MAP domain-containing protein (SAV2205) is a 141-residue protein from Staphylococcus aureus (strain Mu50 / ATCC 700699). This is its AlphaFold structure prediction, created 1 Jun 2022. UniProt accession: A0A0H3K0M1.
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The mean pLDDT of this model is 77.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 51% |
| 70 to 90 | Confident: backbone generally right | 18% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 25% |
What pLDDT means and how to read it
Serine protease inhibitor that acts as an innate immune evasion factor (PubMed:25161283, PubMed:29114958, PubMed:31622584, PubMed:32303641, PubMed:37269950). Specifically inhibits CTSG and ELANE, the most abundant neutrophil serine proteases (PubMed:25161283, PubMed:29114958, PubMed:31622584, PubMed:32303641, PubMed:37269950). Required both to inhibit the activity of neutrophils and protect S.aureus immune evasion proteins from degradation by neutrophil serine proteases (PubMed:26418545)
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6VTM | X-ray | 1.6 Å | B/E/F/H=43-141 |
| 1YN4 | X-ray | 1.8 Å | A=43-141 |
| 4NZL | X-ray | 1.85 Å | B=43-141 |
| 8GDH | NMR | A=31-141 |
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