-strand | 225-229 | 5 | 47 |
| β-strand | 237-239 | 3 | 48 |
| α-helix | 241 | 1 | |
| β-strand | 242 | 1 | 49 |
| α-helix | 243 | 1 | |
| β-strand | 249 | 1 | 49 |
| β-strand | 252-253 | 2 | 48 |
| β-strand | 258 | 1 | 48 |
| β-strand | 261 | 1 | 49 |
| β-strand | 262 | 1 | 50 |
| β-strand | 267 | 1 | 50 |
| β-strand | 279-283 | 5 | 51 |
| α-helix | 288-296 | 9 | |
| β-strand | 310-311 | 2 | 52 |
| β-strand | 312-315 | 4 | 51 |
| β-strand | 319-320 | 2 | 53 |
| β-strand | 323-324 | 2 | 52 |
| β-strand | 330 | 1 | 52 |
| β-strand | 334-335 | 2 | 53 |
| β-strand | 343-346 | 4 | 54 |
| β-strand | 353-356 | 4 | 54 |
| β-strand | 362 | 1 | 54 |
| β-strand | 364-365 | 2 | 55 |
| β-strand | 372-374 | 3 | 55 |
| β-strand | 385-388 | 4 | 43 |
| β-strand | 394-398 | 5 | 43 |
| β-strand | 404-405 | 2 | 43 |
| β-strand | 407-408 | 2 | 43 |
| β-strand | 409 | 1 | 42 |
Chain d: 2 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 10-12 | 3 | 57 |
| α-helix | 15-31 | 17 | |
| α-helix | 35-49 | 15 | |
| β-strand | 53-55 | 3 | 58 |
| β-strand | 59 | 1 | 59 |
| β-strand | 73-75 | 3 | 57 |
| β-strand | 86-88 | 3 | 58 |
Chains D and E: 1 helix, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 4-34 | 31 | |
Chain F: 22 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 417-425 | 9 | |
| α-helix | 427-536 | 110 | |
| α-helix | 559-587 | 29 | |
| α-helix | 602-625 | 24 | |
| α-helix | 626-630 | 5 | |
| α-helix | 645-673 | 29 | |
| α-helix | 679-687 | 9 | |
| α-helix | 689-692 | 4 | |
| α-helix | 693-695 | 3 | |
| α-helix | 697-707 | 11 | |
| α-helix | 718-730 | 13 | |
| α-helix | 731-735 | 5 | |
| α-helix | 739-741 | 3 | |
| α-helix | 742-769 | 28 | |
| α-helix | 772 | 1 | |
| α-helix | 779-801 | 23 | |
| α-helix | 802-804 | 3 | |
| β-strand | 816 | 1 | 56 |
| α-helix | 822-852 | 31 | |
| α-helix | 863-878 | 16 | |
| α-helix | 885-908 | 24 | |
| β-strand | 914 | 1 | 56 |
| α-helix | 920-922 | 3 | |
| α-helix | 923-947 | 25 | |
Chain G: 21 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 412-533 | 122 | |
| α-helix | 559-589 | 31 | |
| α-helix | 594-597 | 4 | |
| α-helix | 602-630 | 29 | |
| α-helix | 634-637 | 4 | |
| α-helix | 645-673 | 29 | |
| α-helix | 679-685 | 7 | |
| α-helix | 689-692 | 4 | |
| α-helix | 697-707 | 11 | |
| α-helix | 718-730 | 13 | |
| α-helix | 731-735 | 5 | |
| α-helix | 742-770 | 29 | |
| α-helix | 772 | 1 | |
| α-helix | 775-777 | 3 | |
| α-helix | 779-802 | 24 | |
| α-helix | 821-851 | 31 | |
| α-helix | 863-876 | 14 | |
| α-helix | 885-889 | 5 | |
| α-helix | 890-909 | 20 | |
| α-helix | 920-922 | 3 | |
| α-helix | 923-947 | 25 | |
Chain i: 2 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 7-12 | 6 | 60 |
| α-helix | 15-31 | 17 | |
| α-helix | 35-49 | 15 | |
| β-strand | 53-55 | 3 | 60 |
| β-strand | 62 | 1 | 59 |
| β-strand | 73-78 | 6 | 60 |
| β-strand | 81-88 | 8 | 60 |
3 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Cytoplasmic dynein 1 heavy chain 1 | A | protein | 4646 | Homo sapiens | Q14204 |
| Platelet-activating factor acetylhydrolase IB subunit beta | B, C | protein | 410 | Homo sapiens | P43034 (AlphaFold model) |
| Cytoplasmic dynein 1 intermediate chain 2 | D, E | protein | 638 | Homo sapiens | Q13409 (AlphaFold model) |
| Dynactin subunit 1 | F, G | protein | 1281 | Homo sapiens | Q14203 (AlphaFold model) |
| Dynein light chain 1, cytoplasmic | d, i | protein | 89 | Homo sapiens | P63167 |
| Dynein light chain Tctex-type 1 | k, v | protein | 113 | Homo sapiens | P63172 |
| Cytoplasmic dynein 1 light intermediate chain 2 | u | protein | 492 | Homo sapiens | O43237 |
Sequence of entity 1 (A), FASTA
>9YNE_1 Cytoplasmic dynein 1 heavy chain 1 (chains A)
MSEPGGGGGEDGSAGLEVSAVQNVADVSVLQKHLRKLVPLLLEDGGEAPAALEAALEEKS
ALEQMRKFLSDPQVHTVLVERSTLKEDVGDEGEEEKEFISYNINIDIHYGVKSNSLAFIK
RTPVIDADKPVSSQLRVLTLSEDSPYETLHSFISNAVAPFFKSYIRESGKADRDGDKMAP
SVEKKIAELEMGLLHLQQNIEIPEISLPIHPMITNVAKQCYERGEKPKVTDFGDKVEDPT
FLNQLQSGVNRWIREIQKVTKLDRDPASGTALQEISFWLNLERALYRIQEKRESPEVLLT
LDILKHGKRFHATVSFDTDTGLKQALETVNDYNPLMKDFPLNDLLSATELDKIRQALVAI
FTHLRKIRNTKYPIQRALRLVEAISRDLSSQLLKVLGTRKLMHVAYEEFEKVMVACFEVF
QTWDDEYEKLQVLLRDIVKRKREENLKMVWRINPAHRKLQARLDQMRKFRRQHEQLRAVI
VRVLRPQVTAVAQQNQGEVPEPQDMKVAEVLFDAADANAIEEVNLAYENVKEVDGLDVSK
EGTEAWEAAMKRYDERIDRVETRITARLRDQLGTAKNANEMFRIFSRFNALFVRPHIRGA
IREYQTQLIQRVKDDIESLHDKFKVQYPQSQACKMSHVRDLPPVSGSIIWAKQIDRQLTA
YMKRVEDVLGKGWENHVEGQKLKQDGDSFRMKLNTQEIFDDWARKVQQRNLGVSGRIFTI
ESTRVRGRTGNVLKLKVNFLPEIITLSKEVRNLKWLGFRVPLAIVNKAHQANQLYPFAIS
LIESVRTYERTCEKVEERNTISLLVAGLKKEVQALIAEGIALVWESYKLDPYVQRLAETV
FNFQEKVDDLLIIEEKIDLEVRSLETCMYDHKTFSEILNRVQKAVDDLNLHSYSNLPIWV
NKLDMEIERILGVRLQAGLRAWTQVLLGQAEDKAEVDMDTDAPQVSHKPGGEPKIKNVVH
ELRITNQVIYLNPPIEECRYKLYQEMFAWKMVVLSLPRIQSQRYQVGVHYELTEEEKFYR
NALTRMPDGPVALEESYSAVMGIVSEVEQYVKVWLQYQCLWDMQAENIYNRLGEDLNKWQ
ALLVQIRKARGTFDNAETKKEFGPVVIDYGKVQSKVNLKYDSWHKEVLSKFGQMLGSNMT
EFHSQISKSRQELEQHSVDTASTSDAVTFITYVQSLKRKIKQFEKQVELYRNGQRLLEKQ
RFQFPPSWLYIDNIEGEWGAFNDIMRRKDSAIQQQVANLQMKIVQEDRAVESRTTDLLTD
WEKTKPVTGNLRPEEALQALTIYEGKFGRLKDDREKCAKAKEALELTDTGLLSGSEERVQ
VALEELQDLKGVWSELSKVWEQIDQMKEQPWVSVQPRKLRQNLDALLNQLKSFPARLRQY
ASYEFVQRLLKGYMKINMLVIELKSEALKDRHWKQLMKRLHVNWVVSELTLGQIWDVDLQ
KNEAIVKDVLLVAQGEMALEEFLKQIREVWNTYELDLVNYQNKCRLIRGWDDLFNKVKEH
INSVSAMKLSPYYKVFEEDALSWEDKLNRIMALFDVWIDVQRRWVYLEGIFTGSADIKHL
LPVETQRFQSISTEFLALMKKVSKSPLVMDVLNIQGVQRSLERLADLLGKIQKALGEYLE
RERSSFPRFYFVGDEDLLEIIGNSKNVAKLQKHFKKMFAGVSSIILNEDNSVVLGISSRE
GEEVMFKTPVSITEHPKINEWLTLVEKEMRVTLAKLLAESVTEVEIFGKATSIDPNTYIT
WIDKYQAQLVVLSAQIAWSENVETALSSMGGGGDAAPLHSVLSNVEVTLNVLADSVLMEQ
PPLRRRKLEHLITELVHQRDVTRSLIKSKIDNAKSFEWLSQMRFYFDPKQTDVLQQLSIQ
MANAKFNYGFEYLGVQDKLVQTPLTDRCYLTMTQALEARLGGSPFGPAGTGKTESVKALG
HQLGRFVLVFNCDETFDFQAMGRIFVGLCQVGAWGCFDEFNRLEERMLSAVSQQVQCIQE
ALREHSNPNYDKTSAPITCELLNKQVKVSPDMAIFITMNPGYAGRSNLPDNLKKLFRSLA
MTKPDRQLIAQVMLYSQGFRTAEVLANKIVPFFKLCDEQLSSQSHYDFGLRALKSVLVSA
GNVKRERIQKIKREKEERGEAVDEGEIAENLPEQEILIQSVCETMVPKLVAEDIPLLFSL
LSDVFPGVQYHRGEMTALREELKKVCQEMYLTYGDGEEVGGMWVEKVLQLYQITQINHGL
MMVGPSGSGKSMAWRVLLKALERLEGVEGVAHIIDPKAISKDHLYGTLDPNTREWTDGLF
THVLRKIIDSVRGELQKRQWIVFDGDVDPEWVENLNSVLDDNKLLTLPNGERLSLPPNVR
IMFEVQDLKYATLATVSRCGMVWFSEDVLSTDMIFNNFLARLRSIPLDEGEDEAQRRRKG
KEDEGEEAASPMLQIQRDAATIMQPYFTSNGLVTKALEHAFQLEHIMDLTRLRCLGSLFS
MLHQACRNVAQYNANHPDFPMQIEQLERYIQRYLVYAILWSLSGDSRLKMRAELGEYIRR
ITTVPLPTAPNIPIIDYEVSISGEWSPWQAKVPQIEVETHKVAAPDVVVPTLDTVRHEAL
LYTWLAEHKPLVLCGPPGSGKTMTLFSALRALPDMEVVGLNFSSATTPELLLKTFDHYCE
YRRTPNGVVLAPVQLGKWLVLFCDEINLPDMDKYGTQRVISFIRQMVEHGGFYRTSDQTW
VKLERIQFVGACNPPTDPGRKPLSHRFLRHVPVVYVDYPGPASLTQIYGTFNRAMLRLIP
SLRTYAEPLTAAMVEFYTMSQERFTQDTQPHYIYSPREMTRWVRGIFEALRPLETLPVEG
LIRIWAHEALRLFQDRLVEDEERRWTDENIDTVALKHFPNIDREKAMSRPILYSNWLSKD
YIPVDQEELRDYVKARLKVFYEEELDVPLVLFNEVLDHVLRIDRIFRQPQGHLLLIGVSG
AGKTTLSRFVAWMNGLSVYQIKVHRKYTGEDFDEDLRTVLRRSGCKNEKIAFIMDESNVL
DSGFLERMNTLLANGEVPGLFEGDEYATLMTQCKEGAQKEGLMLDSHEELYKWFTSQVIR
NLHVVFTMNPSSEGLKDRAATSPALFNRCVLNWFGDWSTEALYQVGKEFTSKMDLEKPNY
IVPDYMPVVYDKLPQPPSHREAIVNSCVFVHQTLHQANARLAKRGGRTMAITPRHYLDFI
NHYANLFHEKRSELEEQQMHLNVGLRKIKETVDQVEELRRDLRIKSQELEVKNAAANDKL
KKMVKDQQEAEKKKVMSQEIQEQLHKQQEVIADKQMSVKEDLDKVEPAVIEAQNAVKSIK
KQHLVEVRSMANPPAAVKLALESICLLLGESTTDWKQIRSIIMRENFIPTIVNFSAEEIS
DAIREKMKKNYMSNPSYNYEIVNRASLACGPMVKWAIAQLNYADMLKRVEPLRNELQKLE
DDAKDNQQKANEVEQMIRDLEASIARYKEEYAVLISEAQAIKADLAAVEAKVNRSTALLK
SLSAERERWEKTSETFKNQMSTIAGDCLLSAAFIAYAGYFDQQMRQNLFTTWSHHLQQAN
IQFRTDIARTEYLSNADERLRWQASSLPADDLCTENAIMLKRFNRYPLIIDPSGQATEFI
MNEYKDRKITRTSFLDDAFRKNLESALRFGNPLLVQDVESYDPVLNPVLNREVRRTGGRV
LITLGDQDIDLSPSFVIFLSTRDPTVEFPPDLCSRVTFVNFTVTRSSLQSQCLNEVLKAE
RPDVDEKRSDLLKLQGEFQLRLRQLEKSLLQALNEVKGRILDDDTIITTLENLKREAAEV
TRKVEETDIVMQEVETVSQQYLPLSTACSSIYFTMESLKQIHFLYQYSLQFFLDIYHNVL
YENPNLKGVTDHTQRLSIITKDLFQVAFNRVARGMLHQDHITFAMLLARIKLKGTVGEPT
YDAEFQHFLRGNEIVLSAGSTPRIQGLTVEQAEAVVRLSCLPAFKDLIAKVQADEQFGIW
LDSSSPEQTVPYLWSEETPATPIGQAIHRLLLIQAFRPDRLLAMAHMFVSTNLGESFMSI
MEQPLDLTHIVGTEVKPNTPVLMCSVPGYDASGHVEDLAAEQNTQITSIAIGSAEGFNQA
DKAINTAVKSGRWVMLKNVHLAPGWLMQLEKKLHSLQPHACFRLFLTMEINPKVPVNLLR
AGRIFVFEPPPGVKANMLRTFSSIPVSRICKSPNERARLYFLLAWFHAIIQERLRYAPLG
WSKKYEFGESDLRSACDTVDTWLDDTAKGRQNISPDKIPWSALKTLMAQSIYGGRVDNEF
DQRLLNTFLERLFTTRSFDSEFKLACKVDGHKDIQMPDGIRREEFVQWVELLPDTQTPSW
LGLPNNAERVLLTTQGVDMISKMLKMQMLEDEDDLAYAETEKKTRTDSTSDGRPAWMRTL
HTTASNWLHLIPQTLSHLKRTVENIKDPLFRFFEREVKMGAKLLQDVRQDLADVVQVCEG
KKKQTNYLRTLINELVKGILPRSWSHYTVPAGMTVIQWVSDFSERIKQLQNISLAAASGG
AKELKNIHVCLGGLFVPEAYITATRQYVAQANSWSLEELCLEVNVTTSQGATLDACSFGV
TGLKLQGATCNNNKLSLSNAISTALPLTQLRWVKQTNTEKKASVVTLPVYLNFTRADLIF
TVDFEIATKEDPRSFYERGVAVLCTE
Sequence of entity 2 (B, C), FASTA
>9YNE_2 Platelet-activating factor acetylhydrolase IB subunit beta (chains B, C)
MVLSQRQRDELNRAIADYLRSNGYEEAYSVFKKEAELDVNEELDKKYAGLLEKKWTSVIR
LQKKVMELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVF
SVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQ
GFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMV
RPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSE
TKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDK
TLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR
Sequence of entity 3 (D, E), FASTA
>9YNE_3 Cytoplasmic dynein 1 intermediate chain 2 (chains D, E)
MSDKSELKAELERKKQRLAQIREEKKRKEEERKKKETDQKKEAVAPVQEESDLEKKRREA
EALLQSMGLTPESPIVFSEYWVPPPMSPSSKSVSTPSEAGSQDSGDGAVGSRTLHWDTDP
SVLQLHSDSDLGRGPIKLGMAKITQVDFPPREIVTYTKETQTPVMAQPKEDEEEDDDVVA
PKPPIEPEEEKTLKKDEENDSKAPPHELTEEEKQQILHSEEFLSFFDHSTRIVERALSEQ
INIFFDYSGRDLEDKEGEIQAGAKLSLNRQFFDERWSKHRVVSCLDWSSQYPELLVASYN
NNEDAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSATFAKFHPNLVVGGTYSGQIVLW
DNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHPQD
SMELVHKQSKAVAVTSMSFPVGDVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQGPIT
GIHCHAAVGAVDFSHLFVTSSFDWTVKLWTTKNNKPLYSFEDNADYVYDVMWSPTHPALF
ACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRWTHSGREIAVGDSEGQIVIYDVG
EQIAVPRNDEWARFGRTLAEINANRADAEEEAATRIPA
Sequence of entity 4 (F, G), FASTA
>9YNE_4 Dynactin subunit 1 (chains F, G)
MAQSKRHVYSRTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGV
ILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLRRE
GTDSNAKTSKLRGPKPKKAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSS
SEPSTPAQTPLAAPIIPTPALTSPGAAPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAE
DKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADT
ADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQL
KQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAE
STIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARE
TELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEA
SVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPG
GDHDCVLVLLLMPRLICKAELIRKQAQEKFDLSENCSERPGLRGAAGEQLSFAAGLVYSL
SLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPL
TKAIKYYQHLYSIHLAEQPEDSTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEASDI
ALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGAQVSDTLLDCRKHLTWVVAV
LQEVAAAAAQLIAPLAENEGLPVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTM
NKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLK
IKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQ
ADIDQLEAEKAELKQRLNSQSKRTIEGIRGPPPSGIATLVSGIAGEEQQRGGAPGQAPGI
VPGPGLVKDSPLLLQQISAMRLHISQLQHENSVLKGAQMKASLAALPPLHVAKLSLPPHE
GPGSELAAGALYRKTNQLLETLNQLSTHTHVVDITRSSPAAKSPSAQLLEQVTQLKSLSD
TIEKLKDEVLKETVSQRPGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGLG
QRHRLVLTQEQLHQLHDRLIS
Sequence of entity 5 (d, i), FASTA
>9YNE_5 Dynein light chain 1, cytoplasmic (chains d, i)
MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKEFDKKYNPTWHCIVGR
NFGSYVTHETKHFIYFYLGQVAILLFKSG
Sequence of entity 6 (k, v), FASTA
>9YNE_6 Dynein light chain Tctex-type 1 (chains k, v)
MEDYQAAEETAFVVDEVSNIVKEAIESAIGGNAYQHSKVNQWTTNVVEQTLSQLTKLGKP
FKYIVTCVIMQKNGAGLHTASSCFWDSSTDGSCTVRWENKTMYCIVSAFGLSI
Sequence of entity 7 (u), FASTA
>9YNE_7 Cytoplasmic dynein 1 light intermediate chain 2 (chains u)
MAPVGVEKKLLLGPNGPAVAAAGDLTSEEEEGQSLWSSILSEVSTRARSKLPSGKNILVF
GEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLK
FAVSAESLPETLVIFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKD
FQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLGDNVLTHNLGIPVLVVCTKCDAVSVL
EKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTYGFHFTTPA
LVVEKDAVFIPAGWDNEKKIAILHENFTTVKPEDAYEDFIVKPPVRKLVHDKELAAEDEQ
VFLMKQQSLLAKQPATPTRASESPARGPSGSPRTQGRGGPASVPSSSPGTSVKKPDPNIK
NNAASEGVLASFFNSLLSKKTGSPGSPGAGGVQSTAKKSGQKTVLSNVQEELDRMTRKPD
SMVTNSSTENEA
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| MG | Magnesium ion | Mg | 2 |
| ATP | Adenosine-5'-triphosphate | C10 H16 N5 O13 P3 | 1 |
| ADP | Adenosine-5'-diphosphate | C10 H15 N5 O10 P2 | 3 |
Primary citation
Roles of microtubules and LIS1 in dynein transport machinery assembly. Rao, Q., Yang, J., Chai, P. et al. Nature (2026) 652:1384-1392. DOI 10.1038/s41586-026-10153-y · PubMed
Other PDB entries of the same protein (UniProt Q14204), best resolution first:
- 5OWO 1.79 Å, Human cytoplasmic Dynein N-Terminus dimerization domain at 1.8 Angstrom resolution
- 9BLZ 2.2 Å, State-1(phi motor) of full-length human dynein-1 in 5mM ATP
- 9BMR 2.6 Å, State-1 of motor domain from full-length human phi dynein-1 in 5 mM ADP
- 9DH5 2.6 Å, State-1 of the motor domain from full-length human dynein-1 in 5mM AMPPNP with 5mM Mg2+
- 9E0X 2.7 Å, Cryo-EM structure of Phi dynein
- 9E10 2.71 Å, Dimeric motor domains from phi dynein-1 under Lis1 condition
- 9BM0 2.8 Å, State-2 of motor domain from full-length human dynein-1 in 5mM ATP
- 9BMF 2.8 Å, State-1(phi motor) of full-length human dynein-1 in 5mM ATPVi
- 9BMH 2.8 Å, State-4 of motor domain from full-length human dynein-1 in 5mM ATPVi
- 9BN3 2.8 Å, The alpha registry-locked dynein motor domain mutant in 5mM ATP condition, class1
- 9BM2 2.82 Å, State-4 of motor domain from full-length human dynein-1 in 5 mM ATP
- 9BMG 2.86 Å, State-2 of full-length human dynein-1 in 5mM ATPVi
Browse structure collections
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