Dynactin subunit 1 (DCTN1) is a 1278-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q14203.
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The mean pLDDT of this model is 76.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 28% |
| 70 to 90 | Confident: backbone generally right | 49% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 16% |
What pLDDT means and how to read it
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the…
Monomer and homodimer (PubMed:23874158). Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The…
Cytoplasm, Cytoplasm, cytoskeleton, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole, Cytoplasm, cytoskeleton, spindle, Nucleus envelope, Cytoplasm, cell cortex
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1TXQ | X-ray | 1.8 Å | A=15-107 |
| 2HQH | X-ray | 1.8 Å | A/B/C/D=15-107 |
| 2HKQ | X-ray | 1.86 Å | B=18-111 |
| 2HKN | X-ray | 1.87 Å | A/B=18-111 |
| 2HL5 | X-ray | 1.93 Å | C/D=18-111 |
| 2HL3 | X-ray | 2.03 Å | A/B=18-111 |
| 3TQ7 | X-ray | 2.3 Å | P/Q=27-97 |
| 3E2U | X-ray | 2.6 Å | A/B/C/D=18-111 |
| 9B7J | EM | 3.49 Å | S/s=1-1278 |
| 9YND | EM | 4.26 Å | H/I=1-1278 |
| 9YNH | EM | 5.5 Å | W/X=1-1278 |
| 9YNE | EM | 8.46 Å | F/G=1-1278 |
| 2COY | NMR | A=1-99 |
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