BICD family-like cargo adapter 1 (Bicdl1) is a 577-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: A0JNT9.
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The mean pLDDT of this model is 75.2 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 50% |
| 70 to 90 | Confident: backbone generally right | 16% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 27% |
What pLDDT means and how to read it
Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor (PubMed:29420470, PubMed:33734450, PubMed:36071160). Component of secretory vesicle machinery in developing neurons that acts as a regulator of neurite outgrowth. Regulates the secretory vesicle transport by controlling the accumulation…
Part of a tripartite complex with dynein and dynactin, acts an adapter linking the dynein motor complex and dynactin (PubMed:29420470, PubMed:33734450, PubMed:36071160). Interacts with KIF1C. Interacts with RAB6A and RAB6B; interaction is specific to Rab6
Cytoplasm, cytoskeleton, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7Z8I | EM | 3.3 Å | X/x=1-577 |
| 7Z8M | EM | 3.37 Å | X=1-577 |
| 6F1U | EM | 3.4 Å | X/x=1-577 |
| 6F1T | EM | 3.5 Å | X/x=1-325 |
| 7Z8J | EM | 3.93 Å | X/x=1-577 |
| 6ZNM | EM | 4.1 Å | X/x=1-325 |
| 7Z8K | EM | 4.37 Å | W/X/w/x=1-577 |
| 9DGU | EM | 7.1 Å | a/b/c/d=1-577 |
| 9DGT | EM | 7.2 Å | c/d=1-577 |
| 7Z8F | EM | 20.0 Å | W/X/w/x=1-577 |
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